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Sickle Cell Anemia News
July 20, 2023

Top Headlines

CRISPR and Single-Cell Sequencing Pinpoint Causal Genetic Variants for Traits and Diseases

A major challenge in human genetics is understanding which parts of the genome drive specific traits or contribute to disease risk. This challenge is even greater for genetic variants found in the 98% of the genome that does not encode proteins. A ...

Prime Editing Shows Proof of Concept for Treating Sickle Cell Disease

Scientists showed how prime editing can correct mutations that cause sickle cell disease in a potentially curative ...

A Link Between Hypoxia and Fetal Hemoglobin Provides Hope for Sickle Cell Disease

Scientists found the cellular response to low oxygen also increases fetal hemoglobin expression in adults, which could lead to novel treatments for some common genetic ...

CRISPR Gene Editing Reveals Biological Mechanism Behind Common Blood Disorder

Researchers have used CRISPR gene editing -- a type of 'molecular scissors' -- to understand how deletions in one area of the genome can affect the expression of nearby genes. The work will help researchers investigate new therapeutic approaches for ...
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Latest Headlines
updated 10:59pm EDT

Earlier Headlines

'Spleen-on-a-Chip' Yields Insight Into Sickle Cell Disease

Researchers have designed a microfluidic device, or 'spleen-on-a-chip,' that can model how the spleen's filters become clogged by sickled red blood cells, leading to a life-threatening ...

New Technique May Lead to Safer Stem Cell Transplants

对小鼠的研究中,研究人员已经开发出一种方法of stem cell transplantation that does not require radiation or chemotherapy. Instead, the strategy takes an immunotherapeutic approach, combining ...

Trials Reveal Efficacy and Safety of Oral Drug for Treating Anemia Associated With Kidney Disease

Pooled results from phase 3 clinical trials demonstrate that roxadustat is efficacious and may be comparable to placebo in studies done to date for treating anemia in patients with chronic kidney ...

Researchers Develop Proof-of-Concept Treatment That Elevates Adult and Fetal Hemoglobin

Researchers have developed a proof-of-concept treatment for blood disorders like sickle cell disease and beta-thalassemia that could raise hemoglobin levels by activating production of both fetal and ...

Researchers Speed Identification of DNA Regions That Regulate Gene Expression

Scientists have developed a highly efficient method to address a major challenge in biology -- identifying the genetic 'switches' that regulate gene ...

Toward a Reliable Oral Treatment for Sickle Cell Disease

For those who have sickle cell disease, there are only a few treatment options, which include bone marrow transplants, gene therapy or other treatments that address a subset of symptoms. Now, ...

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A Better Treatment for Sickle Cell Disease

Sickle cell disease is the most prevalent inherited blood disorder in the world, affecting 70,000 to 100,000 Americans. However, it is considered an orphan disease, meaning it impacts less than ...

Standard Vital Signs Could Help Estimate People's Pain Levels

一项新的研究表明,马赫ine-learning strategies can be applied to routinely collected physiological data, such as heart rate and blood pressure, to provide clues about pain levels in people ...

Sickle Cell Disease: Addressing a Complex World of Pain in a Single Gene Difference

A new review analyzes disparities in experience and treatment of sickle cell ...

Nutrition, Companionship Reduce Pain in Mice With Sickle Cell Disease

Researchers have found that an enriched diet and companionship can reduce pain in mice with sickle cell disease by increasing serotonin. They also discovered that duloxetine, an antidepressant that ...

CRISPR Technology to Cure Sickle Cell Disease

一个新的文章报道两个病人具有吸引力r to have been cured of beta thalassemia and sickle cell disease after their own genes were edited with CRISPR-Cas9 technology. The two researchers who ...

As Genome-Editing Trials Become More Common, Informed Consent Is Changing

As public interest and expanded research in human genome editing grows, many questions remain about ethical, legal and social implications of the technology. People who are seriously ill may ...

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How Dantu Blood Group Protects Against Malaria, and How All Humans Could Benefit

The secret of how the Dantu genetic blood variant helps to protect against malaria has been revealed for the first time. The team found that red blood cells in people with the rare Dantu blood ...