Simulating the shear destruction of red blood cells

Devices used to treat heart failure can create flows that damage red blood cells but understanding the particle dynamics at play may minimize the effect

Date:: November 1, 2022
Source:: American Institute of Physics
Summary:: 红细胞的破坏,或机械hemolysis, is an inevitable complication of interventional devices, so scientists want to gain a better understanding of the phenomenon. Researchers develop a red blood cell destruction model based on simulations of dissipative particle dynamics within a high shear flow. The team discovered that acceleration during shearing is a major factor in red blood cell destruction, beyond exposure time and shear stress. They recommend adding a flow buffer structure to the structural design of ventricular assist devices to reduce part of the hemolysis caused by shear acceleration.
Share:: Facebook Twitter Pinterest LinkedIN Email

FULL STORY

Many medical devices for treating heart failure generate nonphysiological shear flow. This can trigger the destruction of red blood cells after implantation of ventricular assist devices (VADs), artificial heart valves, vascular stents, or interventional thrombectomy devices.

红细胞的破坏,或机械hemolysis, is an inevitable complication of interventional devices, so scientists want to gain a better understanding of the phenomenon.

InPhysics of Fluids, from AIP Publishing, researchers from Tsinghua University developed a red blood cell destruction model based on simulations of dissipative particle dynamics within a high shear flow. They used the results to make recommendations for improvements of VADs.

"After interventional medical devices are implanted inside the human body, the nearby flow field generates a shear flow with a very high shear rate," said co-author Xiwen Zhang. "The velocity change rate of the fluid will deform the red blood cell membrane. Eventually, deformation of the membrane exceeds the ultimate strain, and the membrane is disrupted by shear flow."

The team discovered that acceleration during shearing is a major factor in red blood cell destruction, beyond exposure time and shear stress. They recommend adding a flow buffer structure to the structural design of VADs to reduce part of the hemolysis caused by shear acceleration.

For hemolysis-related research, many researchers focus on macroscale experiments to obtain a series of empirical fitting formulas.

"But our team is exploring the shear destruction process of red blood cells in more detail at the red blood cell scale by using dissipative particle dynamics," said Zhang.

"We hope our study can serve as a bridge between macroscopic hemolysis experiments and microscopic red blood cell simulations (molecular dynamics simulations)," said Zhang. "In future work, we will continue constructing shear failure models of multiple red blood cells and perform shear failure simulations based on whole blood to be able to compare them with macroscopic hemolysis experiments."

The researchers are currently developing a new index to predict the hemolysis of VADs more accurately and help optimize the shape of VADs, which should improve hydraulic performance and reduce hemolysis.

They plan to better represent the diffusion process of hemoglobin after shear damage by adding a transport dissipation particle dynamics model based on this work.