A pheromone-sensing gene that predates land-dwelling vertebrates

Most land-dwelling vertebrates have both an olfactory organ that detects odors and a vomeronasal organ that detects pheromones, which elicit social and sexual behaviors. It has traditionally been believed that the vomeronasal organ evolved when vertebrates transitioned from living in water to living on land. New research by Masato Nikaido and colleagues at Tokyo Tech, however, suggests that this organ may be much older than previously believed.

The vomeronasal organ contains receptors in the V1R protein family that are crucial for pheromone detection. Nikaido et al. identified a gene,ancV1R, that encodes a previously unknown member of the V1R family. However, unlike other V1R genes,ancV1Ris present not only in land-dwelling vertebrates but also in some fish lineages, indicating that it has been conserved over 400 million years of vertebrate evolution. According to Nikaido, this finding was "quite surprising, as this represents the first discovery of a V1R family gene shared between fish and mammals."

The authors identifiedancV1Rin 56 of 115 vertebrate genomes. Interestingly, the loss ofancV1Rin some vertebrate lineages, such as higher primates (including humans, chimpanzees, and gorillas), cetaceans (including whales and dolphins), birds, and crocodiles, corresponds with the loss of the vomeronasal organ in these lineages. The findings suggest not only thatancV1Rmay be a vital component of the vomeronasal organ, but also that this organ predates the transition of vertebrates to land, opening a new avenue of research into its origin.

ancV1Ris also unusual in that it is expressed in most vomeronasal sensory neurons. In contrast, other V1R proteins follow a "one neuron-one receptor" rule, with only a single receptor being expressed in each neuron. This further demonstrates the importance ofancV1Rin pheromone sensing. As noted by Nikaido, "It will be fascinating to further investigate how these patterns of expression are regulated and to determine their functional role in chemosensory signaling."