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First computational reconstruction of a virus in its biological entirety

Date:
January 20, 2023
Source:
Aston University
Summary:
A researcher has created a computer reconstruction of a virus, including its complete native genome. Although other researchers have created similar reconstructions, this is believed to be the first to replicate the exact chemical and 3D structure of a 'live' virus.
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An Aston University researcher has created the first ever computer reconstruction of a virus, including its complete native genome.

Although other researchers have created similar reconstructions, this is the first to replicate the exact chemical and 3D structure of a 'live' virus.

The breakthrough could lead the way to research into an alternative to antibiotics, reducing the threat of anti-bacterial resistance.

The researchReconstruction and validation of entire virus model with complete genome from mixed resolution cryo-EM densityby Dr Dmitry Nerukh, from the Department of Mathematics in the College of Engineering and Physical Sciences at Aston University is published in the journalFaraday Discussions.

The research was conducted using existing data of virus structures measured via cryo-Electron Microscopy (cryo-EM), and computational modelling which took almost three years despite using supercomputers in the UK and Japan.

The breakthrough will open the way for biologists to investigate biological processes which can't currently be fully examined because the genome is missing in the virus model.

This includes finding out how a bacteriophage, which is a type of virus that infects bacteria, kills a specific disease-causing bacterium.

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At the moment it is not known how this happens, but this new method of creating more accurate models will open up further research into using bacteriophage to kill specific life-threatening bacteria.

This could lead to more targeted treatment of illnesses which are currently treated by antibiotics, and therefore help to tackle the increasing threat to humans of antibiotic resistance.

Dr Nerukh said: "Up till now no one else had been able to build a native genome model of an entire virus at such detailed (atomistic) level.

"The ability to study the genome within a virus more clearly is incredibly important. Without the genome it has been impossible to know exactly how a bacteriophage infects a bacterium.

"This development will now allow help virologists answer questions which previously they couldn't answer.

“这可能会导致杀死英航有针对性的治疗cteria which are dangerous to humans, and to reduce the global problem of antibiotic-resistant bacteria which are over time becoming more and more serious."

The team's approach to the modelling has many other potential applications. One of these is creating computational reconstructions to assist cryo-Electron Microscopy -- a technique used to examine life-forms cooled to an extreme temperature.

Story Source:

Materialsprovided byAston University.注:内容可以编辑为圣yle and length.


Journal Reference:

  1. Vladimir S. Farafonov, Michael Stich, Dmitry Nerukh.Reconstruction and validation of entire virus model with complete genome from mixed resolution cryo-EM density.Faraday Discussions, 2022; 240: 152 DOI:10.1039/d2fd00053a

Cite This Page:

Aston University. "First computational reconstruction of a virus in its biological entirety." ScienceDaily. ScienceDaily, 20 January 2023. .
Aston University. (2023, January 20). First computational reconstruction of a virus in its biological entirety.ScienceDaily. Retrieved August 1, 2023 from www.koonmotors.com/releases/2023/01/230120131300.htm
Aston University. "First computational reconstruction of a virus in its biological entirety." ScienceDaily. www.koonmotors.com/releases/2023/01/230120131300.htm (accessed August 1, 2023).

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