Scientists have found a way to prove that biochemical signals sent from cell to cell play an important role in determining how those cells develop.
The study from researchers at the USC Dornsife College of Letters, Arts and Sciences was published in the journalDevelopmenton Dec. 22.
A little background
What's new
"We discovered that the communication process can change the formation of blood cell types dramatically, and that cells that are closer to one another have a greater influence on each other's fate," MacLean said.
A controversy resolved
早期研究人员试图确定什么因素nudge a cell down one developmental path or another have wondered if random fluctuations within the cell are enough to decide which path is taken. Many models have suggested they were, but recent breakthrough studies showed that random fluctuations were not enough, that something else drives cells toward their fate.
The model MacLean and Rommelfanger have developed appears to put an end to the controversy altogether. They show that cell-to-cell communication can, in fact, be the deciding factor that sets cells along a certain path.
"By understanding how blood cell fate decisions are made," MacLean said, "we get closer to being able to identify leukemia cells of origin, and in theory we can design strategies to control or alter cell fate decision-making and stop the development of cancer."
The research could help improve cancer therapies such as bone marrow transplant.
"Better understanding stem cell fate decisions, as our study provides, could provide new insight to improve clinical outcomes for these diseases," MacLean said.
This new model has important implications beyond the blood system.
"Our model is broadly applicable, so researchers working on other cell types can apply it to find out for those other cells how important cell-to-cell communication may be," said MacLean.
What's next
The role of cell-to-cell communication in determining cell fate is in its nascent stages, says MacLean, but further experiments -- and future technologies to integrate these new types of data with sophisticated models -- should help expand understanding.
In addition, the team is developing methods to study the regulation of key genes involved in cell fate decisions, which should further advance their overall theoretical model.
About the study
This work was supported by National Science Foundation grant DMS 2045327 and a USC Women in Science and Engineering Top-up Fellowship.
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Materialsprovided byUniversity of Southern California. Original written by Darrin S. Joy.Note: Content may be edited for style and length.
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