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Scientists reveal how gut microbes can influence bone strength in mice

Date:
2021年1月12日
Source:
eLife
Summary:
Gut microbes passed from female mice to their offspring, or shared between mice that live together, may influence the animals' bone mass.
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Gut microbes passed from female mice to their offspring, or shared between mice that live together, may influence the animals' bone mass, says a new study published today ineLife.

The findings suggest that treatments which alter the gut microbiome could help improve bone structure or treat conditions that weaken bones, such as osteoporosis.

“遗传学账户佛r most of the variability in human bone density, but non-genetic factors such as gut microbes may also play a role," says lead author Abdul Malik Tyagi, Assistant Staff Scientist at the Division of Endocrinology, Metabolism, and Lipids at Emory Microbiome Research Center, Emory University, Georgia, US. "We wanted to investigate the influence of the microbiome on skeletal growth and bone mass development."

To do this, Tyagi and colleagues studied mice that lacked any gut microbes. They transferred fecal material containing a gut microbe called segmented filamentous bacteria (SFB), which stimulates the breakdown of bone, into the animals. Their studies revealed that the offspring of the SFB-treated mice were colonised with these bacteria at birth and had poorer bone structure than identical mice that lacked SFB.

Additionally, mice that lived with others carrying SFB became colonised with the bacteria within four weeks, and developed poorer bone structure as a result. "Our work shows that microbes can be either inherited or transmitted between individuals and significantly affects skeletal development in the animals," Tyagi says.

"Further studies are now needed to determine if the same is true in humans," adds senior author Roberto Pacifici, Garland Herndon Professor of Medicine, and Director of the Division of Endocrinology, Metabolism, and Lipids, at Emory University. "If it is, then it could be possible to develop therapies that change the gut microbiome early in life to allow for healthy skeletal growth.

"It would also suggest the need for caution in the current use of fecal transplants to treat other conditions in patients, to ensure that bone-weakening bacteria aren't inadvertently introduced," Pacifici concludes.

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Materialsprovided byeLife.Note: Content may be edited for style and length.


Journal Reference:

  1. Abdul Malik Tyagi, Trevor M Darby, Emory Hsu, Mingcan Yu, Subhashis Pal, Hamid Dar, Jau-Yi Li, Jonathan Adams, Rheinallt M Jones, Roberto Pacifici.The gut microbiota is a transmissible determinant of skeletal maturation.eLife, 2021; 10 DOI:10.7554/eLife.64237

Cite This Page:

eLife. "Scientists reveal how gut microbes can influence bone strength in mice." ScienceDaily. ScienceDaily, 12 January 2021. /releases/2021/01/210112110053.htm>.
eLife. (2021, January 12). Scientists reveal how gut microbes can influence bone strength in mice.ScienceDaily. Retrieved August 17, 2023 from www.koonmotors.com/releases/2021/01/210112110053.htm
eLife. "Scientists reveal how gut microbes can influence bone strength in mice." ScienceDaily. www.koonmotors.com/releases/2021/01/210112110053.htm (accessed August 17, 2023).

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