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June 14, 2022 —Valproic acid -- a drug used to treat epilepsy, migraine, and bipolar disorder -- can cause birth defects when taken during pregnancy. Now, a study reveals one reason why: valproic acid (VPA) puts ...
Nov. 30, 2020 —Research findings provide insight into the complex mechanism of cellular senescence and present a potential therapeutic strategy for reducing age-related diseases associated with the accumulation of ...
July 6, 2021 —Researchers have revealed the mechanisms by which cells enter senescence because of an imbalance in the number of chromosomes. Chromosomal instability is a common trait in most solid tumors, such as ...
Nov. 9, 2021 —Cancer researchers show for the first time that cellular senescence, which occurs when aging cells stop dividing, is caused by irreversible damage to the genome rather than simply by telomere ...
2022年1月6日-Extra chromosome alters chromosomal conformation and DNA accessibility across the whole genome in neural progenitor cells, disrupting gene transcription and cell functions much like in cellular ...
Mar. 7, 2022 —Researchers have shown that a protein called MondoA can activate the important health-linked process of autophagy, whereby cells are broken down and their components are recycled. MondoA both ...
Dec. 1, 2022 —Scientists have found that neurons from people with Alzheimer's disease show deterioration and undergo a late-life stress process called senescence. These neurons have a loss of functional ...
Dec. 8, 2021 —A study in mice has found that stress and tissue damage initiated by angiotensin II, a molecule that is known to increase blood pressure and stiffening in the linings of blood vessels, leads to ...
July 18, 2022 —Scientists have revealed a novel ADAR1-SIRT1-p16INK4a axis in regulating cellular senescence and its potential implications in tissue ...
Oct. 6, 2022 —Researchers have discovered a cellular partnership that drives the growth of deadly brain tumors and could potentially serve as a novel target for disease treatment. A new study has uncovered a ...