Concordia researchers studying body phenotypes -- the observable characteristics like height, behaviour, appearance and more measurables -- found that regardless of the muscle they had, high levels of fat mass in an individual were associated with poorer overall health.
The findings, published in the journalPreventive Medicine使用数据从一个美国纵向螺栓y. They show that the negative impact of excess adiposity -- fat tissue -- on a person's cardiometabolic health was not offset even by high levels of muscle mass.
The researchers based their study on data from NHANES, a cross-sectional representative sample of the US population collected between 1999 and 2006. The data was collected using dual energy X-ray absorptiometry (DEXA), a diagnostic framework that analyzes adiposity and muscle mass. Based on which side of the 50th percentile they ranked, individuals were categorized into one of four proposed phenotypes: low-adiposity/high-muscle, high-adiposity/high-muscle, low-adiposity/high-muscle or low-adiposity/low-muscle.
The researchers looked at how the adiposity/muscle phenotypes related to lipid levels, including cholesterol and triglycerides, as well as blood sugar glucose and blood pressure. Results were also adjusted for age, sex, race and education.
"We wanted to see whether this proposed categorization was better than the traditional body-mass index (BMI) at predicting all these different cardiometabolic outcomes," says Sylvia Santosa, an associate professor in the Department of Health, Kinesiology and Applied Physiology and one of the authors of the paper.
Surprisingly, they found BMI, though far from perfect, was in some cases a better predictor of cardiometabolic risks like diabetes and hypertension.
Associate professor Lisa Kakinami, Concordia alumna and current Rhodes Scholar Sabine Plummer, BSc 22, PhD student Jessica Murphy and Tamara Cohen of the University of British Columbia co-authored the paper.
Benefits of BMI
Nevertheless, the data did reveal several striking findings. In comparison to the low-adiposity/high-muscle group, which was the healthiest of the four, the researchers noted the following results:
"If we are looking at cardiometabolic risk at the population level, BMI can give you cheap and quick idea about what is happening," Santosa says.
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