疟疾、疾病主要是由寄生虫引起的Plasmodium falciparumandPlasmodium vivax, (P. vivax) is associated with over 400,000 deaths each year. Previously, the spleen was assumed to mostly play a role in parasite destruction, as it eliminates malaria parasites after antimalarial treatment. A study published in the open access journalPLOS Medicineby Steven Kho and Nicholas Anstey at Menzies School of Health Research, Australia, and international colleagues, suggests that in chronicP. vivaxinfections, malaria parasites survive and replicate via a previously undetected lifecycle within the spleen.
A large biomass of intact asexual-stage malaria parasites accumulates in the spleen of asymptomatic human subjects infected withPlasmodium vivax(P. vivax). However, the mechanisms underlying this intense reaction are unknown. To better understand the accumulation of malaria parasites in the spleen, researchers examined the spleen tissue in twenty-two individuals naturally exposed toP. vivaxandP. falciparumundergoing splenectomy in Papua, Indonesia between 2015-2017. The authors then analysed the density of infection, parasites and immature red blood cells, as well as their distribution throughout the spleen.
The researchers found that the human spleen is a reservoir for immature red blood cells that are targeted byP. vivaxfor invasion, and that the examined spleens contained a substantial hidden biomass of malaria parasites, with densities hundreds to thousands of times higher than in circulating peripheral blood, suggesting an undetectable endosplenic lifecycle in asymptomaticP. vivaxinfections. The study had several limitations, such as the small sample size and asymptomatic status of all individuals included in the study. Future research should include acute, symptomatic malaria cases.
According to the authors, "Our findings provide a major contribution to the understanding of malaria biology and pathology and provide insight intoP. vivaxspecific adaptations that have evolved to maximise survival and replication in the spleen."
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