Cells move by controlling the stiffness of their neighbors

The discovery may help scientists better understand how cells migrate during early development and what can happen to them to cause certain developmental disorders. It may also provide new insights on how cancer cells spread and help scientists develop new ways to slow or stop them.

Laboratory studies of cell migration have shown that cells move more quickly and easily across stiffer artificial surfaces, but whether the same conditions promote cell movement in living organisms was still unknown.

“理解的机制控制这个落下帷幕ance of forces between migrating cells and the surfaces they move across in living organisms is essential to understanding how developmental defects caused by aberrant migration and cancer metastasis occur," explains first author Maureen Lamb, Graduate Student at the Department of Anatomy and Cell Biology, University of Iowa Carver College of Medicine, Iowa City, US.

在更自然的circumstanc细胞运动的研究es, Lamb and the team examined the movement of cells in the ovaries of fruit flies. They looked specifically at what happened in cells that were genetically engineered to lack a protein called fascin, which regulates a cell-stiffening protein called myosin.

They found that in the cells lacking fascin, the activity of myosin increased, and both the cells and their neighbouring cells stiffened, hindering their movement. When the team restored fascin to the migrating cells, this led to normal myosin activity and stiffness of the neighbouring cells, which promoted cell movement. They also discovered a mechanism that cells can use to turn fascin on and off.

"We've shown that migrating cells use fascin to control the stiffness of surrounding cells, making it easier for them to move through the body," Lamb says.

The unexpected discovery that cells can control their ability to move by regulating the stiffness of surrounding cells may have important implications for understanding how cancer cells spread. When cancer spreads beyond the original tumour and forms metastases, it becomes more difficult to treat and reduces the patient's chances of survival.

"If cancer cells use the same mechanisms identified in our study, then it may be possible to reduce their spread by altering the tissues that they prefer to move across, so that the tissues don't stiffen in response to the cells," says senior author Tina Tootle, Associate Professor of Anatomy and Cell Biology at the University of Iowa Carver College of Medicine. "The next step is to test this idea in larger organisms to see if it could be a potential strategy to slow or prevent the spread of cancer."