Molecular Biology News -- ScienceDaily
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Molecular biology. Read the latest research on molecular biology or search thousands of news articles with images from leading universities and research institutes.
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Wed, 06 Sep 2023 14:53:28 EDT
Wed, 06 Sep 2023 14:53:28 EDT
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Molecular Biology News -- ScienceDaily
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For more science news, visit ScienceDaily.
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免疫细胞将比以前更独立ly thought
//www.koonmotors.com/releases/2023/09/230906112440.htm
Human immune cells are capable of coordinating their own movement more independently than previously thought. Researchers discovered that immune cells do not just passively follow the chemical cues in their environment. Quite the contrary, they can also shape these cues and navigate in complex environments in a self-organized manner.
Wed, 06 Sep 2023 11:24:40 EDT
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New ribozyme can make RNA molecules accessible for click chemistry in living cells
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Important progress for RNA research: A team has discovered a new ribozyme that can label RNA molecules in living cells.
Tue, 05 Sep 2023 12:50:07 EDT
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Deciphering the 'highway code' of our cells
//www.koonmotors.com/releases/2023/09/230905124935.htm
Cancers, degenerative diseases: deregulation of our cells' internal communication pathways is at the root of many conditions. Microtubules -- microscopic protein filaments -- play a crucial role in controlling these exchanges. However, their mechanisms remain poorly understood. A team has identified a new mechanism, involving two proteins, that governs their growth. The discovery opens up unprecedented prospects for the development of new treatments that can act at the very heart of cells.
Tue, 05 Sep 2023 12:49:35 EDT
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Immune cells shape their own path
//www.koonmotors.com/releases/2023/09/230901143610.htm
When fighting disease, our immune cells need to reach their target quickly. Researchers have now discovered that immune cells actively generate their own guidance system to navigate through complex environments. This challenges earlier notions about these movements. The researchers' findings enhance our knowledge of the immune system and offer potential new approaches to improve human immune response.
Fri, 01 Sep 2023 14:36:10 EDT
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Scientists unpick how lung cells induce immune response to influenza
//www.koonmotors.com/releases/2023/08/230831164228.htm
Researchers have discovered some new and surprising ways that viral RNA and influenza virus are detected by human lung cells, which has potential implications for treating people affected by such viruses.
Thu, 31 Aug 2023 16:42:28 EDT
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How some ion channels form structures permitting drug delivery
//www.koonmotors.com/releases/2023/08/230830131953.htm
成员的离子通道保护的一个重要的类eins can transiently rearrange itself into a larger structure with dramatically altered properties, according to a new study. The discovery is a significant advance in cell biology, likely solves a long-standing mystery about an unusual feature of some ion channels and has implications for the development of drugs targeting these proteins and for drug delivery.
Wed, 30 Aug 2023 13:19:53 EDT
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Bacteria treatment reduces insulin resistance, protects against diabetes
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研究人员发现一种肠道细菌that might help improve insulin resistance, and thus protect against the development of obesity and type-2 diabetes. The study involved genetic and metabolic analysis of human fecal microbiomes and then corroborating experiments in obese mice.
Wed, 30 Aug 2023 13:16:55 EDT
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Newly engineered versions of bacterial enzyme reveal how antibiotics could be more potent
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Researchers applied a new technology to generate the full inventory of mutations in the bacterial species Escherichia coli where the antibiotic rifampicin attaches to and disables an essential bacterial enzyme known as RNA polymerase (RNAP).
Wed, 30 Aug 2023 13:08:46 EDT
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Enhancing cancer therapy using functionalized photosynthetic bacteria
//www.koonmotors.com/releases/2023/08/230829125956.htm
Selective targeting of cancerous cells poses major clinical challenges during cancer therapy. However, this limitation can be overcome by using bioengineered bacteria with highly optimized chemical modifications. A recent study demonstrates the use of chemically modified purple photosynthetic bacteria for the successful detection and elimination of colon cancer cells in a mouse model. The study also sheds light on the underlying mechanism of action.
Tue, 29 Aug 2023 12:59:56 EDT
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New approach to fighting malaria
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Findings can open up new avenues for targeted approaches toward therapeutic strategies against the malaria-causing P. falciparum that are aimed at stopping the parasite's life cycle progression and its sexual differentiation, thus blocking the transmission of the parasite into mosquitoes.
Mon, 28 Aug 2023 16:23:49 EDT
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Unlocking the secrets of cell antennas
//www.koonmotors.com/releases/2023/08/230825140357.htm
The NSL (non-specific lethal) complex regulates thousands of genes in fruit flies and mammals. Silencing the NSL genes leads to the death of the organism, which gave the complex its curious name. Researchers have now discovered that the genes regulated by the NSL complex also include genes of the intraciliary transport system. This enables different cell types to form cilia on their surface, which are important for cell communication. The study shows that these genes are 'switched on' by the NSL complex, regardless of whether a particular cell has cilia or not. The researchers found that this class of cilia-associated genes is crucial for the function of podocytes. This is a highly specialized cell type of the kidney that, paradoxically, does not have cilia. These findings have important implications for ciliopathies and kidney disease.
Fri, 25 Aug 2023 14:03:57 EDT
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Researchers describe rebuilding, regenerating lung cells
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Researchers have discovered a novel approach for engrafting engineered cells into injured lung tissue. These findings may lead to new ways for treating lung diseases, such as emphysema, pulmonary fibrosis and COVID-19. The two studies describe the methodologies for engineering lung stem cells and transplanting them into injured experimental lungs without immunosuppression.
Thu, 24 Aug 2023 11:19:25 EDT
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The 'treadmill conveyor belt' ensuring proper cell division
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Researchers have discovered how proteins work in tandem to regulate 'treadmilling', a mechanism used by the network of microtubules inside cells to ensure proper cell division.
Thu, 24 Aug 2023 11:18:05 EDT
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Researchers target lifecycle of parasite behind Chagas disease
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Researchers are studying the signaling pathway that leads the parasite responsible for Chagas disease to transform and reproduce. They follow that pathway from the beginning when an uninfected kissing bug acquires the parasite by biting an infected mammal host all the way to the time the parasite develops in the insect's gut to be spread to people or animals through the bug's poop.
Wed, 23 Aug 2023 16:54:03 EDT
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Researchers unearth a new process by which algae pass on nurtrients to their coral host
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Researchers have identified a new pathway by which sugar is released by symbiotic algae. This pathway involves the largely overlooked cell wall, showing that this structure not only protects the cell but plays an important role in symbiosis and carbon circulation in the ocean.
Wed, 23 Aug 2023 12:26:36 EDT
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High-fat diets alter gut bacteria, boosting colorectal cancer risk in mice
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Researchers have discovered how high-fat diets can change gut bacteria and alter digestive molecules called bile acids that are modified by those bacteria, predisposing mice to colorectal cancer. The findings bring scientists closer to understanding the causes of and how to prevent colorectal cancer.
Tue, 22 Aug 2023 11:17:28 EDT
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Research team developing a nano-sized force sensor and improving high-precision microscopy technology
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Recent research in cell biology highlights groundbreaking results. An international team of researchers have recently established a tool they developed to study the mechanics of the cell. The tool can be used to study the inner forces of the cell, for example, the stretching of the nuclear membrane. The microscopic force sensor, only about 0.00002 mm long, is constructed of exotic ingredients such as spider web protein parts, fluorescent proteins from jellyfish, and antibodies from alpaca. In addition, the multidisciplinary team of researchers has developed further the sensitivity of super-resolution microscopy technique.
Mon, 21 Aug 2023 11:43:36 EDT
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'Viral relicts' in the genome could fuel neurodegeneration
//www.koonmotors.com/releases/2023/08/230821114333.htm
Genetic remnants of viruses that are naturally present in the human genome could affect the development of neurodegenerative diseases. Researchers come to this conclusion on the basis of studies on cell cultures.
Mon, 21 Aug 2023 11:43:33 EDT
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Ancient metal cauldrons give us clues about what people ate in the Bronze Age
//www.koonmotors.com/releases/2023/08/230818135141.htm
Archaeologists have long been drawing conclusions about how ancient tools were used by the people who crafted them based on written records and context clues. But with dietary practices, they have had to make assumptions about what was eaten and how it was prepared. A new study analyzed protein residues from ancient cooking cauldrons and found that the people of Caucasus ate deer, sheep, goats, and members of the cow family during the Maykop period (3700--2900 BCE).
Fri, 18 Aug 2023 13:51:41 EDT
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Increasing legumes and reducing red meat is safe for bone health and protein intake
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A study has demonstrated that the partial substitution of red and processed meat with pea- and faba bean -- based food products ensured sufficient intake of amino acids in the diet and did not negatively affect bone metabolism.
Fri, 18 Aug 2023 13:49:59 EDT
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Scientists reveal how sensory protein changes shape with nanometer resolution
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The sensory receptor PIEZO1 changes shape in response to mechanical stimuli. The super high-resolution microscopy technology used in this discovery is a breakthrough in enabling protein structures to be studied within the cellular environment.
Wed, 16 Aug 2023 16:00:32 EDT
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Molecules in vegetables can help to ease lung infection
//www.koonmotors.com/releases/2023/08/230816114227.htm
Researchers have found that molecules in vegetables like broccoli or cauliflower help to maintain a healthy barrier in the lung and ease infection.
Wed, 16 Aug 2023 11:42:27 EDT
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Building muscle in the lab
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A new method allows large quantities of muscle stem cells to be safely obtained in cell culture. This provides a potential for treating patients with muscle diseases -- and for those who would like to eat meat, but don't want to kill animals.
Wed, 16 Aug 2023 11:41:21 EDT
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Scientists discover external protein network can help stabilize neural connections
//www.koonmotors.com/releases/2023/08/230816114059.htm
The Noelin family of secreted proteins bind to the external portion of AMPA glutamate receptors and stabilize them on the neuronal cellular membrane, a process necessary for transmission of full-strength signals between neurons, according to a new study.
Wed, 16 Aug 2023 11:40:59 EDT
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Oxygen charge for battling multidrug-resistant pathogens
//www.koonmotors.com/releases/2023/08/230816113637.htm
In antibacterial photodynamic therapy, irradiation is used to produce reactive oxygen species that kill off bacteria. Because it requires external light and oxygen, this method is only suitable for surface infections. A research team has now introduced a molecular 'singlet oxygen battery' that can be 'charged' with reactive oxygen, which it then releases in deep tissue layers to target methicillin-resistant staphylococcus.
Wed, 16 Aug 2023 11:36:37 EDT
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Study explains how part of the nucleolus evolved
//www.koonmotors.com/releases/2023/08/230815131858.htm
Biologists discovered that a scaffolding protein called TCOF1 is responsible for the formation of a biomolecular condensate called the fibrillar center, which forms within the cell nucleolus.
Tue, 15 Aug 2023 13:18:58 EDT
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Images of enzyme in action reveal secrets of antibiotic-resistant bacteria
//www.koonmotors.com/releases/2023/08/230814174547.htm
Advanced microscopy techniques give scientists valuable clues for how to fight an enzyme that is leading to a rise in cases of antibiotic-resistant bacterial infections worldwide.
Mon, 14 Aug 2023 17:45:47 EDT
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Making plant-based meat alternatives more palatable
//www.koonmotors.com/releases/2023/08/230814122358.htm
One of the biggest obstacles to the uptake of plant-based alternatives to meat is their very dry and astringent feel when they are eaten. Scientists are now revolutionizing the sensation of plant proteins, transforming them from a substance that can be experienced as gloopy and dry to one that is juicy and plump. And the only substance they are adding to the plant proteins is water.
Mon, 14 Aug 2023 12:23:58 EDT
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Distribution of genetic information during bacterial cell division
//www.koonmotors.com/releases/2023/08/230814122339.htm
A mathematical model provides new insights into the distribution of genetic information during bacterial cell division
Mon, 14 Aug 2023 12:23:39 EDT
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3D-printed vegan seafood could someday be what's for dinner
//www.koonmotors.com/releases/2023/08/230814122218.htm
More mock seafood options are needed because of unsustainable fishing and aquaculture practices, which can harm the environment. Now, researchers have a new approach for creating desirable vegan seafood mimics that taste good, while maintaining the healthful profile of real fish. They 3D-printed an ink made from microalgae protein and mung bean protein, and their proof-of-concept calamari rings were air-fried into a snack.
Mon, 14 Aug 2023 12:22:18 EDT
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The positional transmitter of statoliths unveiled: It keeps plants from getting lazy
//www.koonmotors.com/releases/2023/08/230810141032.htm
Plants orient their organs in response to the gravity vector, with roots growing towards gravity and shoots growing in the opposite direction. The movement of statoliths responding to the inclination relative to the gravity vector is employed for gravity sensing in both plants and animals. However, in plants, the statolith takes the form of a high-density organelle, known as an amyloplast, which settles toward gravity within the gravity sensing cell. Despite the significance of this gravity sensing mechanism, the exact process behind it has eluded scientists for over a century.
Thu, 10 Aug 2023 14:10:32 EDT
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Biologists find what colors a butterfly's world
//www.koonmotors.com/releases/2023/08/230810141002.htm
As butterflies flit among flowers, they don't all view blossoms the same way. In a phenomenon called sexually dimorphic vision, females of some butterfly species perceive ultraviolet color while the males see light and dark. Biologists have discovered that in at least one species, the variation results from a vision gene's jump onto a sex chromosome. It's the first known finding that this kind of genetic change causes sexually dimorphic vision.
Thu, 10 Aug 2023 14:10:02 EDT
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A therapeutic target for Alzheimer's disease discovered
//www.koonmotors.com/releases/2023/08/230810110325.htm
Scientists have succeeded in reversing certain cognitive manifestations associated with Alzheimer's disease in an animal model of the disease.
Thu, 10 Aug 2023 11:03:25 EDT
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Researchers find new pathway for HIV invasion of cell nucleus
//www.koonmotors.com/releases/2023/08/230810110313.htm
A study has identified a new pathway that human immune deficiency virus (HIV) uses to enter the nucleus of a healthy cell, where it can then replicate and go on to invade other cells.
Thu, 10 Aug 2023 11:03:13 EDT
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Synthetic antibiotic could be effective against drug-resistant superbugs
//www.koonmotors.com/releases/2023/08/230809164729.htm
A scientific journey decades in the making has found a new antibiotic strategy to defeat gram-negative bacteria like Salmonella, Pseudomonas and E. coli, the culprits in many urinary tract infections. The synthetic molecule works fast and is durable. It interferes with synthesis of the bacterial outer membrane by jamming an enzyme. When tested against a clinical collection of 285 bacterial strains, including some that were highly resistant to commercial antibiotics, it killed them all.
Wed, 09 Aug 2023 16:47:29 EDT
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Surprising discovery of low-noise genes
//www.koonmotors.com/releases/2023/08/230809164644.htm
While engaging in cell division research, researchers made a surprisingly quiet discovery. When cells express RNA, there is always some fluctuation, or noise, in how much RNA is produced. The scientists found several genes whose noise dips below a previously established threshold, known as the noise floor, during expression.
Wed, 09 Aug 2023 16:46:44 EDT
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Treatments for poxviruses -- including those causing mpox and smallpox -- may already exist in licensed drugs
//www.koonmotors.com/releases/2023/08/230809130610.htm
The drug tecovirimat is currently in use for the treatment of mpox -- the disease caused by monkeypox virus -- that spread worldwide in 2022. Tecovirimat is an anti-poxviral drug, and its use is driving the emergence of drug-resistant variants of the monkeypox virus. Scientists have identified how monkeypox virus exploits a cellular protein to evade host defenses, allowing it to replicate and spread better. Existing drugs -- developed to treat other viral infections -- also target this cellular protein. When tested against a range of poxviruses, including monkeypox, these drugs were found to have antiviral effects in all cases.
Wed, 09 Aug 2023 13:06:10 EDT
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'Humanized' liver in mice reveals roots of chronic diseases
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研究人员创建了一个功能“人性化”liver in living mice that will help scientists find human-specific mechanisms for regulating cholesterol levels and potentially for treating chronic liver diseases afflicting tens of millions of people in the United States.
Wed, 09 Aug 2023 12:56:29 EDT
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The 'unknome': A database of human genes we know almost nothing about
//www.koonmotors.com/releases/2023/08/230808151054.htm
Researchers hope that a new, publicly available database they have created will shrink, not grow, over time. That's because it is a compendium of the thousands of understudied proteins encoded by genes in the human genome, whose existence is known but whose functions are mostly not.
Tue, 08 Aug 2023 15:10:54 EDT
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'Spider-like' mitochondrial structure initiates cell-wide stress response
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Scientists discovered the unique molecular structure, which could have implications in age-related diseases like neurodegeneration.
Mon, 07 Aug 2023 17:38:03 EDT
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Mineralization of bone matrix regulates tumor cell growth
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Tumor cells are known to be fickle sleeper agents, often lying dormant in distant tissues for years before reactivating and forming metastasis. Numerous factors have been studied to understand why the activation occurs, from cells and molecules to other components in the so-called tissue microenvironment.
Mon, 07 Aug 2023 16:44:13 EDT
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Latest in body art? 'Tattoos' for individual cells
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Engineers have developed nanoscale tattoos -- dots and wires that adhere to live cells -- in a breakthrough that puts researchers one step closer to tracking the health of individual cells.
Mon, 07 Aug 2023 13:38:28 EDT
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How the Epstein-Barr virus transforms B cells
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Epstein-Barr virus (EBV) infection is known to convert resting B lymphocytes into immortal cells that continuously multiply, leading to posttransplant lymphoproliferative disorder (PTLD). Researchers have now uncovered the molecular mechanisms of this growth transformation, demonstrating the crucial role of the cancer-related gene IMPDH2 and nucleolar enlargement. Additionally, the research revealed strong evidence supporting the efficacy of mycophenolate mofetil, an approved immunosuppressant, in inhibiting PTLD, highlighting its therapeutic significance.
Mon, 07 Aug 2023 12:19:25 EDT
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Study finds a surprising new role for a major immune regulator
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The immune regulatory protein STING has a previously unknown function: acting as an ion channel that allows protons to leak into cells. This discovery makes it the first human immune sensor that can translate danger signals into ion flow.
Thu, 03 Aug 2023 14:16:55 EDT
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Ear today, gone tomorrow? A new discovery in a cause of inner-ear bone loss
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The researchers showed how bone erosion caused by cholesteatoma occurs. This study showed that a subset of cells called osteoclastogenic fibroblasts expresses a protein, activin A, which causes the breakdown of the bones. Because of this discovery, novel medical treatments can be developed as first-line management for cholesteatomas.
Thu, 03 Aug 2023 11:29:43 EDT
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An escape signal for the nematode: Artificial intelligence helps elucidate structure of a novel light sensor
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The small Caenorhabditis elegans nematode avoids light. While it does not have eyes, some of its cells contain a protein called LITE-1, which warns it of the sun, whose rays are dangerous for the animal. A team of scientists has now elucidated the structure of LITE-1 -- a completely new type of light-controlled ion channel. Instead of biochemical experiments, the researchers used artificial intelligence to elucidate the structure, and verified their structural model using biological experiments.
Wed, 02 Aug 2023 13:20:35 EDT
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Scientists develop gene-editing technology that eliminates EV-A71 RNA viruses
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A team of scientists has made an important breakthrough in the fight against RNA viruses that cause human diseases and pandemics.
Wed, 02 Aug 2023 10:58:30 EDT
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Deadly fungus beaten with new type of treatment
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Researchers have discovered a new way to attack fungal infections. The key is to block fungi from being able to make fatty acids, the major component of fats. Resistance to anti-fungal drugs is increasing and this new approach will be particularly useful because it works in a new way and affects a broad range of fungal species.
Tue, 01 Aug 2023 10:50:34 EDT
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新的研究揭示了我的闸门机制on channels
//www.koonmotors.com/releases/2023/08/230801105021.htm
Ion channels play a crucial role in many cellular processes, including neuronal communication, muscle contraction or cell proliferation. Most multi subunit ion channels exist in two functional states, either closed or open. During gating, one should expect that all subunits undergo conformational changes. The absence of intermediate conduction levels is surprising and asks for an explanation. A team of researchers has created a smart model system to answer this important question.
Tue, 01 Aug 2023 10:50:21 EDT
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Nanopore technology achieves breakthrough in protein variant detection
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Scientists have achieved a significant breakthrough in detecting modifications on protein structures. The method employs innovative nanopore technology to identify structural variations at the single-molecule level, even deep within long protein chains.
Tue, 01 Aug 2023 10:50:18 EDT
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How flies develop sight: Scientists use single-cell sequencing to identify cell types in the visual system
//www.koonmotors.com/releases/2023/07/230731151600.htm
Researchers have discovered new cell types in the visual system of flies, made possible by their creation of a tool that finds and labels neurons during development. The study combines single-cell sequencing data with a novel algorithm to identify pairs of genes that point to previously unknown cells in the brains of fruit flies.
Mon, 31 Jul 2023 15:16:00 EDT
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Researchers discover method to overcome antimicrobial resistance
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Researchers have described a new class of molecules that inhibit efflux pumps so that antiboitics remain effective.
Mon, 31 Jul 2023 15:15:45 EDT
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New chemical process makes it easier to craft amino acids that don't exist in nature
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化学家们描述一个强大的新方法来创建新的-to-nature, 'unnatural' amino acids, which could find use in protein-based therapies and open up novel branches of organic chemistry.
Mon, 31 Jul 2023 14:41:29 EDT
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Imaging shows how solar-powered microbes turn CO2 into bioplastic
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Researchers have developed a multimodal platform to image biohybrids -- microorganisms that use solar energy to convert carbon dioxide into value-added chemical products -- to better understand how they function and how they can be optimized for more efficient energy conversion.
Fri, 28 Jul 2023 17:06:35 EDT
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Mutation accessibility fuels influenza evolution
//www.koonmotors.com/releases/2023/07/230728170622.htm
Scientists showed that fixed mutations within a viral population most likely stem from how easy it is to acquire that mutation (i.e., mutation accessibility) rather than just its benefit.
Fri, 28 Jul 2023 17:06:22 EDT
//www.koonmotors.com/releases/2023/07/230728170622.htm
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Cell biology: How cellular powerhouses call for help when under stress
//www.koonmotors.com/releases/2023/07/230728113422.htm
Originally, the powerhouses of higher cells, the mitochondria, were independent organisms. Researchers have investigated to what extent their metabolism has blended with that of their host cells in the course of evolution, using the example of a mitochondrial stress response. They have discovered that mitochondria send two different biochemical signals. These are processed together in the cell and trigger a support mechanism to restore cellular balance (homeostasis).
Fri, 28 Jul 2023 11:34:22 EDT
//www.koonmotors.com/releases/2023/07/230728113422.htm
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Researchers develop 'in vivo' RNA-based gene editing model for blood disorders
//www.koonmotors.com/releases/2023/07/230727143923.htm
在进步发展的基因dicines, researchers have developed a proof-of-concept model for delivering gene editing tools to treat blood disorders, allowing for the modification of diseased blood cells directly within the body. If translated into the clinic, this approach could expand access and reduce the cost of gene therapies for blood disorders, many of which currently require patients receive chemotherapy and a stem cell transplant.
Thu, 27 Jul 2023 14:39:23 EDT
//www.koonmotors.com/releases/2023/07/230727143923.htm
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Scientist discover protein required for an effective immune response to invading bacteria
//www.koonmotors.com/releases/2023/07/230726171246.htm
A team has discovered a protein that plays critical roles in alerting the body to a bacterial infection and initiating an effective immune response to fight back against the invasion.
Wed, 26 Jul 2023 17:12:46 EDT
//www.koonmotors.com/releases/2023/07/230726171246.htm
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Unraveling a protein that may inspire a new biotechnology tool
//www.koonmotors.com/releases/2023/07/230726113058.htm
Scientists have unraveled the step-by-step activation process of a protein with a deep evolutionary history in all domains of life, opening the door to harnessing its functions for use as a biotechnology tool.
Wed, 26 Jul 2023 11:30:58 EDT
//www.koonmotors.com/releases/2023/07/230726113058.htm
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Protein found to protect females against obesity
//www.koonmotors.com/releases/2023/07/230725171933.htm
Using a mouse model of high fat diet-induced obesity, a team of scientists has found that, compared to males, female mice are protected against obesity and inflammation because they secrete more of an immune protein called RELMalpha.
Tue, 25 Jul 2023 17:19:33 EDT
//www.koonmotors.com/releases/2023/07/230725171933.htm