Biotechnology News -- ScienceDaily //www.koonmotors.com/news/plants_animals/biotechnology/ Biotechnology News. Read the latest research from around the world on genetic engineering, drug development and more. en-us Fri, 08 Sep 2023 12:23:56 EDT Fri, 08 Sep 2023 12:23:56 EDT 60 Biotechnology News -- ScienceDaily //www.koonmotors.com/images/scidaily-logo-rss.png//www.koonmotors.com/news/plants_animals/biotechnology/ For more science news, visit ScienceDaily. Dog diversity unveiled by international DNA database //www.koonmotors.com/releases/2023/09/230907130404.htm An international consortium of scientists is using an unprecedentedly large database of canine DNA to take an unbiased look at how our furry friends evolved into the various breeds we know and love. Thu, 07 Sep 2023 13:04:04 EDT //www.koonmotors.com/releases/2023/09/230907130404.htm Researchers grow embryonic humanized kidneys inside pigs for 28 days //www.koonmotors.com/releases/2023/09/230907130350.htm Researchers have successfully created chimeric embryos containing a combination of human and pig cells. When transferred into surrogate pig mothers, the developing humanized kidneys had normal structure and tubule formation after 28 days. This is the first time that scientists have been able to grow a solid humanized organ inside another species, though previous studies have used similar methods to generate human tissues such as blood or skeletal muscle in pigs. Thu, 07 Sep 2023 13:03:50 EDT //www.koonmotors.com/releases/2023/09/230907130350.htm Blood-brain barrier governs ant behavior by altering hormone levels //www.koonmotors.com/releases/2023/09/230907130345.htm In many animals, including ants, the blood-brain barrier (BBB) ensures normal brain function by controlling the movement of various substances in and out of the brain. Now, researchers have made the unexpected discovery that the BBB in carpenter ants plays an active role in controlling behavior that's essential to the function of entire ant colonies. The key is production in the BBB of a particular hormone-degrading enzyme. Thu, 07 Sep 2023 13:03:45 EDT //www.koonmotors.com/releases/2023/09/230907130345.htm Genetic tools probe microbial dark matter //www.koonmotors.com/releases/2023/09/230907130329.htm Genetic manipulation of a puzzling, miniscule bacteria that has lived in human mouths at least since the Middle Stone Age is elucidating the genes needed for its unusual lifestyle. These Patescibacteria in the human oral microbiome reside on the surface of another, larger host microbe. Found in many water and land environments, Patescibacteria in general lack the genes required to make many molecules necessary for life, such as the amino acids that make up proteins, the fatty acids that form membranes, and the nucleotides in DNA. This has led researchers to speculate that many of them rely on other bacteria to grow. In a new study, researchers present the first glimpse into the molecular mechanisms behind their relationship with their host cells. They also share details gleaned from fluorescent, time-lapse microsopic imaging of these bacteria as they bud and send out swarms of tiny progeny, only a fraction of which are able to establish a host relationship. Thu, 07 Sep 2023 13:03:29 EDT //www.koonmotors.com/releases/2023/09/230907130329.htm New compound unleashes the immune system on metastases //www.koonmotors.com/releases/2023/09/230907105834.htm A new nanocomplex renders a tumor harmless -- and, on top of that, it trains the immune system to detect and eliminate metastases. Thu, 07 Sep 2023 10:58:34 EDT //www.koonmotors.com/releases/2023/09/230907105834.htm Keeping herpes in check //www.koonmotors.com/releases/2023/09/230907105827.htm Herpes is not only unpleasant but it can, in some cases, also have dangerous complications and life-threatening consequences. A research team has now introduced a completely new approach for treating herpes. Their method is based on the inhibition of an enzyme that is needed for the release of newly formed virus particles from infected cells. Thu, 07 Sep 2023 10:58:27 EDT //www.koonmotors.com/releases/2023/09/230907105827.htm 研究了机制,注释的基因information passed from fathers to offspring //www.koonmotors.com/releases/2023/09/230906161820.htm Scientists have identified a key part of a mechanism that annotates genetic information before it is passed from fathers to their offspring. The findings shed new light on genomic imprinting, a fundamental, biological process in which a gene from one parent is switched off while the copy from the other parent remains active. Errors in imprinting are linked to a host of diseases, such as the rare disease Silver-Russell syndrome along with certain cancers and diabetes. Wed, 06 Sep 2023 16:18:20 EDT //www.koonmotors.com/releases/2023/09/230906161820.htm Discovery of new cell type in thymus //www.koonmotors.com/releases/2023/09/230906115617.htm Biomedical scientists have confirmed that newly discovered cells in the thymus are just like M cells, which are mostly known for their presence in the intestinal epithelium. Wed, 06 Sep 2023 11:56:17 EDT //www.koonmotors.com/releases/2023/09/230906115617.htm Unveiling the mechanism of 3D folding of cell sheets //www.koonmotors.com/releases/2023/09/230906112437.htm A team of researchers has revealed that the Dumpy protein, a component of extracellular matrices -- or ECM -- is the key factor in regulating the stereotypic origami-like folding of wing-cell sheets. Their findings that wing cells never divide during folding nor do they exhibit spatially distinct behaviors suggest how external cues can create consistent 3D tissue structures. Wed, 06 Sep 2023 11:24:37 EDT //www.koonmotors.com/releases/2023/09/230906112437.htm Researchers to study Alzheimer's disease in marmosets //www.koonmotors.com/releases/2023/09/230906112412.htm Neuroscientists created the first non-human primate model of hereditary Alzheimer's in marmosets to accelerate the pace of drug discovery and rebuild the foundation for future translational studies. Wed, 06 Sep 2023 11:24:12 EDT //www.koonmotors.com/releases/2023/09/230906112412.htm New ribozyme can make RNA molecules accessible for click chemistry in living cells //www.koonmotors.com/releases/2023/09/230905125007.htm Important progress for RNA research: A team has discovered a new ribozyme that can label RNA molecules in living cells. Tue, 05 Sep 2023 12:50:07 EDT //www.koonmotors.com/releases/2023/09/230905125007.htm 3D-printed 'living material' could clean up contaminated water //www.koonmotors.com/releases/2023/09/230905124850.htm A 'living material,' made of a natural polymer combined with genetically engineered bacteria, could offer a sustainable and eco-friendly solution to clean pollutants from water. Researchers developed their living material using a seaweed-based polymer and bacteria that have been programmed to produce an enzyme that transforms various organic pollutants into harmless compounds. In tests, heir material decontaminated water solutions tainted with a pollutant from textile manufacturing: indigo carmine, a blue dye that is used to color denim. Tue, 05 Sep 2023 12:48:50 EDT //www.koonmotors.com/releases/2023/09/230905124850.htm Red blood cells exposed to oxygen deficiency protect against myocardial infarction //www.koonmotors.com/releases/2023/09/230901124039.htm Red blood cells exposed to oxygen deficiency protect against myocardial infarction, according to a new study. The study also shows that the protective effect is enhanced by a nitrate-rich vegetable diet. Fri, 01 Sep 2023 12:40:39 EDT //www.koonmotors.com/releases/2023/09/230901124039.htm Mutation rates in whales are much higher than previously reported //www.koonmotors.com/releases/2023/08/230831142901.htm An international team of marine scientists has studied the DNA of family groups from four different whale species to estimate their mutation rates. Using the newly determined rates, the group found that the number of humpback whales in the North Atlantic before whaling was 86 percent lower than earlier studies suggested. Thu, 31 Aug 2023 14:29:01 EDT //www.koonmotors.com/releases/2023/08/230831142901.htm Newly discovered fungus helps destroy a harmful food toxin //www.koonmotors.com/releases/2023/08/230831121739.htm Patulin is a harmful mycotoxin produced by fungi typically found in damaged fruits, including apples, pears, and grapes. In a recent breakthrough, researchers identified a new filamentous fungal strain that can degrade patulin by transforming it into less toxic substances. Their findings provide important insights into the degradation mechanisms for patulin found in nature, and can lead to new ways of controlling patulin toxicity in our food supplies. Thu, 31 Aug 2023 12:17:39 EDT //www.koonmotors.com/releases/2023/08/230831121739.htm The search for the super potato //www.koonmotors.com/releases/2023/08/230831121712.htm As climate change continues to pose severe challenges to ensuring sustainable food supplies around the world, scientists are looking for ways to improve the resilience and nutritional quality of potatoes. Scientists have assembled the genome sequences of nearly 300 varieties of potatoes and its wild relatives to develop more nutritious, disease-free, and weather-proof crop. A team has now created a potato super pangenome to identify genetic traits that can help produce the next super spud. Thu, 31 Aug 2023 12:17:12 EDT //www.koonmotors.com/releases/2023/08/230831121712.htm How some ion channels form structures permitting drug delivery //www.koonmotors.com/releases/2023/08/230830131953.htm A member of an important class of ion channel proteins can transiently rearrange itself into a larger structure with dramatically altered properties, according to a new study. The discovery is a significant advance in cell biology, likely solves a long-standing mystery about an unusual feature of some ion channels and has implications for the development of drugs targeting these proteins and for drug delivery. Wed, 30 Aug 2023 13:19:53 EDT //www.koonmotors.com/releases/2023/08/230830131953.htm Inhalable molecules neutralize SARS-CoV-2 in mice, study finds //www.koonmotors.com/releases/2023/08/230830131708.htm Nanofitins, which are derived from a protein in an archaeal microorganism found in hot springs -- successfully neutralized SARS-CoV-2 in mice and were well-tolerated. When inhaled by the rodents, the engineered nanofitins, which inhibit the virus by binding to its spike proteins, were observed to quickly reach the lungs in high doses both preventing and clearing early infections, researchers report. Wed, 30 Aug 2023 13:17:08 EDT //www.koonmotors.com/releases/2023/08/230830131708.htm New 'droplet battery' could pave the way for miniature bio-integrated devices //www.koonmotors.com/releases/2023/08/230830131650.htm 研究人员已经开发出一种微型电池那t could be used to power tiny devices integrated into human tissues. The design uses an ionic gradient across a chain of droplets -- inspired by how electric eels generate electricity. The device was able to regulate the biological activity of human neurons. This could open the way to the development of tiny bio-integrated devices, with a range of applications in biology and medicine. Wed, 30 Aug 2023 13:16:50 EDT //www.koonmotors.com/releases/2023/08/230830131650.htm Newly engineered versions of bacterial enzyme reveal how antibiotics could be more potent //www.koonmotors.com/releases/2023/08/230830130846.htm Researchers applied a new technology to generate the full inventory of mutations in the bacterial species Escherichia coli where the antibiotic rifampicin attaches to and disables an essential bacterial enzyme known as RNA polymerase (RNAP). Wed, 30 Aug 2023 13:08:46 EDT //www.koonmotors.com/releases/2023/08/230830130846.htm Enhancing cancer therapy using functionalized photosynthetic bacteria //www.koonmotors.com/releases/2023/08/230829125956.htm Selective targeting of cancerous cells poses major clinical challenges during cancer therapy. However, this limitation can be overcome by using bioengineered bacteria with highly optimized chemical modifications. A recent study demonstrates the use of chemically modified purple photosynthetic bacteria for the successful detection and elimination of colon cancer cells in a mouse model. The study also sheds light on the underlying mechanism of action. Tue, 29 Aug 2023 12:59:56 EDT //www.koonmotors.com/releases/2023/08/230829125956.htm Scientists invent new way to sort cells by type using light //www.koonmotors.com/releases/2023/08/230825165925.htm Researchers have developed and demonstrated a new method for high-throughput single-cell sorting that uses stimulated Raman spectroscopy rather than the traditional approach of fluorescence-activated cell sorting. The new approach could offer a label-free, nondestructive way to sort cells for a variety of applications, including microbiology, cancer detection and cell therapy. Fri, 25 Aug 2023 16:59:25 EDT //www.koonmotors.com/releases/2023/08/230825165925.htm Unlocking the secrets of cell antennas //www.koonmotors.com/releases/2023/08/230825140357.htm The NSL (non-specific lethal) complex regulates thousands of genes in fruit flies and mammals. Silencing the NSL genes leads to the death of the organism, which gave the complex its curious name. Researchers have now discovered that the genes regulated by the NSL complex also include genes of the intraciliary transport system. This enables different cell types to form cilia on their surface, which are important for cell communication. The study shows that these genes are 'switched on' by the NSL complex, regardless of whether a particular cell has cilia or not. The researchers found that this class of cilia-associated genes is crucial for the function of podocytes. This is a highly specialized cell type of the kidney that, paradoxically, does not have cilia. These findings have important implications for ciliopathies and kidney disease. Fri, 25 Aug 2023 14:03:57 EDT //www.koonmotors.com/releases/2023/08/230825140357.htm Pros and cons of ChatGPT plugin, Code Interpreter, in education, biology, health //www.koonmotors.com/releases/2023/08/230825122024.htm Researchers see potential in educational settings for the newest official ChatGPT plugin, called Code Interpreter, they've found limitations for its use by scientists who work with biological data utilizing computational methods to prioritize targeted treatment for cancer and genetic disorders. Fri, 25 Aug 2023 12:20:24 EDT //www.koonmotors.com/releases/2023/08/230825122024.htm Epigenetic mechanism that causes bitter taste distortion discovered //www.koonmotors.com/releases/2023/08/230824120153.htm A bitter taste in the mouth is often a symptom or side effect of illness, which may be the result of how the body reacts to pathogens. A new study sheds light on the mechanisms involved in the complex interplay between taste perception and immune function. Their work also highlights the potential of a sequencing tool for investigating epigenetic mechanisms that affect taste-cell gene expression. Thu, 24 Aug 2023 12:01:53 EDT //www.koonmotors.com/releases/2023/08/230824120153.htm Researchers describe rebuilding, regenerating lung cells //www.koonmotors.com/releases/2023/08/230824111925.htm Researchers have discovered a novel approach for engrafting engineered cells into injured lung tissue. These findings may lead to new ways for treating lung diseases, such as emphysema, pulmonary fibrosis and COVID-19. The two studies describe the methodologies for engineering lung stem cells and transplanting them into injured experimental lungs without immunosuppression. Thu, 24 Aug 2023 11:19:25 EDT //www.koonmotors.com/releases/2023/08/230824111925.htm The 'treadmill conveyor belt' ensuring proper cell division //www.koonmotors.com/releases/2023/08/230824111805.htm Researchers have discovered how proteins work in tandem to regulate 'treadmilling', a mechanism used by the network of microtubules inside cells to ensure proper cell division. Thu, 24 Aug 2023 11:18:05 EDT //www.koonmotors.com/releases/2023/08/230824111805.htm Longevity gene from naked mole rats extends lifespan of mice //www.koonmotors.com/releases/2023/08/230823165402.htm In a groundbreaking endeavor, researchers have successfully transferred a longevity gene from naked mole rats to mice, resulting in improved health and an extension of the mouse's lifespan. The research opens exciting possibilities for unlocking the secrets of aging and extending human lifespan. Wed, 23 Aug 2023 16:54:02 EDT //www.koonmotors.com/releases/2023/08/230823165402.htm Biologist gets the scoop on squash bug poop //www.koonmotors.com/releases/2023/08/230823122559.htm A discovery about how a common insect acquires a microbe that is essential for its growth may help in the control of an agricultural pest. Wed, 23 Aug 2023 12:25:59 EDT //www.koonmotors.com/releases/2023/08/230823122559.htm Noncoding DNA explains a majority of the heritability of dairy cattle traits, like milk production and fertility //www.koonmotors.com/releases/2023/08/230823122549.htm Regulatory genes -- genes that control how other genes are used -- are responsible for 69% of the heritability of dairy cattle traits such as milk production and fertility, according to a new study. This contribution is 44% more than expected and much higher than previous studies of regulatory genes in humans. The findings, reported by a team of animal and human geneticists, could improve the efficiency of agricultural breeding programs. The study also helps solve the longstanding mystery of why mammalian genomes contain so much noncoding DNA. Wed, 23 Aug 2023 12:25:49 EDT //www.koonmotors.com/releases/2023/08/230823122549.htm High-fat diets alter gut bacteria, boosting colorectal cancer risk in mice //www.koonmotors.com/releases/2023/08/230822111728.htm Researchers have discovered how high-fat diets can change gut bacteria and alter digestive molecules called bile acids that are modified by those bacteria, predisposing mice to colorectal cancer. The findings bring scientists closer to understanding the causes of and how to prevent colorectal cancer. Tue, 22 Aug 2023 11:17:28 EDT //www.koonmotors.com/releases/2023/08/230822111728.htm Researchers extract ancient DNA from a 2,900-year-old clay brick, revealing a time capsule of plant life //www.koonmotors.com/releases/2023/08/230822111659.htm For the first time, a group of researchers have successfully extracted ancient DNA from a 2,900-year-old clay brick. The analysis provides a fascinating insight into the diversity of plant species cultivated at that time and place, and could open the way to similar studies on clay material from other sites and time periods. Tue, 22 Aug 2023 11:16:59 EDT //www.koonmotors.com/releases/2023/08/230822111659.htm Research team developing a nano-sized force sensor and improving high-precision microscopy technology //www.koonmotors.com/releases/2023/08/230821114336.htm Recent research in cell biology highlights groundbreaking results. An international team of researchers have recently established a tool they developed to study the mechanics of the cell. The tool can be used to study the inner forces of the cell, for example, the stretching of the nuclear membrane. The microscopic force sensor, only about 0.00002 mm long, is constructed of exotic ingredients such as spider web protein parts, fluorescent proteins from jellyfish, and antibodies from alpaca. In addition, the multidisciplinary team of researchers has developed further the sensitivity of super-resolution microscopy technique. Mon, 21 Aug 2023 11:43:36 EDT //www.koonmotors.com/releases/2023/08/230821114336.htm 'Viral relicts' in the genome could fuel neurodegeneration //www.koonmotors.com/releases/2023/08/230821114333.htm Genetic remnants of viruses that are naturally present in the human genome could affect the development of neurodegenerative diseases. Researchers come to this conclusion on the basis of studies on cell cultures. Mon, 21 Aug 2023 11:43:33 EDT //www.koonmotors.com/releases/2023/08/230821114333.htm Novel treatment based on gene editing safely and effectively removes HIV-like virus from genomes of non-human primates //www.koonmotors.com/releases/2023/08/230817164016.htm A single injection of a novel CRISPR gene-editing treatment safely and efficiently removes SIV -- a virus related to the AIDS-causing agent HIV -- from the genomes of non-human primates, scientists now report. The groundbreaking work complements previous experiments as the basis for the first-ever clinical trial of an HIV gene-editing technology in human patients, which was authorized by the Food and Drug Administration (FDA) in 2022. Thu, 17 Aug 2023 16:40:16 EDT //www.koonmotors.com/releases/2023/08/230817164016.htm Data researchers connect diet to changes in the microbiome //www.koonmotors.com/releases/2023/08/230817163903.htm New research shows that intermittent fasting and calorie restriction change the microbiome composition in the gut, which could affect other functions in the body. Thu, 17 Aug 2023 16:39:03 EDT //www.koonmotors.com/releases/2023/08/230817163903.htm Scientists reveal how sensory protein changes shape with nanometer resolution //www.koonmotors.com/releases/2023/08/230816160032.htm 但感官受体PIEZO1改变了形状nse to mechanical stimuli. The super high-resolution microscopy technology used in this discovery is a breakthrough in enabling protein structures to be studied within the cellular environment. Wed, 16 Aug 2023 16:00:32 EDT //www.koonmotors.com/releases/2023/08/230816160032.htm Pig kidney xenotransplantation performing optimally after 32 days in human body //www.koonmotors.com/releases/2023/08/230816114156.htm Surgeons have transplanted a genetically engineered pig kidney that continues to function well after 32 days in a man declared dead by neurologic criteria and maintained with a beating heart on ventilator support. This represents the longest period that a gene-edited pig kidney has functioned in a human, and the latest step toward the advent of an alternate, sustainable supply of organs for transplant. Wed, 16 Aug 2023 11:41:56 EDT //www.koonmotors.com/releases/2023/08/230816114156.htm Building muscle in the lab //www.koonmotors.com/releases/2023/08/230816114121.htm A new method allows large quantities of muscle stem cells to be safely obtained in cell culture. This provides a potential for treating patients with muscle diseases -- and for those who would like to eat meat, but don't want to kill animals. Wed, 16 Aug 2023 11:41:21 EDT //www.koonmotors.com/releases/2023/08/230816114121.htm Protective particles allow engineered probiotics to report gut disease //www.koonmotors.com/releases/2023/08/230816114111.htm Bioengineers developed a platform that enhances survival and function of probiotics engineered to diagnose inflammatory bowel disease in animals. The technology holds promise for minimally invasive disease monitoring and advanced smart therapeutics. Wed, 16 Aug 2023 11:41:11 EDT //www.koonmotors.com/releases/2023/08/230816114111.htm Study explains how part of the nucleolus evolved //www.koonmotors.com/releases/2023/08/230815131858.htm Biologists discovered that a scaffolding protein called TCOF1 is responsible for the formation of a biomolecular condensate called the fibrillar center, which forms within the cell nucleolus. Tue, 15 Aug 2023 13:18:58 EDT //www.koonmotors.com/releases/2023/08/230815131858.htm Weaker transcription factors are better when they work together //www.koonmotors.com/releases/2023/08/230815131818.htm Bioengineers have developed a generalizable method to address 'off-target' binding, a significant problem in the field of synthetic biology. Taking a cue from nature, the researchers showed they could all but eliminate off-target gene activation by designing weak transcription factors that cooperatively assemble. Tue, 15 Aug 2023 13:18:18 EDT //www.koonmotors.com/releases/2023/08/230815131818.htm Images of enzyme in action reveal secrets of antibiotic-resistant bacteria //www.koonmotors.com/releases/2023/08/230814174547.htm Advanced microscopy techniques give scientists valuable clues for how to fight an enzyme that is leading to a rise in cases of antibiotic-resistant bacterial infections worldwide. Mon, 14 Aug 2023 17:45:47 EDT //www.koonmotors.com/releases/2023/08/230814174547.htm Tardigrades: The world is crawling with this highly resilient creature //www.koonmotors.com/releases/2023/08/230814122348.htm They're found on Mount Everest, in the deep seas, aboard the International Space Station and thousands of them have even crash landed and been spilled onto the moon. The microscopic water bear has a nearly unfathomable ability to survive in the most hostile environments. Mon, 14 Aug 2023 12:23:48 EDT //www.koonmotors.com/releases/2023/08/230814122348.htm Distribution of genetic information during bacterial cell division //www.koonmotors.com/releases/2023/08/230814122339.htm A mathematical model provides new insights into the distribution of genetic information during bacterial cell division Mon, 14 Aug 2023 12:23:39 EDT //www.koonmotors.com/releases/2023/08/230814122339.htm Hidden moles in hidden holes //www.koonmotors.com/releases/2023/08/230811115510.htm An international team of scientists has for the first time identified two new underground mammals that could have been living, undetected, in eastern Turkey for up to 3 million years. They say it is rare to find new species of mammals today, and evidence that the true nature of biodiversity can be under-estimated. Fri, 11 Aug 2023 11:55:10 EDT //www.koonmotors.com/releases/2023/08/230811115510.htm Mechanism underlying bacterial resistance to the antibiotic albicidin revealed //www.koonmotors.com/releases/2023/08/230810141052.htm A new analysis shows that infectious bacteria exposed to the antibiotic albicidin rapidly develop up to a 1,000-fold increase in resistance via a gene amplification mechanism. Thu, 10 Aug 2023 14:10:52 EDT //www.koonmotors.com/releases/2023/08/230810141052.htm Global consortium creates large-scale, cross-species database and universal 'clock' to estimate age in all mammalian tissues //www.koonmotors.com/releases/2023/08/230810141041.htm An international research team details changes in DNA that researchers found are shared by humans and other mammals throughout history and are associated with life span and numerous other traits. Thu, 10 Aug 2023 14:10:41 EDT //www.koonmotors.com/releases/2023/08/230810141041.htm Researchers engineer bacteria that can detect tumor DNA //www.koonmotors.com/releases/2023/08/230810140813.htm Creating new technologically advanced sensors, scientists have engineered bacteria that detect the presence of tumor DNA in live organisms. Their innovation could pave the way to new biosensors capable of identifying various infections, cancers and other diseases. Thu, 10 Aug 2023 14:08:13 EDT //www.koonmotors.com/releases/2023/08/230810140813.htm Scientists reverse hearing loss in mice //www.koonmotors.com/releases/2023/08/230810110338.htm New research has successfully reversed hearing loss in mice. Scientists used a genetic approach to fix deafness in mice, restoring their hearing abilities in low and middle frequency ranges. Thu, 10 Aug 2023 11:03:38 EDT //www.koonmotors.com/releases/2023/08/230810110338.htm Researchers find new pathway for HIV invasion of cell nucleus //www.koonmotors.com/releases/2023/08/230810110313.htm A study has identified a new pathway that human immune deficiency virus (HIV) uses to enter the nucleus of a healthy cell, where it can then replicate and go on to invade other cells. Thu, 10 Aug 2023 11:03:13 EDT //www.koonmotors.com/releases/2023/08/230810110313.htm Synthetic antibiotic could be effective against drug-resistant superbugs //www.koonmotors.com/releases/2023/08/230809164729.htm 科学的旅程几十年做傻人nd a new antibiotic strategy to defeat gram-negative bacteria like Salmonella, Pseudomonas and E. coli, the culprits in many urinary tract infections. The synthetic molecule works fast and is durable. It interferes with synthesis of the bacterial outer membrane by jamming an enzyme. When tested against a clinical collection of 285 bacterial strains, including some that were highly resistant to commercial antibiotics, it killed them all. Wed, 09 Aug 2023 16:47:29 EDT //www.koonmotors.com/releases/2023/08/230809164729.htm Surprising discovery of low-noise genes //www.koonmotors.com/releases/2023/08/230809164644.htm While engaging in cell division research, researchers made a surprisingly quiet discovery. When cells express RNA, there is always some fluctuation, or noise, in how much RNA is produced. The scientists found several genes whose noise dips below a previously established threshold, known as the noise floor, during expression. Wed, 09 Aug 2023 16:46:44 EDT //www.koonmotors.com/releases/2023/08/230809164644.htm Turning big data into better breeds and varieties: Can AI help feed the planet? //www.koonmotors.com/releases/2023/08/230809130714.htm Artificial intelligence could hold the key to feeding 10 billion people by 2050 in the face of climate change and rapidly evolving pests and pathogens according to researchers. Wed, 09 Aug 2023 13:07:14 EDT //www.koonmotors.com/releases/2023/08/230809130714.htm Molnupiravir administered at human effect size-equivalent dose blocks SARS-CoV-2 transmission in ferrets, researchers find //www.koonmotors.com/releases/2023/08/230809130619.htm Two oral drugs, molnupiravir and paxlovid (nirmatrelvir/ritonavir), provide equivalent therapeutic benefit in preventing severe COVID-19 in animal models, but only molnupiravir efficiently blocked SARS-CoV-2 transmission when administered at a human effect size-equivalent dose, according to a new study. Wed, 09 Aug 2023 13:06:19 EDT //www.koonmotors.com/releases/2023/08/230809130619.htm Treatments for poxviruses -- including those causing mpox and smallpox -- may already exist in licensed drugs //www.koonmotors.com/releases/2023/08/230809130610.htm The drug tecovirimat is currently in use for the treatment of mpox -- the disease caused by monkeypox virus -- that spread worldwide in 2022. Tecovirimat is an anti-poxviral drug, and its use is driving the emergence of drug-resistant variants of the monkeypox virus. Scientists have identified how monkeypox virus exploits a cellular protein to evade host defenses, allowing it to replicate and spread better. Existing drugs -- developed to treat other viral infections -- also target this cellular protein. When tested against a range of poxviruses, including monkeypox, these drugs were found to have antiviral effects in all cases. Wed, 09 Aug 2023 13:06:10 EDT //www.koonmotors.com/releases/2023/08/230809130610.htm 'Humanized' liver in mice reveals roots of chronic diseases //www.koonmotors.com/releases/2023/08/230809125629.htm Researchers have created a functional 'humanized' liver in living mice that will help scientists find human-specific mechanisms for regulating cholesterol levels and potentially for treating chronic liver diseases afflicting tens of millions of people in the United States. Wed, 09 Aug 2023 12:56:29 EDT //www.koonmotors.com/releases/2023/08/230809125629.htm Inflammation slows malaria parasite growth and reproduction in the body //www.koonmotors.com/releases/2023/08/230808181913.htm New research found that inflammation in the body can slow down the development of malaria parasites in the bloodstream -- a discovery that may constitute a potential new strategy for preventing or limiting severe disease. Tue, 08 Aug 2023 18:19:13 EDT //www.koonmotors.com/releases/2023/08/230808181913.htm The 'unknome': A database of human genes we know almost nothing about //www.koonmotors.com/releases/2023/08/230808151054.htm Researchers hope that a new, publicly available database they have created will shrink, not grow, over time. That's because it is a compendium of the thousands of understudied proteins encoded by genes in the human genome, whose existence is known but whose functions are mostly not. Tue, 08 Aug 2023 15:10:54 EDT //www.koonmotors.com/releases/2023/08/230808151054.htm 'Spider-like' mitochondrial structure initiates cell-wide stress response //www.koonmotors.com/releases/2023/08/230807173803.htm Scientists discovered the unique molecular structure, which could have implications in age-related diseases like neurodegeneration. Mon, 07 Aug 2023 17:38:03 EDT //www.koonmotors.com/releases/2023/08/230807173803.htm