//www.koonmotors.com/news/mind_brain/schizophrenia/ Read current medical research on schizophrenia symptoms, medication and more. Browse health articles on schizophrenia treatments including anti-psychotic drugs. en-us Sat, 09 Sep 2023 10:48:29 EDT Sat, 09 Sep 2023 10:48:29 EDT 60 //www.koonmotors.com/images/scidaily-logo-rss.png//www.koonmotors.com/news/mind_brain/schizophrenia/ For more science news, visit ScienceDaily. //www.koonmotors.com/releases/2023/08/230816160006.htm Researcher discovers possible link of mitochondrial function to the development of schizophrenia. Wed, 16 Aug 2023 16:00:06 EDT //www.koonmotors.com/releases/2023/08/230816160006.htm //www.koonmotors.com/releases/2023/08/230802131952.htm New research has identified age-related changes in brain patterns associated with the risk for developing schizophrenia. The discovery could help clinicians identify the risk for developing mental illness earlier and improve treatment options. Wed, 02 Aug 2023 13:19:52 EDT //www.koonmotors.com/releases/2023/08/230802131952.htm //www.koonmotors.com/releases/2023/07/230706124520.htm As a psychiatric disorder with onset in adulthood, schizophrenia is thought to be triggered by some combination of environmental factors and genetics, although the exact cause is still not fully understood. Researchers have now found a correlation between schizophrenia and somatic copy-number variants, a type of mutation that occurs early in development but after genetic material is inherited. This study is one of the first to rigorously describe the relationship between somatic -- not inherited -- genetic mutations and schizophrenia risk. Thu, 06 Jul 2023 12:45:20 EDT //www.koonmotors.com/releases/2023/07/230706124520.htm //www.koonmotors.com/releases/2023/06/230606111734.htm A new study brings together two schools of thought on the function of the neurotransmitter dopamine: one saying that dopamine provides a learning signal, the other saying that dopamine drives motivation. Tue, 06 Jun 2023 11:17:34 EDT //www.koonmotors.com/releases/2023/06/230606111734.htm //www.koonmotors.com/releases/2023/05/230531150109.htm Links have been reported between schizophrenia and proteins produced by the immune system that can act against one's own body, known as autoantibodies. Researchers have now identified autoantibodies that target a 'synaptic adhesion protein' in a subset of patients with schizophrenia. When injected into mice, the autoantibodies caused many schizophrenia-related changes. Wed, 31 May 2023 15:01:09 EDT //www.koonmotors.com/releases/2023/05/230531150109.htm //www.koonmotors.com/releases/2023/05/230524182026.htm Neuroscientists have shown how vitamin D deficiency affects developing neurons in the brain's dopamine circuit, which may lead to the dopamine dysfunction seen in adults with schizophrenia. Wed, 24 May 2023 18:20:26 EDT //www.koonmotors.com/releases/2023/05/230524182026.htm //www.koonmotors.com/releases/2023/05/230505101659.htm Scientists have found a lipid transporter crucial to regulating the cells that make myelin, the nerve-protecting sheath. Fri, 05 May 2023 10:16:59 EDT //www.koonmotors.com/releases/2023/05/230505101659.htm //www.koonmotors.com/releases/2023/02/230217103942.htm Researchers used the drug fasudil to restore neurons and improve methamphetamine-induced cognitive dysfunction in a mouse model of schizophrenia. Fri, 17 Feb 2023 10:39:42 EST //www.koonmotors.com/releases/2023/02/230217103942.htm //www.koonmotors.com/releases/2023/01/230124192559.htm Researchers present the first evidence of 12-hour cycles of gene activity in the human brain. The study also reveals that some of those 12-hour rhythms are missing or altered in the postmortem brains of patients with schizophrenia. Tue, 24 Jan 2023 19:25:59 EST //www.koonmotors.com/releases/2023/01/230124192559.htm //www.koonmotors.com/releases/2022/11/221130114523.htm Using state-of-the-art whole-genome sequencing and machine learning techniques, researchers conducted one of the first and the largest investigations of tandem repeats in schizophrenia, elucidating their contribution to the development of this devastating disease. Wed, 30 Nov 2022 11:45:23 EST //www.koonmotors.com/releases/2022/11/221130114523.htm //www.koonmotors.com/releases/2022/11/221116113122.htm The ADHD medication lisdexamfetamine was associated with the lowest risk of hospitalization and death in people with amphetamine addiction, when medications generally used among persons with substance use disorders were compared, according to a new study. Wed, 16 Nov 2022 11:31:22 EST //www.koonmotors.com/releases/2022/11/221116113122.htm //www.koonmotors.com/releases/2022/11/221103104939.htm 精神分裂症患者有更少的连接元素een nerve cells. This is believed to be caused by genetic risk variants leading to an excessive elimination of nerve cell connections by the immune cells of the brain. Researchers now report that the levels of protein from the relevant risk gene are elevated in first-episode patients and that inflammation further increases the expression of the risk gene. Thu, 03 Nov 2022 10:49:39 EDT //www.koonmotors.com/releases/2022/11/221103104939.htm //www.koonmotors.com/releases/2022/10/221006092313.htm People with psychotic disorders such as schizophrenia are 2.5 times more likely than those without a psychotic disorder to eventually develop dementia, according to a new review. Thu, 06 Oct 2022 09:23:13 EDT //www.koonmotors.com/releases/2022/10/221006092313.htm //www.koonmotors.com/releases/2022/07/220715105812.htm Researchers have identified specific cells that regulate the transmission of information between brain areas. This discovery forms the basis for the development of new treatment options for neuropsychiatric disorders which are characterized by impaired coordination of information flow in the brain. Fri, 15 Jul 2022 10:58:12 EDT //www.koonmotors.com/releases/2022/07/220715105812.htm //www.koonmotors.com/releases/2022/07/220705162146.htm The gene defect underlying Krabbe disease causes degeneration of neurons directly, independent of its effects on other cell types, according to a new study. The discovery represents a new mechanism of action for the mutant gene, presenting a more accurate picture of the disease process that may help in the development of therapies. Tue, 05 Jul 2022 16:21:46 EDT //www.koonmotors.com/releases/2022/07/220705162146.htm //www.koonmotors.com/releases/2022/06/220616121543.htm The cerebellum is essential for sensorimotor control but also contributes to higher cognitive functions including social behaviors. Researchers uncovered how dopamine in the cerebellum modulates social behaviors via its action on D2 receptors (D2R). These new findings pave the way to determine whether socially related psychiatric disorders are also associated with altered dopamine receptors expression in specific cerebellar cell types. Thu, 16 Jun 2022 12:15:43 EDT //www.koonmotors.com/releases/2022/06/220616121543.htm //www.koonmotors.com/releases/2022/06/220606111527.htm Researchers have found that some people with schizophrenia have autoantibodies -- which are made by the immune system and recognize the body's own proteins, rather than outside threats such as viruses or bacteria -- against NCAM1, a protein that's important for communication between brain cells. The patients' autoantibodies also caused schizophrenia-related behaviors in mice. These findings may improve the diagnosis and treatment of a subset of patients with schizophrenia. Mon, 06 Jun 2022 11:15:27 EDT //www.koonmotors.com/releases/2022/06/220606111527.htm //www.koonmotors.com/releases/2022/05/220524110655.htm Emotion-recognition among people with disorders such as Parkinson's disease or schizophrenia may be affected by changes in the levels dopamine in the brain, say researchers. Tue, 24 May 2022 11:06:55 EDT //www.koonmotors.com/releases/2022/05/220524110655.htm //www.koonmotors.com/releases/2022/05/220520132858.htm Researchers have reported new evidence that cognitive abnormalities seen in neuropsychiatric disorders such as schizophrenia may be traceable to altered activity in the thalamus during adolescence, a time window of heightened vulnerability for schizophrenia. Fri, 20 May 2022 13:28:58 EDT //www.koonmotors.com/releases/2022/05/220520132858.htm //www.koonmotors.com/releases/2022/04/220427100557.htm Researchers have found that the more urban of an environment a child lived in -- proximity to roads, houses with lead paint risks, families in poverty, and income disparity -- the greater number of psychotic like experiences they had over a year's time. Wed, 27 Apr 2022 10:05:57 EDT //www.koonmotors.com/releases/2022/04/220427100557.htm //www.koonmotors.com/releases/2022/04/220419140732.htm 与一般人群相比,severe mental illness, including schizophrenia, have higher levels of cardiovascular-related mortality, and that association has become stronger over recent decades, according to a new study. Tue, 19 Apr 2022 14:07:32 EDT //www.koonmotors.com/releases/2022/04/220419140732.htm //www.koonmotors.com/releases/2022/04/220406132406.htm The largest ever genetic study of schizophrenia has identified large numbers of specific genes that could play important roles in the psychiatric disorder. A group of hundreds of researchers across 45 countries analysed DNA from 76,755 people with schizophrenia and 243,649 without it to better understand the genes and biological processes underpinning the condition. The new study found a much larger number of genetic links to schizophrenia than ever before, in 287 different regions of the genome, the human body's DNA blueprint. Wed, 06 Apr 2022 13:24:06 EDT //www.koonmotors.com/releases/2022/04/220406132406.htm //www.koonmotors.com/releases/2022/03/220330111329.htm A potential link between inflammation and the structure of specific regions of the brain has been identified by researchers. Wed, 30 Mar 2022 11:13:29 EDT //www.koonmotors.com/releases/2022/03/220330111329.htm //www.koonmotors.com/releases/2022/03/220314095732.htm This study's findings will help congenital neurological disease (e.g. spinal muscular atrophy) specialists better understand the mechanisms and components involved in CNS development. Notably, the findings of this work demonstrate unequivocally that Ddx20 is a novel Olig2-interacting factor and a potent suppressor of the p53 pathway, contributing to the maintenance of neuronal and oligodendrocyte progenitor cells during CNS development. Therefore, Ddx20 and Olig2 are promising molecular targets for development of future therapeutic strategies. Mon, 14 Mar 2022 09:57:32 EDT //www.koonmotors.com/releases/2022/03/220314095732.htm //www.koonmotors.com/releases/2022/03/220309090709.htm An analysis of nearly 600,000 adults in the U.S. found people with bipolar disorder, schizophrenia or schizoaffective disorder had up to double the estimated cardiovascular risk levels than those without such illnesses, even at younger ages. The study focused on adults diagnosed with one of those three serious mental illnesses, who were not hospitalized or living in a mental health treatment center and estimated their 10-year and 30-year cardiovascular risk. Earlier identification and management of major cardiovascular risk factors -- including obesity, smoking, diabetes and high blood pressure -- in young adults with a serious mental illness may reduce risk of heart disease and improve outcomes, researchers said. Wed, 09 Mar 2022 09:07:09 EST //www.koonmotors.com/releases/2022/03/220309090709.htm //www.koonmotors.com/releases/2022/03/220303144146.htm Repetitive transcranial magnetic stimulation (rTMS) was associated with a reduction in self-reported cannabis use by up to 60 per cent among people with schizophrenia who have cannabis use disorder (CUD), according to a new study. Thu, 03 Mar 2022 14:41:46 EST //www.koonmotors.com/releases/2022/03/220303144146.htm //www.koonmotors.com/releases/2022/03/220303141227.htm Communication between brain areas is crucial for the brain to correctly process sensory signals and adopt an appropriate behavioural response. Yet, dysfunctions in these communication pathways could be strongly correlated with the onset of schizophrenia. For the first time, a team has succeeded in demonstrating this phenomenon in human beings. By carrying out analyses of the brain activity of children, adolescents and young adults with a genetic risk of the disease, the research team has demonstrated that a reduction in the activation of gamma waves, that are known for their role in the proper transmission of information in the brain, was correlated with the emergence of psychotic symptoms even before full-blown disorders appear. Thu, 03 Mar 2022 14:12:27 EST //www.koonmotors.com/releases/2022/03/220303141227.htm //www.koonmotors.com/releases/2022/01/220126122503.htm New research has shown that over-activity in a specific area of the brain is linked to certain symptoms of Schizophrenia, opening up possibilities for the development of more targeted treatments. Wed, 26 Jan 2022 12:25:03 EST //www.koonmotors.com/releases/2022/01/220126122503.htm //www.koonmotors.com/releases/2022/01/220114074453.htm Scientists have discovered new links between the breakdown in brain cell development and the risk of schizophrenia and other psychiatric disorders. Fri, 14 Jan 2022 07:44:53 EST //www.koonmotors.com/releases/2022/01/220114074453.htm //www.koonmotors.com/releases/2022/01/220111100012.htm Researchers have identified the effects of an environmental stressor, sleep deprivation, that could alter the balance controlled by antipsychotic drugs and impact individuals with schizophrenia. Tue, 11 Jan 2022 10:00:12 EST //www.koonmotors.com/releases/2022/01/220111100012.htm //www.koonmotors.com/releases/2021/12/211223225442.htm Scientists investigating the DNA outside our genes - the 'dark genome' - have discovered recently evolved regions that code for proteins associated with schizophrenia and bipolar disorder. Thu, 23 Dec 2021 22:54:42 EST //www.koonmotors.com/releases/2021/12/211223225442.htm //www.koonmotors.com/releases/2021/12/211213160140.htm New research shows that examining genetic mutations in individuals with severe schizophrenia can improve the ability to detect disease-associated rare genetic variants. Mon, 13 Dec 2021 16:01:40 EST //www.koonmotors.com/releases/2021/12/211213160140.htm //www.koonmotors.com/releases/2021/12/211208123410.htm Psychologists have revealed a surprising finding that could help those who struggle with schizophrenia: While people with the illness tend to manage low-level negative emotions, they struggle to do so as those negative emotions increase. Wed, 08 Dec 2021 12:34:10 EST //www.koonmotors.com/releases/2021/12/211208123410.htm //www.koonmotors.com/releases/2021/09/210909141304.htm An immunological molecule called fractalkine can boost the production of brain cells that produce myelin, a key factor in diseases such as multiple sclerosis, according to recent research. Thu, 09 Sep 2021 14:13:04 EDT //www.koonmotors.com/releases/2021/09/210909141304.htm //www.koonmotors.com/releases/2021/09/210906111313.htm Researchers found that a tool commonly used in research for evaluating a person's genetic risk for a disease, called a polygenic risk score, was no better at predicting the outcome of a schizophrenia patient's disease over time than written reports. The results raise important questions about the use of polygenic risk scores in real-world, clinical situations, and also suggest that a doctor's written report may be an untapped source of predictive information. Mon, 06 Sep 2021 11:13:13 EDT //www.koonmotors.com/releases/2021/09/210906111313.htm //www.koonmotors.com/releases/2021/08/210803105532.htm An innovative strategy that analyzes a region of the genome offers the possibility of early diagnosis of schizophrenia. Tue, 03 Aug 2021 10:55:32 EDT //www.koonmotors.com/releases/2021/08/210803105532.htm //www.koonmotors.com/releases/2021/07/210729183620.htm Researchers have shown how the amygdala, a brain region typically associated with fear, contributes to prepulse inhibition (PPI) by activating small inhibitory neurons in the mouse brain stem. The discovery advances understanding of the systems underlying PPI and efforts to ultimately develop medical therapies for schizophrenia and other disorders by reversing pre-attentive deficits. Thu, 29 Jul 2021 18:36:20 EDT //www.koonmotors.com/releases/2021/07/210729183620.htm //www.koonmotors.com/releases/2021/07/210727163236.htm Subtle differences in perception during late-teen years can predict the development of hallucinations, delusions, and, in some instances, psychosis later in life, according to new research. Tue, 27 Jul 2021 16:32:36 EDT //www.koonmotors.com/releases/2021/07/210727163236.htm //www.koonmotors.com/releases/2021/07/210721172717.htm Researchers have published evidence of the sustained benefits of an investigational antipsychotic treatment for people with dementia-related psychosis. Wed, 21 Jul 2021 17:27:17 EDT //www.koonmotors.com/releases/2021/07/210721172717.htm //www.koonmotors.com/releases/2021/07/210715090847.htm Scientists have opened the door to improved treatment of brain dysfunction which causes psychosis. Thu, 15 Jul 2021 09:08:47 EDT //www.koonmotors.com/releases/2021/07/210715090847.htm //www.koonmotors.com/releases/2021/07/210713184359.htm A scientific team has shown that the release of neurotransmitters in the brain is impaired in patients with schizophrenia who have a rare, single-gene mutation known to predispose people to a range of neurodevelopmental disorders. Tue, 13 Jul 2021 18:43:59 EDT //www.koonmotors.com/releases/2021/07/210713184359.htm //www.koonmotors.com/releases/2021/06/210614131234.htm Researchers performed microtomography experiments the BL20XU beamline of the SPring-8 synchrotron radiation facility and found that brain capillary structures show a correlation with their neuron structures. Mon, 14 Jun 2021 13:12:34 EDT //www.koonmotors.com/releases/2021/06/210614131234.htm //www.koonmotors.com/releases/2021/05/210511201118.htm New research suggests a link between psychosis and a genetic change that affects the brain's immune system. The study may impact the development of modern medicines for bipolar disorder or schizophrenia. Tue, 11 May 2021 20:11:18 EDT //www.koonmotors.com/releases/2021/05/210511201118.htm //www.koonmotors.com/releases/2021/04/210420183144.htm Research points to the involvement of the immune system the brain as a contributor to mental disorders such as schizophrenia. Tue, 20 Apr 2021 18:31:44 EDT //www.koonmotors.com/releases/2021/04/210420183144.htm //www.koonmotors.com/releases/2021/04/210419110136.htm A simple dietary supplement reduces behavioral symptoms in mice with a genetic mutation that causes schizophrenia. After additional experiments, including visualizing the fluorescently stained dancing edge of immature brain cells, researchers concluded that the supplement likely protects proteins that build neurons' cellular skeletons. Mon, 19 Apr 2021 11:01:36 EDT //www.koonmotors.com/releases/2021/04/210419110136.htm //www.koonmotors.com/releases/2021/04/210413114047.htm New research shows that while cannabis users had higher rates of psychotic experiences than non-users across the board, the difference was especially pronounced among those with high genetic predisposition to schizophrenia. Tue, 13 Apr 2021 11:40:47 EDT //www.koonmotors.com/releases/2021/04/210413114047.htm //www.koonmotors.com/releases/2021/04/210401151253.htm A computer game that induces mice to experience hallucination-like events could be a key to understanding the neurobiological roots of psychosis, according to a new study. Thu, 01 Apr 2021 15:12:53 EDT //www.koonmotors.com/releases/2021/04/210401151253.htm //www.koonmotors.com/releases/2021/03/210323150726.htm Psychiatric researchers have identified interactions between genes and sex that might partly explain how major psychiatric disorders affect males and females differently. Tue, 23 Mar 2021 15:07:26 EDT //www.koonmotors.com/releases/2021/03/210323150726.htm //www.koonmotors.com/releases/2021/03/210309132606.htm Researchers have long searched for genetic influences in schizophrenia, a neurodevelopmental disorder that disrupts brain activity producing hallucinations, delusions, and other cognitive disturbances. However the disease's genetic mutations have been identified in only a small fraction -- fewer than a quarter -- of sequenced patients. A new study now shows that 'somatic' gene mutations in brain cells could account for some of the disease neuropathology. Tue, 09 Mar 2021 13:26:06 EST //www.koonmotors.com/releases/2021/03/210309132606.htm //www.koonmotors.com/releases/2021/03/210304112506.htm Glycine can stimulate or inhibit neurons in the brain, thereby controlling complex functions. Unraveling the three-dimensional structure of the glycine transporter, researchers have now come a big step closer to understanding the regulation of glycine in the brain. These results open up opportunities to find effective drugs that inhibit GlyT1 function, with major implications for the treatment of schizophrenia and other mental disorders. Thu, 04 Mar 2021 11:25:06 EST //www.koonmotors.com/releases/2021/03/210304112506.htm //www.koonmotors.com/releases/2021/02/210223192314.htm An international research team used the ultrabright X-rays of the Advanced Photon Source to examine neurons in the brains of schizophrenia patients. What they learned may help neurologists treat this harmful brain disorder. Tue, 23 Feb 2021 19:23:14 EST //www.koonmotors.com/releases/2021/02/210223192314.htm //www.koonmotors.com/releases/2021/02/210208185115.htm A new study suggests that differences in the expression of gene transcripts - readouts copied from DNA that help maintain and build our cells - may hold the key to understanding how mental disorders with shared genetic risk factors result in different patterns of onset, symptoms, course of illness, and treatment responses. Mon, 08 Feb 2021 18:51:15 EST //www.koonmotors.com/releases/2021/02/210208185115.htm //www.koonmotors.com/releases/2021/01/210126171642.htm Researchers have taken a step forward in developing an artificial intelligence tool to predict schizophrenia by analyzing brain scans. The tool was used to analyze functional magnetic resonance images of 57 healthy first-degree relatives (siblings or children) of schizophrenia patients. It accurately identified the 14 individuals who scored highest on a self-reported schizotypal personality trait scale. Tue, 26 Jan 2021 17:16:42 EST //www.koonmotors.com/releases/2021/01/210126171642.htm //www.koonmotors.com/releases/2021/01/210115115231.htm A team of neuroscientists and engineers has created a nasal spray to deliver antipsychotic medication directly to the brain instead of having it pass through the body. Fri, 15 Jan 2021 11:52:31 EST //www.koonmotors.com/releases/2021/01/210115115231.htm //www.koonmotors.com/releases/2021/01/210115110310.htm A new study shows that patients with a schizophrenia spectrum disorder have an increased risk of Parkinson's disease later in life. The increased risk may be due to alterations in the brain's dopamine system caused by dopamine receptor antagonists or neurobiological effects of schizophrenia. Fri, 15 Jan 2021 11:03:10 EST //www.koonmotors.com/releases/2021/01/210115110310.htm //www.koonmotors.com/releases/2020/12/201221134136.htm Using human-induced pluripotent stem cells engineered from a single family's blood samples, a gene signaling pathway linked to a higher risk for developing schizophrenia was discovered. Mon, 21 Dec 2020 13:41:36 EST //www.koonmotors.com/releases/2020/12/201221134136.htm //www.koonmotors.com/releases/2020/12/201216094645.htm Researchers have found that low-intensity exercise, which is associated with improved mental function, has a protective effect against symptoms of schizophrenia in adolescent mice. These findings may facilitate the development of exercise programs to help prevent schizophrenia in humans. Wed, 16 Dec 2020 09:46:45 EST //www.koonmotors.com/releases/2020/12/201216094645.htm //www.koonmotors.com/releases/2020/11/201119153948.htm Scientists have found that the use of long-acting antipsychotic medication combined with the use of cognitive training in group settings led to improved cognition and increased productivity. Thu, 19 Nov 2020 15:39:48 EST //www.koonmotors.com/releases/2020/11/201119153948.htm //www.koonmotors.com/releases/2020/11/201116112914.htm New research into how a common parasite infection alters human behavior could help development of treatments for schizophrenia and other neurological disorders. T. gondii currently infects 2.5 billion people worldwide and causes the disease Toxoplasmosis. Mon, 16 Nov 2020 11:29:14 EST //www.koonmotors.com/releases/2020/11/201116112914.htm //www.koonmotors.com/releases/2020/11/201110112532.htm The use of antipsychotics in young children is declining but doctors continue to prescribe these medications off-label for conditions not approved by the Food and Drug Administration and without the recommended psychiatric consultation, a new study found. Tue, 10 Nov 2020 11:25:32 EST //www.koonmotors.com/releases/2020/11/201110112532.htm