//www.koonmotors.com/news/mind_brain/psychedelic_drugs/ Medical research on LSD and related psychedelic drugs. From mystical experiences induced by "sacred mushrooms" to the potential use of LSD to treat alcoholism, read it all here. en-us Thu, 20 Jul 2023 16:20:00 EDT Thu, 20 Jul 2023 16:20:00 EDT 60 //www.koonmotors.com/images/scidaily-logo-rss.png//www.koonmotors.com/news/mind_brain/psychedelic_drugs/ For more science news, visit ScienceDaily. //www.koonmotors.com/releases/2023/06/230614220630.htm Neuroscientists have long searched for ways to reopen 'critical periods' in the brain, when mammals are more sensitive to signals from their surroundings that can influence periods of brain development. Now, researchers say a new study in mice shows that psychedelic drugs are linked by their common ability to reopen such critical periods, but differ in the length of time the critical period is open -- from two days to four weeks with a single dose. Wed, 14 Jun 2023 22:06:30 EDT //www.koonmotors.com/releases/2023/06/230614220630.htm //www.koonmotors.com/releases/2023/04/230425111218.htm A study takes a closer look at the neurobiology of psychedelic experiences caused by nitrous oxide, ketamine and LSD. Tue, 25 Apr 2023 11:12:18 EDT //www.koonmotors.com/releases/2023/04/230425111218.htm //www.koonmotors.com/releases/2023/03/230320150723.htm Scientists have gleaned new insights into how psychedelics alter conscious experience via their action on brain activity. Mon, 20 Mar 2023 15:07:23 EDT //www.koonmotors.com/releases/2023/03/230320150723.htm //www.koonmotors.com/releases/2023/02/230216161203.htm Location, location, location is the key for psychedelic drugs that could treat mental illness by rapidly rebuilding connections between nerve cells. Researchers show that engaging serotonin 2A receptors inside neurons promotes growth of new connections but engaging the same receptor on the surface of nerve cells does not. Thu, 16 Feb 2023 16:12:03 EST //www.koonmotors.com/releases/2023/02/230216161203.htm //www.koonmotors.com/releases/2023/02/230210115544.htm Researchers have discovered the active compound from an edible mushroom that boosts nerve growth and enhances memory. Fri, 10 Feb 2023 11:55:44 EST //www.koonmotors.com/releases/2023/02/230210115544.htm //www.koonmotors.com/releases/2022/11/221107103158.htm Researchers have participated in the largest and most rigorous clinical trial to date of psilocybin (a psychoactive ingredient in magic mushrooms), pointing to the possibility that COMP360 psilocybin with psychological support could be a beneficial therapeutic strategy for people with treatment-resistant depression (TRD). Mon, 07 Nov 2022 10:31:58 EST //www.koonmotors.com/releases/2022/11/221107103158.htm //www.koonmotors.com/releases/2022/09/220929133454.htm New research in animal models show it's possible to create a compound that hits the same exact target as psychedelic drugs hit -- the 5-HT2A serotonin receptors on the surface of specific neurons -- but does not cause the same psychedelic effects when given to mice. 星期四,2022年9月29日13:34:54美国东部时间 //www.koonmotors.com/releases/2022/09/220929133454.htm //www.koonmotors.com/releases/2022/08/220824152209.htm In a survey study of more than 3,000 adults, researchers compared psychedelic experiences with near-death experiences that were not drug related and found notable similarities in people's attitudes toward death. Wed, 24 Aug 2022 15:22:09 EDT //www.koonmotors.com/releases/2022/08/220824152209.htm //www.koonmotors.com/releases/2022/08/220824120823.htm Two doses of psilocybin, a compound found in psychedelic mushrooms, reduces heavy drinking by 83 percent on average among heavy drinkers when combined with psychotherapy, a new study shows. 结婚,2022年8月24日12:08:23美国东部时间 //www.koonmotors.com/releases/2022/08/220824120823.htm //www.koonmotors.com/releases/2022/08/220822130344.htm Marijuana and hallucinogen use in the past year reported by young adults 19 to 30 years old increased significantly in 2021 compared to five and 10 years ago, reaching historic highs in this age group since 1988, according to a recent study. Mon, 22 Aug 2022 13:03:44 EDT //www.koonmotors.com/releases/2022/08/220822130344.htm //www.koonmotors.com/releases/2022/08/220818122413.htm Hallucinogen use has increased since 2015, overall and particularly among adults 26 and older, while use decreased in adolescents aged 12-17 years according to a new study. Estimates of over 5.5 million people in the U.S. used hallucinogens in the past year in 2019, which represents an increase from 1.7 percent of the population ages 12 years and over in 2002 to 2.2 percent in 2019. Thu, 18 Aug 2022 12:24:13 EDT //www.koonmotors.com/releases/2022/08/220818122413.htm //www.koonmotors.com/releases/2022/07/220727153626.htm Researchers report that common genetic variations in one serotonin receptor could be a reason why people with psychiatric conditions, such as depression, respond differently to psychedelic treatments. Wed, 27 Jul 2022 15:36:26 EDT //www.koonmotors.com/releases/2022/07/220727153626.htm //www.koonmotors.com/releases/2022/04/220411113727.htm Psilocybin fosters greater connections between different regions of the brain in depressed people, freeing them up from long-held patterns of rumination and excessive self-focus, according to a new study. Mon, 11 Apr 2022 11:37:27 EDT //www.koonmotors.com/releases/2022/04/220411113727.htm //www.koonmotors.com/releases/2022/04/220411101254.htm A new paper provides a scientific framework to help shape the rollout of a program in Oregon that will legally permit the use of psilocybin for therapeutic reasons. Mon, 11 Apr 2022 10:12:54 EDT //www.koonmotors.com/releases/2022/04/220411101254.htm //www.koonmotors.com/releases/2022/03/220331134240.htm A new study addresses the question of whether psychedelics might change the attribution of consciousness to a range of living and nonliving things. Thu, 31 Mar 2022 13:42:40 EDT //www.koonmotors.com/releases/2022/03/220331134240.htm //www.koonmotors.com/releases/2022/03/220318131632.htm As Oregon embarks on a voter-approved initiative to permit psychoactive mushrooms in clinical use, a new systematic evidence review reveals a lack of scientific research describing the interactions between widely used psychiatric medications and psychedelics like psilocybin and MDMA. Fri, 18 Mar 2022 13:16:32 EDT //www.koonmotors.com/releases/2022/03/220318131632.htm //www.koonmotors.com/releases/2022/03/220316173309.htm Psychedelics may find new, legitimate roles in treatment for anxiety, depression, stress disorders, addiction, and other mental and behavioral health problems. But ensuring they do requires developing rigorous, standardized methods to study and apply the results, according to a new report. Wed, 16 Mar 2022 17:33:09 EDT //www.koonmotors.com/releases/2022/03/220316173309.htm //www.koonmotors.com/releases/2022/03/220316145736.htm In the world's largest study on psychedelics and the brain, a team of researchers have shown how drug-induced changes in subjective awareness are anatomically rooted in specific neurotransmitter receptor systems. 结婚,2022年3月16日14:57:36 EDT //www.koonmotors.com/releases/2022/03/220316145736.htm //www.koonmotors.com/releases/2022/02/220215090157.htm Previous studies have shown that psychedelic treatment with psilocybin relieved major depressive disorder symptoms in adults for up to a month. Now, in a follow-up study of those participants, the researchers report that the substantial antidepressant effects of psilocybin-assisted therapy, given with supportive psychotherapy, may last at least a year for some patients. Tue, 15 Feb 2022 09:01:57 EST //www.koonmotors.com/releases/2022/02/220215090157.htm //www.koonmotors.com/releases/2022/01/220111100012.htm Researchers have identified the effects of an environmental stressor, sleep deprivation, that could alter the balance controlled by antipsychotic drugs and impact individuals with schizophrenia. Tue, 11 Jan 2022 10:00:12 EST //www.koonmotors.com/releases/2022/01/220111100012.htm //www.koonmotors.com/releases/2021/10/211012102657.htm Mushrooms have been making headlines due to their many health advantages. Not only do they lower one's risk of cancer and premature death, but new research also reveals that these super-foods may benefit a person's mental health. Tue, 12 Oct 2021 10:26:57 EDT //www.koonmotors.com/releases/2021/10/211012102657.htm //www.koonmotors.com/releases/2021/09/210914111315.htm Researchers have discovered changes in the brain, triggered by LSD, that may explain the profound altered behavior associated with LSD, helping to understand how the brain generates behavior. Tue, 14 Sep 2021 11:13:15 EDT //www.koonmotors.com/releases/2021/09/210914111315.htm //www.koonmotors.com/releases/2021/07/210705113923.htm In a new study, researchers show that a single dose of psilocybin given to mice prompted an immediate and long-lasting increase in connections between neurons. The findings are published July 5 in the journal Neuron. Mon, 05 Jul 2021 11:39:23 EDT //www.koonmotors.com/releases/2021/07/210705113923.htm //www.koonmotors.com/releases/2021/05/210525160842.htm 一种新型复合结构相似的心理edelic drug ibogaine, but lacking its toxic and hallucinogenic effects, has been found to rapidly reverse the effects of stress in mice. Researchers found that a single dose of tabernanthalog (TBG) can correct stress-induced behavioral deficits, including anxiety and cognitive inflexibility, and also promotes the regrowth of neuronal connections and restores neural circuits in the brain that are disrupted by stress. Tue, 25 May 2021 16:08:42 EDT //www.koonmotors.com/releases/2021/05/210525160842.htm //www.koonmotors.com/releases/2021/04/210428113805.htm Psychedelic drugs have shown promise for treating neuropsychiatric disorders like depression and posttraumatic stress disorder. However, due to their hallucinatory side effects, some researchers are trying to identify drugs that could offer the benefits of psychedelics without causing hallucinations. Researchers now report they have identified one such drug through the development of a genetically encoded fluorescent sensor -- called psychLight -- that can screen for hallucinogenic potential. Wed, 28 Apr 2021 11:38:05 EDT //www.koonmotors.com/releases/2021/04/210428113805.htm //www.koonmotors.com/releases/2021/04/210413114107.htm Researchers have shown that psilocybin -- the active chemical in 'magic mushrooms' -- still works its antidepressant-like actions, at least in mice, even when the psychedelic experience is blocked. The new findings suggest that psychedelic drugs work in multiple ways in the brain and it may be possible to deliver the fast-acting antidepressant therapeutic benefit without requiring daylong guided therapy sessions. Tue, 13 Apr 2021 11:41:07 EDT //www.koonmotors.com/releases/2021/04/210413114107.htm //www.koonmotors.com/releases/2021/03/210322121311.htm As psychedelics gain ground as a potential therapy for mental health disorders, there remains a pressing concern that patients in clinical trials may have adverse effects to the drugs. New research identifies personality traits that have been associated with positive and negative experiences on psychedelics in previous studies, information that could help predict how future clinical trial participants will respond to the drugs. Mon, 22 Mar 2021 12:13:11 EDT //www.koonmotors.com/releases/2021/03/210322121311.htm //www.koonmotors.com/releases/2021/03/210310100651.htm A team of neuroscientists is uncovering how psychedelics affect brain activity. New work shows a strong connection in rodent models between brain activity and behaviors resulting from psychedelic treatment, a step forward in the quest to better understand their potential therapeutic effects. Wed, 10 Mar 2021 10:06:51 EST //www.koonmotors.com/releases/2021/03/210310100651.htm //www.koonmotors.com/releases/2021/03/210302150033.htm Positive psychological effects associated with taking small doses of psychedelic drugs are likely the result of users' expectations, suggests a new study. Tue, 02 Mar 2021 15:00:33 EST //www.koonmotors.com/releases/2021/03/210302150033.htm //www.koonmotors.com/releases/2021/02/210222092301.htm The Netherlands, United States, Australia and New Zealand are consuming the highest amounts of designer 'party' drugs, according to wastewater samples taken from eight countries over the New Year period. Mon, 22 Feb 2021 09:23:01 EST //www.koonmotors.com/releases/2021/02/210222092301.htm //www.koonmotors.com/releases/2021/02/210202192756.htm Nearly a third of US teens and young adults prescribed a psychoactive drug misuse that drug, with the likelihood of misuse rising with age, suggests an analysis of national survey responses. Tue, 02 Feb 2021 19:27:56 EST //www.koonmotors.com/releases/2021/02/210202192756.htm //www.koonmotors.com/releases/2020/12/201209115232.htm A non-hallucinogenic version of the psychedelic drug ibogaine, with potential for treating addiction, depression and other psychiatric disorders, has been developed by researchers. Wed, 09 Dec 2020 11:52:32 EST //www.koonmotors.com/releases/2020/12/201209115232.htm //www.koonmotors.com/releases/2020/09/200917181259.htm For the first time, scientists solved the high-resolution structure of these compounds when they are actively bound to the 5-HT2A serotonin receptor on the surface of brain cells. This discovery is already leading to the exploration of more precise compounds that could eliminate hallucinations but still have strong therapeutic effects. Psilocybin - the psychedelic compound in mushrooms - has already been granted breakthrough status by the FDA to treat depression. Thu, 17 Sep 2020 18:12:59 EDT //www.koonmotors.com/releases/2020/09/200917181259.htm //www.koonmotors.com/releases/2020/06/200605121512.htm To see how psychedelics impact the claustrum, a mysterious region of the brain believed to control the ego, researchers compared the brain scans of people after they took psilocybin with their scans after taking a placebo. Fri, 05 Jun 2020 12:15:12 EDT //www.koonmotors.com/releases/2020/06/200605121512.htm //www.koonmotors.com/releases/2020/04/200416114535.htm Scientists prove that psilocybin, a potential drug for treating depression and other psychological conditions can be produced in yeast. Thu, 16 Apr 2020 11:45:35 EDT //www.koonmotors.com/releases/2020/04/200416114535.htm //www.koonmotors.com/releases/2020/04/200402111744.htm Before they were banned about a half century ago, psychedelic drugs like LSD and psilocybin showed promise for treating conditions including alcoholism and some psychiatric disorders. Researchers say it's time for regulators, scientists, and the public to 'revisit drugs that were once used but fell out of use because of political machinations, especially the war on drugs.' Thu, 02 Apr 2020 11:17:44 EDT //www.koonmotors.com/releases/2020/04/200402111744.htm //www.koonmotors.com/releases/2020/03/200330181658.htm A new study suggests that, in the right context, some people may experience psychedelic-like effects from placebos alone. The researchers reported some of the strongest placebo effects on consciousness in the literature relating to psychedelic drugs. Indeed, 61% of the participants in the experiment reported some effect after consuming the placebo. Mon, 30 Mar 2020 18:16:58 EDT //www.koonmotors.com/releases/2020/03/200330181658.htm //www.koonmotors.com/releases/2020/01/200128115423.htm Following up on their landmark 2016 study, researchers found that a one-time, single-dose treatment of psilocybin, a compound found in psychedelic mushrooms, combined with psychotherapy appears to be associated with significant improvements in emotional and existential distress in cancer patients. Tue, 28 Jan 2020 11:54:23 EST //www.koonmotors.com/releases/2020/01/200128115423.htm //www.koonmotors.com/releases/2019/11/191126213919.htm A new study found there were more than 67,300 calls to US Poison Control Centers regarding exposures to natural psychoactive substances. The study looked at calls from January 2000 through December 2017, which totaled an average of 3,743 exposures each year, or approximately 10 calls every day. Tue, 26 Nov 2019 21:39:19 EST //www.koonmotors.com/releases/2019/11/191126213919.htm //www.koonmotors.com/releases/2019/11/191119075305.htm Scientists have peered inside the brain to show how taking DMT affects human consciousness by significantly altering the brain's electrical activity. 星期二,2019年11月19日07:53:05 EST //www.koonmotors.com/releases/2019/11/191119075305.htm //www.koonmotors.com/releases/2019/10/191030110012.htm A simple saliva test to detect if someone has recently taken the street drug ''spice'' has been developed. Wed, 30 Oct 2019 11:00:12 EDT //www.koonmotors.com/releases/2019/10/191030110012.htm //www.koonmotors.com/releases/2019/10/191024075003.htm Recent years have seen a renewed interest in the clinical application of classic psychedelics in the treatment of depression and anxiety disorders. Researchers have now shown that mindfulness meditation can enhance the positive long-term effects of a single dose of psilocybin, which is found in certain mushrooms. Thu, 24 Oct 2019 07:50:03 EDT //www.koonmotors.com/releases/2019/10/191024075003.htm //www.koonmotors.com/releases/2019/07/190723085951.htm American teenagers and adults are more likely to try illegal or recreational drugs for the first time in the summer, a new study shows. Tue, 23 Jul 2019 08:59:51 EDT //www.koonmotors.com/releases/2019/07/190723085951.htm //www.koonmotors.com/releases/2019/07/190715103307.htm The practice of taking small, regular doses of psychedelic drugs to enhance mood, creativity, or productivity lacks robust scientific evidence, say scientists. Mon, 15 Jul 2019 10:33:07 EDT //www.koonmotors.com/releases/2019/07/190715103307.htm //www.koonmotors.com/releases/2019/06/190627113951.htm A study in rats has revealed the presence of naturally occurring dimethyltryptamine, a hallucinogen. Thu, 27 Jun 2019 11:39:51 EDT //www.koonmotors.com/releases/2019/06/190627113951.htm //www.koonmotors.com/releases/2019/04/190424153542.htm Scientists used a compound found in a shrub native to Africa to reveal the three major shapes of the serotonin transporter, a protein in the brain linked to anxiety and depression. The discovery opens new avenues for developing medications to treat addiction. Wed, 24 Apr 2019 15:35:42 EDT //www.koonmotors.com/releases/2019/04/190424153542.htm //www.koonmotors.com/releases/2019/04/190423145511.htm In a survey of thousands of people who reported having experienced personal encounters with God, researchers report that more than two-thirds of self-identified atheists shed that label after their encounter, regardless of whether it was spontaneous or while taking a psychedelic. Tue, 23 Apr 2019 14:55:11 EDT //www.koonmotors.com/releases/2019/04/190423145511.htm //www.koonmotors.com/releases/2019/03/190318132628.htm Researchers have discovered that use of the synthetic psychedelic 5-methocy-N,-N-dimethyltryptamine (5-MeO-DMT) appears to be associated with unintended improvements in self-reported depression and anxiety when given in a ceremonial group setting. 5-MeO-DMT is a psychedelic that is found in the venom of Bufo Alvarius toads, in a variety of plants species, and can be produced synthetically. Mon, 18 Mar 2019 13:26:28 EDT //www.koonmotors.com/releases/2019/03/190318132628.htm //www.koonmotors.com/releases/2019/03/190312103702.htm Researchers found that seniors who consume more than two standard portions of mushrooms weekly may have 50 percent reduced odds of having mild cognitive impairment. Tue, 12 Mar 2019 10:37:02 EDT //www.koonmotors.com/releases/2019/03/190312103702.htm //www.koonmotors.com/releases/2019/03/190304100015.htm Microdosing -- taking tiny amounts of psychedelic drugs to boost mood and mental acuity -- is based on anecdotal reports of its benefits. Now, a study in rats suggests microdosing can provide relief for symptoms of depression and anxiety, but also has potential negative effects. Mon, 04 Mar 2019 10:00:15 EST //www.koonmotors.com/releases/2019/03/190304100015.htm //www.koonmotors.com/releases/2018/10/181030102809.htm LSD changes the communication patterns between regions of the brain, new research shows. The study also provides insights into how mental health disorders develop and how these could be treated. Tue, 30 Oct 2018 10:28:09 EDT //www.koonmotors.com/releases/2018/10/181030102809.htm //www.koonmotors.com/releases/2018/10/181025103329.htm The use of minute doses of magic mushrooms and truffles containing psychedelic substances could induce a state of unconstrained thought that may produce more new, creative ideas. 'Microdosing' in this way may allow people to experience the creative benefits of psychedelic drugs without the risk of the so-called 'bad trips' that often come with high doses of such substances. Thu, 25 Oct 2018 10:33:29 EDT //www.koonmotors.com/releases/2018/10/181025103329.htm //www.koonmotors.com/releases/2018/09/180926082159.htm In an evaluation of the safety and abuse research on the drug in hallucinogenic mushrooms, researchers suggest that if it clears phase III clinical trials, psilocybin should be re-categorized from a schedule I drug -- one with no known medical potential -- to a schedule IV drug such as prescription sleep aids, but with tighter control. Wed, 26 Sep 2018 08:21:59 EDT //www.koonmotors.com/releases/2018/09/180926082159.htm //www.koonmotors.com/releases/2018/08/180809141223.htm Many people think of psychedelics as relics from the hippie generation or something taken by ravers and music festival-goers, but they may one day be used to treat disorders ranging from social anxiety to depression, according to new research. Thu, 09 Aug 2018 14:12:23 EDT //www.koonmotors.com/releases/2018/08/180809141223.htm //www.koonmotors.com/releases/2018/06/180612185207.htm Psychedelic drugs may have mind-altering powers in the physical sense, too. A new study has found psychedelics, specifically DOI, DMT, and LSD, can change brain cells in rats and flies, making neurons more likely to branch out and connect with one another. The work supports the theory that psychedelics could help to fight depression, anxiety, addiction, and post-traumatic stress disorder. Tue, 12 Jun 2018 18:52:07 EDT //www.koonmotors.com/releases/2018/06/180612185207.htm //www.koonmotors.com/releases/2018/06/180606093701.htm Researchers have discovered that men who have used psychedelic drugs in the past have a lower likelihood of engaging in violence against their intimate partners. Wed, 06 Jun 2018 09:37:01 EDT //www.koonmotors.com/releases/2018/06/180606093701.htm //www.koonmotors.com/releases/2018/03/180319155948.htm LSD reduces the borders between the experience of our own self and others, and thereby affects social interactions. Researchers have now found that the serotonin 2A receptor in the human brain is critically involved in these intertwined psychological mechanisms. This knowledge could help develop new therapies for psychiatric disorders such as schizophrenia or depression. Mon, 19 Mar 2018 15:59:48 EDT //www.koonmotors.com/releases/2018/03/180319155948.htm //www.koonmotors.com/releases/2018/02/180227115548.htm Psychedelic mushrooms likely developed their "magical" properties to trip up fungi-munching insects, suggests new research. Tue, 27 Feb 2018 11:55:48 EST //www.koonmotors.com/releases/2018/02/180227115548.htm //www.koonmotors.com/releases/2017/11/171109093134.htm A psychedelic drug traditionally used in South America improves people's general sense of wellbeing and may offer a treatment for alcoholism and depression, new research suggests. Thu, 09 Nov 2017 09:31:34 EST //www.koonmotors.com/releases/2017/11/171109093134.htm //www.koonmotors.com/releases/2017/10/171023101753.htm Newly published research suggests that common psychedelic drugs -- such as 'magic mushrooms', LSD and mescaline (a substance derived from the peyote cactus) -- may reduce criminal offenses. The new study found that psychedelic drugs are associated with a decreased likelihood of antisocial criminal behavior. Mon, 23 Oct 2017 10:17:53 EDT //www.koonmotors.com/releases/2017/10/171023101753.htm