//www.koonmotors.com/news/mind_brain/opium/ Read medical research on the effect of opium and related controlled substances such as morphine, codeine, heroin, percocet and methadone on the body. en-us Sat, 14 Oct 2023 15:19:33 EDT Sat, 14 Oct 2023 15:19:33 EDT 60 //www.koonmotors.com/images/scidaily-logo-rss.png//www.koonmotors.com/news/mind_brain/opium/ For more science news, visit ScienceDaily. //www.koonmotors.com/releases/2023/09/230920111118.htm New research has identified an alternative signaling pathway in the brain of mice that relieves pain, even in animals that have developed tolerance to opioids. The study also showed that pain relief through this route did not induce tolerance, did not create withdrawals symptoms after treatment was stopped, and did not activate reward systems, limiting risk for addiction and making it a viable path to developing effective, non-opioid pain relief. Wed, 20 Sep 2023 11:11:18 EDT //www.koonmotors.com/releases/2023/09/230920111118.htm //www.koonmotors.com/releases/2023/09/230919154835.htm It is often hard to understand the source of pain in babies and children, and if they experience it often or for a long time, it can do severe damage. Tue, 19 Sep 2023 15:48:35 EDT //www.koonmotors.com/releases/2023/09/230919154835.htm //www.koonmotors.com/releases/2023/08/230807133810.htm An antibody therapy appears to have advantages over existing opioid-overdose treatments. Mon, 07 Aug 2023 13:38:10 EDT //www.koonmotors.com/releases/2023/08/230807133810.htm //www.koonmotors.com/releases/2023/07/230724122651.htm Neuropathic pain is a debilitating condition estimated to affect as much as 10% of the global population. It results from a damaged or malfunctioning nervous system, stemming from diseases like diabetes, alcoholism, strokes, Parkinson's and other causes like spinal nerve compression, radiation and chemotherapy treatments. Management of neuropathic pain has been particularly challenging as currently prescribed drugs, such as anticonvulsants and antidepressants can have severe adverse effects, are not well-tolerated, take a longer time to work only help a subset of patients. Mon, 24 Jul 2023 12:26:51 EDT //www.koonmotors.com/releases/2023/07/230724122651.htm //www.koonmotors.com/releases/2023/06/230628194941.htm Opioid pain-relieving medicines are not more effective than a placebo in relieving acute back and neck pain and may even cause harm, according to a recent trial. Wed, 28 Jun 2023 19:49:41 EDT //www.koonmotors.com/releases/2023/06/230628194941.htm //www.koonmotors.com/releases/2023/03/230328145531.htm Naloxone -- a fast-acting opioid antidote -- has saved lives, but it's less effective against powerful synthetic opioids, such as fentanyl. In an interesting twist, researchers are now investigating cannabidiol (CBD), a component of marijuana, as a possible alternative to the popular antidote. Today, a team reports compounds based on CBD that reduce fentanyl binding and boost the effects of naloxone. Tue, 28 Mar 2023 14:55:31 EDT //www.koonmotors.com/releases/2023/03/230328145531.htm //www.koonmotors.com/releases/2023/03/230314155101.htm 催眠是一种有效治疗疼痛ny individuals but determining which patients will benefit most can be challenging. Hypnotizability testing requires special training and in-person evaluation rarely available in the clinical setting. Now, investigators have developed a fast, point-of-care molecular diagnostic test that identifies a subset of individuals who are most likely to benefit from hypnosis interventions for pain treatment. Their study also found that a subset of highly hypnotizable individuals may be more likely to experience high levels of postoperative pain. Tue, 14 Mar 2023 15:51:01 EDT //www.koonmotors.com/releases/2023/03/230314155101.htm //www.koonmotors.com/releases/2023/01/230112182111.htm New work provides a comprehensive structural framework that should help drug developers rationally design safer drugs to relieve severe pain. Thu, 12 Jan 2023 18:21:11 EST //www.koonmotors.com/releases/2023/01/230112182111.htm //www.koonmotors.com/releases/2022/12/221201141908.htm Opioid-related overdose is now a leading cause of accidental death in the United States and Canada. A study suggests discontinuing prescribed opioids was associated with increased overdose risk. Thu, 01 Dec 2022 14:19:08 EST //www.koonmotors.com/releases/2022/12/221201141908.htm //www.koonmotors.com/releases/2022/11/221130151450.htm A collaboration of scientists found a novel way to render benign the worst side effects of fentanyl. Wed, 30 Nov 2022 15:14:50 EST //www.koonmotors.com/releases/2022/11/221130151450.htm //www.koonmotors.com/releases/2022/11/221128162139.htm While some feared that New Yorkers would re-fill prescriptions to stockpile opioid medications in the early weeks of the COVID-19 lockdown, New York State opioid prescriptions declined in the period around the March 20, 2020 'PAUSE' order, according to new research. Meanwhile, prescriptions for medications for opioid use disorder (MOUD) were steady, likely thanks to policies to ensure their availability during the same period. Mon, 28 Nov 2022 16:21:39 EST //www.koonmotors.com/releases/2022/11/221128162139.htm //www.koonmotors.com/releases/2022/11/221123113832.htm Sometimes healthcare professionals treat patients with opioids such as morphine to relieve symptoms, but there has been a lack of evidence as to whether this helps with severe chronic breathlessness. A randomized Phase 3 study now finds that morphine does not reduce worst breathlessness. Wed, 23 Nov 2022 11:38:32 EST //www.koonmotors.com/releases/2022/11/221123113832.htm //www.koonmotors.com/releases/2022/11/221114132101.htm A breakthrough discovery could have major implications for the nation's opioid epidemic by becoming a relapse prevention vaccine for people trying to quit using opioids. Mon, 14 Nov 2022 13:21:01 EST //www.koonmotors.com/releases/2022/11/221114132101.htm //www.koonmotors.com/releases/2022/10/221026122723.htm People with opioid-use disorder who enter treatment are at risk for relapse, overdose or death if they engage in less than two outpatient visits in their first month of care, according to a new study. Wed, 26 Oct 2022 12:27:23 EDT //www.koonmotors.com/releases/2022/10/221026122723.htm //www.koonmotors.com/releases/2022/10/221026103211.htm New findings unexpectedly show that heroin, not its metabolites, is the best therapeutic target. Wed, 26 Oct 2022 10:32:11 EDT //www.koonmotors.com/releases/2022/10/221026103211.htm //www.koonmotors.com/releases/2022/10/221019111427.htm 肾上腺素受体激活我的新物质nstead of opioid receptors have a similar pain relieving effect to opiates, but without the negative aspects such as respiratory depression and addiction. New findings are a milestone in the development of non-opioid pain relief. Wed, 19 Oct 2022 11:14:27 EDT //www.koonmotors.com/releases/2022/10/221019111427.htm //www.koonmotors.com/releases/2022/10/221012132337.htm Veterans receiving buprenorphine were more likely to stay on it if they had virtual visits, but phone-based virtual care was especially prominent among those who are Black or lack stable housing, according to a new study. Wed, 12 Oct 2022 13:23:37 EDT //www.koonmotors.com/releases/2022/10/221012132337.htm //www.koonmotors.com/releases/2022/10/221010115348.htm Some smart home technology could help curb opioid overdose. A pilot study showed that a set of noninvasive home sensors could provide accurate information about overnight restlessness and sleep problems for people recovering from opioid use disorder. Disrupted sleep is a major complaint of people trying to quit highly addictive opioids. Although methadone is effective at reducing cravings and withdrawal, it is often prescribed once daily and adjusting for the proper dosage can take time. In the meantime, treatments can wear off during the night, returning withdrawal symptoms and pain -- which increases the risk of resuming drug use and accidental overdose. Researchers found the home sensors matched other monitoring methods for sleep disturbance about 89% of the time. Mon, 10 Oct 2022 11:53:48 EDT //www.koonmotors.com/releases/2022/10/221010115348.htm //www.koonmotors.com/releases/2022/10/221007112106.htm Researchers have observed that the length of daylight hours impacts opioid receptor levels in brown fat. When daylight hours shorten, the receptor activity levels elevate. A similar phenomenon also takes place in the brain. Both phenomena help people and animals in the adaptation to seasonal changes. Fri, 07 Oct 2022 11:21:06 EDT //www.koonmotors.com/releases/2022/10/221007112106.htm //www.koonmotors.com/releases/2022/10/221006111842.htm Results of a new study suggest the prefrontal cortex-habenula circuit is potentially amenable for targeted interventions and prevention. Thu, 06 Oct 2022 11:18:42 EDT //www.koonmotors.com/releases/2022/10/221006111842.htm //www.koonmotors.com/releases/2022/10/221003152153.htm Using data from the Pennsylvania Overdose Information Network from the years 2018-20 and American Community Survey data from 2015-19, geography researchers looked at the prevalence of overdoses in the state and found the availability of the anti-overdose therapeutic naloxone to be a key factor in overdose survival. Mon, 03 Oct 2022 15:21:53 EDT //www.koonmotors.com/releases/2022/10/221003152153.htm //www.koonmotors.com/releases/2022/09/220929133339.htm According to a new study, third-trimester fetuses with in utero opioid exposure exhibited multiple smaller 2D biometric measurements of the brain, as well as altered fetal physiology, on investigational MRI. Thu, 29 Sep 2022 13:33:39 EDT //www.koonmotors.com/releases/2022/09/220929133339.htm //www.koonmotors.com/releases/2022/09/220928094834.htm 在新的研究中,阿片类药物使用视为减少或停止together, following prescription of medical cannabis. Wed, 28 Sep 2022 09:48:34 EDT //www.koonmotors.com/releases/2022/09/220928094834.htm //www.koonmotors.com/releases/2022/09/220906114244.htm Researchers test the efficacy of a soft, bioresorbable, implantable device to block pain signals from sciatic nerves of rat models. Tue, 06 Sep 2022 11:42:44 EDT //www.koonmotors.com/releases/2022/09/220906114244.htm //www.koonmotors.com/releases/2022/08/220831114042.htm The expansion of telehealth services during the COVID-19 pandemic was associated with individuals staying in treatment longer and reducing their risk of medically treated overdose, according to a new study. Wed, 31 Aug 2022 11:40:42 EDT //www.koonmotors.com/releases/2022/08/220831114042.htm //www.koonmotors.com/releases/2022/08/220830135645.htm Fentanyl produces a specific EEG signature distinct from other anesthetic drugs, which could make it possible to monitor its effects to enable safer, more precise, and personalized opioid administration. Tue, 30 Aug 2022 13:56:45 EDT //www.koonmotors.com/releases/2022/08/220830135645.htm //www.koonmotors.com/releases/2022/08/220825120132.htm Mandates to decrease opioid prescriptions in the U.S. have worked, but they also have had an unintended and undesirable public health outcome, according to new research. Thu, 25 Aug 2022 12:01:32 EDT //www.koonmotors.com/releases/2022/08/220825120132.htm //www.koonmotors.com/releases/2022/08/220815112812.htm Methamphetamine remains a stubbornly prevalent illicit substance in large swaths of rural America, according to a new study. The findings show that methamphetamine remains a common drug, and is driving overdoses in rural communities. About four of five people who use drugs in rural areas across 10 states reported using methamphetamines in the past 30 days, according to the study. Mon, 15 Aug 2022 11:28:12 EDT //www.koonmotors.com/releases/2022/08/220815112812.htm //www.koonmotors.com/releases/2022/08/220810161145.htm The number of privately insured adults in the United States prescribed opioid medications for cancer pain and for chronic non-cancer pain declined between 2012 and 2019, according to a new study. Wed, 10 Aug 2022 16:11:45 EDT //www.koonmotors.com/releases/2022/08/220810161145.htm //www.koonmotors.com/releases/2022/07/220728112008.htm Over the past 21 years of opioid overdose deaths, geography has played a role in where they have occurred, reports a new study. But the coming wave will not discriminate between rural and urban areas, the study findings suggest. Every type of county -- from the most rural to the most urban -- is predicted to see dramatic increases in deaths from opioid-involved overdoses. Thu, 28 Jul 2022 11:20:08 EDT //www.koonmotors.com/releases/2022/07/220728112008.htm //www.koonmotors.com/releases/2022/07/220722123302.htm 一项新的研究揭示了低聚物的分子structure of the MOR-Gal1R complex, a component present in the brain which is involved in the analgesic and addictive effects of certain opioids. Fri, 22 Jul 2022 12:33:02 EDT //www.koonmotors.com/releases/2022/07/220722123302.htm //www.koonmotors.com/releases/2022/07/220720102521.htm Scientists have investigated a compound called BnOCPA (benzyloxy-cyclopentyladenosine), found to be a potent and selective analgesic which is non-addictive in test model systems. BnOCPA also has a unique mode of action and potentially opens a new pipeline for the development of new analgesic drugs. Wed, 20 Jul 2022 10:25:21 EDT //www.koonmotors.com/releases/2022/07/220720102521.htm //www.koonmotors.com/releases/2022/07/220719162125.htm Researchers used a new kind of computational tool to parse the complicated genetics that put some people at higher risk of becoming addicted to alcohol, cigarettes, and likely other substances. Tue, 19 Jul 2022 16:21:25 EDT //www.koonmotors.com/releases/2022/07/220719162125.htm //www.koonmotors.com/releases/2022/07/220715085003.htm After the Centers for Disease Control and Prevention released a guideline for prescribing opioids to patients experiencing chronic pain in 2016, the prescribing rate of non-opioid pain medication increased each year above and beyond what would be expected based on the preexisting trends, a new study finds. Researchers say the findings suggest more clinicians are carefully considering the risks of prescribing opioids. Fri, 15 Jul 2022 08:50:03 EDT //www.koonmotors.com/releases/2022/07/220715085003.htm //www.koonmotors.com/releases/2022/07/220711095147.htm Scientists have long noted a connection between opioid use disorder (OUD) and chronic pain, however brain mechanisms linking OUD and chronic pain are poorly understood. A new study has explored one potential mechanism -- central sensitization -- among individuals with OUD. Mon, 11 Jul 2022 09:51:47 EDT //www.koonmotors.com/releases/2022/07/220711095147.htm //www.koonmotors.com/releases/2022/07/220707141845.htm Researchers identified significant changes to the infant gut microbiome of mice associated with maternal exposure to oxycodone, a commonly used and abused opioid. Thu, 07 Jul 2022 14:18:45 EDT //www.koonmotors.com/releases/2022/07/220707141845.htm //www.koonmotors.com/releases/2022/07/220707100950.htm People with two pediatric-onset neurodevelopmental disorders are prescribed opioids at a rate up to five times higher than those who do not have those conditions, a new study finds. Researchers say the findings raise concerns over addiction, overdose and mental health issues. Thu, 07 Jul 2022 10:09:50 EDT //www.koonmotors.com/releases/2022/07/220707100950.htm //www.koonmotors.com/releases/2022/07/220706165347.htm Opioids are the gold standard for treatment of chronic and acute pain; however, their use may result in significant gastrointestinal side effects, including nausea, vomiting, and constipation. The reasons behind these side effects are not well understood. A new study reports on how opioids like morphine cause gastric inflammation and how this condition can be reversed through treatment with proton pump inhibitor drugs like omeprazole, an over-the-counter medication commonly used to reduce stomach acid. Wed, 06 Jul 2022 16:53:47 EDT //www.koonmotors.com/releases/2022/07/220706165347.htm //www.koonmotors.com/releases/2022/06/220630114506.htm Opioids are a cornerstone of cancer pain management, but there is a lack of consensus on how to treat pain in cancer patients who also have struggled with opioid use disorder or prescription opioid misuse. Researchers outline guidance for treating such patients and highlight obstacles and opportunities for better integration of addiction treatment in cancer care. Thu, 30 Jun 2022 11:45:06 EDT //www.koonmotors.com/releases/2022/06/220630114506.htm //www.koonmotors.com/releases/2022/06/220630114451.htm A small tweak to hospitals' prescribing systems might make a big difference in reducing risk from leftover opioid pain medication, while still making sure surgery patients get relief from their post-operation pain, a new study suggests. Thu, 30 Jun 2022 11:44:51 EDT //www.koonmotors.com/releases/2022/06/220630114451.htm //www.koonmotors.com/releases/2022/06/220615113244.htm Initial results of the Canadian OPTIMA study comparing the efficacy of two models of care for treating opioid use disorder have been completed. Wed, 15 Jun 2022 11:32:44 EDT //www.koonmotors.com/releases/2022/06/220615113244.htm //www.koonmotors.com/releases/2022/06/220614141553.htm A new study reveals that opioid analgesic fentanyl may induce autism-like behaviors in young male and female mice. The findings indicate that reduced expression of the gene Grin2b in the anterior cingulate cortex of the brain following fentanyl treatment accounts for the autism-like behavior in the mice. However, there is no current evidence that fentanyl is associated with a similar effect in humans. The outcomes of the animal study are not an indication to avoid fentanyl in clinical use. Tue, 14 Jun 2022 14:15:53 EDT //www.koonmotors.com/releases/2022/06/220614141553.htm //www.koonmotors.com/releases/2022/06/220613124547.htm A new study suggests that the increased rates of overdose and mental health crisis observed during the first year after opioid dose tapering persist through the second year. Mon, 13 Jun 2022 12:45:47 EDT //www.koonmotors.com/releases/2022/06/220613124547.htm //www.koonmotors.com/releases/2022/06/220604082953.htm Pandemic-era changes to prescribing guidelines for the lifesaving drug buprenorphine led to improved treatment outcomes for patients with opioid use disorder in Philadelphia, according to a recently published study. Sat, 04 Jun 2022 08:29:53 EDT //www.koonmotors.com/releases/2022/06/220604082953.htm //www.koonmotors.com/releases/2022/05/220531111811.htm Breathing difficulties are the main cause of death following opioid use. In the UK, the number of adults entering treatment for opioid use was 140,863 in 2020/211 and opioid use remains a significant cause of premature death, contributing to 3,726 drug-related deaths last year. Opioid misuse causes death by supressing respiratory activity. New research points to a novel treatment for respiratory depression associated with opioid use that administers electrical pulses to the back of the neck, helping patients regain respiratory control following high dosage opioid use. This could offer an alternative to pharmacological treatments, which can cause withdrawal symptoms, heart problems and can negatively affect the central nervous system. Tue, 31 May 2022 11:18:11 EDT //www.koonmotors.com/releases/2022/05/220531111811.htm //www.koonmotors.com/releases/2022/05/220512164003.htm Scientists found a chemical from a rainforest tree that binds to opioid receptors in the brain and may have utility as an antidepressant or anti-anxiety drug. Thu, 12 May 2022 16:40:03 EDT //www.koonmotors.com/releases/2022/05/220512164003.htm //www.koonmotors.com/releases/2022/05/220512134142.htm Researchers have evidence validating the benefits of using medication for opioid use disorder during pregnancy. Brain imaging revealed significant improvements in brain function after treatment. Thu, 12 May 2022 13:41:42 EDT //www.koonmotors.com/releases/2022/05/220512134142.htm //www.koonmotors.com/releases/2022/05/220510122420.htm Researchers found that less than half of Americans who received treatment for opioid use disorder over a five-year period were offered a potentially lifesaving medication. The numbers were even lower for those with what's known as polysubstance use disorder -- when opioid users also misuse other substances. Tue, 10 May 2022 12:24:20 EDT //www.koonmotors.com/releases/2022/05/220510122420.htm //www.koonmotors.com/releases/2022/05/220506113309.htm Study finds that patients of orthopaedic and urologic procedures were more likely to dispose of their extra opioid tablets when they received kits in the mail to do so. Fri, 06 May 2022 11:33:09 EDT //www.koonmotors.com/releases/2022/05/220506113309.htm //www.koonmotors.com/releases/2022/04/220425212058.htm In rural communities, structural and community factors during the pandemic have increased anxiety, depression, and loneliness and altered drug use behaviors, according to a new study. Mon, 25 Apr 2022 21:20:58 EDT //www.koonmotors.com/releases/2022/04/220425212058.htm //www.koonmotors.com/releases/2022/04/220420151600.htm From 2003 through 2020, as opioid-related mortality in Ontario, Canada increased five-fold, the age distribution also shifted downward -- with rates now peaking for people in their mid-30s -- according to a new study. Wed, 20 Apr 2022 15:16:00 EDT //www.koonmotors.com/releases/2022/04/220420151600.htm //www.koonmotors.com/releases/2022/04/220419140737.htm The COVID-19 pandemic has spiked the overdose death rate from opioid use. For people who rely on medications (buprenorphine, methadone, and extended-release naltrexone) to treat opioid use disorders, the pandemic and such natural disasters as tornados, hurricanes, and wildfires can disrupt access to medications. And new research finds that the location of medication treatment services makes treatment interruption likely where those disruptions exist. Tue, 19 Apr 2022 14:07:37 EDT //www.koonmotors.com/releases/2022/04/220419140737.htm //www.koonmotors.com/releases/2022/04/220414110828.htm A team of researchers developed a framework that may help clinicians objectively identify and estimate harms and benefits of opioid use for pain management. Thu, 14 Apr 2022 11:08:28 EDT //www.koonmotors.com/releases/2022/04/220414110828.htm //www.koonmotors.com/releases/2022/04/220411101401.htm Hyperbaric oxygen therapy may help people being treated for opioid addiction reduce their methadone dose and better manage pain and withdrawal symptoms, according to a pair of recent studies. The research team recruited participants enrolled in a local opioid treatment program to test the effects of hyperbaric oxygen therapy, a treatment that involves breathing pure oxygen in a pressurized environment. Mon, 11 Apr 2022 10:14:01 EDT //www.koonmotors.com/releases/2022/04/220411101401.htm //www.koonmotors.com/releases/2022/04/220404082859.htm Researchers found that opioid prescriptions for children who underwent one of eight common outpatient surgeries declined over a period of five years. These findings suggest that clinicians are using more discretion when considering which pediatric patients require an opioid prescription after their procedures. Mon, 04 Apr 2022 08:28:59 EDT //www.koonmotors.com/releases/2022/04/220404082859.htm //www.koonmotors.com/releases/2022/03/220331101612.htm Global opioid sales increased by an estimated 4% annually from 2015 to 2019, but massive disparities in access to essential pain relief medications persist between countries, a new study finds. Thu, 31 Mar 2022 10:16:12 EDT //www.koonmotors.com/releases/2022/03/220331101612.htm //www.koonmotors.com/releases/2022/03/220324184711.htm Receiving psychosocial and behavioral therapy alongside medications for opioid use disorder leads to better treatment engagement and continuity, according to researchers. Thu, 24 Mar 2022 18:47:11 EDT //www.koonmotors.com/releases/2022/03/220324184711.htm //www.koonmotors.com/releases/2022/03/220302185942.htm Researchers found that blood pressure medications have an unanticipated effect on the brain. Wed, 02 Mar 2022 18:59:42 EST //www.koonmotors.com/releases/2022/03/220302185942.htm //www.koonmotors.com/releases/2022/03/220301192410.htm Results from a new clinical trial demonstrate that an eight-week mindfulness-based therapy decreased opioid use and misuse while reducing chronic pain symptoms, with effects lasting as long as nine months. Tue, 01 Mar 2022 19:24:10 EST //www.koonmotors.com/releases/2022/03/220301192410.htm //www.koonmotors.com/releases/2022/01/220112154936.htm A study in mice shows that removing chemical messengers in the brain that are involved in both wakefulness and addiction may make withdrawal from opioids easier and help prevent relapse. Wed, 12 Jan 2022 15:49:36 EST //www.koonmotors.com/releases/2022/01/220112154936.htm