//www.koonmotors.com/news/mind_brain/illegal_drugs/ 阅读最新的科学研究大麻,cocaine, and other controlled substances, including the effect on the body, possible medicinal uses and more. en-us Mon, 16 Oct 2023 18:19:16 EDT Mon, 16 Oct 2023 18:19:16 EDT 60 //www.koonmotors.com/images/scidaily-logo-rss.png//www.koonmotors.com/news/mind_brain/illegal_drugs/ For more science news, visit ScienceDaily. //www.koonmotors.com/releases/2023/09/230912113528.htm When you're under stress, your brain may release its own cannabinoid molecules to calm you, activating the same brain receptors as THC derived from cannabis plants. But the brain activity regulated by these cannabinoid molecules were not well known. A new study in mice has discovered a key emotional brain center, the amygdala, releases cannabinoid molecules under stress that dampen the incoming stress alarm from the hippocampus, a memory and emotion center in the brain. The finding may reveal novel therapeutic targets for the treatment of stress-related disorders. Tue, 12 Sep 2023 11:35:28 EDT //www.koonmotors.com/releases/2023/09/230912113528.htm //www.koonmotors.com/releases/2023/07/230706160116.htm Researchers showed that consuming THC while pregnant could potentially affect development of the fetus and lead to life-long health impacts for offspring. Thu, 06 Jul 2023 16:01:16 EDT //www.koonmotors.com/releases/2023/07/230706160116.htm //www.koonmotors.com/releases/2023/05/230522131310.htm Researchers analyzed THC levels in the breath of people who use cannabis regularly, both before and after they smoked marijuana. The researchers found that THC levels spanned a similar range across pre- and post-use samples. 'In many cases, we would not have been able to tell whether the person smoked within the last hour based on the concentration of THC in their breath,' said study author. Mon, 22 May 2023 13:13:10 EDT //www.koonmotors.com/releases/2023/05/230522131310.htm //www.koonmotors.com/releases/2023/04/230420135331.htm Marijuana (cannabis) is well known for giving people the 'munchies.' Not only does it make people want to eat more, but it also makes them crave the tastiest, most high-calorie foods. Now a new study shows that well-studied nematode worms (C. elegans) react to those chemicals known as cannabinoids in precisely the same way. Thu, 20 Apr 2023 13:53:31 EDT //www.koonmotors.com/releases/2023/04/230420135331.htm //www.koonmotors.com/releases/2023/03/230322140341.htm By combing through genomic data of over 1 million people of European or African descent, scientists have identified genes commonly inherited across addiction disorders, regardless of the substance being used. This dataset -- one of largest and most diverse of its kind -- may help reveal new treatment targets across multiple substance use disorders, including for people diagnosed with more than one. The findings also reinforce the role of the dopamine system in addiction, by showing that the combination of genes underlying addiction disorders was also associated with regulation of dopamine signaling. Wed, 22 Mar 2023 14:03:41 EDT //www.koonmotors.com/releases/2023/03/230322140341.htm //www.koonmotors.com/releases/2023/02/230215100417.htm Psychostimulants interacting with the dopamine transporter are found in the therapy of neuro-psychiatric disorders, such as ADHD or depression, as well as on the illicit drug market. In order to better understand their exact mode of action and undesirable effects, a research team has been working on the question of why different substances in this group of substances have different effects: According to their results the answer lies in the respective binding time of the substances to the dopamine transporter. This study has just been published in the journal Proceedings of the National Academy of Sciences (PNAS). Wed, 15 Feb 2023 10:04:17 EST //www.koonmotors.com/releases/2023/02/230215100417.htm //www.koonmotors.com/releases/2022/12/221219123953.htm Craving is known to be a key factor in substance use disorders and can increase the likelihood of future drug use or relapse. Yet its neural basis -- or, how the brain gives rise to craving -- is not well understood. In a new study, researchers from have identified a stable brain pattern, or neuromarker, for drug and food craving. Mon, 19 Dec 2022 12:39:53 EST //www.koonmotors.com/releases/2022/12/221219123953.htm //www.koonmotors.com/releases/2022/12/221212140658.htm Simultaneous cannabis and alcohol use, defined as using both substances at the same time so their effects overlap, increased in adults from 2008 to 2019, according to new research. Shifts in cannabis legislation have raised questions about unintended effects on cannabis and alcohol use patterns, whereby policy changes might lead people to use both substances. Until now, the relationships between recreational cannabis laws (RCLs) and changes in simultaneous cannabis/alcohol use prevalence had remain untested. Mon, 12 Dec 2022 14:06:58 EST //www.koonmotors.com/releases/2022/12/221212140658.htm //www.koonmotors.com/releases/2022/11/221130151450.htm A collaboration of scientists found a novel way to render benign the worst side effects of fentanyl. Wed, 30 Nov 2022 15:14:50 EST //www.koonmotors.com/releases/2022/11/221130151450.htm //www.koonmotors.com/releases/2022/11/221130114634.htm Scientists have successfully identified the urinary biomarkers of an emerging subclass of synthetic cannabinoids, called OXIZID, to monitor potential abuse. Wed, 30 Nov 2022 11:46:34 EST //www.koonmotors.com/releases/2022/11/221130114634.htm //www.koonmotors.com/releases/2022/11/221129184438.htm Excessive television viewing as a child can lead to a higher risk of tobacco use and gambling disorders in adulthood, a new study shows. Tue, 29 Nov 2022 18:44:38 EST //www.koonmotors.com/releases/2022/11/221129184438.htm //www.koonmotors.com/releases/2022/11/221129112845.htm Pregnant women living in U.S. states where cannabis is legal must be screened for the drug, for the health of both mother and baby, claim scientists who in a new national study have found that they are far more likely to use the substance. Tue, 29 Nov 2022 11:28:45 EST //www.koonmotors.com/releases/2022/11/221129112845.htm //www.koonmotors.com/releases/2022/11/221128101208.htm States that legalized recreational cannabis saw a slight population-level uptick in alcohol consumption that was largely driven by young adults and men, according to new research. Mon, 28 Nov 2022 10:12:08 EST //www.koonmotors.com/releases/2022/11/221128101208.htm //www.koonmotors.com/releases/2022/11/221116085946.htm New research has found no evidence that cannabidiol (CBD) reduces the negative effects of cannabis. Wed, 16 Nov 2022 08:59:46 EST //www.koonmotors.com/releases/2022/11/221116085946.htm //www.koonmotors.com/releases/2022/11/221115114107.htm Currently, various classes of drugs are available for the treatment of mental illnesses -- such as depression and anxiety disorders. However, although these drugs confer benefits, they are also associated with adverse side-effects. Conseqeuntly, medical researchers continuously thrive to improve the pharmacological properties of therapeutic agents to optimize the benefit-to-side-effect ratio. Tue, 15 Nov 2022 11:41:07 EST //www.koonmotors.com/releases/2022/11/221115114107.htm //www.koonmotors.com/releases/2022/11/221114132101.htm 一个突破性的发现会有重大implications for the nation's opioid epidemic by becoming a relapse prevention vaccine for people trying to quit using opioids. Mon, 14 Nov 2022 13:21:01 EST //www.koonmotors.com/releases/2022/11/221114132101.htm //www.koonmotors.com/releases/2022/11/221101111556.htm Common gut bacteria can enhance the effects of cocaine in mice, researchers report. Their study demonstrates how cocaine use supports the growth of the bacteria, which in turn eat up a chemical, glycine, that contributes to normal brain function. As levels of glycine become depleted, mice exhibit a higher response to the drug with behavior abnormalities, such as significantly increasing drug-induced locomotion and seeking behaviors. Tue, 01 Nov 2022 11:15:56 EDT //www.koonmotors.com/releases/2022/11/221101111556.htm //www.koonmotors.com/releases/2022/10/221026114401.htm Public health researchers have found that the prevalence of school discipline and school policing -- core elements of the school-to-prison pipeline -- predict subsequent school-average levels of substance use and developmental risk. Wed, 26 Oct 2022 11:44:01 EDT //www.koonmotors.com/releases/2022/10/221026114401.htm //www.koonmotors.com/releases/2022/10/221006111842.htm Results of a new study suggest the prefrontal cortex-habenula circuit is potentially amenable for targeted interventions and prevention. Thu, 06 Oct 2022 11:18:42 EDT //www.koonmotors.com/releases/2022/10/221006111842.htm //www.koonmotors.com/releases/2022/10/221004213341.htm Chemists have developed a fuel cell sensor that they hope to develop into a handheld analyzer to detect THC on a person's breath. When THC is introduced into their laboratory-scale device it oxidizes, creating an electric current whose strength indicates how much of the psychoactive compound is present. Tue, 04 Oct 2022 21:33:41 EDT //www.koonmotors.com/releases/2022/10/221004213341.htm //www.koonmotors.com/releases/2022/09/220928094834.htm In new study, opioid use seen to reduce or stop altogether, following prescription of medical cannabis. Wed, 28 Sep 2022 09:48:34 EDT //www.koonmotors.com/releases/2022/09/220928094834.htm //www.koonmotors.com/releases/2022/09/220921093012.htm Substance abuse among U.S. adolescents is diminishing, except for an uptake in cannabis and vaping use, according to a new study. The findings show that low social engagement and participation in structured activities seemed to be the overall best predictors of substance abuse avoidance. Wed, 21 Sep 2022 09:30:12 EDT //www.koonmotors.com/releases/2022/09/220921093012.htm //www.koonmotors.com/releases/2022/08/220827092455.htm A new first-of-its-kind study of twins finds that residents of states where recreational marijuana is legal use it 24% more frequently than those in states where it's illegal. It's among the strongest evidence yet that legalization increases use. Sat, 27 Aug 2022 09:24:55 EDT //www.koonmotors.com/releases/2022/08/220827092455.htm //www.koonmotors.com/releases/2022/08/220826113253.htm Illicit drug use is associated with a nearly nine-fold greater risk of death or life-threatening emergencies in intensive cardiac care unit (ICCU) patients, according to new research. Fri, 26 Aug 2022 11:32:53 EDT //www.koonmotors.com/releases/2022/08/220826113253.htm //www.koonmotors.com/releases/2022/08/220823135701.htm People who use therapeutic cannabis are more likely to also use nicotine products than the general population, according to a new study. Tue, 23 Aug 2022 13:57:01 EDT //www.koonmotors.com/releases/2022/08/220823135701.htm //www.koonmotors.com/releases/2022/08/220822130344.htm Marijuana and hallucinogen use in the past year reported by young adults 19 to 30 years old increased significantly in 2021 compared to five and 10 years ago, reaching historic highs in this age group since 1988, according to a recent study. Mon, 22 Aug 2022 13:03:44 EDT //www.koonmotors.com/releases/2022/08/220822130344.htm //www.koonmotors.com/releases/2022/08/220818122413.htm Hallucinogen use has increased since 2015, overall and particularly among adults 26 and older, while use decreased in adolescents aged 12-17 years according to a new study. Estimates of over 5.5 million people in the U.S. used hallucinogens in the past year in 2019, which represents an increase from 1.7 percent of the population ages 12 years and over in 2002 to 2.2 percent in 2019. Thu, 18 Aug 2022 12:24:13 EDT //www.koonmotors.com/releases/2022/08/220818122413.htm //www.koonmotors.com/releases/2022/08/220815112812.htm Methamphetamine remains a stubbornly prevalent illicit substance in large swaths of rural America, according to a new study. The findings show that methamphetamine remains a common drug, and is driving overdoses in rural communities. About four of five people who use drugs in rural areas across 10 states reported using methamphetamines in the past 30 days, according to the study. Mon, 15 Aug 2022 11:28:12 EDT //www.koonmotors.com/releases/2022/08/220815112812.htm //www.koonmotors.com/releases/2022/08/220810161156.htm Nicotine activates the dopamine reward network in the brain, but at high doses it also activates a parallel aversive dopamine network. This discovery and identification of the nicotine receptor responsible for the negative effects of high-dose nicotine provides a target for drug developers. In the future, therapeutics could tweak the network to make nicotine aversive at lower doses in order to help smokers quit. Wed, 10 Aug 2022 16:11:56 EDT //www.koonmotors.com/releases/2022/08/220810161156.htm //www.koonmotors.com/releases/2022/08/220804102555.htm Commonly used in medicine as an anaesthetic, ketamine is also increasingly prescribed to relieve depressive symptoms. This very fast-acting psychotropic drug is particularly indicated for the treatment of patients resistant to conventional antidepressants. However, its prescription has been the subject of debate: some believe that it presents a strong addictive risk. Thu, 04 Aug 2022 10:25:55 EDT //www.koonmotors.com/releases/2022/08/220804102555.htm //www.koonmotors.com/releases/2022/08/220802121714.htm 植物生物学家已经定义了高效'hacks' that cannabis cells use to make cannabinoids (THC/CBD). Although many biotechnology companies are currently trying to engineer THC/CBD outside the plant in yeast or cell cultures, it is largely unknown how the plant does it naturally. Tue, 02 Aug 2022 12:17:14 EDT //www.koonmotors.com/releases/2022/08/220802121714.htm //www.koonmotors.com/releases/2022/07/220728112008.htm Over the past 21 years of opioid overdose deaths, geography has played a role in where they have occurred, reports a new study. But the coming wave will not discriminate between rural and urban areas, the study findings suggest. Every type of county -- from the most rural to the most urban -- is predicted to see dramatic increases in deaths from opioid-involved overdoses. Thu, 28 Jul 2022 11:20:08 EDT //www.koonmotors.com/releases/2022/07/220728112008.htm //www.koonmotors.com/releases/2022/07/220726132617.htm Relapse presents a major barrier to recovery from substance use disorders -- when people begin taking drugs such as cocaine again after a period of abstinence. Sleep disruptions have long been associated with drug withdrawal and relapse. Now, a new study provides a more detailed picture of recovery-related sleep that could lead to insights for better recovery treatments. Tue, 26 Jul 2022 13:26:17 EDT //www.koonmotors.com/releases/2022/07/220726132617.htm //www.koonmotors.com/releases/2022/07/220726132538.htm People with a parent with a history of alcohol problems are at greater risk for showing signs of addiction to highly processed foods, a new study found. Tue, 26 Jul 2022 13:25:38 EDT //www.koonmotors.com/releases/2022/07/220726132538.htm //www.koonmotors.com/releases/2022/07/220725203611.htm Largest ever study into the health effects of different types of cannabis highlights concerns about stronger forms of the drug. Mon, 25 Jul 2022 20:36:11 EDT //www.koonmotors.com/releases/2022/07/220725203611.htm //www.koonmotors.com/releases/2022/07/220722123302.htm A new study reveals the oligomeric molecular structure of the MOR-Gal1R complex, a component present in the brain which is involved in the analgesic and addictive effects of certain opioids. Fri, 22 Jul 2022 12:33:02 EDT //www.koonmotors.com/releases/2022/07/220722123302.htm //www.koonmotors.com/releases/2022/07/220719162133.htm A new study found that rates of cannabis use and daily cannabis use have increased across the U.S., and current cannabis use and daily use are substantially higher among individuals residing in states that have legalized recreational cannabis use. Rates of cannabis use are even higher among Americans 12 and older who smoke cigarettes, and who reside in states with recreational cannabis laws, compared to those who live in states where cannabis was illegal in 2017. Tue, 19 Jul 2022 16:21:33 EDT //www.koonmotors.com/releases/2022/07/220719162133.htm //www.koonmotors.com/releases/2022/07/220719162125.htm Researchers used a new kind of computational tool to parse the complicated genetics that put some people at higher risk of becoming addicted to alcohol, cigarettes, and likely other substances. Tue, 19 Jul 2022 16:21:25 EDT //www.koonmotors.com/releases/2022/07/220719162125.htm //www.koonmotors.com/releases/2022/07/220701102757.htm Adolescents are over three times more vulnerable to developing a cannabis addiction than adults, but may not be at increased risk of other mental health problems related to the drug, according to a new study. Fri, 01 Jul 2022 10:27:57 EDT //www.koonmotors.com/releases/2022/07/220701102757.htm //www.koonmotors.com/releases/2022/06/220628133914.htm Researchers have found that blocking certain acetylcholine receptors in the lateral habenula (LHb), an area of the brain that balances reward and aversion, made it harder to resist seeking cocaine in a rat model of impulsive behavior. These findings identify a new role for these receptors that may represent a future target for the development of treatments for cocaine use disorder. There are currently no approved medications to treat cocaine use disorder. Tue, 28 Jun 2022 13:39:14 EDT //www.koonmotors.com/releases/2022/06/220628133914.htm //www.koonmotors.com/releases/2022/06/220628083257.htm A new study found visits to the emergency department and hospitalizations are 22 per cent higher among individuals who use cannabis compared with those who do not. The findings also show serious physical injury and respiratory-reasons were the two leading causes of ED visits and hospitalizations among cannabis users. Tue, 28 Jun 2022 08:32:57 EDT //www.koonmotors.com/releases/2022/06/220628083257.htm //www.koonmotors.com/releases/2022/06/220615130834.htm With stay-at-home orders during the COVID-19 pandemic, youth spent more time at home with family and were more isolated from in-person interaction with peers. Largely due to this social isolation from peers, substance use among youth declined, according to researchers. Wed, 15 Jun 2022 13:08:34 EDT //www.koonmotors.com/releases/2022/06/220615130834.htm //www.koonmotors.com/releases/2022/06/220606181234.htm Evidence behind the effectiveness of cannabis-related products to treat chronic pain is surprisingly thin, according to a new systematic evidence review. Voters in a number of states have legalized medical and recreational marijuana; however, the researchers found many of the products now available at U.S. dispensaries have not been well studied. Mon, 06 Jun 2022 18:12:34 EDT //www.koonmotors.com/releases/2022/06/220606181234.htm //www.koonmotors.com/releases/2022/06/220602095129.htm Scientists have long known that cocaine works by latching on to molecular connectors on the surface of brain cells, allowing dopamine, a chemical that promotes feelings of pleasure and reward, to accumulate in the space between brain cells. Now scientists say they have found a molecular connector, known as the BASP1 receptor, that binds cocaine, even when the drug is present in very low doses. Thu, 02 Jun 2022 09:51:29 EDT //www.koonmotors.com/releases/2022/06/220602095129.htm //www.koonmotors.com/releases/2022/05/220527121416.htm Dopamine is an important signalling molecule for nerve cells. Its concentration could not be precisely determined with both high spatial or temporal resolution until now. A new method has now made this possible: A research team used modified carbon nanotubes that glow brighter in the presence of the messenger substance dopamine. These sensors visualize the release of dopamine from nerve cells with unprecedented resolution. Fri, 27 May 2022 12:14:16 EDT //www.koonmotors.com/releases/2022/05/220527121416.htm //www.koonmotors.com/releases/2022/05/220519115311.htm Cannabis vaping is increasing as the most popular method of cannabis delivery among all adolescents in the U.S., as is the frequency of cannabis vaping, according to researchers. Thu, 19 May 2022 11:53:11 EDT //www.koonmotors.com/releases/2022/05/220519115311.htm //www.koonmotors.com/releases/2022/05/220518130707.htm Students at four-year colleges and universities drink nearly twice as much alcohol as their peers in two-year colleges, according to a survey of college students in the Seattle area. On the other hand, students in community colleges and other two-year institutions use marijuana nearly twice as often as four-year students. Wed, 18 May 2022 13:07:07 EDT //www.koonmotors.com/releases/2022/05/220518130707.htm //www.koonmotors.com/releases/2022/05/220518101746.htm Researchers have discovered a new piece in the puzzle of the brain's 'feel good' substance, dopamine. According to one of the researchers behind the new study, the discovery may facilitate the development of drugs for i.e. cocaine addiction and ADHD and is most likely to change the general notion of how dopamine is removed from the brain. Wed, 18 May 2022 10:17:46 EDT //www.koonmotors.com/releases/2022/05/220518101746.htm //www.koonmotors.com/releases/2022/05/220510122420.htm Researchers found that less than half of Americans who received treatment for opioid use disorder over a five-year period were offered a potentially lifesaving medication. The numbers were even lower for those with what's known as polysubstance use disorder -- when opioid users also misuse other substances. Tue, 10 May 2022 12:24:20 EDT //www.koonmotors.com/releases/2022/05/220510122420.htm //www.koonmotors.com/releases/2022/05/220503190221.htm New research finds that drug withdrawal-induced anxiety and reinstatement of drug seeking behaviors are controlled by a single pathway in the brain and centered around dopamine cells. Tue, 03 May 2022 19:02:21 EDT //www.koonmotors.com/releases/2022/05/220503190221.htm //www.koonmotors.com/releases/2022/04/220419092355.htm Some cannabis edibles look remarkably like popular snack foods and may be easily confused for them, finds a new study. Tue, 19 Apr 2022 09:23:55 EDT //www.koonmotors.com/releases/2022/04/220419092355.htm //www.koonmotors.com/releases/2022/04/220405102900.htm Clinical awareness of connection between alcohol and dementia is paramount to providing the best patient care management. Tue, 05 Apr 2022 10:29:00 EDT //www.koonmotors.com/releases/2022/04/220405102900.htm //www.koonmotors.com/releases/2022/04/220401122203.htm People who reported multiple symptoms consistent with severe substance use disorder at age 18 exhibited two or more of these symptoms in adulthood, according to a new analysis of a nationwide survey in the United States. These individuals were also more likely, as adults, to use and misuse prescription medications, as well as self-treat with opioids, sedatives, or tranquillizers. Fri, 01 Apr 2022 12:22:03 EDT //www.koonmotors.com/releases/2022/04/220401122203.htm //www.koonmotors.com/releases/2022/03/220331101458.htm Cannabis use among pregnant women is on the rise and may be associated with negative health outcomes in children, according to a new study. Thu, 31 Mar 2022 10:14:58 EDT //www.koonmotors.com/releases/2022/03/220331101458.htm //www.koonmotors.com/releases/2022/03/220330130520.htm A new study sheds light on the little-known phenomenon of binaural beats, where sounds purportedly evoke psychoactive effects. Wed, 30 Mar 2022 13:05:20 EDT //www.koonmotors.com/releases/2022/03/220330130520.htm //www.koonmotors.com/releases/2022/03/220329114730.htm A new study reports that, among youth with substance use and depression, a significant proportion show early improvements in depression during their treatment for substance use. Youth who are using cannabis less frequently prior to treatment and those without conduct disorder are more likely to experience early depression improvement. Tue, 29 Mar 2022 11:47:30 EDT //www.koonmotors.com/releases/2022/03/220329114730.htm //www.koonmotors.com/releases/2022/03/220328112358.htm The rates of older adults getting treatment for substance abuse rose sharply from 2000-2017, in tandem with the Baby Boom cohort reaching older adulthood. Mon, 28 Mar 2022 11:23:58 EDT //www.koonmotors.com/releases/2022/03/220328112358.htm //www.koonmotors.com/releases/2022/03/220324184711.htm Receiving psychosocial and behavioral therapy alongside medications for opioid use disorder leads to better treatment engagement and continuity, according to researchers. Thu, 24 Mar 2022 18:47:11 EDT //www.koonmotors.com/releases/2022/03/220324184711.htm //www.koonmotors.com/releases/2022/03/220318110249.htm A new study shows that using cannabis products to treat pain, anxiety and depression failed to improve these symptoms while doubling the risk of developing the addictive symptoms of cannabis use disorder. People seeking cannabis to treat symptoms of anxiety and depression were at greatest risk of CUD. Contrary to evidence-based medicine, people with medical marijuana cards choose their own products and dosing, suggesting the need for better controls over dispensing, use, and professional follow-up of these patients. Fri, 18 Mar 2022 11:02:49 EDT //www.koonmotors.com/releases/2022/03/220318110249.htm //www.koonmotors.com/releases/2022/03/220311115311.htm A new study establishes important conceptual connections between the fields of circadian rhythms, metabolism, and addiction. Going beyond current studies on substance use disorders, which focus on the impact of addictive drugs on the brain, this new research highlights an existing connection between specific neurons and peripheral organs. Fri, 11 Mar 2022 11:53:11 EST //www.koonmotors.com/releases/2022/03/220311115311.htm