//www.koonmotors.com/news/mind_brain/dementia/ Read the latest medical research on dementia. Causes, symptoms, lowering the risks, care, medications and new treatments for dementia. en-us Thu, 13 Jul 2023 15:18:52 EDT Thu, 13 Jul 2023 15:18:52 EDT 60 //www.koonmotors.com/images/scidaily-logo-rss.png//www.koonmotors.com/news/mind_brain/dementia/ For more science news, visit ScienceDaily. //www.koonmotors.com/releases/2023/07/230712165229.htm Older people who have little social contact with others may be more likely to have loss of overall brain volume, and in areas of the brain affected by dementia, than people with more frequent social contact, according to a new study. Wed, 12 Jul 2023 16:52:29 EDT //www.koonmotors.com/releases/2023/07/230712165229.htm //www.koonmotors.com/releases/2023/07/230710180512.htm Although most people don't associate oral disease with serious health problems, increasing evidence shows that oral bacteria play a significant role in systemic diseases like colon cancer and heart disease. Now, new research shows a link between periodontal (gum) disease and the formation of amyloid plaque, a hallmark of Alzheimer's disease. Mon, 10 Jul 2023 18:05:12 EDT //www.koonmotors.com/releases/2023/07/230710180512.htm //www.koonmotors.com/releases/2023/07/230705194620.htm A new study looked at cognitive function over 10 years in 8,958 people aged 50 and over in England. The research team investigated how different combinations of sleep and physical activity habits might affect people's cognitive function over time. Wed, 05 Jul 2023 19:46:20 EDT //www.koonmotors.com/releases/2023/07/230705194620.htm //www.koonmotors.com/releases/2023/07/230705171104.htm 老年人有波动的胆固醇水平terol and triglycerides may have a higher risk of Alzheimer's disease and related dementias compared to people who have steady levels, according to new research. While the study found a link, it does not prove that fluctuating levels of cholesterol and triglycerides cause dementia. Wed, 05 Jul 2023 17:11:04 EDT //www.koonmotors.com/releases/2023/07/230705171104.htm //www.koonmotors.com/releases/2023/07/230705171101.htm Taking good care of your teeth may be linked to better brain health, according to a new study. The study found that gum disease and tooth loss were linked to brain shrinkage in the hippocampus, which plays a role in memory and Alzheimer's disease. The study does not prove that gum disease or tooth loss causes Alzheimer's disease; it only shows an association. Wed, 05 Jul 2023 17:11:01 EDT //www.koonmotors.com/releases/2023/07/230705171101.htm //www.koonmotors.com/releases/2023/06/230614220554.htm Alzheimer's disease causes changes to the brain that begin two decades or more before symptoms appear. A study reveals that the bacteria that live in the gut also change before Alzheimer's symptoms arise, a discovery that could lead to diagnostics or treatments for Alzheimer's disease that target the gut microbiome. Wed, 14 Jun 2023 22:05:54 EDT //www.koonmotors.com/releases/2023/06/230614220554.htm //www.koonmotors.com/releases/2023/06/230607124048.htm Researchers found where plaques are found in the brain may impact hearing in Alzheimer's disease. Wed, 07 Jun 2023 12:40:48 EDT //www.koonmotors.com/releases/2023/06/230607124048.htm //www.koonmotors.com/releases/2023/06/230606111503.htm Researchers have shown that defective myelin actively promotes disease-related changes in Alzheimer's disease. Tue, 06 Jun 2023 11:15:03 EDT //www.koonmotors.com/releases/2023/06/230606111503.htm //www.koonmotors.com/releases/2023/05/230531150058.htm About two-thirds of the risk for Alzheimer's disease (AD) is thought to arise from genetic influences, but about a third could be influenced by environment and lifestyle, opening the door for behavioral interventions that could delay or prevent pathophysiological changes that occur with AD. Now a new study in a mouse model of AD examines the effects of environmental enrichment on AD symptom progression and pathology. Wed, 31 May 2023 15:00:58 EDT //www.koonmotors.com/releases/2023/05/230531150058.htm //www.koonmotors.com/releases/2023/05/230530125414.htm Low sexual satisfaction in middle age may serve as an early warning sign for future cognitive decline, according to a new study. The study, which tracked associations between erectile function, sexual satisfaction and cognition in hundreds of men aged 56 through 68, found that declines in sexual satisfaction and erectile function were correlated with future memory loss. Tue, 30 May 2023 12:54:14 EDT //www.koonmotors.com/releases/2023/05/230530125414.htm //www.koonmotors.com/releases/2023/05/230525135932.htm Regular walks strengthen connections in and between brain networks, according to new research, adding to growing evidence linking exercise with slowing the onset of Alzheimer's disease. The study examined the brains and story recollection abilities of older adults with normal brain function and those diagnosed with mild cognitive impairment, which is a slight decline in mental abilities like memory, reasoning and judgment and a risk factor for Alzheimer's. Thu, 25 May 2023 13:59:32 EDT //www.koonmotors.com/releases/2023/05/230525135932.htm //www.koonmotors.com/releases/2023/05/230524182040.htm Researchers have discovered that the oldest-old, those who live to be 90+ and have superior cognitive skills, have similar levels of brain pathology as Alzheimer's patients, however, they also have less brain pathology of other neurodegenerative diseases that cause memory and thinking problems. Wed, 24 May 2023 18:20:40 EDT //www.koonmotors.com/releases/2023/05/230524182040.htm //www.koonmotors.com/releases/2023/05/230515132043.htm Engineers have discovered a new way to program robots to help people with dementia locate medicine, glasses, phones and other objects they need but have lost. Mon, 15 May 2023 13:20:43 EDT //www.koonmotors.com/releases/2023/05/230515132043.htm //www.koonmotors.com/releases/2023/05/230515131951.htm 新鲜见解的传播破坏蛋白质s that build up in the brains of people with Alzheimer's disease could hold the key to stopping the condition progressing, a study says. Mon, 15 May 2023 13:19:51 EDT //www.koonmotors.com/releases/2023/05/230515131951.htm //www.koonmotors.com/releases/2023/05/230510120523.htm Researchers described the structure of a special type of amyloid beta plaque protein associated with Alzheimer's disease (AD) progression. Scientists showed the small aggregates of the amyloid beta protein could float through the brain tissue fluid, reaching many brain regions and disrupting local neuron functioning. The research also provided evidence that a newly approved AD treatment could neutralize these small, diffusible aggregates. Wed, 10 May 2023 12:05:23 EDT //www.koonmotors.com/releases/2023/05/230510120523.htm //www.koonmotors.com/releases/2023/05/230504094948.htm Deep sleep, also known as non-REM slow-wave sleep, can act as a 'cognitive reserve factor' that may increase resilience against a protein in the brain called beta-amyloid that is linked to memory loss caused by dementia. Thu, 04 May 2023 09:49:48 EDT //www.koonmotors.com/releases/2023/05/230504094948.htm //www.koonmotors.com/releases/2023/05/230502155413.htm Researchers describe how exposure to ambient air pollution, such as car exhaust and power plant emissions -- is associated with a measurably greater risk of developing dementia over time. Tue, 02 May 2023 15:54:13 EDT //www.koonmotors.com/releases/2023/05/230502155413.htm //www.koonmotors.com/releases/2023/05/230502132313.htm Stress causes the levels of Alzheimer's proteins to rise in females' brains but not males' brains, according to a new study. This difference may contribute to women's greater risk of developing Alzheimer's disease. Tue, 02 May 2023 13:23:13 EDT //www.koonmotors.com/releases/2023/05/230502132313.htm //www.koonmotors.com/releases/2023/05/230501085855.htm It's generally accepted we will lose muscle strength and slow down as we age, making it more difficult to perform simple tasks such as getting up, walking and sitting down. But new research indicates this could also be a signal for another sinister health concern of ageing: late-life dementia. Mon, 01 May 2023 08:58:55 EDT //www.koonmotors.com/releases/2023/05/230501085855.htm //www.koonmotors.com/releases/2023/04/230425111215.htm A new trial has found a new genetic therapy for Alzheimer's disease that is able to safely and successfully lower levels of the harmful tau protein known to cause the disease. Tue, 25 Apr 2023 11:12:15 EDT //www.koonmotors.com/releases/2023/04/230425111215.htm //www.koonmotors.com/releases/2023/04/230420135302.htm People with dementia have protein build-up in astrocytes that may trigger abnormal antiviral activity and memory loss, according to a preclinical study. Thu, 20 Apr 2023 13:53:02 EDT //www.koonmotors.com/releases/2023/04/230420135302.htm //www.koonmotors.com/releases/2023/04/230420110130.htm A new study found that signs of common infections in a sample of middle-aged and older adults were associated with poorer performance on a test of global cognitive function. Thu, 20 Apr 2023 11:01:30 EDT //www.koonmotors.com/releases/2023/04/230420110130.htm //www.koonmotors.com/releases/2023/04/230420110128.htm Two doses of an FDA-approved sleeping pill reduced levels of Alzheimer's proteins in a small study of healthy volunteers. The study hints at the potential of sleep medications to slow or stop the progression of Alzheimer's disease, although much more work needs to be done to confirm the viability of such an approach. Thu, 20 Apr 2023 11:01:28 EDT //www.koonmotors.com/releases/2023/04/230420110128.htm //www.koonmotors.com/releases/2023/04/230420080724.htm Scientists hope the new tool could be used to make it easier for GPs and patients to get information on dementia risk factors. Thu, 20 Apr 2023 08:07:24 EDT //www.koonmotors.com/releases/2023/04/230420080724.htm //www.koonmotors.com/releases/2023/04/230419201936.htm In people with no thinking and memory problems, a simple test may predict the risk of developing cognitive impairment years later, according to a new study. Wed, 19 Apr 2023 20:19:36 EDT //www.koonmotors.com/releases/2023/04/230419201936.htm //www.koonmotors.com/releases/2023/04/230419142759.htm Researchers have identified neurons in the brain that may contribute to some of the earliest symptoms of Alzheimer's disease, making it a good target for potential new drugs to treat the disease. Wed, 19 Apr 2023 14:27:59 EDT //www.koonmotors.com/releases/2023/04/230419142759.htm //www.koonmotors.com/releases/2023/04/230419142741.htm A new study in Science Advances adds weight to a growing body of evidence that iron dysregulation may play an important role in Alzheimer's disease and therefore might provide a better target for treatments than amyloid beta plaques. Wed, 19 Apr 2023 14:27:41 EDT //www.koonmotors.com/releases/2023/04/230419142741.htm //www.koonmotors.com/releases/2023/04/230413154333.htm Neuroscientists found a way to reverse neurodegeneration and other symptoms of Alzheimer's disease in mice by using a peptide to interfere with an enzyme that is typically overactive in the brains of Alzheimer's patients. Thu, 13 Apr 2023 15:43:33 EDT //www.koonmotors.com/releases/2023/04/230413154333.htm //www.koonmotors.com/releases/2023/04/230412131158.htm Early diagnosis and treatment of Alzheimer's disease requires reliable and cost-effective screening methods. Researchers have now discovered that a type of sugar molecule in blood is associated with the level of tau, a protein that plays a critical role in the development of severe dementia. The study can pave the way for a simple screening procedure able to predict onset ten years in advance. Wed, 12 Apr 2023 13:11:58 EDT //www.koonmotors.com/releases/2023/04/230412131158.htm //www.koonmotors.com/releases/2023/04/230406113950.htm People with Alzheimer's disease develop defects in cognitive functions like memory as well as problems with noncognitive functions that can lead to anxiety and depression. Investigators used mice to study a process through which new neurons are generated in adulthood, called adult hippocampus neurogenesis (AHN). The research showed that deep brain stimulation of new neurons helped restore both cognitive and noncognitive functions in mouse models of Alzheimer's disease. Thu, 06 Apr 2023 11:39:50 EDT //www.koonmotors.com/releases/2023/04/230406113950.htm //www.koonmotors.com/releases/2023/04/230406075657.htm Researchers used a computer simulation model to show that the four dementia-care interventions saved between $2,800 and $13,000 in societal costs, depending on the type of intervention, and all reduced nursing home admissions and improved quality of life compared to usual care. Thu, 06 Apr 2023 07:56:57 EDT //www.koonmotors.com/releases/2023/04/230406075657.htm //www.koonmotors.com/releases/2023/04/230403162627.htm Women are more likely than men to develop Alzheimer's disease (AD), with women making up two-thirds of the population living with AD. A new study sheds light on the relationship between the risk of Alzheimer's disease and age of menopause and use of hormone therapy (HT). Mon, 03 Apr 2023 16:26:27 EDT //www.koonmotors.com/releases/2023/04/230403162627.htm //www.koonmotors.com/releases/2023/03/230330102239.htm A new mouse study has identified a gene-enzyme interaction that appears to play a key role in how the brain forms memories. The findings provide insights into how PDE inhibitor medications may help diseases like Alzheimer's. Thu, 30 Mar 2023 10:22:39 EDT //www.koonmotors.com/releases/2023/03/230330102239.htm //www.koonmotors.com/releases/2023/03/230322190926.htm Changes in the brain caused by Alzheimer's disease are associated with shortening of the telomeres -- the protective caps on the ends of chromosomes that shorten as cells age -- according to a new study. Wed, 22 Mar 2023 19:09:26 EDT //www.koonmotors.com/releases/2023/03/230322190926.htm //www.koonmotors.com/releases/2023/03/230322190844.htm People who have low bone density may have an increased risk of developing dementia compared to people who have higher bone density. The study does not prove that low bone density causes dementia. It only shows an association. Wed, 22 Mar 2023 19:08:44 EDT //www.koonmotors.com/releases/2023/03/230322190844.htm //www.koonmotors.com/releases/2023/03/230309125010.htm Sometimes the best things in life come by chance, when we happen to be in the right place at the right time. Now, researchers have found a way to ensure that new medications are delivered to the right place in the body and at the right point in time during disease progression, so that they have the best effect. Thu, 09 Mar 2023 12:50:10 EST //www.koonmotors.com/releases/2023/03/230309125010.htm //www.koonmotors.com/releases/2023/03/230308201051.htm People who eat diets rich in green leafy vegetables as well as other vegetables, fruits, whole grains, olive oil, beans, nuts and fish may have fewer amyloid plaques and tau tangles in their brain -- signs of Alzheimer's disease -- than people who do not consume such diets, according to a new study. Wed, 08 Mar 2023 20:10:51 EST //www.koonmotors.com/releases/2023/03/230308201051.htm //www.koonmotors.com/releases/2023/03/230308112107.htm In Alzheimer's and related neurodegenerative diseases, the brain protein tau is closely linked to brain damage and cognitive decline. A new study indicates that T cells play a key role in tau-related neurodegeneration, a finding that suggests new treatment strategies for Alzheimer's and related diseases. Wed, 08 Mar 2023 11:21:07 EST //www.koonmotors.com/releases/2023/03/230308112107.htm //www.koonmotors.com/releases/2023/03/230307144330.htm Reducing the methylation of a key messenger RNA can promote migration of macrophages into the brain and ameliorate symptoms of Alzheimer's disease in a mouse model, according to a new study. The results illuminate one pathway for entrance of peripheral immune cells into the brain, and may provide a new target for treatment of Alzheimer's disease. Tue, 07 Mar 2023 14:43:30 EST //www.koonmotors.com/releases/2023/03/230307144330.htm //www.koonmotors.com/releases/2023/03/230306143443.htm Adding to the growing body of evidence on sleep disturbances and cognitive impairment, new research finds significant links between three measures of sleep disturbance and the risk for developing dementia over a 10-year period. The results associate sleep-initiation insomnia (trouble falling asleep within 30 minutes) and sleep medication use with higher risk for developing dementia. The investigators also found that people who reported having sleep-maintenance insomnia (trouble falling back to sleep after waking) were less likely to develop dementia over the course of the study. Mon, 06 Mar 2023 14:34:43 EST //www.koonmotors.com/releases/2023/03/230306143443.htm //www.koonmotors.com/releases/2023/03/230303105418.htm Researchers have taken an important new step in understanding the complex effects of Alzheimer's disease on the retina, a layer of tissue at the back of the eye. Fri, 03 Mar 2023 10:54:18 EST //www.koonmotors.com/releases/2023/03/230303105418.htm //www.koonmotors.com/releases/2023/03/230301101511.htm Taking vitamin D supplements may help ward off dementia, according to a new, large-scale study. Researchers explored the relationship between vitamin D supplementation and dementia in more than 12,388 participants of the US National Alzheimer's Coordinating Center, who had a mean age of 71 and were dementia-free when they signed up. Of the group, 37 per cent (4,637) took vitamin D supplements. Wed, 01 Mar 2023 10:15:11 EST //www.koonmotors.com/releases/2023/03/230301101511.htm //www.koonmotors.com/releases/2023/02/230228205244.htm Researchers have identified gut bacteria that are associated with dementia with Lewy bodies. Changing the levels of three bacteria, Collinsella, Ruminococcus, and Bifidobacterium, may delay the onset and progression of this neurodegenerative disease. Tue, 28 Feb 2023 20:52:44 EST //www.koonmotors.com/releases/2023/02/230228205244.htm //www.koonmotors.com/releases/2023/02/230223181808.htm Researchers have determined that the naturally occurring dietary supplement, nicotinamide riboside (NR), can enter the brain. The finding is significant because it supports the idea that NR, upon reaching the brain, can alter the metabolism of relevant biological pathways involved in neurodegenerative diseases like Alzheimer's. Thu, 23 Feb 2023 18:18:08 EST //www.koonmotors.com/releases/2023/02/230223181808.htm //www.koonmotors.com/releases/2023/02/230223132845.htm Using ensemble learning techniques and longitudinal data from a large naturalistic driving study, researchers have developed a novel, interpretable and highly accurate algorithm for predicting mild cognitive impairment and dementia in older drivers. Digital markers refer to variables generated from data captured through recording devices in the real-world setting. These data could be processed to measure driving behavior, performance and tempo-spatial pattern in exceptional detail. Thu, 23 Feb 2023 13:28:45 EST //www.koonmotors.com/releases/2023/02/230223132845.htm //www.koonmotors.com/releases/2023/02/230222210529.htm People who regularly use laxatives, a common treatment for constipation, may have more than a 50% increased risk of developing dementia than people who do not use laxatives, according to a new study. Researchers also found people who used only osmotic laxatives, a type of laxative that attracts water to the colon to soften stool, had an even greater risk. Other types of laxatives are bulk-forming, stool-softening, and stimulating. The study does not prove that laxatives cause dementia. It only shows an association. Wed, 22 Feb 2023 21:05:29 EST //www.koonmotors.com/releases/2023/02/230222210529.htm //www.koonmotors.com/releases/2023/02/230214153901.htm Scientists are not yet clear on how the tau protein changes from a benign protein essential for normal function in our brains into the toxic neurofibrillary tangles that are a signature of Alzheimer's and other neurodegenerative diseases. Tue, 14 Feb 2023 15:39:01 EST //www.koonmotors.com/releases/2023/02/230214153901.htm //www.koonmotors.com/releases/2023/02/230208155700.htm The risk factors linked to cognitive decline in older adults explain a surprisingly modest amount about the large variation in mental abilities between older people, according to a new national study. Wed, 08 Feb 2023 15:57:00 EST //www.koonmotors.com/releases/2023/02/230208155700.htm //www.koonmotors.com/releases/2023/02/230206104118.htm Researchers have developed small abiotic and drugable cyclic peptides that have proven effective in animal models in diagnosing early pre-symptomatic stage of Alzheimer's and treating the disease by targeting oligomers. When these molecules were combined in a test tube with the small protein amyloid beta, the generation of oligomers was completely blocked, and no subsequent aggregation occurred. Mon, 06 Feb 2023 10:41:18 EST //www.koonmotors.com/releases/2023/02/230206104118.htm //www.koonmotors.com/releases/2023/01/230131101908.htm Memory loss, behavioural changes, cognitive deficits: Alzheimer's disease leads to a dramatic loss of autonomy for those affected and has a heavy impact on health costs. Its prevention has become a real social challenge. An international task force is setting out guidelines for innovative services to prevent Alzheimer's disease. These will soon be an integral part of second generation memory clinics. Tue, 31 Jan 2023 10:19:08 EST //www.koonmotors.com/releases/2023/01/230131101908.htm //www.koonmotors.com/releases/2023/01/230131101852.htm A new study finds a correlation between neurodegeneration in obese people and Alzheimer's disease (AD) patients, suggesting that losing excess weight could slow cognitive decline in aging and lower risk for AD. Tue, 31 Jan 2023 10:18:52 EST //www.koonmotors.com/releases/2023/01/230131101852.htm //www.koonmotors.com/releases/2023/01/230131101833.htm A new study shows that sleep medications increase the risk of dementia in whites. But the type and quantity of the medication may be factors in explaining the higher risk. Tue, 31 Jan 2023 10:18:33 EST //www.koonmotors.com/releases/2023/01/230131101833.htm //www.koonmotors.com/releases/2023/01/230127131207.htm New research has established a blood-based test that could be used to predict the risk of Alzheimer's disease up to 3.5 years before clinical diagnosis. Fri, 27 Jan 2023 13:12:07 EST //www.koonmotors.com/releases/2023/01/230127131207.htm //www.koonmotors.com/releases/2023/01/230126100245.htm 早期患者心血管疾病的可能re likely to have memory and thinking problems and worse brain health in middle age, according to new research. Thu, 26 Jan 2023 10:02:45 EST //www.koonmotors.com/releases/2023/01/230126100245.htm //www.koonmotors.com/releases/2023/01/230125085831.htm Senior women were less likely to develop mild cognitive impairment or dementia if they did more daily walking and moderate-to-vigorous physical activity. Wed, 25 Jan 2023 08:58:31 EST //www.koonmotors.com/releases/2023/01/230125085831.htm //www.koonmotors.com/releases/2023/01/230117193006.htm Choline, an essential nutrient produced in small amounts in the liver and found in foods including eggs, broccoli, beans, meat and poultry, is a vital ingredient for human health. A new study explores deficiency in dietary choline adversely affects the body and may be a missing piece in the puzzle of Alzheimer's disease. Tue, 17 Jan 2023 19:30:06 EST //www.koonmotors.com/releases/2023/01/230117193006.htm //www.koonmotors.com/releases/2023/01/230114142747.htm Hormone Replacement Therapy (HRT) could help prevent Alzheimer's Dementia among women at risk of developing the disease -- according to new research. Sat, 14 Jan 2023 14:27:47 EST //www.koonmotors.com/releases/2023/01/230114142747.htm //www.koonmotors.com/releases/2023/01/230112090936.htm A new study has shed light on the many and varied fall-risk factors facing older adults in community-living environments. The research examined a comprehensive set of potential fall-risk factors -- including environmental factors, in addition to health and function -- in older community-living adults in the U.S., both with and without dementia. Thu, 12 Jan 2023 09:09:36 EST //www.koonmotors.com/releases/2023/01/230112090936.htm //www.koonmotors.com/releases/2023/01/230110191410.htm Alzheimer disease begins decades before any symptoms, such as memory loss, start to show. Consequently, early diagnosis increases the chances of slowing the disease down with drugs. A new study on an inherited form of the disease shows that a protein called GFAP is a possible biomarker for very early stages of the disease. The study could one day lead to an earlier detection of this serious and common disease. Tue, 10 Jan 2023 19:14:10 EST //www.koonmotors.com/releases/2023/01/230110191410.htm //www.koonmotors.com/releases/2023/01/230110150943.htm A new study has found that older adults with greater severity of hearing loss were more likely to have dementia, but the likelihood of dementia was lower among hearing aid users compared to non-users. Tue, 10 Jan 2023 15:09:43 EST //www.koonmotors.com/releases/2023/01/230110150943.htm