//www.koonmotors.com/news/mind_brain/cocaine/ Medical research on cocaine. Read the latest research on how cocaine affects the human body, cravings, cocaine addiction and more. en-us Mon, 16 Oct 2023 18:49:20 EDT Mon, 16 Oct 2023 18:49:20 EDT 60 //www.koonmotors.com/images/scidaily-logo-rss.png//www.koonmotors.com/news/mind_brain/cocaine/ For more science news, visit ScienceDaily. //www.koonmotors.com/releases/2022/11/221101111556.htm Common gut bacteria can enhance the effects of cocaine in mice, researchers report. Their study demonstrates how cocaine use supports the growth of the bacteria, which in turn eat up a chemical, glycine, that contributes to normal brain function. As levels of glycine become depleted, mice exhibit a higher response to the drug with behavior abnormalities, such as significantly increasing drug-induced locomotion and seeking behaviors. Tue, 01 Nov 2022 11:15:56 EDT //www.koonmotors.com/releases/2022/11/221101111556.htm //www.koonmotors.com/releases/2022/10/221006111842.htm Results of a new study suggest the prefrontal cortex-habenula circuit is potentially amenable for targeted interventions and prevention. Thu, 06 Oct 2022 11:18:42 EDT //www.koonmotors.com/releases/2022/10/221006111842.htm //www.koonmotors.com/releases/2022/08/220826113253.htm Illicit drug use is associated with a nearly nine-fold greater risk of death or life-threatening emergencies in intensive cardiac care unit (ICCU) patients, according to new research. Fri, 26 Aug 2022 11:32:53 EDT //www.koonmotors.com/releases/2022/08/220826113253.htm //www.koonmotors.com/releases/2022/08/220804102555.htm Commonly used in medicine as an anaesthetic, ketamine is also increasingly prescribed to relieve depressive symptoms. This very fast-acting psychotropic drug is particularly indicated for the treatment of patients resistant to conventional antidepressants. However, its prescription has been the subject of debate: some believe that it presents a strong addictive risk. Thu, 04 Aug 2022 10:25:55 EDT //www.koonmotors.com/releases/2022/08/220804102555.htm //www.koonmotors.com/releases/2022/07/220728112008.htm Over the past 21 years of opioid overdose deaths, geography has played a role in where they have occurred, reports a new study. But the coming wave will not discriminate between rural and urban areas, the study findings suggest. Every type of county -- from the most rural to the most urban -- is predicted to see dramatic increases in deaths from opioid-involved overdoses. Thu, 28 Jul 2022 11:20:08 EDT //www.koonmotors.com/releases/2022/07/220728112008.htm //www.koonmotors.com/releases/2022/07/220726132617.htm Relapse presents a major barrier to recovery from substance use disorders -- when people begin taking drugs such as cocaine again after a period of abstinence. Sleep disruptions have long been associated with drug withdrawal and relapse. Now, a new study provides a more detailed picture of recovery-related sleep that could lead to insights for better recovery treatments. Tue, 26 Jul 2022 13:26:17 EDT //www.koonmotors.com/releases/2022/07/220726132617.htm //www.koonmotors.com/releases/2022/07/220719162125.htm Researchers used a new kind of computational tool to parse the complicated genetics that put some people at higher risk of becoming addicted to alcohol, cigarettes, and likely other substances. Tue, 19 Jul 2022 16:21:25 EDT //www.koonmotors.com/releases/2022/07/220719162125.htm //www.koonmotors.com/releases/2022/06/220628133914.htm Researchers have found that blocking certain acetylcholine receptors in the lateral habenula (LHb), an area of the brain that balances reward and aversion, made it harder to resist seeking cocaine in a rat model of impulsive behavior. These findings identify a new role for these receptors that may represent a future target for the development of treatments for cocaine use disorder. There are currently no approved medications to treat cocaine use disorder. Tue, 28 Jun 2022 13:39:14 EDT //www.koonmotors.com/releases/2022/06/220628133914.htm //www.koonmotors.com/releases/2022/06/220602095129.htm Scientists have long known that cocaine works by latching on to molecular connectors on the surface of brain cells, allowing dopamine, a chemical that promotes feelings of pleasure and reward, to accumulate in the space between brain cells. Now scientists say they have found a molecular connector, known as the BASP1 receptor, that binds cocaine, even when the drug is present in very low doses. Thu, 02 Jun 2022 09:51:29 EDT //www.koonmotors.com/releases/2022/06/220602095129.htm //www.koonmotors.com/releases/2022/05/220518101746.htm Researchers have discovered a new piece in the puzzle of the brain's 'feel good' substance, dopamine. According to one of the researchers behind the new study, the discovery may facilitate the development of drugs for i.e. cocaine addiction and ADHD and is most likely to change the general notion of how dopamine is removed from the brain. Wed, 18 May 2022 10:17:46 EDT //www.koonmotors.com/releases/2022/05/220518101746.htm //www.koonmotors.com/releases/2022/05/220503190221.htm New research finds that drug withdrawal-induced anxiety and reinstatement of drug seeking behaviors are controlled by a single pathway in the brain and centered around dopamine cells. Tue, 03 May 2022 19:02:21 EDT //www.koonmotors.com/releases/2022/05/220503190221.htm //www.koonmotors.com/releases/2022/03/220328112358.htm The rates of older adults getting treatment for substance abuse rose sharply from 2000-2017, in tandem with the Baby Boom cohort reaching older adulthood. Mon, 28 Mar 2022 11:23:58 EDT //www.koonmotors.com/releases/2022/03/220328112358.htm //www.koonmotors.com/releases/2022/03/220311115311.htm A new study establishes important conceptual connections between the fields of circadian rhythms, metabolism, and addiction. Going beyond current studies on substance use disorders, which focus on the impact of addictive drugs on the brain, this new research highlights an existing connection between specific neurons and peripheral organs. Fri, 11 Mar 2022 11:53:11 EST //www.koonmotors.com/releases/2022/03/220311115311.htm //www.koonmotors.com/releases/2022/01/220118144314.htm Researchers used high-resolution technologies to see how dopamine circuitry in mice is affected by addictive drugs. The results answered older structural questions, while raising new ones about plasticity and recovery in the brain. Tue, 18 Jan 2022 14:43:14 EST //www.koonmotors.com/releases/2022/01/220118144314.htm //www.koonmotors.com/releases/2021/12/211215113229.htm A molecular switch influences addiction behavior and determines how strong the response to addictive drugs is. A research team made the discovery in mice treated with cocaine. The researchers demonstrated that the protein Npas4 regulates the structure and function of nerve cells that control addiction behavior in mice. If the quantity of Npas4 was reduced in an experiment, the animals' response to cocaine was much weaker. Wed, 15 Dec 2021 11:32:29 EST //www.koonmotors.com/releases/2021/12/211215113229.htm //www.koonmotors.com/releases/2021/09/210927143649.htm Researchers describe how withdrawal from nicotine, methamphetamine and cocaine alters the functional architecture and patterns in the brains of mice, compared to control animals, a key to developing addiction treatments. Mon, 27 Sep 2021 14:36:49 EDT //www.koonmotors.com/releases/2021/09/210927143649.htm //www.koonmotors.com/releases/2021/09/210909141233.htm By identifying the role of serotonin during cocaine use, scientists explain why only one in five persons becomes addicted to this drug. Thu, 09 Sep 2021 14:12:33 EDT //www.koonmotors.com/releases/2021/09/210909141233.htm //www.koonmotors.com/releases/2021/06/210610091004.htm People who have a high sensation-seeking trait in the brain could be more susceptible to drug addition, according to a new study. Thu, 10 Jun 2021 09:10:04 EDT //www.koonmotors.com/releases/2021/06/210610091004.htm //www.koonmotors.com/releases/2021/05/210519120728.htm The latest findings show that with clever science, a single fingerprint left at a crime scene could be used to determine whether someone has touched or ingested class A drugs. Wed, 19 May 2021 12:07:28 EDT //www.koonmotors.com/releases/2021/05/210519120728.htm //www.koonmotors.com/releases/2021/04/210426154802.htm Researchers have created to novel biobanks of diverse tissues from animals to further explore the biological bases and consequences of addiction to cocaine and oxycodone. Mon, 26 Apr 2021 15:48:02 EDT //www.koonmotors.com/releases/2021/04/210426154802.htm //www.koonmotors.com/releases/2021/02/210222092301.htm The Netherlands, United States, Australia and New Zealand are consuming the highest amounts of designer 'party' drugs, according to wastewater samples taken from eight countries over the New Year period. Mon, 22 Feb 2021 09:23:01 EST //www.koonmotors.com/releases/2021/02/210222092301.htm //www.koonmotors.com/releases/2021/02/210215211040.htm Recreational drinking, smoking, and drug use is linked to premature heart disease in young people, particularly younger women. Mon, 15 Feb 2021 21:10:40 EST //www.koonmotors.com/releases/2021/02/210215211040.htm //www.koonmotors.com/releases/2020/12/201207153927.htm Cocaine continues to be one of the most commonly abused illicit drugs in the United States. Pre-clinical literature suggests that targeting glucagon-like peptide-1 receptors (GLP-1Rs) in the brain may represent a novel approach to treating cocaine use disorder. Specifically, GLP-1R agonists, which are FDA-approved for treating diabetes and obesity, have been shown to reduce voluntary drug taking and seeking in preclinical models of cocaine used disorder. Mon, 07 Dec 2020 15:39:27 EST //www.koonmotors.com/releases/2020/12/201207153927.htm //www.koonmotors.com/releases/2020/11/201102133331.htm Sleep deprivation may pave the way to cocaine addiction. Too-little sleep can increase the rewarding properties of cocaine, according to new research. Mon, 02 Nov 2020 13:33:31 EST //www.koonmotors.com/releases/2020/11/201102133331.htm //www.koonmotors.com/releases/2020/07/200723115904.htm Do you remember where you were when you first heard that two planes had crashed into New York's Twin Towers? Or where you had your first kiss? Our brains are wired to retain information that relates to the context in which highly significant events occurred. This mechanism also underlies drug addiction and is the reason why hanging out in an environment or with people associated with memories of drug use often leads to relapse. Thu, 23 Jul 2020 11:59:04 EDT //www.koonmotors.com/releases/2020/07/200723115904.htm //www.koonmotors.com/releases/2020/07/200709172848.htm 研究人员使用single-nucleus核糖核酸测序技术compare transcriptional responses to acute cocaine in 16 unique cell populations from the brain nucleus accumbens. The atlas is part of a major study that used multiple cutting-edge technologies to describe a dopamine-induced gene expression signature that regulates the brain's response to cocaine. The study shows neurobiological processes that control drug-related adaptations and reveals new information about how transcriptional mechanisms regulate activity-dependent processes within the central nervous system. Thu, 09 Jul 2020 17:28:48 EDT //www.koonmotors.com/releases/2020/07/200709172848.htm //www.koonmotors.com/releases/2020/07/200706140918.htm Motherhood takes over the brain's decision-making regions to prioritize caring for offspring, according to new research. Mon, 06 Jul 2020 14:09:18 EDT //www.koonmotors.com/releases/2020/07/200706140918.htm //www.koonmotors.com/releases/2020/06/200602110057.htm Researchers have discovered that dopamine D2 receptors (DRD2s) in cholinergic interneurons (ChINs) play a crucial role in cocaine addiction. Tue, 02 Jun 2020 11:00:57 EDT //www.koonmotors.com/releases/2020/06/200602110057.htm //www.koonmotors.com/releases/2020/05/200528115822.htm 科学家开发出了一种合成分子that selectively controls the physiological rewards of cocaine in mice. It also may represent a new class of small-molecule drugs that are more specific and have fewer side effects. The molecule selectively activates beta-arrestin without activating the G protein, making its signal to the cell much more specific. Thu, 28 May 2020 11:58:22 EDT //www.koonmotors.com/releases/2020/05/200528115822.htm //www.koonmotors.com/releases/2020/04/200422214053.htm A new study explains how cocaine modifies functions in the brain revealing a potential target for therapies aimed at treating cocaine addiction. Wed, 22 Apr 2020 21:40:53 EDT //www.koonmotors.com/releases/2020/04/200422214053.htm //www.koonmotors.com/releases/2020/04/200420165718.htm Cannabis use makes young brains more sensitive to the first exposure to cocaine, according to a new study on rodents. By monitoring the brains of both adolescent and adult rats after giving them synthetic psychoactive cannabinoids followed by cocaine, the research team identified key molecular and epigenetic changes that occurred in the brains of adolescents -- but not adults. Mon, 20 Apr 2020 16:57:18 EDT //www.koonmotors.com/releases/2020/04/200420165718.htm //www.koonmotors.com/releases/2020/04/200409141543.htm Scientists have discovered a new role for the brain chemical dopamine that is independent of classic neurotransmission. The new role appears to be critical to changes in gene expression related to chronic exposure to, or abuse of, cocaine. Thu, 09 Apr 2020 14:15:43 EDT //www.koonmotors.com/releases/2020/04/200409141543.htm //www.koonmotors.com/releases/2020/01/200115132310.htm Researchers have discovered gender-based differences in response to therapeutic oxytocin treatment in cocaine-addicted individuals with a history of childhood trauma. Oxytocin has been shown previously to function as a potential therapeutic in cases of addiction by reducing cravings. This study found that only men with past trauma had a reduction in cravings after oxytocin. Surprisingly, women with past trauma had a greater response to visual drug cues following oxytocin. Wed, 15 Jan 2020 13:23:10 EST //www.koonmotors.com/releases/2020/01/200115132310.htm //www.koonmotors.com/releases/2019/12/191205101815.htm The reward pathway of the brain causes feelings of happiness but is also involved in behavioral disorders like schizophrenia and addiction. A breakthrough study has now identified the role of a protein called Npas4 in the reward pathway, mediated by the well-known proteins MAPK and CBP, opening doors to potential therapies for associated disorders. Cocaine-treated mice with inactivated Npas4 exhibited considerable reduction in cocaine-seeking behavior, emphasizing the relevance of the protein. Thu, 05 Dec 2019 10:18:15 EST //www.koonmotors.com/releases/2019/12/191205101815.htm //www.koonmotors.com/releases/2019/10/191030082825.htm Construction workers are more likely to use drugs than workers in other professions, finds a new study. Wed, 30 Oct 2019 08:28:25 EDT //www.koonmotors.com/releases/2019/10/191030082825.htm //www.koonmotors.com/releases/2019/10/191029182501.htm Opioid overdose deaths in Connecticut doubled in the past 6 years, largely driven by use of multiple drugs together, according to a team of researchers. Tue, 29 Oct 2019 18:25:01 EDT //www.koonmotors.com/releases/2019/10/191029182501.htm //www.koonmotors.com/releases/2019/10/191023093445.htm A seven-year project monitoring illicit drug use in 37 countries via wastewater samples shows that cocaine use was skyrocketing in Europe in 2017 and Australia had a serious problem with methamphetamine. Wed, 23 Oct 2019 09:34:45 EDT //www.koonmotors.com/releases/2019/10/191023093445.htm //www.koonmotors.com/releases/2019/09/190909144059.htm Scientists have shed light on poorly understood brain mechanisms that suppress drug and alcohol cravings, uncovering new insights that may help in the development of better addiction medicines. Mon, 09 Sep 2019 14:40:59 EDT //www.koonmotors.com/releases/2019/09/190909144059.htm //www.koonmotors.com/releases/2019/09/190902135306.htm Chronic cocaine use changes gene expression in the hippocampus, according to new research in mice. Mon, 02 Sep 2019 13:53:06 EDT //www.koonmotors.com/releases/2019/09/190902135306.htm //www.koonmotors.com/releases/2019/08/190820081846.htm Spending on cannabis, cocaine, heroin and methamphetamine fluctuated between $120 billion and $145 billion each year from 2006 to 2016, rivaling what Americans spend each year on alcohol, according to a new study. Tue, 20 Aug 2019 08:18:46 EDT //www.koonmotors.com/releases/2019/08/190820081846.htm //www.koonmotors.com/releases/2019/07/190729132336.htm Blocking dopamine receptors in different regions of the amygdala reduces drug seeking and taking behavior with varying longevity. Mon, 29 Jul 2019 13:23:36 EDT //www.koonmotors.com/releases/2019/07/190729132336.htm //www.koonmotors.com/releases/2019/07/190723085951.htm American teenagers and adults are more likely to try illegal or recreational drugs for the first time in the summer, a new study shows. Tue, 23 Jul 2019 08:59:51 EDT //www.koonmotors.com/releases/2019/07/190723085951.htm //www.koonmotors.com/releases/2019/05/190521162430.htm Research is revealing new insights into how genes impact drug use and addiction through a novel study of susceptibility to the effects of cocaine and methamphetamine in fruit flies. Tue, 21 May 2019 16:24:30 EDT //www.koonmotors.com/releases/2019/05/190521162430.htm //www.koonmotors.com/releases/2019/04/190415104958.htm Scientists have revealed neuronal mechanisms underlying the formation and retrieval of cocaine use-associated memories. Their research sheds light on how drug addiction develops and reveals pathways that can be exploited for the development of strategies to treat cocaine addiction. Mon, 15 Apr 2019 10:49:58 EDT //www.koonmotors.com/releases/2019/04/190415104958.htm //www.koonmotors.com/releases/2019/04/190408113944.htm Performance-enhancing steroid use could increase the risk of cocaine use and addiction in teens, according to a new rodent study. The combination of these drugs could also impair fertility in young women. Mon, 08 Apr 2019 11:39:44 EDT //www.koonmotors.com/releases/2019/04/190408113944.htm //www.koonmotors.com/releases/2019/03/190318144312.htm Researchers have identified which neurons are responsible for cocaine-seeking behaviors in rodents and where these neurons exert their effects within the brain. Their work opens a new line of addiction research that could lead to novel therapeutic approaches for preventing relapse. Mon, 18 Mar 2019 14:43:12 EDT //www.koonmotors.com/releases/2019/03/190318144312.htm //www.koonmotors.com/releases/2019/03/190305105703.htm Menstrual cycle may influence addiction risk in women, according to a new study. Tue, 05 Mar 2019 10:57:03 EST //www.koonmotors.com/releases/2019/03/190305105703.htm //www.koonmotors.com/releases/2019/02/190227124848.htm Besides triggering the brain's emotional and stimulus-response systems, environmental cues activate areas where memories are processed, according to this study. Prompting these memory processing systems makes it extra difficult to counter addiction because the classic stimulus-response mechanisms are reinforced by the memory effects of environmental drug cues. While this double effect makes it hard to treat drug abuse, this finding may offer a way to use cues to improve cognitive behavioural therapy. Wed, 27 Feb 2019 12:48:48 EST //www.koonmotors.com/releases/2019/02/190227124848.htm //www.koonmotors.com/releases/2019/02/190208161442.htm Female-specific interventions are needed, but in the meantime, treatment centers could use this study to educate women about their stronger mental connections to places and objects. Fri, 08 Feb 2019 16:14:42 EST //www.koonmotors.com/releases/2019/02/190208161442.htm //www.koonmotors.com/releases/2019/01/190122115001.htm Researchers identified the brain circuits that form memories associating environmental cues with cocaine use. Targeting these memories may improve the success of exposure therapy to prevent relapse. Tue, 22 Jan 2019 11:50:01 EST //www.koonmotors.com/releases/2019/01/190122115001.htm //www.koonmotors.com/releases/2019/01/190116090630.htm 一项研究发现一个令人惊讶的对可卡因a novel strain of mutant mice -- they failed to show hyperactivity seen in normal mice when given cocaine and didn't run around. In other tests, they still found cocaine appealing, but displayed an inability to shake the memory of cocaine's actions when the drug was no longer administered. The key change that blocks cocaine's stimulant effects in these mice is serotonin, not dopamine, which is responsible for producing a high. Wed, 16 Jan 2019 09:06:30 EST //www.koonmotors.com/releases/2019/01/190116090630.htm //www.koonmotors.com/releases/2019/01/190110141803.htm Researchers have revealed significant insight into cocaine addiction, a phenomenon which has grown significantly in the United States since 2015. Thu, 10 Jan 2019 14:18:03 EST //www.koonmotors.com/releases/2019/01/190110141803.htm //www.koonmotors.com/releases/2018/11/181114120317.htm The siren call of addictive drugs can be hard to resist, and returning to the environment where drugs were previously taken can make resistance that much harder. However, addicts who exercise appear to be less vulnerable to the impact of these environmental cues. Now, research with mice suggests that exercise might strengthen a drug user's resolve by altering the production of peptides in the brain. Wed, 14 Nov 2018 12:03:17 EST //www.koonmotors.com/releases/2018/11/181114120317.htm //www.koonmotors.com/releases/2018/11/181108164314.htm Rats given the drug that reduced dopamine were much less likely to work for preferred morsels of food. But when these rats were then given one of the experimental drugs, they regained their motivation to work for the treat. Thu, 08 Nov 2018 16:43:14 EST //www.koonmotors.com/releases/2018/11/181108164314.htm //www.koonmotors.com/releases/2018/11/181101133851.htm Emergency department physicians are calling for more readily available testing strips to identify the presence of fentanyl in patients experiencing a drug overdose, and a rapid, coordinated response among health care providers and city agencies to help curb overdoses and identify high potency high risk drugs. Thu, 01 Nov 2018 13:38:51 EDT //www.koonmotors.com/releases/2018/11/181101133851.htm //www.koonmotors.com/releases/2018/10/181031101028.htm People who regularly take cocaine cut with the animal anti-worming agent levamisole demonstrate impaired cognitive performance and a thinned prefrontal cortex. These findings from two recent studies indicate that levamisole could have a toxic effect on the brain. Drug-checking programs should therefore be expanded, argue the researchers. Wed, 31 Oct 2018 10:10:28 EDT //www.koonmotors.com/releases/2018/10/181031101028.htm //www.koonmotors.com/releases/2018/09/180926082159.htm In an evaluation of the safety and abuse research on the drug in hallucinogenic mushrooms, researchers suggest that if it clears phase III clinical trials, psilocybin should be re-categorized from a schedule I drug -- one with no known medical potential -- to a schedule IV drug such as prescription sleep aids, but with tighter control. Wed, 26 Sep 2018 08:21:59 EDT //www.koonmotors.com/releases/2018/09/180926082159.htm //www.koonmotors.com/releases/2018/09/180920161028.htm Death rates from drug overdoses in the US have been on an exponential growth curve that began at least 15 years before the mid-1990s surge in opioid prescribing, suggesting that overdose death rates may continue along this same historical growth trajectory for years to come. These findings suggest that, to be successful, prevention efforts must extend beyond control of specific drugs to address deeper factors driving the epidemic. Thu, 20 Sep 2018 16:10:28 EDT //www.koonmotors.com/releases/2018/09/180920161028.htm //www.koonmotors.com/releases/2018/09/180917111609.htm A new study shows that skin stem cells, modified via CRISPR and transplanted back to donor mice, can protect addicted mice from cocaine-seeking and overdose. Mon, 17 Sep 2018 11:16:09 EDT //www.koonmotors.com/releases/2018/09/180917111609.htm //www.koonmotors.com/releases/2018/09/180912111856.htm A new study identifies a critical role of the orexin system in the expression of an addicted state in rats. Wed, 12 Sep 2018 11:18:56 EDT //www.koonmotors.com/releases/2018/09/180912111856.htm