//www.koonmotors.com/news/mind_brain/brain_injury/ Medical research on concussion, stoke an other brain injury. Learn how CT scans may not show extent of brain damage and that some brain cells can regenerate. Read about brain injury recovery. en-us Mon, 16 Oct 2023 12:18:31 EDT Mon, 16 Oct 2023 12:18:31 EDT 60 //www.koonmotors.com/images/scidaily-logo-rss.png//www.koonmotors.com/news/mind_brain/brain_injury/ For more science news, visit ScienceDaily. //www.koonmotors.com/releases/2023/10/231012013448.htm Researchers have identified a new way of mapping ‘phosphenes’ – the visual perception of the bright flashes we see when no light is entering the eye – to improve the outcome of surgery for patients receiving a cortical visual prosthesis (‘bionic eye’). Thu, 12 Oct 2023 01:34:48 EDT //www.koonmotors.com/releases/2023/10/231012013448.htm //www.koonmotors.com/releases/2023/10/231011182302.htm New guidance has been issued for clinicians on the determination of brain death, also known as death by neurologic criteria. Wed, 11 Oct 2023 18:23:02 EDT //www.koonmotors.com/releases/2023/10/231011182302.htm //www.koonmotors.com/releases/2023/10/231004105151.htm Researchers have produced an engineered tissue representing a simplified cerebral cortex by 3D printing human stem cells. When implanted into mouse brain slices, the structures became integrated with the host tissue. The technique may ultimately be developed into tailored repairs to treat brain injuries. Wed, 04 Oct 2023 10:51:51 EDT //www.koonmotors.com/releases/2023/10/231004105151.htm //www.koonmotors.com/releases/2023/10/231002211341.htm Novel brain biometrics could help inform whether an athlete is ready to return to play following a concussion, according to new research. Mon, 02 Oct 2023 21:13:41 EDT //www.koonmotors.com/releases/2023/10/231002211341.htm //www.koonmotors.com/releases/2023/10/231002124357.htm A significant breakthrough sheds light on the underlying mechanisms of Parkinson's disease, offering the potential for innovative treatments in the future. Mon, 02 Oct 2023 12:43:57 EDT //www.koonmotors.com/releases/2023/10/231002124357.htm //www.koonmotors.com/releases/2023/09/230920152424.htm Researchers found that college athletes had worse post-injury outcomes related to concussions they experienced outside of sports than those they experienced while playing sports. Additionally, female athletes who sustained their injury outside of sports had more severe symptoms and more days in sports lost to injury relative to male athletes. These findings suggest the need for improved concussion recognition, reporting, and monitoring outside of sports. Wed, 20 Sep 2023 15:24:24 EDT //www.koonmotors.com/releases/2023/09/230920152424.htm //www.koonmotors.com/releases/2023/09/230918195926.htm Is it possible that a single biomarker can detect all types of diseases related to dopamine deficiency in the brain? Yes, that's what a research group is discovering. 'We have observed that an enzyme in cerebrospinal fluid and in blood is a useful marker for identifying all types of Parkinson's-related diseases with high accuracy,' says the study leader. Mon, 18 Sep 2023 19:59:26 EDT //www.koonmotors.com/releases/2023/09/230918195926.htm //www.koonmotors.com/releases/2023/09/230906161815.htm A study of twins shows that having a concussion early in life is tied to having lower scores on tests of thinking and memory skills decades later as well as having more rapid decline in those scores than twins who did not have a concussion, or traumatic brain injury (TBI). Wed, 06 Sep 2023 16:18:15 EDT //www.koonmotors.com/releases/2023/09/230906161815.htm //www.koonmotors.com/releases/2023/09/230906143429.htm Not only does a lack of sleep make you feel awful, research has shown it impairs the brain. What's more, sleep loss over long periods can even increase risk for Alzheimer's and other neurological diseases. Researchers want to understand how sleep deprivation causes this harm. In a new study, a team working with mice has identified a protective protein whose level declines with sleep deprivation, leading to neuronal death. Wed, 06 Sep 2023 14:34:29 EDT //www.koonmotors.com/releases/2023/09/230906143429.htm //www.koonmotors.com/releases/2023/08/230821135640.htm A new study has demonstrated the ability for gene therapy to repair neural connections for those with the rare genetic brain disorder known as Hurler syndrome. Mon, 21 Aug 2023 13:56:40 EDT //www.koonmotors.com/releases/2023/08/230821135640.htm //www.koonmotors.com/releases/2023/08/230817164030.htm Researchers have found an injection of a specific blood factor can replicate the benefits of exercise in the brain. They've discovered that platelets secrete a protein, exerkine CXCL4/Platelet factor 4 or PF4, that rejuvenates neurons in aged mice in a similar way to physical exercise. This protein, which is released from platelets after exercise, results in regenerative and cognitive improvements when injected into aged mice. Thu, 17 Aug 2023 16:40:30 EDT //www.koonmotors.com/releases/2023/08/230817164030.htm //www.koonmotors.com/releases/2023/08/230815131855.htm Developing a framework for future research requires a comprehensive approach based on diagnosis, stage of recovery, and domain. Tue, 15 Aug 2023 13:18:55 EDT //www.koonmotors.com/releases/2023/08/230815131855.htm //www.koonmotors.com/releases/2023/08/230814122410.htm Researchers have identified brain circuits that, when injured, make conscious patients with acute brain injury appear unresponsive, a phenomenon known as hidden consciousness. Mon, 14 Aug 2023 12:24:10 EDT //www.koonmotors.com/releases/2023/08/230814122410.htm //www.koonmotors.com/releases/2023/08/230811172143.htm A new digital headset designed to measure alterations in brain function could change decisions about how quickly an athlete is ready to return to play after a concussion. In an evaluation of the device, researchers found it revealed brain changes even in athletes whose concussion symptoms had gone away, suggesting they could be playing too soon. Fri, 11 Aug 2023 17:21:43 EDT //www.koonmotors.com/releases/2023/08/230811172143.htm //www.koonmotors.com/releases/2023/08/230810110118.htm Partial recovery after ischemic stroke is possible, but the mechanisms involved in this process remain unclear. Researchers identified a whole new pathway promoting brain repair. They discovered lipids secreted from neurons surrounding the area of cell death can trigger brain-autonomous neural repair after ischemic brain injury. These findings might contribute to developing new compounds to stimulate the brain's intrinsic repair mechanisms. Thu, 10 Aug 2023 11:01:18 EDT //www.koonmotors.com/releases/2023/08/230810110118.htm //www.koonmotors.com/releases/2023/08/230809130628.htm Alzheimer's, stroke, multiple sclerosis and other neurological diseases cause severe damage due to neuroinflammation mediated by immune cells. Managing this inflammation poses a significant medical challenge because the brain is protected by the skull and additional surrounding membranes that make the brain less accessible for treatment approaches. Scientists had previously discovered pathways going from the bone marrow of the skull towards the brain, allowing immune cell movement. Now, new research revealed that cells in the skull's bone marrow are unique in their composition and in their disease response. These findings offer new possibilities for the diagnosis and treatment of neurological diseases and revolutionize brain health monitoring in the future with non-invasive skull imaging. Wed, 09 Aug 2023 13:06:28 EDT //www.koonmotors.com/releases/2023/08/230809130628.htm //www.koonmotors.com/releases/2023/07/230725123050.htm How does the brain adapt our behavior in response to an infection or injury? Scientists have revealed the existence of a circuit involved in sensing and also in the regulation of the anti-inflammatory response orchestrated by different brain regions. This circuit detects inflammation in the blood and organizes and regulates the immune response. It embodies a two-way connection between the brain and immune system. Tue, 25 Jul 2023 12:30:50 EDT //www.koonmotors.com/releases/2023/07/230725123050.htm //www.koonmotors.com/releases/2023/07/230724122745.htm A new study hascrevealed that the progression of Alzheimer's disease (AD) can be slowed by suppressing a specific protein in the brain that causes corrosion. Mon, 24 Jul 2023 12:27:45 EDT //www.koonmotors.com/releases/2023/07/230724122745.htm //www.koonmotors.com/releases/2023/07/230717115826.htm A new study finds concussions don't reduce the IQ of children. Findings may help to reduce parental fears regarding these common and concerning head injuries. Researchers looked at socioeconomic status, patient sex, severity of injuries, concussion history, and whether there was a loss of consciousness at the time of injury. None of these factors made a difference. Across the board, concussion was not associated with lower IQ. Mon, 17 Jul 2023 11:58:26 EDT //www.koonmotors.com/releases/2023/07/230717115826.htm //www.koonmotors.com/releases/2023/07/230705105847.htm Neuroscientists say the brain's auditory lexicon, a catalog of verbal language, is actually located in the front of the primary auditory cortex, not in back of it -- a finding that upends a century-long understanding of this area of the brain. The new understanding matters because it may impact recovery and rehabilitation following a brain injury such as a stroke. Wed, 05 Jul 2023 10:58:47 EDT //www.koonmotors.com/releases/2023/07/230705105847.htm //www.koonmotors.com/releases/2023/07/230704110920.htm A cochlear signal, the exact role of which has been unclear since its discovery around 70 years ago, probably gives the brain information on whether the ear is functioning normally or not. These new findings are an important piece of the puzzle in explaining what happens in the ear in hearing impairment caused by harmful noise, and may in the long run contribute to diagnosing noise-induced hearing injury. Tue, 04 Jul 2023 11:09:20 EDT //www.koonmotors.com/releases/2023/07/230704110920.htm //www.koonmotors.com/releases/2023/06/230627123030.htm 处于全球阿片类流行一个团队啊f scientists is exploring natural killer (NK) cells as an alternative treatment for neuropathic pain. Researchers gather existing evidence for the impact of NK cells in pain, pointing to their ability to prune the damaged nerve cells that may cause it. They urge the scientific community to explore biological mechanisms underlying NK cell activity to move towards a realistic pain therapy that is both effective and safe. Tue, 27 Jun 2023 12:30:30 EDT //www.koonmotors.com/releases/2023/06/230627123030.htm //www.koonmotors.com/releases/2023/06/230616161943.htm Concussions are an unfortunate reality of contact sports at junior and senior levels. Now, sports experts are suggesting extended recovery times may be needed for youth athletes suffering from head trauma as new research shows a concussion can increase future injury risk by 50%. Fri, 16 Jun 2023 16:19:43 EDT //www.koonmotors.com/releases/2023/06/230616161943.htm //www.koonmotors.com/releases/2023/06/230615183107.htm A new study has identified a treatment that could repair myelin in the cortex, undoing some of the damage caused by MS. Thu, 15 Jun 2023 18:31:07 EDT //www.koonmotors.com/releases/2023/06/230615183107.htm //www.koonmotors.com/releases/2023/06/230606111503.htm Researchers have shown that defective myelin actively promotes disease-related changes in Alzheimer's disease. Tue, 06 Jun 2023 11:15:03 EDT //www.koonmotors.com/releases/2023/06/230606111503.htm //www.koonmotors.com/releases/2023/05/230530125434.htm An artificial intelligence computer program that processes magnetic resonance imaging (MRI) can accurately identify changes in brain structure that result from repeated head injury, a new study in student athletes shows. These variations have not been captured by other traditional medical images such as computerized tomography (CT) scans. The new technology, researchers say, may help design new diagnostic tools to better understand subtle brain injuries that accumulate over time. Tue, 30 May 2023 12:54:34 EDT //www.koonmotors.com/releases/2023/05/230530125434.htm //www.koonmotors.com/releases/2023/05/230524181908.htm Recent research has identified a new compound that can stimulate nerve regeneration after injury, as well as protect cardiac tissue from the sort of damage seen in heart attack. Wed, 24 May 2023 18:19:08 EDT //www.koonmotors.com/releases/2023/05/230524181908.htm //www.koonmotors.com/releases/2023/05/230522131308.htm Researchers have recorded pain-related data from inside the brain of individuals with chronic pain disorders caused by stroke or amputation (phantom limb pain). A long sought-after goal has been to understand how pain is represented by brain activity and how to modulate that activity to relieve suffering from chronic pain. Data were collected over months while patients were at home, and they were analyzed using machine learning tools. Doing so, the researchers identified an area of the brain associated with chronic pain and objective biomarkers of chronic pain in individual patients. Mon, 22 May 2023 13:13:08 EDT //www.koonmotors.com/releases/2023/05/230522131308.htm //www.koonmotors.com/releases/2023/05/230504111839.htm Neuropathic pain -- abnormal hypersensitivity to stimuli -- is associated with impaired quality of life and is often poorly managed. Estimates suggest that 3 percent to 17 percent of adults suffer from neuropathic pain, including a quarter of people with diabetes and a third of people with HIV. Researchers report that a mechanism involving the enzyme Tiam1 in dorsal horn excitatory neurons of the spinal cord both initiates and maintains neuropathic pain. Moreover, they show that targeting spinal Tiam1 with anti-sense oligonucleotides injected into the cerebrospinal fluid effectively alleviated neuropathic pain hypersensitivity. Thu, 04 May 2023 11:18:39 EDT //www.koonmotors.com/releases/2023/05/230504111839.htm //www.koonmotors.com/releases/2023/04/230425205339.htm Even mild concussion can cause long-lasting effects to the brain, according to researchers. Using data from a Europe-wide study, the team has shown that for almost a half of all people who receive a knock to the head, there are changes in how regions of the brain communicate with each other, potentially causing long term symptoms such as fatigue and cognitive impairment. Tue, 25 Apr 2023 20:53:39 EDT //www.koonmotors.com/releases/2023/04/230425205339.htm //www.koonmotors.com/releases/2023/04/230417142415.htm Researchers have found that a promising stroke therapy, known as antisense oligonucleotides, is preferentially taken up from the blood into areas of stroke damage in the brain when the molecules are linked to a specific kind of lipid. This therapy can be given relatively late after a stroke occurs, and is hoped to lead to reduced stroke-related disabilities. Mon, 17 Apr 2023 14:24:15 EDT //www.koonmotors.com/releases/2023/04/230417142415.htm //www.koonmotors.com/releases/2023/04/230404140740.htm In a new study, researchers found that after traumatic brain injury, the brain's immune system cells' internal recycling function slowed dramatically, allowing waste products to build up and interfere with recovery from injury. Tue, 04 Apr 2023 14:07:40 EDT //www.koonmotors.com/releases/2023/04/230404140740.htm //www.koonmotors.com/releases/2023/03/230310103513.htm Researchers have identified a new therapeutic target that could lead to more effective treatment of glaucoma. Fri, 10 Mar 2023 10:35:13 EST //www.koonmotors.com/releases/2023/03/230310103513.htm //www.koonmotors.com/releases/2023/03/230308171550.htm Scientists have shed new light on aging processes in the brain. By linking the increased presence of specialized immune cells to conditions such as Alzheimer's disease and traumatic brain injury for the first time, they have unearthed a possible new target for therapies aimed at treating age-related neurological diseases. Wed, 08 Mar 2023 17:15:50 EST //www.koonmotors.com/releases/2023/03/230308171550.htm //www.koonmotors.com/releases/2023/03/230308112107.htm In Alzheimer's and related neurodegenerative diseases, the brain protein tau is closely linked to brain damage and cognitive decline. A new study indicates that T cells play a key role in tau-related neurodegeneration, a finding that suggests new treatment strategies for Alzheimer's and related diseases. Wed, 08 Mar 2023 11:21:07 EST //www.koonmotors.com/releases/2023/03/230308112107.htm //www.koonmotors.com/releases/2023/03/230306143450.htm CTE is a progressive neurodegenerative disease frequently found in contact sports athletes. However, many former contact sports athletes suffer from thinking problems and impulsive behavior in the absence of CTE, or with very mild CTE. This new study suggests that a separate type of brain damage, which can appear earlier than CTE, may underlie some of these symptoms. Mon, 06 Mar 2023 14:34:50 EST //www.koonmotors.com/releases/2023/03/230306143450.htm //www.koonmotors.com/releases/2023/03/230303105233.htm More than 350 former NFL players were studied on average 29 years after their playing careers ended. Retirees who experienced concussion symptoms during their playing careers were found to perform worse on a battery of cognitive tests. When comparing the retired players to more than 5,000 men who did not play football, cognitive performance was generally worse for former players, with older players performing worse. Fri, 03 Mar 2023 10:52:33 EST //www.koonmotors.com/releases/2023/03/230303105233.htm //www.koonmotors.com/releases/2023/02/230227132712.htm 一个新的混合水凝胶,安全地送杆cells to brain injury sites in mice has been developed. This solves a major challenge -- keeping stem cells alive for long enough to evolve into the cells required to create new tissue after insertion into a damaged part of the body. Mon, 27 Feb 2023 13:27:12 EST //www.koonmotors.com/releases/2023/02/230227132712.htm //www.koonmotors.com/releases/2023/02/230224135101.htm Synthetic hydrogels were shown to provide an effective scaffold for neuronal tissue growth in areas of brain damage, providing a possible approach for brain tissue reconstruction. Fri, 24 Feb 2023 13:51:01 EST //www.koonmotors.com/releases/2023/02/230224135101.htm //www.koonmotors.com/releases/2023/02/230224135003.htm 先前的研究已经暗示可能存在联系tween head injury and increased rates of brain tumors but evidence has been limited and often inconclusive. A team has now identified a possible mechanism to explain this link, implicating genetic mutations acting in concert with brain tissue inflammation to change the behavior of cells, making them more likely to become cancerous. Although this study was largely carried out in mice, it suggests that it would be important to explore the relevance of these findings to human gliomas. Fri, 24 Feb 2023 13:50:03 EST //www.koonmotors.com/releases/2023/02/230224135003.htm //www.koonmotors.com/releases/2023/02/230206170556.htm The proteins responsible for forming memories in neurons change depending on experience, a hint at how our brains build memory. Mon, 06 Feb 2023 17:05:56 EST //www.koonmotors.com/releases/2023/02/230206170556.htm //www.koonmotors.com/releases/2023/02/230202112654.htm Researchers show that brain organoids -- clumps of lab-grown neurons -- can integrate with rat brains and respond to visual stimulation like flashing lights. Thu, 02 Feb 2023 11:26:54 EST //www.koonmotors.com/releases/2023/02/230202112654.htm //www.koonmotors.com/releases/2023/02/230201134234.htm A researcher is one step closer to demonstrating the potential of a brain molecule called fractalkine to halt and even reverse the effects of multiple sclerosis and other neurodegenerative diseases. Researchers injected fractalkine into mice with chemically induced MS. They found the treatment increased the number of new oligodendrocytes -- vital brain and spinal cord cells that produce myelin in both embryonic and adult brains -- which are damaged during the MS autoimmune attack. Wed, 01 Feb 2023 13:42:34 EST //www.koonmotors.com/releases/2023/02/230201134234.htm //www.koonmotors.com/releases/2023/01/230130213948.htm Experiencing three or more concussions is linked with worsened brain function in later life, according to major new research. The study -- the largest of its kind -- also found having just one moderate-to-severe concussion, or traumatic brain injury (TBI), can have a long-term impact on brain function, including memory. Mon, 30 Jan 2023 21:39:48 EST //www.koonmotors.com/releases/2023/01/230130213948.htm //www.koonmotors.com/releases/2023/01/230124192613.htm Understanding the neural interface within the brain is critical to understanding aging, learning, disease progression and more. A newly developed, pop-up electrode device could gather more in-depth information about individual neurons and their interactions with each other while limiting the potential for brain tissue damage. Tue, 24 Jan 2023 19:26:13 EST //www.koonmotors.com/releases/2023/01/230124192613.htm //www.koonmotors.com/releases/2023/01/230120130916.htm 神经学家发现两种不同的细胞群in the striatum are affected differently by Huntington's disease. They believe neurodegeneration of one of these populations leads to motor impairments, while damage to the other population, located in a structure called the striosome, may account for the mood disorders that are often see in the early stages of the disease. Fri, 20 Jan 2023 13:09:16 EST //www.koonmotors.com/releases/2023/01/230120130916.htm //www.koonmotors.com/releases/2023/01/230120093105.htm Traumatic injury to the brain, spinal cord and optic nerve in the central nervous system (CNS) are the leading cause of disability and the second leading cause of death worldwide. CNS injuries often result in a catastrophic loss of sensory, motor and visual functions, which is the most challenging problem faced by clinicians and research scientists. Neuroscientists have recently identified and demonstrated a small molecule that can effectively stimulate nerve regeneration and restore visual functions after optic nerve injury, offering great hope for patients with optic nerve injury, such as glaucoma-related vision loss. Fri, 20 Jan 2023 09:31:05 EST //www.koonmotors.com/releases/2023/01/230120093105.htm //www.koonmotors.com/releases/2023/01/230117133707.htm Researchers have developed a new method to look at the cerebellum in detail. Tue, 17 Jan 2023 13:37:07 EST //www.koonmotors.com/releases/2023/01/230117133707.htm //www.koonmotors.com/releases/2023/01/230112155812.htm Gut bacteria can influence brain health, according to a study of mice genetically predisposed to develop Alzheimer's-like brain damage. The study indicates that gut bacteria produce compounds that influence the behavior of immune cells, including ones in the brain that can cause neurodegeneration. The findings suggest a new approach to treating Alzheimer's and other neurodegenerative diseases. Thu, 12 Jan 2023 15:58:12 EST //www.koonmotors.com/releases/2023/01/230112155812.htm //www.koonmotors.com/releases/2023/01/230110191410.htm Alzheimer disease begins decades before any symptoms, such as memory loss, start to show. Consequently, early diagnosis increases the chances of slowing the disease down with drugs. A new study on an inherited form of the disease shows that a protein called GFAP is a possible biomarker for very early stages of the disease. The study could one day lead to an earlier detection of this serious and common disease. Tue, 10 Jan 2023 19:14:10 EST //www.koonmotors.com/releases/2023/01/230110191410.htm //www.koonmotors.com/releases/2022/12/221228092247.htm A team of researchers has mapped the parts of the brain that support our ability to solve problems without prior experience -- otherwise known as fluid intelligence. Wed, 28 Dec 2022 09:22:47 EST //www.koonmotors.com/releases/2022/12/221228092247.htm //www.koonmotors.com/releases/2022/12/221213121557.htm Researchers demonstrate in animal models that water enriched with hydrogen molecules (H2) improves the symptomatology of neuropathic pain and related emotional disturbances. Tue, 13 Dec 2022 12:15:57 EST //www.koonmotors.com/releases/2022/12/221213121557.htm //www.koonmotors.com/releases/2022/12/221207163034.htm People who take cholesterol-lowering drugs called statins may have a lower risk of having a type of stroke called an intracerebral hemorrhage, according to a new study. An intracerebral hemorrhage is caused by bleeding in the brain. Wed, 07 Dec 2022 16:30:34 EST //www.koonmotors.com/releases/2022/12/221207163034.htm //www.koonmotors.com/releases/2022/11/221129112834.htm Researchers demonstrate in a zebrafish model that two proteins prevent scar formation in the brain, thereby improving the ability of tissue to regenerate. Tue, 29 Nov 2022 11:28:34 EST //www.koonmotors.com/releases/2022/11/221129112834.htm //www.koonmotors.com/releases/2022/11/221117102829.htm Researchers discover link between the protein medin and Alzheimer's disease. Thu, 17 Nov 2022 10:28:29 EST //www.koonmotors.com/releases/2022/11/221117102829.htm //www.koonmotors.com/releases/2022/11/221116164911.htm A study yields clues to why certain parts of the brain are particularly vulnerable to Alzheimer's damage. It comes down to the gene APOE, the greatest genetic risk factor for Alzheimer's disease. The parts of the brain where APOE is most active are the areas that sustain the most damage, they found. Wed, 16 Nov 2022 16:49:11 EST //www.koonmotors.com/releases/2022/11/221116164911.htm //www.koonmotors.com/releases/2022/11/221114095305.htm It's not uncommon for people to lose their sense of taste and smell due to a COVID-19 infection. In others, the disease has had an even stronger impact on the nervous system, with effects ranging from lasting concentration problems to strokes. Now, researchers have reported new insights into the development of 'neuro-COVID'. Mon, 14 Nov 2022 09:53:05 EST //www.koonmotors.com/releases/2022/11/221114095305.htm //www.koonmotors.com/releases/2022/10/221024102523.htm Medical researchers have identified a new type of microglia associated with stroke in the ischemia/reperfusion (I/R) injured brain. Mon, 24 Oct 2022 10:25:23 EDT //www.koonmotors.com/releases/2022/10/221024102523.htm //www.koonmotors.com/releases/2022/10/221021132728.htm Scientists have successfully placed a bioinspired steerable catheter into the brain of an animal. Fri, 21 Oct 2022 13:27:28 EDT //www.koonmotors.com/releases/2022/10/221021132728.htm //www.koonmotors.com/releases/2022/10/221014135723.htm Neurons that sense pain protect the gut from inflammation and associated tissue damage by regulating the microbial community living in the intestines, according to a new study. Fri, 14 Oct 2022 13:57:23 EDT //www.koonmotors.com/releases/2022/10/221014135723.htm