//www.koonmotors.com/news/health_medicine/vioxx/ Vioxx News. Read about side effects of Vioxx, Bextra and Celebrex. Read the latest medical and scientific information on Vioxx and the link between certain medications and heart attacks. en-us Fri, 14 Jul 2023 22:45:28 EDT Fri, 14 Jul 2023 22:45:28 EDT 60 //www.koonmotors.com/images/scidaily-logo-rss.png//www.koonmotors.com/news/health_medicine/vioxx/ For more science news, visit ScienceDaily. //www.koonmotors.com/releases/2020/02/200205132318.htm About 29 million Americans use over-the-counter nonsteroidal anti-inflammatory drugs (NSAIDs) to treat pain. Every year in the US, NSAID use is attributed to approximately 100,000 hospitalizations and 17,000 deaths. All of these drugs have benefits and risks, but deciding which one to use is complicated for health care providers and their patients. To assist in clinical decision-making, researchers address cardiovascular risks and beyond, which include gastrointestinal and kidney side effects of pain relievers. Wed, 05 Feb 2020 13:23:18 EST //www.koonmotors.com/releases/2020/02/200205132318.htm //www.koonmotors.com/releases/2017/08/170828094844.htm Ibuprofen is associated with increased blood pressure and hypertension compared to celecoxib in patients with osteoarthritis or rheumatoid arthritis and increased risk of cardiovascular disease, according to new research. Mon, 28 Aug 2017 09:48:44 EDT //www.koonmotors.com/releases/2017/08/170828094844.htm //www.koonmotors.com/releases/2017/07/170721084701.htm 在临床前研究中,肿瘤consitutivelyexpressed the protein indoleamine 2,3-dioxygenase (IDO1) responded to the cyclooxygenase-2 (COX-2) inhibitor celecoxib (Celebrex) and had improved infiltration of certain subsets of T cells, making them more likely to respond to anti-PD1 therapies, report researcher. Fri, 21 Jul 2017 08:47:01 EDT //www.koonmotors.com/releases/2017/07/170721084701.htm //www.koonmotors.com/releases/2017/05/170509192112.htm People who use commonly prescribed non-steroidal anti-inflammatory drugs (NSAIDs) to treat pain and inflammation could be raising their risk of having a heart attack, as early as in the first week of use and especially within the first month of taking high doses of such medication, suggests a study. Doctors and patients urged to weigh the risks and benefits of ibuprofen, diclofenac, celecoxib, and naproxen. Tue, 09 May 2017 19:21:12 EDT //www.koonmotors.com/releases/2017/05/170509192112.htm //www.koonmotors.com/releases/2016/11/161110145921.htm Giving severely depressed patients the arthritis drug celecoxib (Celebrex®) dramatically boosted the effectiveness of their antidepressant medication, a new study has found. Thu, 10 Nov 2016 14:59:21 EST //www.koonmotors.com/releases/2016/11/161110145921.htm //www.koonmotors.com/releases/2016/05/160525132610.htm Scientists have found that one of the most widely prescribed pain and anti-inflammation drugs slows the growth rate of a specific kind of cancer in animal models and suggests the medication could have the same effect on other types of tumors. Wed, 25 May 2016 13:26:10 EDT //www.koonmotors.com/releases/2016/05/160525132610.htm //www.koonmotors.com/releases/2015/08/150831085459.htm 在老年患者关节炎和没有的历史cardiovascular disease, chronic use of any non-steroidal anti-inflammatory drug appears safe from a cardiovascular and gastrointestinal stand-point, and regular, non-selective NSAIDs such as ibuprofen and diclofenac appear just as safe as the selective cyclooxygenase-2 (COX-2) inhibitor celecoxib according to results the SCOT trial. Mon, 31 Aug 2015 08:54:59 EDT //www.koonmotors.com/releases/2015/08/150831085459.htm //www.koonmotors.com/releases/2014/12/141210114212.htm A class of drug for treating arthritis - all but shelved over fears about side effects - may be given a new lease of life, following the discovery of a possible way to identify which patients should avoid using it. A new study sheds light on the 10-year-old question of how COX-2 inhibitors -- a type of non-steroidal anti-inflammatory drug (NSAID) -- can increase the risk of heart attack in some people. Wed, 10 Dec 2014 11:42:12 EST //www.koonmotors.com/releases/2014/12/141210114212.htm //www.koonmotors.com/releases/2014/11/141105165053.htm Commonly prescribed, older drugs for arthritis and pain may increase the risk of death from stroke, according to a study. "Our study supports stepping up efforts to make sure people with a higher risk of stroke are not prescribed these medications when other options are available," authors concluded. Wed, 05 Nov 2014 16:50:53 EST //www.koonmotors.com/releases/2014/11/141105165053.htm //www.koonmotors.com/releases/2014/10/141002101214.htm Nonsteroidal anti-inflammatory drugs -- such as ibuprofen and aspirin -- increase one's risk of upper gastrointestinal bleeding. When taken in combination with other drugs, this risk is significantly higher, according to new research. Thu, 02 Oct 2014 10:12:14 EDT //www.koonmotors.com/releases/2014/10/141002101214.htm //www.koonmotors.com/releases/2014/04/140421151834.htm Building on previous work that showed that deleting an enzyme in the COX-2 pathway in a mouse model of heart disease slowed the development of atherosclerosis, researchers have now extended this observation by clarifying that the consequence of deleting the enzyme mPEGS-1 differs, depending on the cell type in which it is taken away. They are now working on ways to deliver inhibitors of mPGES-1 selectively to the macrophages. Mon, 21 Apr 2014 15:18:34 EDT //www.koonmotors.com/releases/2014/04/140421151834.htm //www.koonmotors.com/releases/2012/11/121107132918.htm Researchers have found that duration of ibuprofen use was associated with a reduced risk of bladder cancer in patients in northern New England, which has a high mortality rate of this disease. Wed, 07 Nov 2012 13:29:18 EST //www.koonmotors.com/releases/2012/11/121107132918.htm //www.koonmotors.com/releases/2012/05/120502143846.htm After nearly 13 years of study and intense debate, a pair of new articles have confirmed exactly how a once-popular class of anti-inflammatory drugs leads to cardiovascular risk for people taking it. Wed, 02 May 2012 14:38:46 EDT //www.koonmotors.com/releases/2012/05/120502143846.htm //www.koonmotors.com/releases/2011/10/111003131412.htm A new study in mice points toward potential new therapies for stroke, a leading cause of death and foremost single cause of severe neurological disability. The study also may reveal why a much-heralded class of blockbuster drugs failed to live up to their promise. Mon, 03 Oct 2011 13:14:12 EDT //www.koonmotors.com/releases/2011/10/111003131412.htm //www.koonmotors.com/releases/2011/09/110913111410.htm Celecoxib reduces the risk of developing precancerous colon polyps, at the cost of increased heart disease risk. By looking closely at how celecoxib acts in the cell, it may be possible to get the benefit without the added risk. Celecoxib inhibits the enzyme GSK3, possibly accounting for its anticancer effects in multiple cell types. Tue, 13 Sep 2011 11:14:10 EDT //www.koonmotors.com/releases/2011/09/110913111410.htm //www.koonmotors.com/releases/2011/02/110222083511.htm New research shows that medications which have raised safety concerns over heart attack and stroke risks may not have gotten approval from the US Food and Drug Administration if the cardiovascular effects of fluid retention had been better understood. Tue, 22 Feb 2011 08:35:11 EST //www.koonmotors.com/releases/2011/02/110222083511.htm //www.koonmotors.com/releases/2011/01/110111184132.htm Commonly used painkillers for treating inflammation can increase the risk of heart attacks and strokes, according to an analysis of the evidence. Tue, 11 Jan 2011 18:41:32 EST //www.koonmotors.com/releases/2011/01/110111184132.htm //www.koonmotors.com/releases/2010/12/101202124213.htm A widely used arthritis drug reduces the incidence of non-melanoma skin cancers -- the most common cancers in humans -- according to a new study. The COX-2 inhibitor celecoxib (Celebrex), which is approved for the treatment of arthritis and acute pain, led to a 62 percent reduction in non-melanoma skin cancers. In the future, a combination of medications that include sunscreens and COX inhibitors or other protective therapies may be used to decrease the incidence of skin cancer. Thu, 02 Dec 2010 12:42:13 EST //www.koonmotors.com/releases/2010/12/101202124213.htm //www.koonmotors.com/releases/2010/11/101129160948.htm Celecoxib (also known by its brand name Celebrex) may help prevent non-melanoma skin cancers in patients with extensive actinic keratosis, which is often a precursor to these cancers, according to a randomized clinical trial. Mon, 29 Nov 2010 16:09:48 EST //www.koonmotors.com/releases/2010/11/101129160948.htm //www.koonmotors.com/releases/2010/09/100913153632.htm Researchers have discovered a novel mechanism as to why the long-term, high-dosage use of the well-known arthritis pain medication, Vioxx, led to heart attacks and strokes. Their groundbreaking research may pave the way for a safer drug for millions of arthritis patients who suffer acute and chronic pain. Mon, 13 Sep 2010 15:36:32 EDT //www.koonmotors.com/releases/2010/09/100913153632.htm //www.koonmotors.com/releases/2010/05/100513143538.htm Researchers are testing whether celecoxib, known by its brand name Celebrex, can help prevent the growth of precancerous polyps that form in the colon, rectum and small intestine of children with an inheritable genetic disease called familial adenomatous polyposis. Thu, 13 May 2010 14:35:38 EDT //www.koonmotors.com/releases/2010/05/100513143538.htm //www.koonmotors.com/releases/2009/12/091214173750.htm Millions of Americans take Celebrex for arthritis or other pain. Many, if they are middle-aged or older, also take a low-dose aspirin tablet daily to reduce the risk of heart attack and stroke. Yet they may be getting little protection, because Celebrex keeps the aspirin from doing its job effectively, a new study suggests. Mon, 14 Dec 2009 17:37:50 EST //www.koonmotors.com/releases/2009/12/091214173750.htm //www.koonmotors.com/releases/2009/11/091123171412.htm Evidence of cardiovascular risks associated with taking Vioxx, the popular, nonsteroidal anti-inflammatory drug (rofecoxib), could have been identified nearly four years before its manufacturer, Merck & Co. Inc., voluntarily pulled the drug from the market. Mon, 23 Nov 2009 17:14:12 EST //www.koonmotors.com/releases/2009/11/091123171412.htm //www.koonmotors.com/releases/2009/05/090518173315.htm 一项新的研究发现,那些较低的前女友pression of the "Celebrex gene," 15-PGDH, are actually resistant to Celebrex treatment when used to prevent colon cancer. Mon, 18 May 2009 17:33:15 EDT //www.koonmotors.com/releases/2009/05/090518173315.htm //www.koonmotors.com/releases/2009/04/090429172422.htm In searching for a simple way to identify individuals with smoking-related lung injury, scientists at have stumbled upon a potential explanation for why the class of pain-relievers known as COX-2 inhibitors increases the risk of heart problems among users. Wed, 29 Apr 2009 17:24:22 EDT //www.koonmotors.com/releases/2009/04/090429172422.htm //www.koonmotors.com/releases/2009/03/090324081433.htm A chemical component of licorice may offer a new approach to preventing colorectal cancer without the adverse side effects of other preventive therapies, researchers report. Tue, 24 Mar 2009 08:14:33 EDT //www.koonmotors.com/releases/2009/03/090324081433.htm //www.koonmotors.com/releases/2008/12/081215140940.htm Atherosclerosis -- a disease that includes the buildup of fatty, cholesterol-laden lumps of cells inside the artery wall -- is the underlying cause of heart attacks and strokes. Researchers have now demonstrated that a receptor for prostaglandin-E2 plays a key role in the development of atherosclerosis. The findings point to this receptor and its signaling pathways as molecular targets for modulating atherosclerosis development. Mon, 15 Dec 2008 14:09:40 EST //www.koonmotors.com/releases/2008/12/081215140940.htm //www.koonmotors.com/releases/2008/05/080515215852.htm Celecoxib, the anti-inflammatory medication also known by the trade name Celebrex, has proven to be safe and reduces a specific proliferation measurement of precancerous lesions in the lung, according to a new study. This finding demonstrates the significance of COX-2 inhibition toward preventing lung cancer in individuals at higher risk of developing the disease. Thu, 15 May 2008 21:58:52 EDT //www.koonmotors.com/releases/2008/05/080515215852.htm //www.koonmotors.com/releases/2008/04/080414170953.htm Colon adenoma prevention with celecoxib, a non-steroidal anti-inflammatory drug (NSAID), is effective and can be safe for patients without underlying cardiovascular risk factors, according to five-year data of a randomized phase III trial. "There has been a significant amount of negative press about Cox-2 inhibitors including celecoxib, and clearly these drugs are risky for some patients. However, our study also shows that for patients without major cardiovascular risk factors, celecoxib at low doses protects against high-risk lesions that can lead to colon cancer," said an associate professor of surgery at the Brigham and Women's Hospital. Mon, 14 Apr 2008 17:09:53 EDT //www.koonmotors.com/releases/2008/04/080414170953.htm //www.koonmotors.com/releases/2008/04/080414113215.htm Researchers have shown that administering a combination of the widely used drugs Celebrex (celecoxib, a nonsteroidal anti-inflammatory drug) and Lipitor (atorvastatin, a cholesterol lowering drug) stops the transition of early prostate cancer to its more aggressive and potentially fatal stage. Mon, 14 Apr 2008 11:32:15 EDT //www.koonmotors.com/releases/2008/04/080414113215.htm //www.koonmotors.com/releases/2008/02/080228150351.htm The identification of two cellular receptors that likely contribute to the genesis of hormone-dependent breast cancer points the way to new, highly targeted therapies against the disease. The finding also helps explain how daily use of medicines such as aspirin might help keep these breast tumors at bay. Thu, 28 Feb 2008 15:03:51 EST //www.koonmotors.com/releases/2008/02/080228150351.htm //www.koonmotors.com/releases/2008/01/080124161621.htm Celebrex, a popular arthritis drug that blocks pain by inhibiting an enzyme known as COX-2, has been shown in laboratory studies to induce arrhythmia, or irregular beating of the heart, via a novel pathway unrelated to its COX-2 inhibition. Thu, 24 Jan 2008 16:16:21 EST //www.koonmotors.com/releases/2008/01/080124161621.htm //www.koonmotors.com/releases/2008/01/080122203145.htm When low back pain strikes, many people turn to non-steroidal anti-inflammatory drugs (NSAIDs), like naproxen and ibuprofen, or their newer COX-2 inhibitor cousin Celebrex. However, these drugs work no better than old faithful acetaminophen (Tylenol), according to a new review of studies. Review data “support guidelines for the management of low back pain in primary care that recommend NSAIDs as a treatment option after paracetamol has been tried, since there are fewer side effects with paracetamol,” said lead reviewer. Paracetamol is the European version of Tylenol. Tue, 22 Jan 2008 20:31:45 EST //www.koonmotors.com/releases/2008/01/080122203145.htm //www.koonmotors.com/releases/2008/01/080114173854.htm cox - 2抑制剂塞来昔布等受到了scrutiny lately due to adverse cardiovascular side-effects stemming from COX-2 reduction. In both fruit fly and rat models, researchers reveal another adverse effect of Celecoxib; this drug can induce arrhythmia. More interestingly, this effect is independent of the COX-2 enzyme. Mon, 14 Jan 2008 17:38:54 EST //www.koonmotors.com/releases/2008/01/080114173854.htm //www.koonmotors.com/releases/2007/08/070827095231.htm Vioxx and related pain medications were taken off the market in 2004 because they caused dangerous heart problems in some people. Scientists may now have figured out how these drugs trigger these life-threatening side-effects. Mon, 27 Aug 2007 09:52:31 EDT //www.koonmotors.com/releases/2007/08/070827095231.htm //www.koonmotors.com/releases/2007/08/070818102805.htm Adjunctive use of the COX-2 inhibitor celcoxib after stent implantation in patients with coronary artery disease appears safe and can reduce the need for revascularisation of the target lesion, conclude authors of a new article. But an accompanying comment warns that clinical trials suggest long-term use of celecoxib can expose patients to an additional risk of heart attack. Sat, 18 Aug 2007 10:28:05 EDT //www.koonmotors.com/releases/2007/08/070818102805.htm //www.koonmotors.com/releases/2007/05/070523181627.htm A colon cancer researcher has laid out in a recent article how he thinks medical science should employ aspirin and new aspirin-like drugs for use in preventing colon cancer in certain high-risk individuals. Wed, 23 May 2007 18:16:27 EDT //www.koonmotors.com/releases/2007/05/070523181627.htm //www.koonmotors.com/releases/2007/05/070517101745.htm Certain nonsteroidal anti-inflammatory drugs may be better suited to treating cancer, in combination with standard therapies, rather than preventing it, according to new research. Thu, 17 May 2007 10:17:45 EDT //www.koonmotors.com/releases/2007/05/070517101745.htm //www.koonmotors.com/releases/2007/04/070424155532.htm The US Food and Drug Administration has caused an unnecessary scare about some pain relievers by adding a warning to drugs that are safe, says Curt Furberg, M.D., Ph.D., from Wake Forest University School of Medicine. At the same time, he says the agency has failed to recognize the harm of a pain reliever that should be taken off the market. Tue, 24 Apr 2007 15:55:32 EDT //www.koonmotors.com/releases/2007/04/070424155532.htm //www.koonmotors.com/releases/2007/03/070301081810.htm Drinking a nice warm cup of green tea has long been touted for its healthful benefits, both real and anecdotal. But now researchers have found that a component of green tea, combined with low doses of a COX-2 inhibitor, could slow the spread of human prostate cancer. Thu, 01 Mar 2007 08:18:10 EST //www.koonmotors.com/releases/2007/03/070301081810.htm //www.koonmotors.com/releases/2007/02/070205201537.htm Neuroblastoma is a form of cancer that develops in the nervous system and it affects small children more commonly than any other tumour type. Now, however, scientists at Karolinska Institutet in Sweden can show that a common painkiller can inhibit the development of neuroblastoma and help make treatment of the disease more effective. Mon, 05 Feb 2007 20:15:37 EST //www.koonmotors.com/releases/2007/02/070205201537.htm //www.koonmotors.com/releases/2006/11/061128084827.htm Efforts to understand the link between the cyclooxygenase-2 (COX-2) inhibitor arthritis drugs and heart disease have had an unanticipated benefit in leading to development of an engineered protein with "great potential" as a new treatment for heart disease, according to a new scientific report. Tue, 28 Nov 2006 08:48:27 EST //www.koonmotors.com/releases/2006/11/061128084827.htm //www.koonmotors.com/releases/2006/11/061120060431.htm A paper appearing this week in the Public Library of Science journal PLoS Clinical Trials presents findings from a large National Institutes of Health sponsored trial regarding the cardiovascular and cerebrovascular safety of two non-steroidal anti-inflammatory drugs, celecoxib and naproxen. The trial was initially conducted to test whether these drugs might prevent or delay the onset of Alzheimer's disease. Mon, 20 Nov 2006 06:04:31 EST //www.koonmotors.com/releases/2006/11/061120060431.htm //www.koonmotors.com/releases/2006/09/060925113458.htm The University of Cincinnati has developed a faster approach for informing consumers online when the Food and Drug Administration (FDA) withdraws a medication. Researchers hope this new 24-hour update method will become the standard response system for Web sites carrying critical consumer health information. Mon, 25 Sep 2006 11:34:58 EDT //www.koonmotors.com/releases/2006/09/060925113458.htm //www.koonmotors.com/releases/2006/09/060915203524.htm Two new review studies evaluating the safety of the pain-relieving medications selective cyclooxygenase 2 (COX-2) inhibitors and non-steroidal anti-inflammatory drugs (NSAIDs) find increased cardiovascular and kidney risks. The studies and an accompanying editorial were posted online today by JAMA because of the public health implications of the findings. The articles will appear in the October 4 print issue of JAMA. Fri, 15 Sep 2006 20:35:24 EDT //www.koonmotors.com/releases/2006/09/060915203524.htm //www.koonmotors.com/releases/2006/09/060912230236.htm Researchers at the University of Pennsylvania School of Medicine have found that deleting an inflammation enzyme in a mouse model of heart disease slowed the development of atherosclerosis. What's more, the composition of the animals' blood vessels showed that the disease process had not only slowed, but also stabilized. This study points to the possibility of a new class of nonsteroidal anti-inflammatory drugs that steer clear of heart-disease risk and work to reduce it. Tue, 12 Sep 2006 23:02:36 EDT //www.koonmotors.com/releases/2006/09/060912230236.htm //www.koonmotors.com/releases/2006/08/060830220508.htm An international team of scientists reports that a single 400-milligram daily dose of celecoxib, commonly called Celebrex and manufactured by Pfizer, significantly reduced recurrence of adenomas -- or pre-malignant colon tumors -- within three years of previous adenoma removal. Wed, 30 Aug 2006 22:05:08 EDT //www.koonmotors.com/releases/2006/08/060830220508.htm //www.koonmotors.com/releases/2006/08/060830215121.htm A researcher from Dartmouth reports the results of a clinical trial that shows that the cyclooxygenase-2 inhibitor rofecoxib reduces the risk of colorectal adenomas, or polyps. Wed, 30 Aug 2006 21:51:21 EDT //www.koonmotors.com/releases/2006/08/060830215121.htm //www.koonmotors.com/releases/2006/08/060828211618.htm A newly discovered enzyme inhibitor, identified by researchers originally looking for biological pest controls, may lead to pain relief for sufferers of arthritis and other inflammatory diseases, say researchers at the University of California, Davis. The finding, hailed by a noted inflammatory disease expert "as the most important discovery in inflammation in more than a decade," may also reduce side effects associated with the painkiller, Vioxx. Mon, 28 Aug 2006 21:16:18 EDT //www.koonmotors.com/releases/2006/08/060828211618.htm //www.koonmotors.com/releases/2006/06/060602074341.htm High doses of some traditional non-steroidal anti-inflammatory drugs (NSAIDS) are associated with similar cardiovascular risks as the new generation of anti-inflammatory drugs known as COX 2 inhibitors (like Vioxx), finds a study in this week's British Medical Journal. Fri, 02 Jun 2006 07:43:41 EDT //www.koonmotors.com/releases/2006/06/060602074341.htm //www.koonmotors.com/releases/2006/05/060529102245.htm COX-1 and COX-2 enzymes may be blocked by pain medications such as Advil and Vioxx in a more complex manner than was previously understood, a Queen's University study has found. Mon, 29 May 2006 10:22:45 EDT //www.koonmotors.com/releases/2006/05/060529102245.htm //www.koonmotors.com/releases/2006/05/060504081246.htm A new study led by Queen's University researcher Linda Lévesque shows that heart attacks related to the use of Vioxx -- a drug once popular for the treatment of pain and inflammation -- can occur within the first two weeks of use. Thu, 04 May 2006 08:12:46 EDT //www.koonmotors.com/releases/2006/05/060504081246.htm //www.koonmotors.com/releases/2006/05/060502172943.htm A quarter of patients who suffered a heart attack while taking Vioxx did so within the first two weeks of taking the drug, a new study published by MUHC investigators reveals. The research, scheduled for early online publication in the Canadian Medical Association Journal (CMAJ) today, demonstrates that cardiovascular risks from taking Vioxx may occur much earlier than previously believed. Tue, 02 May 2006 17:29:43 EDT //www.koonmotors.com/releases/2006/05/060502172943.htm //www.koonmotors.com/releases/2006/04/060417124231.htm Researchers at Queen's University and the University of Pennsylvania have identified one reason why drugs like Celebrex and Vioxx -- once popular for the treatment of pain and inflammation -- cause heart problems. Mon, 17 Apr 2006 12:42:31 EDT //www.koonmotors.com/releases/2006/04/060417124231.htm //www.koonmotors.com/releases/2006/04/060415115521.htm Researchers at the University of Pennsylvania School of Medicine have clarified the mechanism by which drugs like Celebrex and Vioxx cause heart problems, in multiple animal models. The findings offer the prospect of a new generation of anti-inflammatory drugs that bypass this issue. Sat, 15 Apr 2006 11:55:21 EDT //www.koonmotors.com/releases/2006/04/060415115521.htm //www.koonmotors.com/releases/2006/04/060403130703.htm Results from a new, five-year study show that regular use of popular prescription pain relievers may reduce the risk of breast cancer by up to 71 percent and may offer similar benefit in the prevention of prostate, colon and lung cancers. Mon, 03 Apr 2006 13:07:03 EDT //www.koonmotors.com/releases/2006/04/060403130703.htm //www.koonmotors.com/releases/2006/01/060130032351.htm Regular use of selective COX-2 inhibitors significantly reduces the risk of breast cancer. A case-control study published today in the open access journal BMC Cancer observed that daily use of selective COX-2 inhibitors, including celecoxib (Celebrex) and rofecoxib (Vioxx), was associated with a 71 percent reduction in the risk of breast cancer. Non-selective COX-2 inhibitors, such as aspirin and ibuprofen, also reduced the risk of breast cancer. Mon, 30 Jan 2006 03:23:51 EST //www.koonmotors.com/releases/2006/01/060130032351.htm //www.koonmotors.com/releases/2006/01/060118214940.htm Scientists believe that despite the current concerns around anti-inflammatory drugs like Vioxx, they may still be the best option for treating some forms of arthritis. Wed, 18 Jan 2006 21:49:40 EST //www.koonmotors.com/releases/2006/01/060118214940.htm //www.koonmotors.com/releases/2006/01/060105085659.htm A study published in the January issue of the American Gastroenterological Association (AGA) journal Gastroenterology found a difference in how people responded to popular painkillers and that up to 30 percent of this variability can be attributed to an individual's genetic make-up. This variation can influence both how useful the drugs are in affording relief from pain and inflammation, and the number and severity of the adverse effects. Thu, 05 Jan 2006 08:56:59 EST //www.koonmotors.com/releases/2006/01/060105085659.htm //www.koonmotors.com/releases/2005/11/051114112914.htm Taking either COX-2 inhibitors or other non-steroidal anti-inflammatory drugs (NSAIDs) after a heart attack, especially in high doses, increases the risk of death, researchers reported at the American Heart Association's Scientific Sessions 2005. Mon, 14 Nov 2005 11:29:14 EST //www.koonmotors.com/releases/2005/11/051114112914.htm