//www.koonmotors.com/news/health_medicine/tuberculosis/ Tuberculosis. Read the latest research news on tuberculosis, including a quick new TB test, new TB treatment options, and the latest news on tuberculosis infections. en-us Sat, 08 Jul 2023 22:45:42 EDT Sat, 08 Jul 2023 22:45:42 EDT 60 //www.koonmotors.com/images/scidaily-logo-rss.png//www.koonmotors.com/news/health_medicine/tuberculosis/ For more science news, visit ScienceDaily. //www.koonmotors.com/releases/2023/05/230509122018.htm New research found that people living with HIV that have had pulmonary tuberculosis had broader and more potent HIV antibody responses and differences in HIV sequences predicted to be antibody resistant as compared to those without suspected or documented tuberculosis. Tue, 09 May 2023 12:20:18 EDT //www.koonmotors.com/releases/2023/05/230509122018.htm //www.koonmotors.com/releases/2023/04/230424162847.htm 研究人员已经开发出一种新颖的和高度有效率cient method for rapid antibiotic susceptibility testing using optical microscopy. The technique, called Optical Nanomotion Detection, is extremely rapid, single-cell sensitive, label-free, and requires only a basic traditional optical microscope, equipped with a camera or a mobile phone. Mon, 24 Apr 2023 16:28:47 EDT //www.koonmotors.com/releases/2023/04/230424162847.htm //www.koonmotors.com/releases/2023/03/230323135449.htm Researchers have found that the body's process of removing old and damaged cell parts, is also an essential part of tackling infections that take hold within our cells, like TB. If this natural process can be harnessed with new treatments, it could present an alternative to, or improve use of antibiotics, especially where bacteria have become resistant to existing drugs. Thu, 23 Mar 2023 13:54:49 EDT //www.koonmotors.com/releases/2023/03/230323135449.htm //www.koonmotors.com/releases/2023/03/230313162715.htm A team of faculty has discovered new technology that will quickly and easily detect active Mycobacterium tuberculosis (TB) infection antibodies. Mon, 13 Mar 2023 16:27:15 EDT //www.koonmotors.com/releases/2023/03/230313162715.htm //www.koonmotors.com/releases/2023/03/230309101132.htm Neutrophils induce anti-inflammatory -- or M2 -- macrophages deep in their granulocyte core. The dense globular structures of granulomas in animals, particularly in the lungs, have been studied. Microbes and cancer cells may manipulate this permissive microenvironment to favor their survival. A lung granuloma model in guinea pigs demonstrates the specific accumulation of Neutrophil S100A9 deep in the cores of granulomas. Thu, 09 Mar 2023 10:11:32 EST //www.koonmotors.com/releases/2023/03/230309101132.htm //www.koonmotors.com/releases/2023/02/230215100410.htm The microbes responsible for some infections can rapidly mutate into variants that evade detection and treatment. Now, a newly developed procedure could help researchers catch up to these sneaky pathogens. Wed, 15 Feb 2023 10:04:10 EST //www.koonmotors.com/releases/2023/02/230215100410.htm //www.koonmotors.com/releases/2023/01/230131101915.htm 一个研究小组已经开发了一个新的化学l to reveal how bacteria adapt to the host environment and control host cells. This tool can be used to investigate bacterial interactions with the host in real-time during an infection, which cannot be easily achieved by other methods. Tue, 31 Jan 2023 10:19:15 EST //www.koonmotors.com/releases/2023/01/230131101915.htm //www.koonmotors.com/releases/2023/01/230127131141.htm Findings in animal models show that a U.S. Food and Drug Administration (FDA)-approved antibiotic regimen for multidrug-resistant (MDR) tuberculosis (TB) may not work for TB meningitis. Fri, 27 Jan 2023 13:11:41 EST //www.koonmotors.com/releases/2023/01/230127131141.htm //www.koonmotors.com/releases/2022/12/221220113025.htm Researchers have designed and synthesized analogs of a new antibiotic that is effective against multidrug-resistant bacteria, opening a new front in the fight against these infections. Tue, 20 Dec 2022 11:30:25 EST //www.koonmotors.com/releases/2022/12/221220113025.htm //www.koonmotors.com/releases/2022/12/221216131105.htm Researchers hope their genome-assembly tool will spur the development of new treatments for bacterial infections. Fri, 16 Dec 2022 13:11:05 EST //www.koonmotors.com/releases/2022/12/221216131105.htm //www.koonmotors.com/releases/2022/10/221003143938.htm The bacterium that causes tuberculosis has a cousin you've never heard of: MAC. This bacterial complex is everywhere, but most people never show symptoms. Yet some people get very, very sick. Researchers have now uncovered an immunologic defect that could explain this difference. Mon, 03 Oct 2022 14:39:38 EDT //www.koonmotors.com/releases/2022/10/221003143938.htm //www.koonmotors.com/releases/2022/09/220914180013.htm Researchers used data from large studies that contained laboratory measurements of two-drug combinations of 12 anti-tuberculosis drugs. Using mathematical models, the team discovered a set of rules that drug pairs need to satisfy to be potentially good treatments as part of three- and four-drug cocktails. Wed, 14 Sep 2022 18:00:13 EDT //www.koonmotors.com/releases/2022/09/220914180013.htm //www.koonmotors.com/releases/2022/09/220907192541.htm A potential new treatment combining natural manuka honey with a widely used drug has been developed by scientists to treat a potentially lethal lung infection and greatly reduce side effects of one of the current drugs used for its treatment. Wed, 07 Sep 2022 19:25:41 EDT //www.koonmotors.com/releases/2022/09/220907192541.htm //www.koonmotors.com/releases/2022/08/220822174822.htm Many bladder cancer patients cannot tolerate the strong side effects of the gold standard treatment. Researchers have found a way to minimize those side effects and are poised to move into clinical trials. Mon, 22 Aug 2022 17:48:22 EDT //www.koonmotors.com/releases/2022/08/220822174822.htm //www.koonmotors.com/releases/2022/08/220815112842.htm Researchers are hoping the results of a new study will spur a larger scale study of the effects of the BCG vaccine in patients with type 1 diabetes, considered among the most vulnerable groups to COVID-19. Mon, 15 Aug 2022 11:28:42 EDT //www.koonmotors.com/releases/2022/08/220815112842.htm //www.koonmotors.com/releases/2022/08/220809194937.htm An international consortium analyzed the genetic sequences and antibiotic susceptibility of more than 10,000 global Mycobacterium tuberculosis isolates. Tue, 09 Aug 2022 19:49:37 EDT //www.koonmotors.com/releases/2022/08/220809194937.htm //www.koonmotors.com/releases/2022/08/220809194901.htm Amid debate on the effectiveness of the tuberculosis vaccine, a new study suggests that the vaccine is protective against TB in children under 5, but adolescents and adults in high-burden countries may need additional protection to maintain immunity. Tue, 09 Aug 2022 19:49:01 EDT //www.koonmotors.com/releases/2022/08/220809194901.htm //www.koonmotors.com/releases/2022/08/220808162118.htm Research in animal models showed the potential of delivering a TB drug with one injection that lasts at least four months, in lieu of the current standard treatment requiring constant adherence to a daily drug regimen. Mon, 08 Aug 2022 16:21:18 EDT //www.koonmotors.com/releases/2022/08/220808162118.htm //www.koonmotors.com/releases/2022/08/220802105014.htm The vaccine candidate VPM1002 shows its safety in a study with HIV- and non-HIV-exposed newborns. Tue, 02 Aug 2022 10:50:14 EDT //www.koonmotors.com/releases/2022/08/220802105014.htm //www.koonmotors.com/releases/2022/07/220721141515.htm Mycobacterium tuberculosis, the causative agent of tuberculosis, remains the leading cause of infectious disease worldwide, affecting approximately a quarter of the globe's population. Treatment of infections is problematic due to the emergence of drug-resistant strains; however, an expert in antibiotic resistance is leading research on new potential therapeutic treatments for the disease. Thu, 21 Jul 2022 14:15:15 EDT //www.koonmotors.com/releases/2022/07/220721141515.htm //www.koonmotors.com/releases/2022/06/220622101357.htm Seven out of 10 pregnant women were cured of their multidrug-resistant tuberculosis and delivered healthy babies after taking a medication that had previously been considered unsafe in pregnancy, a new study has found. Wed, 22 Jun 2022 10:13:57 EDT //www.koonmotors.com/releases/2022/06/220622101357.htm //www.koonmotors.com/releases/2022/06/220621114712.htm Researchers have identified how the bacterium that causes tuberculosis (TB) can evolve rapidly in response to new environments. Tue, 21 Jun 2022 11:47:12 EDT //www.koonmotors.com/releases/2022/06/220621114712.htm //www.koonmotors.com/releases/2022/06/220601142835.htm Researchers have developed a new highly sensitive blood test for tuberculosis (TB) that screens for DNA fragments of the Mycobacterium tuberculosis bacteria that causes the deadly disease. Wed, 01 Jun 2022 14:28:35 EDT //www.koonmotors.com/releases/2022/06/220601142835.htm //www.koonmotors.com/releases/2022/05/220531143051.htm According to a new study, a new class of antibiotics is highly effective against drug-resistant tuberculosis. If validated in clinical trials, the new drug class would represent a major advance in the treatment of tuberculosis. Tue, 31 May 2022 14:30:51 EDT //www.koonmotors.com/releases/2022/05/220531143051.htm //www.koonmotors.com/releases/2022/05/220525103001.htm Treatment of severe infections caused by pathogenic bacteria relies on 'last resort' antibiotics, but rising resistance by 'superbugs' to most clinically approved drugs leaves patients exposed to possible fatalities. Researchers are focusing on how bacterial cells adapt and resist antimicrobial medications -- with a new article focusing on a hospital strain of Acinetobacter baumannii and its cellular response to important antibiotic colistin. Wed, 25 May 2022 10:30:01 EDT //www.koonmotors.com/releases/2022/05/220525103001.htm //www.koonmotors.com/releases/2022/05/220509100917.htm Researchers have identified rare genetic markers in M. tuberculosis that could improve early detection of drug-resistant strains of the disease, helping prevent their spread. Mon, 09 May 2022 10:09:17 EDT //www.koonmotors.com/releases/2022/05/220509100917.htm //www.koonmotors.com/releases/2022/04/220427171440.htm 活动性结核病患者,免疫活性ity can promote bacterial clearance, but in some situations, bacteria persist and grow. New research in an animal model of tuberculosis reveals which cellular and molecular features are associated with these different scenarios. Developing a vaccine that targets one or more of these features may effectively combat tuberculosis, which remains a major global health threat. Wed, 27 Apr 2022 17:14:40 EDT //www.koonmotors.com/releases/2022/04/220427171440.htm //www.koonmotors.com/releases/2022/04/220426153634.htm A potential game-changer in the tuberculosis epidemic was how the tuberculosis community viewed rapid molecular tests for tuberculosis and tuberculosis drug resistance. This was 12 years ago, with the launch of Xpert MTB/RIF, which gives results in less than two hours, simultaneously diagnosing tuberculosis and testing if the bacteria have rifampicin resistance, a type of drug-resistant tuberculosis. Multidrug-resistant tuberculosis is caused by resistance to at least both rifampicin and isoniazid, the two most effective first-line drugs used to treat tuberculosis. Tue, 26 Apr 2022 15:36:34 EDT //www.koonmotors.com/releases/2022/04/220426153634.htm //www.koonmotors.com/releases/2022/04/220416161124.htm Two strains of the bacterium causing tuberculosis have only minor genetic differences but attack the lungs in completely different fashion, according to researchers. Sat, 16 Apr 2022 16:11:24 EDT //www.koonmotors.com/releases/2022/04/220416161124.htm //www.koonmotors.com/releases/2022/03/220330103313.htm Mycobacteria are a group of pathogenic bacteria that cause diseases like leprosy and tuberculosis in humans. Now, a new study finds that mycobacteria are associated with red blood cells at lung infection sites, an interaction that has escaped scientific notice for 140 years since the discovery of the organism causing tuberculosis. The new research, published in Microbiology Spectrum, illuminated the interaction of mycobacteria with red blood cells and its role in lung disease. Wed, 30 Mar 2022 10:33:13 EDT //www.koonmotors.com/releases/2022/03/220330103313.htm //www.koonmotors.com/releases/2022/03/220324143753.htm In mice, the immune response mounted against tuberculosis prevents them from developing COVID-19, according to a new study. Thu, 24 Mar 2022 14:37:53 EDT //www.koonmotors.com/releases/2022/03/220324143753.htm //www.koonmotors.com/releases/2022/03/220324130315.htm Researchers found that the cells of humans and animals who have recovered from tuberculosis had prematurely aged up to 12 to 14 years. It's possible that this premature cellular aging is one reason why survivors of tuberculosis have a high risk of mortality. Thu, 24 Mar 2022 13:03:15 EDT //www.koonmotors.com/releases/2022/03/220324130315.htm //www.koonmotors.com/releases/2022/03/220321162717.htm A research team has discovered that drugs used to treat malaria are also effective at treating a pulmonary disease similar to tuberculosis. Mon, 21 Mar 2022 16:27:17 EDT //www.koonmotors.com/releases/2022/03/220321162717.htm //www.koonmotors.com/releases/2022/02/220225085901.htm A regional corner of Africa is a hotspot for cases of HIV, tuberculosis and malaria, prompting researchers to call for targeted health support rather than a national response. Fri, 25 Feb 2022 08:59:01 EST //www.koonmotors.com/releases/2022/02/220225085901.htm //www.koonmotors.com/releases/2022/02/220215152857.htm Medication against the nonhuman primate version of HIV given two weeks after infection helped keep tuberculosis in check. Tue, 15 Feb 2022 15:28:57 EST //www.koonmotors.com/releases/2022/02/220215152857.htm //www.koonmotors.com/releases/2021/12/211215082030.htm Scientists have spotted signs of 'pre-resistance' in bacteria for the first time -- signs that particular bacteria are likely to become resistant to antibiotics in the future -- in a new study. Wed, 15 Dec 2021 08:20:30 EST //www.koonmotors.com/releases/2021/12/211215082030.htm //www.koonmotors.com/releases/2021/11/211123131333.htm A cellular study of telaprevir shows that the antiviral blocks the function of essential proteins in bacteria, revealing opportunity to repurpose drug to use alongside antibiotics. Tue, 23 Nov 2021 13:13:33 EST //www.koonmotors.com/releases/2021/11/211123131333.htm //www.koonmotors.com/releases/2021/08/210821113857.htm Innovators have created a novel strategy for developing an effective vaccine for a widespread form of tuberculosis. Sat, 21 Aug 2021 11:38:57 EDT //www.koonmotors.com/releases/2021/08/210821113857.htm //www.koonmotors.com/releases/2021/07/210729143508.htm University of Maryland researchers discovered a way that Mycobacterium tuberculosis (Mtb), the bacterium that causes tuberculosis, can cause a person's immune cells to lower their defenses. Specifically, they identified a gene in the bacterium that suppresses immune defenses in infected human cells, which could exacerbate the infection. The findings were published on July 29, 2021, in the journal PLOS Pathogens Thu, 29 Jul 2021 14:35:08 EDT //www.koonmotors.com/releases/2021/07/210729143508.htm //www.koonmotors.com/releases/2021/07/210728140351.htm MicroCT of infected human lung tissue, along with histology and immunohistochemistry, was used to construct images of TB granulomas, airways and vasculature. Wed, 28 Jul 2021 14:03:51 EDT //www.koonmotors.com/releases/2021/07/210728140351.htm //www.koonmotors.com/releases/2021/07/210722131359.htm Researchers have developed a way to analyze how individual immune cells react to the bacteria that cause tuberculosis. It could pave the way for new vaccine strategies and provide insights into fighting other infectious diseases. Thu, 22 Jul 2021 13:13:59 EDT //www.koonmotors.com/releases/2021/07/210722131359.htm //www.koonmotors.com/releases/2021/07/210712122134.htm A new study has uncovered how cells infected with tuberculosis bacteria can die, and that using new medicines to enhance particular forms of cell death decreased the severity of the disease in a preclinical model. Mon, 12 Jul 2021 12:21:34 EDT //www.koonmotors.com/releases/2021/07/210712122134.htm //www.koonmotors.com/releases/2021/06/210619160806.htm Researchers have discovered that the use of a common antibiotic, doxycycline, in combination with TB drug treatment, reduces the size of lung cavities and accelerates markers of lung recovery. This was done in a trial with 30 pulmonary tuberculosis patients. Sat, 19 Jun 2021 16:08:06 EDT //www.koonmotors.com/releases/2021/06/210619160806.htm //www.koonmotors.com/releases/2021/05/210519132627.htm A study of tuberculosis drug therapy found that a two-drug, four-month regimen can be used to treat TB as effectively as the standard regimen that lasts six months and consists of four drugs. Wed, 19 May 2021 13:26:27 EDT //www.koonmotors.com/releases/2021/05/210519132627.htm //www.koonmotors.com/releases/2021/05/210518114837.htm 研究人员已经开发出一种bloo高度敏感d test that can find traces of the bacteria that causes tuberculosis (TB) in infants a year before they develop the deadly disease, according to a new study. Tue, 18 May 2021 11:48:37 EDT //www.koonmotors.com/releases/2021/05/210518114837.htm //www.koonmotors.com/releases/2021/05/210510104329.htm A pioneering study has discovered the presence of a harmful inflammatory protein in patients with symptomatic tuberculosis (TB). Researchers say, by targeting the IL-17 cytokine, a component produced naturally by the immune system in response to infection, excessive and damaging lung inflammation caused by TB may be significantly reduced to help speed up patient recovery. Mon, 10 May 2021 10:43:29 EDT //www.koonmotors.com/releases/2021/05/210510104329.htm //www.koonmotors.com/releases/2021/05/210503100007.htm The successful treatment of multidrug-resistant tuberculosis requires clarification in advance as to which antibiotics the pathogens are resistant to. Classic testing is very time-consuming and delays the start of therapy. Researchers have now prepared a catalogue of all mutations in the genome of tuberculosis bacteria and on the basis of a genome sequencing can quickly and cheaply predict which medicines are most effective for tuberculosis treatment. Mon, 03 May 2021 10:00:07 EDT //www.koonmotors.com/releases/2021/05/210503100007.htm //www.koonmotors.com/releases/2021/04/210408152324.htm Six years ago, researchers described the first toxin ever found for the deadly pathogen Mycobacterium tuberculosis. However, the mechanism for its secretion from the bacterium was unknown. Now, researchers describe two small Esx proteins that form pores in bacterial membranes and are essential for toxin release. This transport system may be widespread across many Gram-positive bacteria that contain proteins in the WXG100 super-family. Thu, 08 Apr 2021 15:23:24 EDT //www.koonmotors.com/releases/2021/04/210408152324.htm //www.koonmotors.com/releases/2021/03/210319125513.htm A new antibiotic compound clears infection of multi-drug resistant gonorrhea in mice in a single oral dose, according to a new study. The compound targets a molecular pathway found in bacteria but not humans and could lead to new treatments for gonorrhea and infections from other bacteria, such as tuberculosis and MRSA. Fri, 19 Mar 2021 12:55:13 EDT //www.koonmotors.com/releases/2021/03/210319125513.htm //www.koonmotors.com/releases/2021/03/210308165229.htm Researchers have identified a critical mechanism that allows deadly bacteria to gain resistance to antibiotics. Mon, 08 Mar 2021 16:52:29 EST //www.koonmotors.com/releases/2021/03/210308165229.htm //www.koonmotors.com/releases/2021/03/210304112449.htm A new study employing ancient human DNA reveals how tuberculosis has affected European populations over the past 2,000 years, specifically the impact that disease has had on the human genome. This work has implications for studying not only evolutionary genetics, but also how genetics can influence the immune system. Thu, 04 Mar 2021 11:24:49 EST //www.koonmotors.com/releases/2021/03/210304112449.htm //www.koonmotors.com/releases/2021/02/210219111806.htm The treatment of tuberculosis (TB) is long and demanding. In particular, in cases of resistant tuberculosis, the WHO generally recommends a standard treatment duration of at least 18 months, as there are no reliable biomarkers for an early termination. Scientists have now succeeded in identifying a biomarker that points to an individual end of therapy based on the activity of 22 genes. In many cases, this probably allows the treatment to be shortened safely. Fri, 19 Feb 2021 11:18:06 EST //www.koonmotors.com/releases/2021/02/210219111806.htm //www.koonmotors.com/releases/2021/02/210216092830.htm Researchers may have found a new pathway to treat and control tuberculosis (TB), the disease caused by Mycobacterium tuberculosis (Mtb). Using single-cell RNA sequencing (scRNAseq), a next-generation sequencing technology, scientists were able to further define the mechanisms that lead to TB infection and latency. Tue, 16 Feb 2021 09:28:30 EST //www.koonmotors.com/releases/2021/02/210216092830.htm //www.koonmotors.com/releases/2021/01/210118161156.htm A new method to synthesize vaccines safely and quickly should see much faster pre-clinical testing to pursue strategies to combat novel pathogens, something the COVID pandemic has shown is necessary. Mon, 18 Jan 2021 16:11:56 EST //www.koonmotors.com/releases/2021/01/210118161156.htm //www.koonmotors.com/releases/2021/01/210106142645.htm Drug-resistant bacteria could lead to more deaths than cancer by 2050, according to a report commissioned by the United Kingdom in 2014 and jointly supported by the U.K. government and the Wellcome Trust. In an effort to reduce the potential infection-caused 10 million deaths worldwide, Penn State researcher Scott Medina has developed a peptide, or small protein, that can target a specific pathogen without damaging the good bacteria that bolsters the immune system. Wed, 06 Jan 2021 14:26:45 EST //www.koonmotors.com/releases/2021/01/210106142645.htm //www.koonmotors.com/releases/2021/01/210105095606.htm Researchers have developed a new imaging method to see where antibiotics have reached bacteria within tissues. The method could be used to help develop more effective antibiotic treatments, reducing the risk of antibiotic resistance. Tue, 05 Jan 2021 09:56:06 EST //www.koonmotors.com/releases/2021/01/210105095606.htm //www.koonmotors.com/releases/2020/12/201208142644.htm Scientists have developed a possible new antibiotic for a pathogen that is notoriously resistant to medications and frequently lethal for people with cystic fibrosis and other lung ailments. Tue, 08 Dec 2020 14:26:44 EST //www.koonmotors.com/releases/2020/12/201208142644.htm //www.koonmotors.com/releases/2020/11/201124122925.htm Scientists have developed a lung-on-chip model to study how the body responds to early tuberculosis (TB) infection. Tue, 24 Nov 2020 12:29:25 EST //www.koonmotors.com/releases/2020/11/201124122925.htm //www.koonmotors.com/releases/2020/11/201119083925.htm These slow growing bacteria have long puzzled TB researchers with their fairly rapid resistance to antibiotics. Researchers may have been barking up the wrong tree in exploring genetics, because the answer seems to lie in the epigenetic domain. Thu, 19 Nov 2020 08:39:25 EST //www.koonmotors.com/releases/2020/11/201119083925.htm //www.koonmotors.com/releases/2020/07/200730092610.htm Compounds tested for their potential as antibiotics have demonstrated promising activity against one of the deadliest infectious diseases - tuberculosis (TB). Thu, 30 Jul 2020 09:26:10 EDT //www.koonmotors.com/releases/2020/07/200730092610.htm