//www.koonmotors.com/news/health_medicine/sickle_cell_anemia/ Read articles summarizing medical research on sickle-cell anemia. en-us Wed, 06 Sep 2023 14:46:49 EDT Wed, 06 Sep 2023 14:46:49 EDT 60 //www.koonmotors.com/images/scidaily-logo-rss.png//www.koonmotors.com/news/health_medicine/sickle_cell_anemia/ For more science news, visit ScienceDaily. //www.koonmotors.com/releases/2023/08/230830195934.htm A clinical trial has tested a potentially curative stem cell gene therapy for sickle cell disease. The results were promising. Wed, 30 Aug 2023 19:59:34 EDT //www.koonmotors.com/releases/2023/08/230830195934.htm //www.koonmotors.com/releases/2023/08/230809164732.htm A study shows new steps toward more patients getting gene therapy. Wed, 09 Aug 2023 16:47:32 EDT //www.koonmotors.com/releases/2023/08/230809164732.htm //www.koonmotors.com/releases/2023/07/230727143923.htm In a step forward in the development of genetic medicines, researchers have developed a proof-of-concept model for delivering gene editing tools to treat blood disorders, allowing for the modification of diseased blood cells directly within the body. If translated into the clinic, this approach could expand access and reduce the cost of gene therapies for blood disorders, many of which currently require patients receive chemotherapy and a stem cell transplant. Thu, 27 Jul 2023 14:39:23 EDT //www.koonmotors.com/releases/2023/07/230727143923.htm //www.koonmotors.com/releases/2023/05/230504155645.htm A major challenge in human genetics is understanding which parts of the genome drive specific traits or contribute to disease risk. This challenge is even greater for genetic variants found in the 98% of the genome that does not encode proteins. A new approach combines genetic association studies, gene editing, and single-cell sequencing to address these challenges and discover causal variants and genetic mechanisms for blood cell traits. Thu, 04 May 2023 15:56:45 EDT //www.koonmotors.com/releases/2023/05/230504155645.htm //www.koonmotors.com/releases/2023/04/230417142413.htm 科学家们展示了如何'编辑可以纠正μtations that cause sickle cell disease in a potentially curative approach. Mon, 17 Apr 2023 14:24:13 EDT //www.koonmotors.com/releases/2023/04/230417142413.htm //www.koonmotors.com/releases/2023/03/230316114009.htm While research has long established disparities in health outcomes among individuals living with sickle cell disease (SCD), few studies have quantified these gaps. A new study finds that the average life expectancy of publicly insured patients living with SCD is roughly 52.6 years. In contrast, the CDC reports that the average life expectancy in the United States is 73.5 years for men and 79.3 years for women, demonstrating the considerable burden SCD can have on affected populations. Thu, 16 Mar 2023 11:40:09 EDT //www.koonmotors.com/releases/2023/03/230316114009.htm //www.koonmotors.com/releases/2023/01/230130150116.htm Researchers have designed a microfluidic device, or 'spleen-on-a-chip,' that can model how the spleen's filters become clogged by sickled red blood cells, leading to a life-threatening condition known as acute splenic sequestration. Mon, 30 Jan 2023 15:01:16 EST //www.koonmotors.com/releases/2023/01/230130150116.htm //www.koonmotors.com/releases/2022/10/221024102909.htm Researchers are working to reveal potential threats to the efficacy of CRISPR/Cas9 gene editing, even when it appears to be working as planned. Mon, 24 Oct 2022 10:29:09 EDT //www.koonmotors.com/releases/2022/10/221024102909.htm //www.koonmotors.com/releases/2022/10/221012132603.htm Scientists found the cellular response to low oxygen also increases fetal hemoglobin expression in adults, which could lead to novel treatments for some common genetic anemias. Wed, 12 Oct 2022 13:26:03 EDT //www.koonmotors.com/releases/2022/10/221012132603.htm //www.koonmotors.com/releases/2022/04/220414110900.htm Results from a phase 3 clinical indicate that the oral drug mitapivat is safe and effective for treating adults with pyruvate kinase deficiency, a genetic condition that causes red blood cell destruction. The trial's results led to the drug's approval by the U.S. Food and Drug Administration in February. Thu, 14 Apr 2022 11:09:00 EDT //www.koonmotors.com/releases/2022/04/220414110900.htm //www.koonmotors.com/releases/2022/04/220408103142.htm Researchers have used CRISPR gene editing -- a type of 'molecular scissors' -- to understand how deletions in one area of the genome can affect the expression of nearby genes. The work will help researchers investigate new therapeutic approaches for one of the world's most devastating genetic blood disorders -- sickle cell disease. Asymptomatic sickle cell disease patients actually lack a tiny part of the genome, scientists have shown. Fri, 08 Apr 2022 10:31:42 EDT //www.koonmotors.com/releases/2022/04/220408103142.htm //www.koonmotors.com/releases/2022/02/220216170214.htm Sickle cell anemia is an inherited blood disorder where red blood cells become sickle/crescent shaped. It causes frequent infections, swelling in the hands and legs, pain, severe tiredness and delayed growth or puberty. Treatment typically focuses on controlling symptoms and may include pain medicines during crises; hydroxyurea to reduce the number of pain episodes; antibiotics and vaccines to prevent bacterial infections and blood transfusions. While a remedy for this severe disease has remained elusive, a recent study, if proven applicable, may be a possible cure. Wed, 16 Feb 2022 17:02:14 EST //www.koonmotors.com/releases/2022/02/220216170214.htm //www.koonmotors.com/releases/2022/01/220114115708.htm A world-first study has revealed how space travel can cause lower red blood cell counts, known as space anemia. Analysis of 14 astronauts showed their bodies destroyed 54 percent more red blood cells in space than they normally would on Earth, according to a new study. Fri, 14 Jan 2022 11:57:08 EST //www.koonmotors.com/releases/2022/01/220114115708.htm //www.koonmotors.com/releases/2021/12/211213160126.htm An experimental gene therapy for sickle cell disease restored blood cells to their normal shape and eliminated severe pain crises for years after treatment, a multicenter study has found. Mon, 13 Dec 2021 16:01:26 EST //www.koonmotors.com/releases/2021/12/211213160126.htm //www.koonmotors.com/releases/2021/12/211210103054.htm Organ-on-a-chip technology has provided a push to discover new drugs for a variety of rare and ignored diseases for which current models either don't exist or lack precision. In particular, these platforms can include the cells of a patient, resulting in patient-specific discovery. Fri, 10 Dec 2021 10:30:54 EST //www.koonmotors.com/releases/2021/12/211210103054.htm //www.koonmotors.com/releases/2021/11/211111154254.htm Studying mice, researchers have developed a method of stem cell transplantation that does not require radiation or chemotherapy. Instead, the strategy takes an immunotherapeutic approach, combining the targeted elimination of blood-forming stem cells in the bone marrow with immune-modulating drugs to prevent the immune system from rejecting the new donor stem cells. 星期四,2021年11月11日15:42:54 EST //www.koonmotors.com/releases/2021/11/211111154254.htm //www.koonmotors.com/releases/2021/09/210921091738.htm 一个多方面的微fluidic in vitro assay is helping to identify the role of hypoxia on red blood cell aging via the biomechanical pathways. It holds promise for investigating hypoxic effects on the metastatic potential and relevant drug resistance of cancer cells. It also can be a useful tool to predict the mechanical performance of natural and artificial red blood cells for transfusion purposes and to further extend to red blood cells in other blood diseases and other cell types. Tue, 21 Sep 2021 09:17:38 EDT //www.koonmotors.com/releases/2021/09/210921091738.htm //www.koonmotors.com/releases/2021/08/210806171916.htm Pooled results from phase 3 clinical trials demonstrate that roxadustat is efficacious and may be comparable to placebo in studies done to date for treating anemia in patients with chronic kidney disease who do not require dialysis. Fri, 06 Aug 2021 17:19:16 EDT //www.koonmotors.com/releases/2021/08/210806171916.htm //www.koonmotors.com/releases/2021/07/210701120659.htm New research finds that certain factors, such as a history of severe pain episodes and coexisting organ conditions, increase the risk of severe COVID-19 illness, including hospitalization, in individuals living with sickle cell disease (SCD). According to researchers, the study results underscore the need for COVID-19 risk reduction strategies and vaccination for this medically vulnerable population. Thu, 01 Jul 2021 12:06:59 EDT //www.koonmotors.com/releases/2021/07/210701120659.htm //www.koonmotors.com/releases/2021/06/210603171156.htm Sickle cell disease leads to chronic pain, organ failure, and early death in patients worldwide. A team has demonstrated a gene editing approach that efficiently corrects the mutation underlying SCD in patient blood stem cells and in mice. This treatment rescued disease symptoms in animal models, enabling long-lasting production of healthy blood cells, and could inspire a therapeutic strategy for SCD. Thu, 03 Jun 2021 17:11:56 EDT //www.koonmotors.com/releases/2021/06/210603171156.htm //www.koonmotors.com/releases/2021/06/210601135730.htm Researchers have developed a proof-of-concept treatment for blood disorders like sickle cell disease and beta-thalassemia that could raise hemoglobin levels by activating production of both fetal and adult hemoglobin. Using a viral vector engineered to reactivate fetal hemoglobin production, suppress mutant hemoglobin, and supply functional adult hemoglobin, the researchers developed an approach that could produce more hemoglobin through a single vector. Tue, 01 Jun 2021 13:57:30 EDT //www.koonmotors.com/releases/2021/06/210601135730.htm //www.koonmotors.com/releases/2021/05/210506125820.htm Scientists have developed a highly efficient method to address a major challenge in biology -- identifying the genetic 'switches' that regulate gene expression. Thu, 06 May 2021 12:58:20 EDT //www.koonmotors.com/releases/2021/05/210506125820.htm //www.koonmotors.com/releases/2021/04/210409093609.htm For those who have sickle cell disease, there are only a few treatment options, which include bone marrow transplants, gene therapy or other treatments that address a subset of symptoms. Now, researchers report discovery of a small molecule that could treat sickle cell disease by boosting levels of fetal hemoglobin, a healthy form that adults normally do not make. Fri, 09 Apr 2021 09:36:09 EDT //www.koonmotors.com/releases/2021/04/210409093609.htm //www.koonmotors.com/releases/2021/03/210324113513.htm Sickle cell disease is the most prevalent inherited blood disorder in the world, affecting 70,000 to 100,000 Americans. However, it is considered an orphan disease, meaning it impacts less than 200,000 people nationally, and is therefore underrepresented in therapeutic research. Wed, 24 Mar 2021 11:35:13 EDT //www.koonmotors.com/releases/2021/03/210324113513.htm //www.koonmotors.com/releases/2021/03/210311152759.htm A new study demonstrates that machine-learning strategies can be applied to routinely collected physiological data, such as heart rate and blood pressure, to provide clues about pain levels in people with sickle cell disease. Thu, 11 Mar 2021 15:27:59 EST //www.koonmotors.com/releases/2021/03/210311152759.htm //www.koonmotors.com/releases/2021/03/210301133621.htm A new review analyzes disparities in experience and treatment of sickle cell disease. Mon, 01 Mar 2021 13:36:21 EST //www.koonmotors.com/releases/2021/03/210301133621.htm //www.koonmotors.com/releases/2021/02/210201090814.htm Researchers have found that an enriched diet and companionship can reduce pain in mice with sickle cell disease by increasing serotonin. They also discovered that duloxetine, an antidepressant that boosts serotonin levels, could be an alternative to opioids in treating chronic pain. Mon, 01 Feb 2021 09:08:14 EST //www.koonmotors.com/releases/2021/02/210201090814.htm //www.koonmotors.com/releases/2021/01/210121131904.htm A new article reports two patients appear to have been cured of beta thalassemia and sickle cell disease after their own genes were edited with CRISPR-Cas9 technology. The two researchers who invented this technology received the Nobel Prize in Chemistry in 2020. Thu, 21 Jan 2021 13:19:04 EST //www.koonmotors.com/releases/2021/01/210121131904.htm //www.koonmotors.com/releases/2020/10/201012132021.htm As public interest and expanded research in human genome editing grows, many questions remain about ethical, legal and social implications of the technology. People who are seriously ill may overestimate the benefits of early clinical trials while underestimating the risks. This makes properly understanding informed consent, the full knowledge of risks and benefits of treatments, especially important. Mon, 12 Oct 2020 13:20:21 EDT //www.koonmotors.com/releases/2020/10/201012132021.htm //www.koonmotors.com/releases/2020/09/200916113538.htm The secret of how the Dantu genetic blood variant helps to protect against malaria has been revealed for the first time. The team found that red blood cells in people with the rare Dantu blood variant have a higher surface tension that prevents them from being invaded by the world's deadliest malaria parasite, Plasmodium falciparum. Wed, 16 Sep 2020 11:35:38 EDT //www.koonmotors.com/releases/2020/09/200916113538.htm //www.koonmotors.com/releases/2020/07/200717133236.htm Cannabis appears to be a safe and potentially effective treatment for the chronic pain that afflicts people with sickle cell disease, according to a new clinical trial. Fri, 17 Jul 2020 13:32:36 EDT //www.koonmotors.com/releases/2020/07/200717133236.htm //www.koonmotors.com/releases/2020/05/200521102110.htm Researchers have developed a way to use smartphone images of a person's eyelids to assess blood hemoglobin levels. The ability to perform one of the most common clinical lab tests without a blood draw could help reduce the need for in-person clinic visits, make it easier to monitor patients who are in critical condition, and improve care in low- and middle-income countries where access to testing laboratories is limited. 星期四,2020年5月21日10:21:10美国东部时间 //www.koonmotors.com/releases/2020/05/200521102110.htm //www.koonmotors.com/releases/2020/04/200408142732.htm A new analysis supports prior reports that people with sickle cell disease have lower rates of human immunodeficiency virus (HIV) infection, but follow-up cell studies did not reveal a mechanism to explain the reduced risk. Wed, 08 Apr 2020 14:27:32 EDT //www.koonmotors.com/releases/2020/04/200408142732.htm //www.koonmotors.com/releases/2019/12/191211115522.htm Findings from the ABC-PICU study on critically ill children may alter policies at hospitals where fresh red cells are preferentially used. Wed, 11 Dec 2019 11:55:22 EST //www.koonmotors.com/releases/2019/12/191211115522.htm //www.koonmotors.com/releases/2019/10/191002102804.htm Researchers have developed a new and improved viral vector -- a virus-based vehicle that delivers therapeutic genes -- for use in gene therapy for sickle cell disease. In advanced lab tests using animal models, the new vector was up to 10 times more efficient at incorporating corrective genes into bone marrow stem cells than the conventional vectors currently used, and it had a carrying capacity of up to six times higher, the researchers report. Wed, 02 Oct 2019 10:28:04 EDT //www.koonmotors.com/releases/2019/10/191002102804.htm //www.koonmotors.com/releases/2019/10/191001110822.htm For the first time ever, a professor has observed a crystallized iron product called hemozoin being made in mammals, with widespread implications for future research and treatment of blood disorders. Findings could be used to treat sickle cell disease and malaria patients, while opening up diverse research avenues across immunology, parasitology, neuroscience, microbiology, and even urology. Tue, 01 Oct 2019 11:08:22 EDT //www.koonmotors.com/releases/2019/10/191001110822.htm //www.koonmotors.com/releases/2019/09/190917100443.htm Researchers have developed a novel way to measure how mechanical fatigue affects biological cells. They also have established the important role of this effect in influencing physical properties of biological cells such as red blood cells (RBCs). This new technique assesses the mechanical integrity and fatigue behavior of RBCs using a general microfluidics method that incorporates amplitude-modulated electro-deformation. This method has important applications for mechanical fatigue studies in conjunction with other microenvironments related to health and materials engineering. Tue, 17 Sep 2019 10:04:43 EDT //www.koonmotors.com/releases/2019/09/190917100443.htm //www.koonmotors.com/releases/2019/08/190822101423.htm A new computer model that captures the dynamics of the red blood cell sickling process could help in evaluating drugs for treating sickle cell disease. Thu, 22 Aug 2019 10:14:23 EDT //www.koonmotors.com/releases/2019/08/190822101423.htm //www.koonmotors.com/releases/2019/07/190731145815.htm Researchers have used CRISPR-Cas9 to edit long-lived blood stem cells to reverse the clinical symptoms observed with several blood disorders, including sickle cell disease and beta-thalassemia. Wed, 31 Jul 2019 14:58:15 EDT //www.koonmotors.com/releases/2019/07/190731145815.htm //www.koonmotors.com/releases/2019/07/190713103944.htm Most non-traumatic fatalities among high school and college football athletes do not occur while playing the game of football, but rather during conditioning sessions which are often associated with overexertion or punishment drills required by coaches and team staff, according to new research. Sat, 13 Jul 2019 10:39:44 EDT //www.koonmotors.com/releases/2019/07/190713103944.htm //www.koonmotors.com/releases/2019/07/190702112908.htm Chemists are reporting a new finding on how sickle cells are formed, which may lead not only to stopping their formation, but to new avenues for making uniformly-sized nanoparticles for industry. Tue, 02 Jul 2019 11:29:08 EDT //www.koonmotors.com/releases/2019/07/190702112908.htm //www.koonmotors.com/releases/2019/06/190619174535.htm An investigational drug for the treatment of sickle cell disease is showing early promise in clinical trials for impacting biomarkers of the disease in patients, reported researchers. Wed, 19 Jun 2019 17:45:35 EDT //www.koonmotors.com/releases/2019/06/190619174535.htm //www.koonmotors.com/releases/2019/06/190613095211.htm Researchers have developed a rapid and reliable new method to continuously monitor sickle cell disease using a microfluidics-based electrical impedance sensor. This novel technology can characterize the dynamic cell sickling and unsickling processes in sickle blood without the use of microscopic imaging or biochemical markers. The technology is being developed with the hope of providing patients with a portable, standalone sensor to conveniently self-monitor the hematological parameters of their disease and evaluate their risk of vaso-occlusion. Thu, 13 Jun 2019 09:52:11 EDT //www.koonmotors.com/releases/2019/06/190613095211.htm //www.koonmotors.com/releases/2019/06/190603124713.htm Researchers advancing gene-editing techniques to help patients with sickle cell disease discover an unexpected boost in fetal hemoglobin production, which mutes the effect of the disease. Mon, 03 Jun 2019 12:47:13 EDT //www.koonmotors.com/releases/2019/06/190603124713.htm //www.koonmotors.com/releases/2019/05/190509105332.htm A genetic variation known to affect sickle cell disease might be the reason why some college football players experience adverse clinical outcomes during periods of extreme physical exertion and others do not. Thu, 09 May 2019 10:53:32 EDT //www.koonmotors.com/releases/2019/05/190509105332.htm //www.koonmotors.com/releases/2019/03/190328150912.htm 患者血液干细胞的基因编辑可以锅entially cure many blood disorders. But introducing targeted edits into these cells has been challenging, and the edits aren't always stable once the cells engraft in the bone marrow. Researchers now report a CRISPR approach that overcomes these technical challenges. Thu, 28 Mar 2019 15:09:12 EDT //www.koonmotors.com/releases/2019/03/190328150912.htm //www.koonmotors.com/releases/2019/03/190328112552.htm In a breakthrough study of sickle cell disease, biomedical engineers have revealed that the building blocks of the disease are much less efficient at organizing than previously thought. The findings open the door to new treatments, including new medicines that could be prescribed at lower doses, for the approximately 20 million people worldwide who suffer from the lifelong disease. Thu, 28 Mar 2019 11:25:52 EDT //www.koonmotors.com/releases/2019/03/190328112552.htm //www.koonmotors.com/releases/2019/03/190314084538.htm Doubling the low amount of total body radiation delivered to patients undergoing bone marrow transplants with donor cells that are only 'half-matched' increased the rate of engraftment from only about 50 percent to nearly 100 percent, according to a new study. Thu, 14 Mar 2019 08:45:38 EDT //www.koonmotors.com/releases/2019/03/190314084538.htm //www.koonmotors.com/releases/2019/02/190228113609.htm A new study finds that samples of Candida albicans from patients frequently lack one copy of a vital master regulator, which gives them flexibility to lose the other copy and adapt to different environments. Thu, 28 Feb 2019 11:36:09 EST //www.koonmotors.com/releases/2019/02/190228113609.htm //www.koonmotors.com/releases/2019/02/190228113532.htm Malaria, which claims hundreds of thousands of lives each year -- mainly children and especially in Africa -, is one of the leading causes of death by an infectious agent, the Plasmodium falciparum parasite. In research on malaria, the genetic mutation that causes sickle cell anemia (also known as drepanocytosis), a chronic disease that is often fatal in children under five, caught the attention of the scientific community very early on because it also provides protection against malaria. Thu, 28 Feb 2019 11:35:32 EST //www.koonmotors.com/releases/2019/02/190228113532.htm //www.koonmotors.com/releases/2019/02/190206115626.htm Silent strokes are a common symptom of sickle cell disease, though they can be debilitating. Researchers recently showed that silent strokes may be caused by decreased oxygen delivery to a part of the brain called the white matter. Wed, 06 Feb 2019 11:56:26 EST //www.koonmotors.com/releases/2019/02/190206115626.htm //www.koonmotors.com/releases/2018/12/181204095344.htm After over a decade of preclinical research and development, a new gene therapy treatment for sickle cell anemia (SCA) is reversing disease symptoms in two adults and showing early potential for transportability to resource-challenged parts of the world where SCA is most common. Tue, 04 Dec 2018 09:53:44 EST //www.koonmotors.com/releases/2018/12/181204095344.htm //www.koonmotors.com/releases/2018/09/180926110637.htm Japanese scientists have revealed a biological 'switch' that influences whether an immature blood cell would develop into a red blood cell or a subtype of white blood cell called myeloid cells in response to infection or inflammation within the body. Wed, 26 Sep 2018 11:06:37 EDT //www.koonmotors.com/releases/2018/09/180926110637.htm //www.koonmotors.com/releases/2018/09/180903152916.htm A new study describes how sickled red blood cells get stuck in tiny blood vessels of patients with sickle-cell disease. The findings may help researchers predict more accurately when such a vaso-occlusive pain crisis might occur. Mon, 03 Sep 2018 15:29:16 EDT //www.koonmotors.com/releases/2018/09/180903152916.htm //www.koonmotors.com/releases/2018/08/180802115657.htm Researchers have found how hypoxia (a low concentration of oxygen) decreases Protein S, a natural anticoagulant, resulting in an increased risk for the development of potentially life-threatening blood clots (thrombosis). Although hypoxia has been associated with an increased risk for thrombosis, this research showed for the first time a molecular cause. Thu, 02 Aug 2018 11:56:57 EDT //www.koonmotors.com/releases/2018/08/180802115657.htm //www.koonmotors.com/releases/2018/07/180730161843.htm Scientists discovered that a well-known DNA repair pathway, the Fanconi anemia pathway, surprisingly plays a key role in repairing double-strand DNA breaks created by CRISPR-Cas9. It acts as a traffic cop to steer repair to simple end-joining or to patching the cut with new, single-strand DNA. Scientists could potentially tweak proteins involved in the pathway to preferentially steer the outcome toward replacement with DNA, which is important for gene therapy for hereditary diseases. Mon, 30 Jul 2018 16:18:43 EDT //www.koonmotors.com/releases/2018/07/180730161843.htm //www.koonmotors.com/releases/2018/07/180724193646.htm Scientists have discovered that some treatments for cancer and sickle cell disease can destroy the germ cells that go on to develop into sperm in the testes of young boys. In some pre-pubescent boys, the treatment for sickle cell disease results in complete destruction of all their germ cells, which are called spermatogonia. Tue, 24 Jul 2018 19:36:46 EDT //www.koonmotors.com/releases/2018/07/180724193646.htm //www.koonmotors.com/releases/2018/07/180719142047.htm Medical researchers have identified a key signaling protein that regulates hemoglobin production in red blood cells, offering a possible target for a future innovative drug to treat sickle cell disease. Experiments in cultured human cells reveal that blocking the protein reduces the characteristic sickling that distorts the shape of red blood cells and gives the disease its name. Thu, 19 Jul 2018 14:20:47 EDT //www.koonmotors.com/releases/2018/07/180719142047.htm //www.koonmotors.com/releases/2018/06/180611133816.htm Therapeutic use of gene editing with the so-called CRISPR-Cas9 technique may inadvertently increase the risk of cancer, according to a new study. Researchers say that more studies are required in order to guarantee the safety of these 'molecular scissors' for gene-editing therapies. Mon, 11 Jun 2018 13:38:16 EDT //www.koonmotors.com/releases/2018/06/180611133816.htm //www.koonmotors.com/releases/2018/04/180425093843.htm Doctors have cured seven adult patients of sickle cell disease, an inherited blood disorder primarily affecting the black community, using stem cells from donors previously thought to be incompatible, thanks to a new transplant treatment protocol. Wed, 25 Apr 2018 09:38:43 EDT //www.koonmotors.com/releases/2018/04/180425093843.htm