//www.koonmotors.com/news/health_medicine/psoriasis/ Psoriasis research. Learn about psoriasis medication as well as the effect of smoking, diet and genetics on psoriasis symptoms. Read about new treatment strategies for skin disorders. en-us Thu, 29 Jun 2023 13:46:36 EDT Thu, 29 Jun 2023 13:46:36 EDT 60 //www.koonmotors.com/images/scidaily-logo-rss.png//www.koonmotors.com/news/health_medicine/psoriasis/ For more science news, visit ScienceDaily. //www.koonmotors.com/releases/2023/01/230104085301.htm A common fatty acid found in the Western diet breaks down into compounds that contribute to increased temperature and pain -- but not itch -- sensitivity in psoriatic lesions. Wed, 04 Jan 2023 08:53:01 EST //www.koonmotors.com/releases/2023/01/230104085301.htm //www.koonmotors.com/releases/2022/12/221216142625.htm Scientists have made an important breakthrough in understanding how inflammation is regulated. They have just discovered that a key immune alarm protein previously believed to calm down the immune response actually does the opposite. Their work has numerous potential impacts, especially in the context of understanding and responding to autoimmune disorders and inflammation. Fri, 16 Dec 2022 14:26:25 EST //www.koonmotors.com/releases/2022/12/221216142625.htm //www.koonmotors.com/releases/2022/10/221011161308.htm Researchers have found that acute exposure of the skin to thirdhand smoke -- residual pollutants from tobacco smoke that remain on surfaces and in dust after tobacco has been smoked -- elevates biomarkers associated with the initiation of skin diseases, such as contact dermatitis and psoriasis. Tue, 11 Oct 2022 16:13:08 EDT //www.koonmotors.com/releases/2022/10/221011161308.htm //www.koonmotors.com/releases/2022/09/220923153043.htm Two recent studies reveal how skin forms differently across different areas of the body from the face and underarms to the palms of our hands and feet. By profiling the changes in skin, researchers found that the differences have a direct impact for how various skin diseases form across the body. Fri, 23 Sep 2022 15:30:43 EDT //www.koonmotors.com/releases/2022/09/220923153043.htm //www.koonmotors.com/releases/2022/07/220706133304.htm About one third of those who suffer from psoriasis develop inflammation in their joints (psoriatic arthritis) as a result of the chronic skin condition. A research team has now discovered a key starting point for inhibiting inflammation in both psoriasis and psoriatic arthritis. The researchers' findings may form the basis for developing new treatment, diagnostic and prevention strategies. Wed, 06 Jul 2022 13:33:04 EDT //www.koonmotors.com/releases/2022/07/220706133304.htm //www.koonmotors.com/releases/2022/06/220624092436.htm The female hormone estradiol was found to suppress psoriasis in mice by regulating neutrophil and macrophage cells. The conditional knockout mice without the natural ovarian hormones estradiol showed symptoms of severe skin inflammation. Fri, 24 Jun 2022 09:24:36 EDT //www.koonmotors.com/releases/2022/06/220624092436.htm //www.koonmotors.com/releases/2021/11/211119155451.htm About 7.5 million Americans suffer from psoriasis, an autoimmune disease that shows up as patches of red, inflamed skin and painful, scaly rashes. Although there are effective treatments for psoriasis, not everyone responds to these therapies -- and for many, the relief is temporary. Scientists have discovered how a key protein called TWEAK damages skin cells in psoriasis patients. Their findings, in mice and with human skin cells, suggest targeting TWEAK may help control the disease. Fri, 19 Nov 2021 15:54:51 EST //www.koonmotors.com/releases/2021/11/211119155451.htm //www.koonmotors.com/releases/2021/10/211022171455.htm Interleukin-12 -- a messenger molecule of immune cells -- was long considered to trigger the development of psoriasis. Now, researchers have shown that interleukin-12 does not actually cause the skin disease but protects against it. This also explains why common psoriasis drugs that block the messenger show insufficient treatment efficacy. Fri, 22 Oct 2021 17:14:55 EDT //www.koonmotors.com/releases/2021/10/211022171455.htm //www.koonmotors.com/releases/2021/10/211004104229.htm Patients with psoriasis have reported that glycerin, an inexpensive, harmless, slightly sweet liquid high on the list of ingredients in many skin lotions, is effective at combating their psoriasis and now scientists have objective evidence to support their reports. Mon, 04 Oct 2021 10:42:29 EDT //www.koonmotors.com/releases/2021/10/211004104229.htm //www.koonmotors.com/releases/2021/08/210812092737.htm Results from a new study reveal that targeting interferon kappa, a protein made by skin cells, may reduce the severity of psoriasis. Researchers say the findings will bring physicians one step closer to optimizing treatments for patients with the autoimmune disease. Thu, 12 Aug 2021 09:27:37 EDT //www.koonmotors.com/releases/2021/08/210812092737.htm //www.koonmotors.com/releases/2021/06/210622161046.htm Diet rich in sugar and fat leads to disruption in the gut's microbial culture and contributes to inflammatory skin diseases such as psoriasis. Research shows that switching to a more balanced diet restores the gut's health and suppresses inflammation. Tue, 22 Jun 2021 16:10:46 EDT //www.koonmotors.com/releases/2021/06/210622161046.htm //www.koonmotors.com/releases/2021/05/210528114010.htm A research team has designed a simple electromechanical device that can be used for deep tissue pathology diagnosis, such as psoriasis, in an automated and non-invasive fashion. The findings will lay a foundation for future applications in the clinical evaluation of skin cancers and other dermatology diseases. Fri, 28 May 2021 11:40:10 EDT //www.koonmotors.com/releases/2021/05/210528114010.htm //www.koonmotors.com/releases/2021/01/210121163142.htm Scientists have created a highly detailed map of skin, which reveals that cellular processes from development are re-activated in cells from patients with eczema and psoriasis inflammatory skin diseases. The study offers potential new drug targets for treating these painful skin diseases and provides a new understanding of inflammatory disease. The research could also provide a template for regenerating healthy skin in the laboratory. Thu, 21 Jan 2021 16:31:42 EST //www.koonmotors.com/releases/2021/01/210121163142.htm //www.koonmotors.com/releases/2021/01/210112110116.htm Scientists have now demonstrated a connection between inferior physical fitness in young adults and elevated risk of the autoimmune disease psoriasis. For the male recruits to compulsory military training who were rated as the least fit, the risk of developing psoriasis later was 35 percent higher than for the fittest. Tue, 12 Jan 2021 11:01:16 EST //www.koonmotors.com/releases/2021/01/210112110116.htm //www.koonmotors.com/releases/2020/11/201119103039.htm In the treatment of leukemia, stem cell transplantation subsequent to chemotherapy and radiation can often engender severe adverse inflammatory reactions - especially in the skin or in the gut, since these so-called barrier organs are more frequently affected. Up until now, the reason for this was unclear. A team of researchers has now identified an immune mechanism that is partially responsible for this. Thu, 19 Nov 2020 10:30:39 EST //www.koonmotors.com/releases/2020/11/201119103039.htm //www.koonmotors.com/releases/2020/09/200915090119.htm Biologic therapy for psoriasis - protein-based infusions to suppress inflammation - was associated with a significant reduction in high-risk plaque in heart arteries, over one-year, according to new research. The positive association between biologic therapy and a decrease in high-risk plaque in heart arteries was significant after adjusting for cardiovascular risk factors and psoriasis severity. Tue, 15 Sep 2020 09:01:19 EDT //www.koonmotors.com/releases/2020/09/200915090119.htm //www.koonmotors.com/releases/2020/09/200914160746.htm Patients on immunosuppressive therapy for common skin and rheumatic diseases like psoriasis and rheumatoid arthritis are not at increased risk for contracting COVID-19 and should continue taking their medicine as prescribed, according to a new study. Mon, 14 Sep 2020 16:07:46 EDT //www.koonmotors.com/releases/2020/09/200914160746.htm //www.koonmotors.com/releases/2020/07/200722142742.htm 牛皮癣折磨全球数以百万计的人们,but treatments are limited to small molecules like steroids, which can cause skin thinning and lose their effectiveness over time. Medical researchers have circumvented those problems by using a topical ionic liquid to effectively deliver an RNA-based therapy directly into the skin of mice with psoriasis, which reduced multiple psoriasis-related gene products as well as redness and inflammation, resolving the longstanding challenge of delivering nucleic acids into cells. Wed, 22 Jul 2020 14:27:42 EDT //www.koonmotors.com/releases/2020/07/200722142742.htm //www.koonmotors.com/releases/2020/02/200218161720.htm Dietary components, rather than obesity itself, may lead to skin inflammation and the development of psoriasis, a study has found. Tue, 18 Feb 2020 16:17:20 EST //www.koonmotors.com/releases/2020/02/200218161720.htm //www.koonmotors.com/releases/2019/10/191030100041.htm Itch is a very common symptom in patients suffering from skin diseases. In a new study on the psychological burden of itch, investigators report that the presence of itch in dermatological patients was significantly associated with clinical depression, suicidal ideation and stress. They recommend providing patients with access to a multidisciplinary team to prevent and manage problems associated with itch. Wed, 30 Oct 2019 10:00:41 EDT //www.koonmotors.com/releases/2019/10/191030100041.htm //www.koonmotors.com/releases/2019/10/191017075554.htm Not all fats are equal in how they affect our skin, according to a new study. The investigators found that different ketogenic diets impacted skin inflammation differently in psoriasiform-like skin inflammation in mice. Ketogenic diets heavy in medium-chain triglycerides (MCTs) such as coconut, especially in combination with omega-3 fatty acids from fish oil and plant sources like nuts and seeds, exacerbated psoriasis. Thu, 17 Oct 2019 07:55:54 EDT //www.koonmotors.com/releases/2019/10/191017075554.htm //www.koonmotors.com/releases/2019/09/190918093054.htm A treatment for psoriasis could be repurposed to treat a rare but aggressive form of youth cancer, new findings suggest. Wed, 18 Sep 2019 09:30:54 EDT //www.koonmotors.com/releases/2019/09/190918093054.htm //www.koonmotors.com/releases/2019/08/190830112817.htm Researchers have found a new way to treat the inflammation involved in chronic diseases such as psoriasis, asthma and HIV. A group of transmitter substances (cytokines) in the immune system, the so-called IL-1 family, has been shown to play an important role in many of these diseases by regulating the body's immune responses. Fri, 30 Aug 2019 11:28:17 EDT //www.koonmotors.com/releases/2019/08/190830112817.htm //www.koonmotors.com/releases/2019/07/190731131128.htm 研究人员发现,抗炎临床生物ogic therapies used to treat moderate to severe psoriasis can significantly reduce coronary inflammation in patients with the chronic skin condition. Scientists said the findings are particularly notable because of the use of a novel imaging biomarker, the perivascular fat attenuation index (FAI), that was able to measure the effect of the therapy in reducing the inflammation. Wed, 31 Jul 2019 13:11:28 EDT //www.koonmotors.com/releases/2019/07/190731131128.htm //www.koonmotors.com/releases/2019/07/190731113010.htm Data from over 12,000 multiple sclerosis (MS) patients formed the basis of a new study which investigated the population's vaccination behavior in relation to MS. It showed that five years before their diagnosis, MS patients were statistically less likely to receive vaccinations than comparator groups. Consequently, there was no positive correlation between vaccinations and the development of MS. Wed, 31 Jul 2019 11:30:10 EDT //www.koonmotors.com/releases/2019/07/190731113010.htm //www.koonmotors.com/releases/2019/06/190620104901.htm A recent survey from the GW School of Medicine and Health Sciences found patients with psoriasis frequently use complementary or alternative therapies to treat their symptoms when traditional treatments fail. Thu, 20 Jun 2019 10:49:01 EDT //www.koonmotors.com/releases/2019/06/190620104901.htm //www.koonmotors.com/releases/2019/05/190514162212.htm People who have inadequate vitamin A in their diets are more susceptible to skin infection, yet how that vitamin affects skin immunity has been unclear. New research sheds some light on that mystery by identifying a previously unknown bacteria-killing protein on the epidermis that requires the vitamin to work. Tue, 14 May 2019 16:22:12 EDT //www.koonmotors.com/releases/2019/05/190514162212.htm //www.koonmotors.com/releases/2019/05/190511083931.htm Dermatologists found a decreased risk of infection in patients with psoriasis using some of the newer, more targeted medications compared to those taking methotrexate, a drug widely used since the 1960s as a first line treatment for moderate-to-severe psoriasis. Sat, 11 May 2019 08:39:31 EDT //www.koonmotors.com/releases/2019/05/190511083931.htm //www.koonmotors.com/releases/2019/03/190318111958.htm Researchers have demonstrated that the same immune cells that protect us against skin fungi also encourage the inflammatory symptoms of atopic dermatitis. An antibody therapy could alleviate this chronic inflammatory skin disease. Mon, 18 Mar 2019 11:19:58 EDT //www.koonmotors.com/releases/2019/03/190318111958.htm //www.koonmotors.com/releases/2019/02/190205090521.htm Researchers have found that treating psoriasis, a chronic inflammatory skin disease, with biologic drugs that target immune system activity can reduce the early plaque buildup that clogs arteries, restricts blood flow, and leads to heart attacks and stroke. The findings highlight how immunotherapies that treat inflammatory conditions might play a role in the reduction of cardiovascular disease risks. Tue, 05 Feb 2019 09:05:21 EST //www.koonmotors.com/releases/2019/02/190205090521.htm //www.koonmotors.com/releases/2018/12/181220080003.htm Scientists have discovered a protein that could hold the key to novel gene therapies for skin problems including psoriasis - a common, chronic skin disease that affects over 100 million people worldwide. Thu, 20 Dec 2018 08:00:03 EST //www.koonmotors.com/releases/2018/12/181220080003.htm //www.koonmotors.com/releases/2018/11/181108130543.htm Autoimmune diseases such as psoriasis, lupus and rheumatoid arthritis more than double the risk of cardiovascular disease. A new study shows that immune cells that arise during autoimmune disease cause cholesterol to become trapped inside blood vessels. Thu, 08 Nov 2018 13:05:43 EST //www.koonmotors.com/releases/2018/11/181108130543.htm //www.koonmotors.com/releases/2018/08/180830102537.htm The stigma associated with the autoimmune disease psoriasis may lead people to avoid patients who show signs of the condition, including not wanting to date, shake hands, or have people in their homes if they suffer from the disease. New multidisciplinary research involving both psychologists and dermatologists is the first to examine how common this stigma may be among the general population of the United States as well as among medical students. Thu, 30 Aug 2018 10:25:37 EDT //www.koonmotors.com/releases/2018/08/180830102537.htm //www.koonmotors.com/releases/2018/05/180504122347.htm Research has shown that targeting metabolism in growing cells holds promise for the treatment of skin diseases like psoriasis that are characterized by skin overgrowth resulting from excess cell division, known as hyperproliferation. Fri, 04 May 2018 12:23:47 EDT //www.koonmotors.com/releases/2018/05/180504122347.htm //www.koonmotors.com/releases/2018/04/180418144708.htm A compound from the body's own immune cells can treat psoriasis in mice and holds promise for other autoimmune diseases such as multiple sclerosis, according to a new study. Wed, 18 Apr 2018 14:47:08 EDT //www.koonmotors.com/releases/2018/04/180418144708.htm //www.koonmotors.com/releases/2018/02/180216110541.htm An antibody used to treat the skin disease psoriasis is also effective at reducing aortic inflammation, a key marker of future risk of major cardiovascular events. Fri, 16 Feb 2018 11:05:41 EST //www.koonmotors.com/releases/2018/02/180216110541.htm //www.koonmotors.com/releases/2018/01/180117104011.htm An international team of researchers has unraveled a crucial aspect of the molecular basis of autoimmune and inflammatory diseases such as psoriasis, rheumatoid arthritis and Crohn's disease. Focusing on the immunomodulatory cytokine IL-23 they discovered that its pro-inflammatory activity, which underlies a wide range of inflammatory diseases, critically depends on structural activation of the cytokine by its receptor, IL-23R. Wed, 17 Jan 2018 10:40:11 EST //www.koonmotors.com/releases/2018/01/180117104011.htm //www.koonmotors.com/releases/2017/11/171129120240.htm Small amounts of artificial vanilla extract, also known as vanillin, are in a wide range of products, from baked goods to perfumes. But vanillin's versatility doesn't stop there. In a recent mouse study researchers report that this compound could also prevent or reduce psoriatic skin inflammation. Wed, 29 Nov 2017 12:02:40 EST //www.koonmotors.com/releases/2017/11/171129120240.htm //www.koonmotors.com/releases/2017/11/171114123341.htm People with psoriasis are at a higher risk to develop type 2 diabetes than those without psoriasis, and the risk increases dramatically based on the severity of the disease. Researchers found people with psoriasis that covers 10 percent of their body or more are 64 percent more likely to develop diabetes than those without psoriasis, independent of traditional risk factors such as body weight. Tue, 14 Nov 2017 12:33:41 EST //www.koonmotors.com/releases/2017/11/171114123341.htm //www.koonmotors.com/releases/2017/11/171108124217.htm Researchers report the discovery of a key underlying immune mechanism that explains why to how our skin becomes inflamed from conditions such as atopic dermatitis, more commonly known as eczema. Toxin-producing bacteria on the surface of our skin induces a protein that causes our own cells to react and cause inflammation. Wed, 08 Nov 2017 12:42:17 EST //www.koonmotors.com/releases/2017/11/171108124217.htm //www.koonmotors.com/releases/2017/10/171018132831.htm Stem cells in the skin remember an injury, helping them close recurring wounds faster, researchers have found. The discovery could advance research and treatment of psoriasis and other inflammatory diseases. Wed, 18 Oct 2017 13:28:31 EDT //www.koonmotors.com/releases/2017/10/171018132831.htm //www.koonmotors.com/releases/2017/09/170928121701.htm New research helps address a longstanding question about the inflammatory skin condition psoriasis: Why do skin lesions that have resolved with therapy recur in the same locations after a patient stops using topical steroids? Thu, 28 Sep 2017 12:17:01 EDT //www.koonmotors.com/releases/2017/09/170928121701.htm //www.koonmotors.com/releases/2017/09/170911095922.htm Solenopsins, the main toxic components of fire ant venom, chemically resemble ceramides, which are lipid-like molecules essential for maintaining for the barrier function of the skin. Solenopsin analogs can reduce skin thickening and inflammation in a mouse model of psoriasis, scientists have shown. Mon, 11 Sep 2017 09:59:22 EDT //www.koonmotors.com/releases/2017/09/170911095922.htm //www.koonmotors.com/releases/2017/08/170829113854.htm The more the surface area of the body is covered by psoriasis, the greater the risk of death for the patient suffering from the condition, according to a new analysis. Patients with psoriasis on 10 percent or more of their body are at almost double the risk of death. Tue, 29 Aug 2017 11:38:54 EDT //www.koonmotors.com/releases/2017/08/170829113854.htm //www.koonmotors.com/releases/2017/07/170719100529.htm Researchers focusing on the common debilitating skin disease Hidradenitis suppurativa (HS), which causes deep, painful lesions and leads to a poor quality of life have isolated new treatment options after performing a comparative analysis that showed which cells were active - and responsive to medication -- in those living with HS. Wed, 19 Jul 2017 10:05:29 EDT //www.koonmotors.com/releases/2017/07/170719100529.htm //www.koonmotors.com/releases/2017/06/170628095850.htm Biological treatment of psoriasis shows a good efficacy in clinical trials. Since most analyses have focused on short-term outcomes of single biological agents, little has been known about long-term outcomes in clinical practice, where switching between biological agents is common. A study that followed 583 individuals for up to 10 years shows a satisfactory long-term effectiveness of biologic treatments. Wed, 28 Jun 2017 09:58:50 EDT //www.koonmotors.com/releases/2017/06/170628095850.htm //www.koonmotors.com/releases/2017/06/170616102159.htm Despite mixed evidence recently about an association between atopic dermatitis and cardiovascular disease, a new study that analyzed more than 250,000 medical records suggests there is no link. Fri, 16 Jun 2017 10:21:59 EDT //www.koonmotors.com/releases/2017/06/170616102159.htm //www.koonmotors.com/releases/2017/06/170606101415.htm 一项新的研究测试tildrakizumab的功效,an antibody that targets only a very specific immune system pathway. More than 60 percent of all patients who received the active medication showed improvement, compared to less than 10 percent of patients who received placebos. Tue, 06 Jun 2017 10:14:15 EDT //www.koonmotors.com/releases/2017/06/170606101415.htm //www.koonmotors.com/releases/2017/06/170602112803.htm There were notably more remissions with Secukinumab and ixekizumab than under the comparator therapies for psoriasis. In future, the analysis of symptoms should not be limited to improvements at one time point. Fri, 02 Jun 2017 11:28:03 EDT //www.koonmotors.com/releases/2017/06/170602112803.htm //www.koonmotors.com/releases/2017/05/170531110758.htm HDAC inhibitors, already widely used to treat cancer, may be an effective therapy for psoriasis as well, scientists report. Wed, 31 May 2017 11:07:58 EDT //www.koonmotors.com/releases/2017/05/170531110758.htm //www.koonmotors.com/releases/2017/05/170531092502.htm A newly developed tissue scanner allows looking under the skin of psoriasis patients. This provides clinically relevant information, such as the structure of skin layers and blood vessels, without the need for contrast agents or radiation exposure. Wed, 31 May 2017 09:25:02 EDT //www.koonmotors.com/releases/2017/05/170531092502.htm //www.koonmotors.com/releases/2017/05/170524191620.htm Patients with psoriatic arthritis for whom standard-of-care pharmaceutical treatments have provided no lasting relief experienced a significant reduction in symptoms, including joint tenderness and swelling, have reported promising results when they were given a new drug. Wed, 24 May 2017 19:16:20 EDT //www.koonmotors.com/releases/2017/05/170524191620.htm //www.koonmotors.com/releases/2017/05/170524084343.htm The identification of 16 additional genetic markers will help researchers get closer to understanding how -- and why -- psoriasis develops. Wed, 24 May 2017 08:43:43 EDT //www.koonmotors.com/releases/2017/05/170524084343.htm //www.koonmotors.com/releases/2017/05/170522080757.htm Superficially, psoriasis and atopic dermatitis may appear similar but their commonalities are only skin deep. Atopic dermatitis, also known as eczema, is primarily driven by an allergic reaction, while psoriasis is considered an autoimmune disease. Nevertheless, researchers were able to pinpoint a common driver of skin inflammation in both diseases. Mon, 22 May 2017 08:07:57 EDT //www.koonmotors.com/releases/2017/05/170522080757.htm //www.koonmotors.com/releases/2017/04/170418094315.htm Cannabinoids contain anti-inflammatory properties that could make them useful in the treatment of a wide-range of skin diseases, according to researchers. Tue, 18 Apr 2017 09:43:15 EDT //www.koonmotors.com/releases/2017/04/170418094315.htm //www.koonmotors.com/releases/2017/03/170324104829.htm The fact that men are overrepresented in psoriasis registers and consume more psoriasis care have long led researchers to believe that the common skin disease disproportionately affects men. A unique study with 5,438 Swedish psoriasis patients now reveals that women have a statistically significant lower incidence of severe psoriasis compared to men. Fri, 24 Mar 2017 10:48:29 EDT //www.koonmotors.com/releases/2017/03/170324104829.htm //www.koonmotors.com/releases/2017/02/170222102553.htm Scientists have revealed a potent inflammatory molecule released by dying cells triggers inflammation during necroptosis, a recently described form of cell death linked to inflammatory disease. The discovery could lead to new and existing medicines that target the molecule being investigated as a way of treating inflammatory diseases, such as psoriasis and inflammatory bowel disease. Wed, 22 Feb 2017 10:25:53 EST //www.koonmotors.com/releases/2017/02/170222102553.htm //www.koonmotors.com/releases/2017/02/170222082300.htm Psoriasis is a lifelong disease that is associated with significant cosmetic and physical disability and puts patients at increased risk for many major medical disorders. A multidisciplinary team of researchers has found that psoriasis patients who developed depression were at a 37 percent greater risk of subsequently developing psoriatic arthritis, compared with psoriasis patients who did not develop depression. Wed, 22 Feb 2017 08:23:00 EST //www.koonmotors.com/releases/2017/02/170222082300.htm //www.koonmotors.com/releases/2017/02/170220085304.htm With the aid of thousands of skin biopsies and over a hundred kilograms of skin, researchers have observed how two subgroups of immune cell behave in healthy skin. This functional dichotomy is preserved in the inflammatory diseases psoriasis and vitiligo. The study opens the way for more targeted local treatments for patchy inflammatory skin disorders. Mon, 20 Feb 2017 08:53:04 EST //www.koonmotors.com/releases/2017/02/170220085304.htm //www.koonmotors.com/releases/2017/02/170202122735.htm A substantial part of people, one in five, undergoing systemic treatment for psoriasis (i.e. pills taken orally, injections or infusions) still have considerable problems with their disease, according to a recent study. Thu, 02 Feb 2017 12:27:35 EST //www.koonmotors.com/releases/2017/02/170202122735.htm