//www.koonmotors.com/news/health_medicine/personalized_medicine/ New developments in personalized medicine. en-us Wed, 06 Sep 2023 14:48:20 EDT Wed, 06 Sep 2023 14:48:20 EDT 60 //www.koonmotors.com/images/scidaily-logo-rss.png//www.koonmotors.com/news/health_medicine/personalized_medicine/ For more science news, visit ScienceDaily. //www.koonmotors.com/releases/2023/08/230822151743.htm Scientists have discovered a potential target for gastric cancers associated with Epstein-Barr Virus. Tue, 22 Aug 2023 15:17:43 EDT //www.koonmotors.com/releases/2023/08/230822151743.htm //www.koonmotors.com/releases/2023/08/230814122255.htm A new study reveals findings from over 800 clinical assays performed for kidney patients with MiTF family gene mutations. Mon, 14 Aug 2023 12:22:55 EDT //www.koonmotors.com/releases/2023/08/230814122255.htm //www.koonmotors.com/releases/2023/08/230810180107.htm The best heart rate for burning fat differs for each individual and often does not align with the 'fat burning zone' on commercial exercise machines, researchers report. Instead, the researchers said, clinical exercise testing -- a diagnostic procedure to measure a person's physiological response to exercise -- may be a more useful tool to help individuals achieve intended fat loss goals. Thu, 10 Aug 2023 18:01:07 EDT //www.koonmotors.com/releases/2023/08/230810180107.htm //www.koonmotors.com/releases/2023/08/230810141004.htm A change in just one letter in the code that makes up a cancer-causing gene can significantly affect how aggressive a tumor is or how well a patient with cancer responds to a particular therapy. A new, very precise gene-editing tool will enable scientists to study the impact of these specific genetic changes in preclinical models rather than being limited to more broadly targeted tactics, such as deleting the entire gene. Thu, 10 Aug 2023 14:10:04 EDT //www.koonmotors.com/releases/2023/08/230810141004.htm //www.koonmotors.com/releases/2023/08/230809130623.htm New findings may lead to relapse-free treatment for a sizeable subgroup of lung cancer patients. In a study in mice, scientists have identified a biomarker that may help physicians select lung cancer patients who can be treated with a single antibody-based drug that is likely to bring about full remission, without cancer relapse. Wed, 09 Aug 2023 13:06:23 EDT //www.koonmotors.com/releases/2023/08/230809130623.htm //www.koonmotors.com/releases/2023/08/230807121416.htm The OncoNPC machine-learning model may help identify sites of origin for cancers whose origins are unknown, which could enable targeted tumor treatments. Mon, 07 Aug 2023 12:14:16 EDT //www.koonmotors.com/releases/2023/08/230807121416.htm //www.koonmotors.com/releases/2023/07/230731170148.htm Researchers have identified two subtypes of human papillomavirus positive head and neck cancers, giving them a better glimpse into why some patients respond better to treatment than others. Mon, 31 Jul 2023 17:01:48 EDT //www.koonmotors.com/releases/2023/07/230731170148.htm //www.koonmotors.com/releases/2023/07/230727144239.htm Conventional wisdom holds that storing fat around your belly puts you at increased risk for type 2 diabetes. But unexpected new findings suggest that, for some people, conventional wisdom may be wrong. Thu, 27 Jul 2023 14:42:39 EDT //www.koonmotors.com/releases/2023/07/230727144239.htm //www.koonmotors.com/releases/2023/07/230721113135.htm Researchers have identified a process by which enzymes can help prevent heart damage in chemotherapy patients. Fri, 21 Jul 2023 11:31:35 EDT //www.koonmotors.com/releases/2023/07/230721113135.htm //www.koonmotors.com/releases/2023/07/230712124752.htm Cancer therapies that target specific genetic abnormalities in tumors have revolutionized treatment possibilities over the past two decades. While quality of life and survival are improved with targeted therapies, relapse is common due to the evolution of new tumor cells that are resistant to the targeted therapy. A new study reveals how lung tumors may develop drug resistance over time, pointing to a protein, called APOBEC3A, that could be a promising target. Results may help researchers develop new solutions for tumor resistance to targeted cancer therapies. Wed, 12 Jul 2023 12:47:52 EDT //www.koonmotors.com/releases/2023/07/230712124752.htm //www.koonmotors.com/releases/2023/07/230711133316.htm A new national study has found whole genome sequencing (WGS) to be nearly twice as effective as a targeted gene sequencing test at identifying abnormalities responsible for genetic disorders in newborns and infants. Tue, 11 Jul 2023 13:33:16 EDT //www.koonmotors.com/releases/2023/07/230711133316.htm //www.koonmotors.com/releases/2023/04/230420135317.htm Investigators are developing a novel way to treat amyotrophic lateral sclerosis (ALS) and retinitis pigmentosa using engineered stem cells that may eventually lead to personalized treatments. Thu, 20 Apr 2023 13:53:17 EDT //www.koonmotors.com/releases/2023/04/230420135317.htm //www.koonmotors.com/releases/2023/03/230327114822.htm As health care professionals, researchers and consumers increasingly use genetic testing, they are uncovering incidental genetic abnormalities, or variants, that are associated with cardiovascular diseases. The statement writing committee cautions that incidentally identified single gene variants may or may not be risk factors for disease, so it is important to interpret them correctly and cautiously. The new scientific statement offers a framework to support health care professionals in appropriately assessing individual genetic variants, communicating findings with patients and families, and, when needed, how to create a strong multidisciplinary team for individualized care. Mon, 27 Mar 2023 11:48:22 EDT //www.koonmotors.com/releases/2023/03/230327114822.htm //www.koonmotors.com/releases/2023/03/230322140341.htm By combing through genomic data of over 1 million people of European or African descent, scientists have identified genes commonly inherited across addiction disorders, regardless of the substance being used. This dataset -- one of largest and most diverse of its kind -- may help reveal new treatment targets across multiple substance use disorders, including for people diagnosed with more than one. The findings also reinforce the role of the dopamine system in addiction, by showing that the combination of genes underlying addiction disorders was also associated with regulation of dopamine signaling. Wed, 22 Mar 2023 14:03:41 EDT //www.koonmotors.com/releases/2023/03/230322140341.htm //www.koonmotors.com/releases/2023/03/230314155101.htm Hypnosis is an effective treatment for pain for many individuals but determining which patients will benefit most can be challenging. Hypnotizability testing requires special training and in-person evaluation rarely available in the clinical setting. Now, investigators have developed a fast, point-of-care molecular diagnostic test that identifies a subset of individuals who are most likely to benefit from hypnosis interventions for pain treatment. Their study also found that a subset of highly hypnotizable individuals may be more likely to experience high levels of postoperative pain. Tue, 14 Mar 2023 15:51:01 EDT //www.koonmotors.com/releases/2023/03/230314155101.htm //www.koonmotors.com/releases/2023/03/230308112159.htm Researchers identify potential therapeutic for acute myeloid leukemia that targets a DNA repair protein. Wed, 08 Mar 2023 11:21:59 EST //www.koonmotors.com/releases/2023/03/230308112159.htm //www.koonmotors.com/releases/2023/03/230301120642.htm Decisions on cancer treatment could become better tailored to individual patients with the adoption of a new imaging method that maps the chemical makeup of a patient's tumor. Wed, 01 Mar 2023 12:06:42 EST //www.koonmotors.com/releases/2023/03/230301120642.htm //www.koonmotors.com/releases/2023/02/230228113753.htm Using whole genome sequencing, researchers identified a single variant in a microRNA gene, MIR145-5p, as the source of multisystemic smooth muscle dysfunction syndrome, which had gone undiagnosed in a child for years. Tue, 28 Feb 2023 11:37:53 EST //www.koonmotors.com/releases/2023/02/230228113753.htm //www.koonmotors.com/releases/2023/01/230118195938.htm Advances in understanding the many different genetic causes of childhood-onset hearing loss indicate that genomic testing could assist in individualizing treatment planning, including the optimal timing of treatment. New findings show that genetic testing is a valuable tool in determining prognosis for a child's hearing loss and in predicting how useful a cochlear implant could be for that child's understanding of speech. With genetic diagnosis, it is possible to anticipate future hearing loss across sound frequencies, progression with age, and severity. Wed, 18 Jan 2023 19:59:38 EST //www.koonmotors.com/releases/2023/01/230118195938.htm //www.koonmotors.com/releases/2023/01/230117193002.htm Many genetic diseases are caused by diverse mutations spread across an entire gene, and designing genome editing approaches for each patient's mutation would be impractical and costly. Tue, 17 Jan 2023 19:30:02 EST //www.koonmotors.com/releases/2023/01/230117193002.htm //www.koonmotors.com/releases/2023/01/230117192937.htm Combining a map of gene regulatory sites with disease-associated loci has uncovered a new genetic risk factor of adult-onset macular degeneration (AMD), according to a new study. The finding advances the understanding of the leading cause of visual impairment in adults. Tue, 17 Jan 2023 19:29:37 EST //www.koonmotors.com/releases/2023/01/230117192937.htm //www.koonmotors.com/releases/2023/01/230112155835.htm An international consortium has identified at least some of the genetic drivers of a mysterious form of pediatric epilepsy. Thu, 12 Jan 2023 15:58:35 EST //www.koonmotors.com/releases/2023/01/230112155835.htm //www.koonmotors.com/releases/2023/01/230105151327.htm Scientists have performed the largest study yet examining drug sensitivity in childhood acute lymphoblastic leukemia across genomic subtypes and its association with treatment response. Thu, 05 Jan 2023 15:13:27 EST //www.koonmotors.com/releases/2023/01/230105151327.htm //www.koonmotors.com/releases/2023/01/230105151305.htm Researchers have published an assessment of 13 studies that took a genotype-first approach to patient care. This approach contrasts with the typical phenotype-first approach to clinical research, which starts with clinical findings. A genotype-first approach to patient care involves selecting patients with specific genomic variants and then studying their traits and symptoms; this finding uncovered new relationships between genes and clinical conditions, broadened the traits and symptoms associated with known disorders, and offered insights into newly described disorders. Thu, 05 Jan 2023 15:13:05 EST //www.koonmotors.com/releases/2023/01/230105151305.htm //www.koonmotors.com/releases/2023/01/230104085239.htm New research leads the discovery of applying amniotic fluid cells obtained during 16-24 weeks of pregnancy as a novel sample type for RNA-sequencing in prenatal diagnosis to help more families with tailored clinical management. This is a proof-of-concept study to demonstrate the potential clinical utility of amniotic fluid cells RNA-sequencing in the literature. Wed, 04 Jan 2023 08:52:39 EST //www.koonmotors.com/releases/2023/01/230104085239.htm //www.koonmotors.com/releases/2022/12/221228130358.htm An enzyme that defends human cells against viruses can help drive cancer evolution towards greater malignancy by causing myriad mutations in cancer cells, according to a new study. The finding suggests that the enzyme may be a potential target for future cancer treatments. Wed, 28 Dec 2022 13:03:58 EST //www.koonmotors.com/releases/2022/12/221228130358.htm //www.koonmotors.com/releases/2022/12/221221165112.htm Researchers have made an advancement in genetic testing that allows for more accurate prediction of which parent's genes led to an individual's increased cancer risk. This improves the efficiency of familial testing strategies and could eliminate concern for patients at high risk of cancer caused by genes inherited from a parent. Wed, 21 Dec 2022 16:51:12 EST //www.koonmotors.com/releases/2022/12/221221165112.htm //www.koonmotors.com/releases/2022/12/221220113055.htm 3D Patient Tumor Avatar technology has great potential to enable optimum, precision treatment selections for cancer patients in a clinical setting. The benefits and challenges, as well as the future steps needed to implement this technology are described here. Tue, 20 Dec 2022 11:30:55 EST //www.koonmotors.com/releases/2022/12/221220113055.htm //www.koonmotors.com/releases/2022/12/221208114719.htm A new study is one of the first to associate long COVID symptoms with changes in gene expression during acute COVID-19. Thu, 08 Dec 2022 11:47:19 EST //www.koonmotors.com/releases/2022/12/221208114719.htm //www.koonmotors.com/releases/2022/12/221201123138.htm 单个基因的变化有害开门gut bacteria to set off the inflammation that drives Crohn's disease, according to a new study. These findings could one day help doctors better select targeted treatments for patients with this immune disorder. This particular host gene, called AGR2, encodes part of the cell's machinery that helps prepare new proteins properly so that they can help repel 'bad' bacteria. When anything from microbes to inflammatory conditions disrupts this process, protein production gets backed up, stressing the cell. Extremes in the expression of AGR2 -- when it becomes too active or just silent -- are associated with such stress and the cell's response to it, and formed the basis of the study described Nov. 15 in Cell Reports. Thu, 01 Dec 2022 12:31:38 EST //www.koonmotors.com/releases/2022/12/221201123138.htm //www.koonmotors.com/releases/2022/11/221129165854.htm A family history of cancer and genetic variants that might be inherited appear to be important risk factors for Black men diagnosed with early-onset prostate cancer, a study has found. Tue, 29 Nov 2022 16:58:54 EST //www.koonmotors.com/releases/2022/11/221129165854.htm //www.koonmotors.com/releases/2022/11/221123125121.htm Investigators have reported highly promising early results for CAR T therapy in a small set of patients with the autoimmune disease lupus. Wed, 23 Nov 2022 12:51:21 EST //www.koonmotors.com/releases/2022/11/221123125121.htm //www.koonmotors.com/releases/2022/11/221115114038.htm An international team of researchers have discovered a new genetic variant that is responsible for close to 7% of all cases of diabetes in Greenland. People with this form of diabetes, caused by the high-impact genetic variant, may require special treatment, which will be possible through improved genetic screening of patients. Tue, 15 Nov 2022 11:40:38 EST //www.koonmotors.com/releases/2022/11/221115114038.htm //www.koonmotors.com/releases/2022/11/221103104939.htm Schizophrenia patients have fewer connections between nerve cells. This is believed to be caused by genetic risk variants leading to an excessive elimination of nerve cell connections by the immune cells of the brain. Researchers now report that the levels of protein from the relevant risk gene are elevated in first-episode patients and that inflammation further increases the expression of the risk gene. Thu, 03 Nov 2022 10:49:39 EDT //www.koonmotors.com/releases/2022/11/221103104939.htm //www.koonmotors.com/releases/2022/11/221102135650.htm In a recent trial, nine patients whose tumors were resistant to androgen-blocking therapy continued that therapy but were also given a CD105 inhibitor called carotuximab. Forty percent of those patients experienced progression-free survival, based on radiographic imaging Wed, 02 Nov 2022 13:56:50 EDT //www.koonmotors.com/releases/2022/11/221102135650.htm //www.koonmotors.com/releases/2022/10/221020122945.htm A new study identifies common and rare gene mutations that impact radiation resistance and sensitivity, an important step toward providing more individualized and effective radiotherapy for patients with cancer. The discovery ultimately could allow radiation dosage to be calibrated based on genetic mutations. Radiotherapy continues to be delivered using generic schedules and doses, unlike newer targeted drug therapy that are guided by the genomics of an individual's cancer. Thu, 20 Oct 2022 12:29:45 EDT //www.koonmotors.com/releases/2022/10/221020122945.htm //www.koonmotors.com/releases/2022/10/221012163509.htm As more patients with cancer have their tumors genomically profiled, and more therapies targeting genomic alterations enter clinical trials, the task of connecting patients to trials for which they are eligible can be especially challenging. A computer platform makes the matching process both easier and faster, its designers report in a new study. Wed, 12 Oct 2022 16:35:09 EDT //www.koonmotors.com/releases/2022/10/221012163509.htm //www.koonmotors.com/releases/2022/10/221011125230.htm Researchers have identified a common diabetes medication, metformin, as a possible treatment for atrial fibrillation. They used advanced computation and genetic sequencing to determine that metformin's targets overlap significantly with genes dysregulated in atrial fibrillation. Tue, 11 Oct 2022 12:52:30 EDT //www.koonmotors.com/releases/2022/10/221011125230.htm //www.koonmotors.com/releases/2022/10/221007112116.htm Researchers mapped the organization of human retinal cell chromatin, the fibers that package 3 billion nucleotide-long DNA molecules into compact structures that fit into chromosomes within each cell's nucleus. The resulting comprehensive gene regulatory network provides insights into regulation of gene expression in general, and in retinal function, in both rare and common eye diseases. Fri, 07 Oct 2022 11:21:16 EDT //www.koonmotors.com/releases/2022/10/221007112116.htm //www.koonmotors.com/releases/2022/10/221006154709.htm Scientists have made a significant genetic discovery that sheds light on the use of the drug caspofungin to treat a deadly fungal infection, Aspergillus fumigatus, which kills some 100,000 severely immunocompromised people each year. Thu, 06 Oct 2022 15:47:09 EDT //www.koonmotors.com/releases/2022/10/221006154709.htm //www.koonmotors.com/releases/2022/09/220922124513.htm Researchers have identified critical genomic changes in response to abiraterone acetate/prednisone, a standard treatment option for men with progressive, incurable and castration-resistant prostate cancer. Thu, 22 Sep 2022 12:45:13 EDT //www.koonmotors.com/releases/2022/09/220922124513.htm //www.koonmotors.com/releases/2022/09/220916112522.htm The information could help doctors identify patients at high risk for poor outcomes and quickly begin tailored treatment. Fri, 16 Sep 2022 11:25:22 EDT //www.koonmotors.com/releases/2022/09/220916112522.htm //www.koonmotors.com/releases/2022/09/220901135805.htm Scientists have created a roadmap of the genetic mutations present in the most common childhood cancer, acute lymphoblastic leukemia (ALL). The study supplies a comprehensive view of the genomics of all subtypes of ALL. Thu, 01 Sep 2022 13:58:05 EDT //www.koonmotors.com/releases/2022/09/220901135805.htm //www.koonmotors.com/releases/2022/09/220901135802.htm Researchers provide an overview of the latest technologies in precision oncology. Translating these into clinical application is still a major challenge. Thu, 01 Sep 2022 13:58:02 EDT //www.koonmotors.com/releases/2022/09/220901135802.htm //www.koonmotors.com/releases/2022/08/220830131642.htm Breast tissue features apparent on MRI are linked with future second breast cancer risk in women with a personal history of breast cancer, according to a new study. Tue, 30 Aug 2022 13:16:42 EDT //www.koonmotors.com/releases/2022/08/220830131642.htm //www.koonmotors.com/releases/2022/08/220829112918.htm 心脏病的女性更有可能是致命的than in men. The reasons are differences in age and in comorbidity burden which makes risk assessment in women a challenge. Researchers have now developed a novel artificial-intelligence-based risk score that improves personalized care for female patients with heart attacks. Mon, 29 Aug 2022 11:29:18 EDT //www.koonmotors.com/releases/2022/08/220829112918.htm //www.koonmotors.com/releases/2022/08/220818122424.htm A Rutgers analysis of dozens of artificial intelligence (AI) software programs used in precision, or personalized, medicine to prevent, diagnose and treat disease found that no program exists that can be used for all treatments. Thu, 18 Aug 2022 12:24:24 EDT //www.koonmotors.com/releases/2022/08/220818122424.htm //www.koonmotors.com/releases/2022/08/220816175045.htm 一群famil遗传变异识别ies who are prone to diabetes and kidney failure increases the levels of a type of fat, called ceramides. Therapeutics that prevent this change could be beneficial more broadly to anyone at risk for these conditions. Tue, 16 Aug 2022 17:50:45 EDT //www.koonmotors.com/releases/2022/08/220816175045.htm //www.koonmotors.com/releases/2022/08/220804145554.htm 心肌病并不是一个统一的疾病。相反,我ndividual genetic defects lead to heart failure in different ways, an international consortium reports. Thu, 04 Aug 2022 14:55:54 EDT //www.koonmotors.com/releases/2022/08/220804145554.htm //www.koonmotors.com/releases/2022/08/220804145551.htm Investigators set out to identify molecules and pathways that may contribute to heart failure, with the aim of informing more effective and personalized treatment. Using single nucleus RNA sequencing (snRNAseq) to gain insight into the specific changes that occur in different cell types and cell states, the team made several surprising discoveries. They found that while there are some shared genetic signatures, others are distinct, providing new candidate targets for therapy and predicting that personalized treatment could improve patient care. Thu, 04 Aug 2022 14:55:51 EDT //www.koonmotors.com/releases/2022/08/220804145551.htm //www.koonmotors.com/releases/2022/08/220804130616.htm Investigators have identified genetic signatures that could predict whether tumors in patients with bladder and other cancers will respond to immunotherapy. Thu, 04 Aug 2022 13:06:16 EDT //www.koonmotors.com/releases/2022/08/220804130616.htm //www.koonmotors.com/releases/2022/08/220801181021.htm Scientists have developed a novel 3D tissue-engineered model of the glioblastoma tumor microenvironment that can be used to learn why the tumors return and what treatments will be most effective at eradicating them -- right down to a patient-specific level. Mon, 01 Aug 2022 18:10:21 EDT //www.koonmotors.com/releases/2022/08/220801181021.htm //www.koonmotors.com/releases/2022/07/220727153626.htm Researchers report that common genetic variations in one serotonin receptor could be a reason why people with psychiatric conditions, such as depression, respond differently to psychedelic treatments. Wed, 27 Jul 2022 15:36:26 EDT //www.koonmotors.com/releases/2022/07/220727153626.htm //www.koonmotors.com/releases/2022/07/220726093642.htm Better diagnosis and treatment of the incurable eye disease age-related macular degeneration is a step closer, thanks to the discovery of new genetic signatures of the disease. Tue, 26 Jul 2022 09:36:42 EDT //www.koonmotors.com/releases/2022/07/220726093642.htm //www.koonmotors.com/releases/2022/07/220720121044.htm Researchers have developed a new blood test that provides unprecedented insight into a patient's cancer make-up, potentially allowing doctors to better select treatment options that will improve patient outcomes. Wed, 20 Jul 2022 12:10:44 EDT //www.koonmotors.com/releases/2022/07/220720121044.htm //www.koonmotors.com/releases/2022/07/220720102540.htm 一个团队开发了一种新的工具来预测和客户tomize the rate of DNA editing, paving the way for more personalized, efficient genetic and cell therapies for diseases such as diabetes and cancer. Wed, 20 Jul 2022 10:25:40 EDT //www.koonmotors.com/releases/2022/07/220720102540.htm //www.koonmotors.com/releases/2022/07/220714145133.htm 男性性染色体的损失是许多男人ag)e causes the heart muscle to scar and can lead to deadly heart failure, new research shows. The finding may help explain why men die, on average, several years younger than women. Thu, 14 Jul 2022 14:51:33 EDT //www.koonmotors.com/releases/2022/07/220714145133.htm //www.koonmotors.com/releases/2022/07/220705112253.htm The ideal method of determining what type of cancer mutation a patient has is to compare two samples from the same patient, one from the tumor and one from healthy tissue. Such tests can be complicated and costly, however, so researchers hit upon another idea -- using massive public DNA databases to look for common cell mutations that tend to be benign, so that researchers can identify rarer mutations that have the potential to be cancerous. Tue, 05 Jul 2022 11:22:53 EDT //www.koonmotors.com/releases/2022/07/220705112253.htm //www.koonmotors.com/releases/2022/07/220705103841.htm A new study reveals 42 hereditary genes which predispose individuals to a higher number of mutations that correlate with a greater probability of developing cancer. Tue, 05 Jul 2022 10:38:41 EDT //www.koonmotors.com/releases/2022/07/220705103841.htm //www.koonmotors.com/releases/2022/06/220627141400.htm In a pair of studies, scientists have deepened investigations into the genetic origins of nonalcoholic fatty liver disease in children, describing multiple gene variants that contribute to disease risk. Mon, 27 Jun 2022 14:14:00 EDT //www.koonmotors.com/releases/2022/06/220627141400.htm