//www.koonmotors.com/news/health_medicine/pancreatic_cancer/ Read about the latest medical research concerning pancreatic cancer and other disorders of the pancreas. Consider new treatment options. en-us Wed, 06 Sep 2023 14:45:38 EDT Wed, 06 Sep 2023 14:45:38 EDT 60 //www.koonmotors.com/images/scidaily-logo-rss.png//www.koonmotors.com/news/health_medicine/pancreatic_cancer/ For more science news, visit ScienceDaily. //www.koonmotors.com/releases/2023/09/230906112428.htm Scientists identified new set of molecules that drive the growth of human pancreatic cancer cell lines, explaining how genetic mutations can activate genetic 'super-enhancers' that promote out-of-control pancreatic cancer growth. They show the efficacy of an experimental drug that targets a super-enhancer related protein, demonstrating the promise of therapeutics that block the effects of super-enhancers. Wed, 06 Sep 2023 11:24:28 EDT //www.koonmotors.com/releases/2023/09/230906112428.htm //www.koonmotors.com/releases/2023/08/230829125932.htm Early laboratory results in mice show the drug PXS-5505 increases survival when combined with chemotherapy in the treatment of pancreatic ductal adenocarcinomas. Tue, 29 Aug 2023 12:59:32 EDT //www.koonmotors.com/releases/2023/08/230829125932.htm //www.koonmotors.com/releases/2023/08/230803112928.htm Scientists have developed a nanoengineered bioink with improved bonding and cross-linking capabilities for 3D bioprinted tumor models. These capabilities are enabled by the addition of Laponite, highly charged, disk-shaped nanoparticles which enhance and retain the biological signaling that occurs in the tumor microenvironment so that more accurate tumor models can be created for study and anti-tumor drug development. Thu, 03 Aug 2023 11:29:28 EDT //www.koonmotors.com/releases/2023/08/230803112928.htm //www.koonmotors.com/releases/2023/08/230803112355.htm Four years ago, a report that a common species of fungus might fuel pancreatic cancer offered a promising new view of the deadly disease. But in working to validate the finding, researchers have found no such association. Thu, 03 Aug 2023 11:23:55 EDT //www.koonmotors.com/releases/2023/08/230803112355.htm //www.koonmotors.com/releases/2023/07/230717115358.htm Giving patients with operable pancreatic cancers a three-pronged combination immunotherapy treatment consisting of the pancreatic cancer vaccine GVAX, the immune checkpoint therapy nivolumab and urelemab, an anti-CD137 agonist antibody treatment, is safe, it increases the amount of cancer-killing immune system T cells in the tumors and it appears effective when given two weeks prior to cancer-removal surgery, according to new research. Mon, 17 Jul 2023 11:53:58 EDT //www.koonmotors.com/releases/2023/07/230717115358.htm //www.koonmotors.com/releases/2023/06/230628125341.htm Researchers find a combination of drugs outperformed other treatments in human and mouse models of pancreatic cancer; now urge clinical trial. Wed, 28 Jun 2023 12:53:41 EDT //www.koonmotors.com/releases/2023/06/230628125341.htm //www.koonmotors.com/releases/2023/05/230518120901.htm Researchers have discovered a new nutrient source that pancreatic cancer cells use to grow. The molecule, uridine, offers insight into both biochemical processes and possible therapeutic pathways. The findings show that cancer cells can adapt when they don't have access to glucose. Thu, 18 May 2023 12:09:01 EDT //www.koonmotors.com/releases/2023/05/230518120901.htm //www.koonmotors.com/releases/2023/04/230413154303.htm Nanomedicine researchers have found a way to tame pancreatic cancer -- one of the most aggressive and difficult to treat cancers -- by delivering immunotherapy directly into the tumor with a device that is smaller than a grain of rice. Thu, 13 Apr 2023 15:43:03 EDT //www.koonmotors.com/releases/2023/04/230413154303.htm //www.koonmotors.com/releases/2023/03/230317184937.htm A research team has identified a set of biomarkers that could help distinguish whether cysts on the pancreas are likely to develop into cancer or remain benign. Fri, 17 Mar 2023 18:49:37 EDT //www.koonmotors.com/releases/2023/03/230317184937.htm //www.koonmotors.com/releases/2023/01/230119133348.htm Researchers describe how pancreatic cancer stem cells leverage a protein in a family of proteins that normally suppress tumors to instead do the opposite, boosting their resistance to conventional treatments and spurring growth. Thu, 19 Jan 2023 13:33:48 EST //www.koonmotors.com/releases/2023/01/230119133348.htm //www.koonmotors.com/releases/2023/01/230116112552.htm 科学家发现一种分子通路关键to the initiation of pancreatic tumors. The findings may inspire new chemotherapeutic drugs targeting early stages of tumor formation and spread. Mon, 16 Jan 2023 11:25:52 EST //www.koonmotors.com/releases/2023/01/230116112552.htm //www.koonmotors.com/releases/2022/12/221230142240.htm Researchers have discovered a novel immunotherapy combination, targeting checkpoints in both T cells and myeloid suppressor cells, that successfully reprogrammed the tumor immune microenvironment (TIME) and significantly improved anti-tumor responses in preclinical models of pancreatic cancer. Fri, 30 Dec 2022 14:22:40 EST //www.koonmotors.com/releases/2022/12/221230142240.htm //www.koonmotors.com/releases/2022/12/221208114721.htm A new study showcases chemotherapy treatment before and after surgery for pancreatic cancer as the most effective combination for patients. Thu, 08 Dec 2022 11:47:21 EST //www.koonmotors.com/releases/2022/12/221208114721.htm //www.koonmotors.com/releases/2022/12/221206105910.htm A small molecule inhibitor that attacks the difficult to target, cancer-causing gene mutation KRAS, found in nearly 30 percent of all human tumors, successfully shrunk tumors or stopped cancer growth in preclinical models of pancreatic cancer, researchers showed. Tue, 06 Dec 2022 10:59:10 EST //www.koonmotors.com/releases/2022/12/221206105910.htm //www.koonmotors.com/releases/2022/11/221130114525.htm New research points to the inactivation of a previously unidentified gene as a likely culprit in the development of pancreatic cancer. The findings could alter the scientific understanding of this deadly disease and inform the establishment of novel treatments. Wed, 30 Nov 2022 11:45:25 EST //www.koonmotors.com/releases/2022/11/221130114525.htm //www.koonmotors.com/releases/2022/11/221107114447.htm Researchers show that a molecule called T-cadherin can be secreted in a soluble form. Soluble T-cadherin interacts with pancreatic insulin-producing beta cells via the Notch signaling pathway to promote their proliferation and increase the production of insulin. Recombinant T-cadherin stimulated Notch signaling in isolated mouse pancreatic islets, which contain beta cells, indicating that T-cadherin may have therapeutic potential for diabetes. Mon, 07 Nov 2022 11:44:47 EST //www.koonmotors.com/releases/2022/11/221107114447.htm //www.koonmotors.com/releases/2022/10/221027170415.htm Overall cancer death rates continued to decline among men, women, children, and adolescents and young adults in every major racial and ethnic group in the United States from 2015 to 2019, according to the latest Annual Report to the Nation on the Status of Cancer. Thu, 27 Oct 2022 17:04:15 EDT //www.koonmotors.com/releases/2022/10/221027170415.htm //www.koonmotors.com/releases/2022/10/221020201434.htm Biomedical engineers have demonstrated the most effective treatment for pancreatic cancer in mouse models ever recorded. While most mouse trials consider simply halting growth a success, the new treatment completely eliminated tumors in 80% of mice across several model types, including those considered the most difficult to treat. The approach combines traditional chemotherapy drugs with a new method for irradiating the tumor. Thu, 20 Oct 2022 20:14:34 EDT //www.koonmotors.com/releases/2022/10/221020201434.htm //www.koonmotors.com/releases/2022/10/221019172134.htm Two drugs -- one brand new -- reverse pancreatic cell changes that presage one of the hardest cancers to treat. Tested in cells, the drugs would be a promising early cancer treatment if they work in clinical trials. Wed, 19 Oct 2022 17:21:34 EDT //www.koonmotors.com/releases/2022/10/221019172134.htm //www.koonmotors.com/releases/2022/10/221012163433.htm 我科学家区分特定的基因签名ndicative of mitochondrial reprogramming in tumors that correlates with poor patient outcome. Wed, 12 Oct 2022 16:34:33 EDT //www.koonmotors.com/releases/2022/10/221012163433.htm //www.koonmotors.com/releases/2022/10/221010115335.htm Investigators have examined the microbiome of pancreatic tumors and identified particular microorganisms at single cell resolution that are associated with inflammation and with poor survival. According to the researchers, these microorganisms may be new targets for earlier diagnosis or treatment of pancreatic cancer, which is the fourth leading cause of cancer death for both men and women in the United States. Mon, 10 Oct 2022 11:53:35 EDT //www.koonmotors.com/releases/2022/10/221010115335.htm //www.koonmotors.com/releases/2022/10/221006141500.htm Researchers have discovered that the organization of different types of immune cells within pancreatic tumors is associated with how well patients with pancreatic cancer respond to treatment and how long they survive. Thu, 06 Oct 2022 14:15:00 EDT //www.koonmotors.com/releases/2022/10/221006141500.htm //www.koonmotors.com/releases/2022/10/221005111910.htm A molecular test called PancreaSeq accurately classifies pancreatic cysts as potentially cancerous or benign, according to a large, multi-center study. Wed, 05 Oct 2022 11:19:10 EDT //www.koonmotors.com/releases/2022/10/221005111910.htm //www.koonmotors.com/releases/2022/10/221005111902.htm Researchers have found a possible way to overcome barriers that block effective anti-cancer immune responses, thereby opening the potential for more effective immunotherapies. They report the STimulator of INterferon Genes (STING) has the promise of powerfully provoking multiple parts of the immune system and breaking established barriers. Their laboratory findings could have implications for treating solid tumors, including breast and pancreatic cancers. Wed, 05 Oct 2022 11:19:02 EDT //www.koonmotors.com/releases/2022/10/221005111902.htm //www.koonmotors.com/releases/2022/09/220913110443.htm An artificial intelligence (AI) tool is highly effective at detecting pancreatic cancer on CT, according to a new study. Tue, 13 Sep 2022 11:04:43 EDT //www.koonmotors.com/releases/2022/09/220913110443.htm //www.koonmotors.com/releases/2022/08/220831210044.htm Researchers have outlined the comprehensive immune landscape and microbiome of pancreatic cysts as they progress from benign cysts to pancreatic cancer. The findings could reveal the mechanism of neoplastic progression and provide targets for immunotherapy to inhibit progression or treat invasive disease. Wed, 31 Aug 2022 21:00:44 EDT //www.koonmotors.com/releases/2022/08/220831210044.htm //www.koonmotors.com/releases/2022/08/220822130236.htm A detailed analysis of pancreatic cancer by researchers at Washington University School of Medicine in St. Louis has revealed details of two key transition points in the development of these tumors -- the shift from normal cells to precancerous cells, and the change from precancerous to cancerous cells. Understanding these transitions will help lead to the development of novel therapies. Mon, 22 Aug 2022 13:02:36 EDT //www.koonmotors.com/releases/2022/08/220822130236.htm //www.koonmotors.com/releases/2022/07/220722082419.htm Scientists have discovered a pathway to the regeneration of insulin in pancreatic stem cells, a major breakthrough toward new therapies to treat Type 1 and Type 2 diabetes. Using the pancreas stem cells of a type 1 diabetic donor, researchers were able to effectively reactivate them to become insulin-expressing and functionally resemble beta-like cells through the use of a drug approved by the US Food and Drug Administration but not currently licensed for diabetes treatment. Fri, 22 Jul 2022 08:24:19 EDT //www.koonmotors.com/releases/2022/07/220722082419.htm //www.koonmotors.com/releases/2022/07/220713114610.htm Surveillance programs for people at high risk of developing pancreatic cancers can help detect precancerous conditions and cancers early, when they are most treatable, according to a new multicenter study. Wed, 13 Jul 2022 11:46:10 EDT //www.koonmotors.com/releases/2022/07/220713114610.htm //www.koonmotors.com/releases/2022/06/220629121124.htm Scientists have shown it is possible to reverse a key process that allows pancreatic cancer cells to grow and spread around the body. These findings show that a protein called GREM1 is key to regulating the type of cells found in pancreatic cancer -- and manipulating its levels can both fuel and reverse the ability of these cells to change into a more aggressive subtype. Researchers hope, in the future, to use this knowledge to find ways to reverse more advanced pancreatic cancer into a less aggressive form, which is easier to treat. Wed, 29 Jun 2022 12:11:24 EDT //www.koonmotors.com/releases/2022/06/220629121124.htm //www.koonmotors.com/releases/2022/06/220614164431.htm Researchers have successfully treated type 1 diabetes in mice using pancreatic beta-cell, target-specific, chimeric antigen-receptor (CAR) regulatory T cells (Tregs), and demonstrated the feasibility of their approach to treat the human condition according to new data. Tue, 14 Jun 2022 16:44:31 EDT //www.koonmotors.com/releases/2022/06/220614164431.htm //www.koonmotors.com/releases/2022/06/220609155820.htm A drug currently used in just 1% of cancers has significant potential against the remaining 99%, according to a new study. Ivosidenib, or AG-120, is currently used against cancers that have a mutation in the IDH1 gene. However, study results show that Ivosidenib is also effective against unmutated, or 'wild-type' IDH1. The protein coded by the IDH1 gene in cancers helps cancer cells survive in a stressful tumor environment, so any inhibitor medication that could weaken this defense mechanism is considered a promising therapy. Thu, 09 Jun 2022 15:58:20 EDT //www.koonmotors.com/releases/2022/06/220609155820.htm //www.koonmotors.com/releases/2022/06/220609131941.htm Successful treatment of cancer frequently depends on early detection. However, many cancers are detected late, often after metastasizing to other sites. New research aims to improve early detection and cancer prevention using advanced biomarkers and radiomics. Thu, 09 Jun 2022 13:19:41 EDT //www.koonmotors.com/releases/2022/06/220609131941.htm //www.koonmotors.com/releases/2022/06/220601170205.htm A study suggests that substances touted to improve athletic performance can activate a receptor that accelerates the progression of pre-cancerous lesions to pancreatic cancer in mice. Wed, 01 Jun 2022 17:02:05 EDT //www.koonmotors.com/releases/2022/06/220601170205.htm //www.koonmotors.com/releases/2022/05/220505143826.htm Scar-like细胞构成了相当大的一部分malignant pancreatic tumors and shield these cancers from immune attack are derived from mesothelial cells that line tissues and organs, a new study suggests. The findings could offer a new strategy to fight pancreatic cancer, a deadly disease for which no truly effective treatments exist. Thu, 05 May 2022 14:38:26 EDT //www.koonmotors.com/releases/2022/05/220505143826.htm //www.koonmotors.com/releases/2022/05/220505143759.htm Nanotechnology research has uncovered a potential new therapy for pancreatic cancer, whose survival rate is among the lowest of all malignancies. Thu, 05 May 2022 14:37:59 EDT //www.koonmotors.com/releases/2022/05/220505143759.htm //www.koonmotors.com/releases/2022/05/220505085613.htm Researchers report that the therapeutic use of mesenchymal stem cells is effective at suppressing the onset of diabetes induced by immune checkpoint inhibitors used to treat cancer. Mesenchymal stem cells therefore have potential as a new type of adjuvant cell therapy. Thu, 05 May 2022 08:56:13 EDT //www.koonmotors.com/releases/2022/05/220505085613.htm //www.koonmotors.com/releases/2022/04/220426153718.htm An artificial intelligence (AI) tool can accurately predicted who would develop pancreatic cancer based on what their CT scan images looked like years prior to being diagnosed with the disease. The findings may help prevent death through early detection of one of the most challenging cancers to treat. Tue, 26 Apr 2022 15:37:18 EDT //www.koonmotors.com/releases/2022/04/220426153718.htm //www.koonmotors.com/releases/2022/04/220422094328.htm Pancreatic cancer has a significantly poor prognosis; therefore, the development of effective treatments is an unmet clinical need. The major drawback in this field was the lack of useful model animals, which delayed the establishment of markers for early diagnosis and therapeutic options. The research group established an effective carcinogenesis method with wild-type rats by selectively introducing oncogenes into the pancreas, using the pancreas-targeted hydrodynamic gene delivery method that has been developed by the group. Fri, 22 Apr 2022 09:43:28 EDT //www.koonmotors.com/releases/2022/04/220422094328.htm //www.koonmotors.com/releases/2022/04/220421100132.htm Scientists report that a protein known as estrogen-related receptor gamma is critical for preventing pancreatic auto-digestion in mice. Moreover, they discovered that people with pancreatitis have lower levels of this protein in cells affected by this inflammation. Thu, 21 Apr 2022 10:01:32 EDT //www.koonmotors.com/releases/2022/04/220421100132.htm //www.koonmotors.com/releases/2022/04/220419092324.htm Scientists show that endocrine stem cells in the pancreas disappear after birth, and detail the genetic identity of the different types of pancreatic hormone-producing cells. Tue, 19 Apr 2022 09:23:24 EDT //www.koonmotors.com/releases/2022/04/220419092324.htm //www.koonmotors.com/releases/2022/04/220405102823.htm Using a fully-automated artificial intelligence (AI) deep learning model, researchers were able to identify early signs of type 2 diabetes on abdominal CT scans, according to a new study. Tue, 05 Apr 2022 10:28:23 EDT //www.koonmotors.com/releases/2022/04/220405102823.htm //www.koonmotors.com/releases/2022/03/220329114707.htm Researchers discovered that two distinct classes of fibroblast cells accumulate in pancreatic tumors and play opposing roles to promote and restrain pancreatic cancer growth. Appropriately targeting these cells may offer options to improve treatment outcomes. Tue, 29 Mar 2022 11:47:07 EDT //www.koonmotors.com/releases/2022/03/220329114707.htm //www.koonmotors.com/releases/2022/03/220323151658.htm Pancreatic cancer is notoriously difficult to cure or even treat. Now, a new strategy has succeeded in making pancreatic tumors visible to the immune systems of mice and vulnerable to immune attack, reducing cancer metastases by 87%. Wed, 23 Mar 2022 15:16:58 EDT //www.koonmotors.com/releases/2022/03/220323151658.htm //www.koonmotors.com/releases/2022/03/220322122830.htm The findings of a new study suggest that a ketogenic diet -- which is low in carbohydrates and protein, but high in fat -- helps to kill pancreatic cancer cells when combined with a triple-drug therapy. In laboratory experiments, the ketogenic diet decreased glucose (sugar) levels in the tumor, suggesting the diet helped starve the cancer. In addition, this diet elevated ketone bodies produced by the liver, which put additional stress on the cancer cells. Tue, 22 Mar 2022 12:28:30 EDT //www.koonmotors.com/releases/2022/03/220322122830.htm //www.koonmotors.com/releases/2022/03/220307113043.htm A new study -- in mice -- suggests that blocking a major inflammatory pathway that is activated in pancreatic cancer makes the tumors sensitive to chemotherapy and a type of immunotherapy that prompts the immune system's T cells to attack the cancer cells. The therapy more than doubled survival in a mouse model of pancreatic cancer. Mon, 07 Mar 2022 11:30:43 EST //www.koonmotors.com/releases/2022/03/220307113043.htm //www.koonmotors.com/releases/2022/03/220303120803.htm Researchers have carried out pioneering efforts to optimize the functionality of pancreatic cells produced from stem cells. In a new study, the group has demonstrated that stem cells can form cells that closely mimic normal pancreatic islets, in terms of both structure and function. Thu, 03 Mar 2022 12:08:03 EST //www.koonmotors.com/releases/2022/03/220303120803.htm //www.koonmotors.com/releases/2022/02/220224112613.htm Drug resistance is a major obstacle in the treatment of cancers. In an aggressive type of pancreatic cancer, for instance, drug resistance is associated with the suppression of programmed cell death, which results in the uncontrolled growth of cancer cells. Until recently, the process underlying this phenomenon had remained unknown. A team of researchers has now elucidated the way in which different factors interact in order to enable these cancer cells to survive. They were able to show that inhibition of a key protein limits cancer growth. The researchers' findings may herald a new treatment target for aggressive cancers. Thu, 24 Feb 2022 11:26:13 EST //www.koonmotors.com/releases/2022/02/220224112613.htm //www.koonmotors.com/releases/2022/02/220216083000.htm Researchers found that some cancer cells weave a deactivating signal into a protective coat of armor, immobilizing and excluding T cells that would otherwise kill them. This immune deactivation pathway offers a promising new therapeutic approach for pancreatic, breast, and colorectal cancers. Wed, 16 Feb 2022 08:30:00 EST //www.koonmotors.com/releases/2022/02/220216083000.htm //www.koonmotors.com/releases/2022/02/220208113544.htm Researchers have shown how probiotic bacteria in the gut could undermine immunity in pancreatic cancer, pointing toward more personalized cancer treatments. Tue, 08 Feb 2022 11:35:44 EST //www.koonmotors.com/releases/2022/02/220208113544.htm //www.koonmotors.com/releases/2022/01/220127120154.htm Hyaluronic acid, or HA, is a known presence in pancreatic tumors, but a new study shows that hyaluronic acid also acts as food to the cancer cells. These findings provide insight into how pancreatic cancer cells grow and indicate new possibilities to treat them. Thu, 27 Jan 2022 12:01:54 EST //www.koonmotors.com/releases/2022/01/220127120154.htm //www.koonmotors.com/releases/2022/01/220125162420.htm Faulty versions of the BRCA1 and BRCA2 genes are well known to increase the risk of breast cancer in men and women, and in ovarian cancer. Now BRCA1 and BRCA2 have been linked to several other cancers, including those that affect men. Tue, 25 Jan 2022 16:24:20 EST //www.koonmotors.com/releases/2022/01/220125162420.htm //www.koonmotors.com/releases/2021/11/211124154110.htm Bacteria from the digestive system seem to have the potential to cause damage to pancreatic cells, increasing the risk of malignant tumors. Now for the first time, live bacteria from cystic pancreatic lesions that are precursors to pancreatic cancer, have been analyzed by researchers. The study can lead to prophylactic interventions using local antibiotics. Wed, 24 Nov 2021 15:41:10 EST //www.koonmotors.com/releases/2021/11/211124154110.htm //www.koonmotors.com/releases/2021/11/211118203604.htm Immune checkpoint inhibitors strengthen the immune response against cancer cells, but the medications are ineffective against certain tumors. Results from a new clinical trial indicate that adding radiation may overcome this resistance to immune checkpoint inhibitors. Thu, 18 Nov 2021 20:36:04 EST //www.koonmotors.com/releases/2021/11/211118203604.htm //www.koonmotors.com/releases/2021/11/211108081631.htm Researchers have identified a series of symptoms associated with pancreatic cancer, including two previously unrecognised symptoms -- feeling thirsty and having dark urine. Mon, 08 Nov 2021 08:16:31 EST //www.koonmotors.com/releases/2021/11/211108081631.htm //www.koonmotors.com/releases/2021/11/211104162559.htm New findings help better understand the how one of the most commonly mutated genetic drivers of cancer passes signals that cause the disease. Thu, 04 Nov 2021 16:25:59 EDT //www.koonmotors.com/releases/2021/11/211104162559.htm //www.koonmotors.com/releases/2021/11/211104081448.htm An experimental drug enhanced the benefit of an immunotherapy to fight pancreatic cancer in mice by increasing the number of immune cells in the immediate vicinity of the tumor, leading to a reduction in tumor growth, and in some mice, eliminating their cancer. Thu, 04 Nov 2021 08:14:48 EDT //www.koonmotors.com/releases/2021/11/211104081448.htm //www.koonmotors.com/releases/2021/10/211029103155.htm 开创性的研究显示,腺泡的细胞pancreas form new cell types to mitigate injury but are then susceptible to cancerous mutations. Fri, 29 Oct 2021 10:31:55 EDT //www.koonmotors.com/releases/2021/10/211029103155.htm //www.koonmotors.com/releases/2021/10/211006132334.htm Care for the 15 most prevalent types of cancer in the U.S. cost approximately $156.2 billion in 2018, according to a team researchers. The team also found that medication was the biggest expense and that medication expense for breast, lung, lymphoma and colorectal cancers incurred the most costs. Wed, 06 Oct 2021 13:23:34 EDT //www.koonmotors.com/releases/2021/10/211006132334.htm //www.koonmotors.com/releases/2021/09/210930140715.htm What makes pancreatic cancer so deadly is its covert and quick spread. Now, a 'time machine' has shown a way to reverse the course of cancer before it spreads throughout the pancreas. Thu, 30 Sep 2021 14:07:15 EDT //www.koonmotors.com/releases/2021/09/210930140715.htm