//www.koonmotors.com/news/health_medicine/osteoporosis/ What is osteoporosis? Learn about osteoporosis symptoms, prevention and treatment. Find out the causes of osteoporosis and the effect of diet, exercise and drugs. Find the latest medical research here. en-us Fri, 08 Sep 2023 17:16:47 EDT Fri, 08 Sep 2023 17:16:47 EDT 60 //www.koonmotors.com/images/scidaily-logo-rss.png//www.koonmotors.com/news/health_medicine/osteoporosis/ For more science news, visit ScienceDaily. //www.koonmotors.com/releases/2023/07/230719112646.htm As life expectancy increases worldwide, age-associated diseases such as osteoporosis are having an increasing impact. Although early detection could help physicians intervene as soon as possible -- when treatment might offer the greatest benefit -- this type of detection is not yet possible with current osteoporosis diagnostic tests. Now, researchers have developed a biosensor that could someday help identify those most at risk for osteoporosis using less than a drop of blood. Wed, 19 Jul 2023 11:26:46 EDT //www.koonmotors.com/releases/2023/07/230719112646.htm //www.koonmotors.com/releases/2023/04/230419125102.htm Scientists have pinpointed a key driver of low bone density, a discovery that may lead to improved treatments with fewer side effects for women with osteoporosis. The findings reveal that loss of an epigenetic modulator, KDM5C, preserves bone mass in mice. KDM5C works by altering epigenetic 'marks,' which are akin to 'on' and 'off' switches that ensure the instructions written in DNA are used at the right time and in the right place. Wed, 19 Apr 2023 12:51:02 EDT //www.koonmotors.com/releases/2023/04/230419125102.htm //www.koonmotors.com/releases/2023/03/230322190844.htm People who have low bone density may have an increased risk of developing dementia compared to people who have higher bone density. The study does not prove that low bone density causes dementia. It only shows an association. Wed, 22 Mar 2023 19:08:44 EDT //www.koonmotors.com/releases/2023/03/230322190844.htm //www.koonmotors.com/releases/2023/02/230221132129.htm Elevated levels of air pollutants are associated with bone damage among postmenopausal women, according to new research. The effects were most evident on the lumbar spine, with nitrous oxides twice as damaging to the area than seen with normal aging. Tue, 21 Feb 2023 13:21:29 EST //www.koonmotors.com/releases/2023/02/230221132129.htm //www.koonmotors.com/releases/2022/12/221220113003.htm In our bones, specialized cells called osteoblasts are responsible for building up bone substance. A team of researchers has now identified an enzyme that controls the activity of osteoblasts. An agent that inhibits the activity of this enzyme reduced cancer-related bone loss and the number of bone metastases in multiple myeloma and in lung and breast cancer models in mice. Tue, 20 Dec 2022 11:30:03 EST //www.koonmotors.com/releases/2022/12/221220113003.htm //www.koonmotors.com/releases/2022/12/221206204809.htm Researchers identified an oral compound that influences components of the parathyroid hormone signaling pathway to increase bone formation and bone mass in mice. Tue, 06 Dec 2022 20:48:09 EST //www.koonmotors.com/releases/2022/12/221206204809.htm //www.koonmotors.com/releases/2022/11/221115114019.htm Scientists have made bone marrow 'organoids' that capture the key features of human bone marrow. Tue, 15 Nov 2022 11:40:19 EST //www.koonmotors.com/releases/2022/11/221115114019.htm //www.koonmotors.com/releases/2022/11/221101151932.htm 繁殖永久改变女性的骨骼ways not previously known, a team of anthropologists has found. Its discovery, based on an analysis of primates, sheds new light on how giving birth can permanently change the body. Tue, 01 Nov 2022 15:19:32 EDT //www.koonmotors.com/releases/2022/11/221101151932.htm //www.koonmotors.com/releases/2022/09/220920103425.htm Scientists have shown that high-fat diets can cause rapid changes in the bone marrow of mice, driving the production of inflammatory immune cells, according to new findings. Tue, 20 Sep 2022 10:34:25 EDT //www.koonmotors.com/releases/2022/09/220920103425.htm //www.koonmotors.com/releases/2022/09/220913110416.htm Researchers have developed a novel screening method to identify a drug that mimics the effects of exercise on muscle and bone. Locamidazole (LAMZ) improved muscle width and function and promoted bone formation while reducing bone resorption. LAMZ serves as a potential therapy for the treatment of locomotor diseases, such as sarcopenia and osteoporosis. Tue, 13 Sep 2022 11:04:16 EDT //www.koonmotors.com/releases/2022/09/220913110416.htm //www.koonmotors.com/releases/2022/09/220907105451.htm 一项新的研究在老鼠身上发现高血压的可能linked to significant bone loss. Bone quality in young mice with high blood pressure was similar to the bones of older mice without high blood pressure, suggesting that the effects of hypertension on bone quality, which includes strength, may mimic that of aging. The researchers suggest early detection and treatment of high blood pressure may help to deter loss of bone quality as people age. Wed, 07 Sep 2022 10:54:51 EDT //www.koonmotors.com/releases/2022/09/220907105451.htm //www.koonmotors.com/releases/2022/08/220809141221.htm Scientists have developed a new mathematical model that may help clinicians decide on the best combination of osteoporosis medications for patients and the order in which they should be taken. Tue, 09 Aug 2022 14:12:21 EDT //www.koonmotors.com/releases/2022/08/220809141221.htm //www.koonmotors.com/releases/2022/07/220729173222.htm Long periods in space damage bone structure irreparably in some cases and can make parts of the human skeleton age prematurely by up to 10 years, according to new research. Adapted training programs in conjunction with medication could provide better protection for astronauts on future space missions. The research findings also have implications for treating rheumatic conditions in clinical practice. Fri, 29 Jul 2022 17:32:22 EDT //www.koonmotors.com/releases/2022/07/220729173222.htm //www.koonmotors.com/releases/2022/06/220609155731.htm Researchers have identified the role of transcription factors Runx1 and Runx2 in the inhibition of fibrosis, the abnormal build-up of connective tissue with severe hematopoietic defects, in the bone marrow. Mice lacking both Runx1 and Runx2 in CAR cells, a major component of the hematopoietic stem cell niche, demonstrated severe myelofibrosis and defects in the production of blood cells. Runx1 and Runx2 may act as potential targets in the diagnosis and treatment of myelofibrosis. Thu, 09 Jun 2022 15:57:31 EDT //www.koonmotors.com/releases/2022/06/220609155731.htm //www.koonmotors.com/releases/2022/06/220603124824.htm Researchers have determined chemical parameters that affect the rate of calcium phosphate ceramic conversion into hydroxyapatite in a simulated body fluid. Shorter carbon chain lengths in the phosphate ester facilitated faster remodeling than longer chains. These findings will help researchers design bone substitutes that better meet the needs of real medical practice and improve outcomes from bone repair surgeries. Fri, 03 Jun 2022 12:48:24 EDT //www.koonmotors.com/releases/2022/06/220603124824.htm //www.koonmotors.com/releases/2022/05/220503091558.htm Per- and polyfluoroalkyl substances (PFAS) and phthalates (two types of endocrine-disrupting chemicals) may be associated with lower bone mineral density in male teens, according to a new study. Tue, 03 May 2022 09:15:58 EDT //www.koonmotors.com/releases/2022/05/220503091558.htm //www.koonmotors.com/releases/2022/04/220404082846.htm Physicians may be able to determine if menopause-related bone loss is already in progress or about to begin by measuring the level of a hormone called anti-Mullerian hormone that declines as women approach their final menstrual period. The findings could help physicians determine when, and how, to treat bone loss in women as they age before that bone loss causes significant health issues. Mon, 04 Apr 2022 08:28:46 EDT //www.koonmotors.com/releases/2022/04/220404082846.htm //www.koonmotors.com/releases/2022/02/220224091005.htm What determines the switch from bone formation to resorption has been unclear. Researchers show that intercellular communication via extracellular vesicles from bone-making osteoblasts is a key factor for this switch through a microRNA-mediated mechanism. Thu, 24 Feb 2022 09:10:05 EST //www.koonmotors.com/releases/2022/02/220224091005.htm //www.koonmotors.com/releases/2022/02/220216140408.htm To enhance the regeneration of bone, the Food and Drug Administration (FDA) approved recombinant human bone morphogenetic protein-2, or BMP-2. However, it is expensive and only moderately effective. It also produces side effects -- some severe. Researchers may have a viable, less risky alternative: messenger RNA. This well-known platform for vaccines has already proven to be safe in human use by the FDA. Wed, 16 Feb 2022 14:04:08 EST //www.koonmotors.com/releases/2022/02/220216140408.htm //www.koonmotors.com/releases/2022/02/220210114053.htm Men with high levels of body fat have lower bone density and may be more likely to break a bone than those with normal levels of body fat, according to a new study. Thu, 10 Feb 2022 11:40:53 EST //www.koonmotors.com/releases/2022/02/220210114053.htm //www.koonmotors.com/releases/2022/02/220209112110.htm Researchers found that prunes can help prevent or delay bone loss in postmenopausal women, possibly due to their ability to reduce inflammation and oxidative stress, both of which contribute to bone loss. Wed, 09 Feb 2022 11:21:10 EST //www.koonmotors.com/releases/2022/02/220209112110.htm //www.koonmotors.com/releases/2022/02/220208113938.htm Channels on the surface of bone cells called osteocytes help build stronger bones in response to mechanical stress, shows a new study. Tue, 08 Feb 2022 11:39:38 EST //www.koonmotors.com/releases/2022/02/220208113938.htm //www.koonmotors.com/releases/2022/01/220105094547.htm Drugs we take like prednisone can weaken our bones and so can aging, and scientists working to prevent both have some of the first evidence that the best target may not be the logical one. They are finding that in aging bone, the mineralocorticoid receptor, better known for its role in blood pressure regulation, is a key factor in bone health. Wed, 05 Jan 2022 09:45:47 EST //www.koonmotors.com/releases/2022/01/220105094547.htm //www.koonmotors.com/releases/2021/11/211112083106.htm Chronic inflammation caused by obesity may trigger the development of cells that break down bone tissue, including the bone that holds teeth in place, according to new research that sought to improve understanding of the connection between obesity and gum disease. The study, completed in an animal model and published in October in the Journal of Dental Research, found that excessive inflammation resulting from obesity raises the number of myeloid-derived suppressor cells (MDSC), a group of immune cells that increase during illness to regulate immune function. MDSCs, which originate in the bone marrow, develop into a range of different cell types, including osteoclasts (a cell that breaks down bone tissue). Fri, 12 Nov 2021 08:31:06 EST //www.koonmotors.com/releases/2021/11/211112083106.htm //www.koonmotors.com/releases/2021/10/211027122047.htm Bone mineral density at the femoral neck bone in postmenopausal women decreased by an average of 10% during a 25-year follow-up, according to a new study. Being the world's hitherto longest follow-up of changes in bone mineral density in postmenopausal women, the study shows that bone loss after menopause is significantly lower than has previously been assumed on the basis of earlier studies. Wed, 27 Oct 2021 12:20:47 EDT //www.koonmotors.com/releases/2021/10/211027122047.htm //www.koonmotors.com/releases/2021/10/211014100223.htm A new discovery about osteoporosis suggests a potential treatment target for that brittle-bone disease and for bone loss from rheumatoid arthritis. Thu, 14 Oct 2021 10:02:23 EDT //www.koonmotors.com/releases/2021/10/211014100223.htm //www.koonmotors.com/releases/2021/10/211008105744.htm Researchers have identified a subpopulation of mesenchymal stem cells in the bone marrow that express the marker CD73. These cells have a higher potential for proliferation and differentiation, and play a significant role in bone healing, migrating to the site of a fracture and developing into cartilage and bone cells as part of the repair process. These cells have potential for regenerative medicine. Fri, 08 Oct 2021 10:57:44 EDT //www.koonmotors.com/releases/2021/10/211008105744.htm //www.koonmotors.com/releases/2021/09/210914124958.htm Epigenetic changes in old age increase risk of osteoporosis and bone fractures. Tue, 14 Sep 2021 12:49:58 EDT //www.koonmotors.com/releases/2021/09/210914124958.htm //www.koonmotors.com/releases/2021/07/210721102417.htm A 16-year study has revealed a link between cognitive decline, bone loss and fracture risk in women. Wed, 21 Jul 2021 10:24:17 EDT //www.koonmotors.com/releases/2021/07/210721102417.htm //www.koonmotors.com/releases/2021/06/210623144856.htm Researchers develop an antibody conjugate called BonTarg that delivers drugs to bone tumors and inhibits metastasis. Wed, 23 Jun 2021 14:48:56 EDT //www.koonmotors.com/releases/2021/06/210623144856.htm //www.koonmotors.com/releases/2021/05/210524110252.htm Researchers found that risk of subsequent moderate or worse hearing loss was up to 40 percent higher in study participants with osteoporosis or LBD. Mon, 24 May 2021 11:02:52 EDT //www.koonmotors.com/releases/2021/05/210524110252.htm //www.koonmotors.com/releases/2021/05/210506183351.htm Thin and brittle bones are strongly linked to women's heart disease risk, with thinning of the lower (lumbar) spine, top of the thigh bone (femoral neck), and hip especially predictive of a heightened heart attack and stroke risk. Thu, 06 May 2021 18:33:51 EDT //www.koonmotors.com/releases/2021/05/210506183351.htm //www.koonmotors.com/releases/2021/05/210505075019.htm New research has now mapped the unique genetic profile of the skeleton's 'master regulator' cells, known as osteocytes. Wed, 05 May 2021 07:50:19 EDT //www.koonmotors.com/releases/2021/05/210505075019.htm //www.koonmotors.com/releases/2021/02/210224143512.htm Scientists have identified the specialized environment, known as a niche, in the bone marrow where new bone and immune cells are produced. The study also shows that movement-induced stimulation is required for the maintenance of this niche, as well as the bone and immune-forming cells that it contains. Together, these findings identify a new way that exercise strengthens bones and immune function. Wed, 24 Feb 2021 14:35:12 EST //www.koonmotors.com/releases/2021/02/210224143512.htm //www.koonmotors.com/releases/2021/02/210216114906.htm Researchers have identified the role a critical enzyme plays in skeletal aging and bone loss, putting them one step closer to understanding the complex biological mechanisms that lead to osteoporosis, the bone disease that afflicts some 200 million people worldwide. Findings could hold an important key to developing more effective treatments for osteoporosis and improving the lives of an aging population. Tue, 16 Feb 2021 11:49:06 EST //www.koonmotors.com/releases/2021/02/210216114906.htm //www.koonmotors.com/releases/2021/02/210209113843.htm Researchers have developed a model to predict the biological age of bones that may improve the management of osteoporotic fractures. Tue, 09 Feb 2021 11:38:43 EST //www.koonmotors.com/releases/2021/02/210209113843.htm //www.koonmotors.com/releases/2021/01/210127085213.htm 一个多学科的研究小组已经开发了一个technique to replicate bone tissue complexity and bone-remodeling processes. This breakthrough could help researchers further their study of bone biology and assist in improving development of drugs for osteoporosis. Wed, 27 Jan 2021 08:52:13 EST //www.koonmotors.com/releases/2021/01/210127085213.htm //www.koonmotors.com/releases/2021/01/210125094414.htm 3D printers may one day become a permanent fixture of the operating theatre after scientists showed they could print bone-like structures containing living cells. Mon, 25 Jan 2021 09:44:14 EST //www.koonmotors.com/releases/2021/01/210125094414.htm //www.koonmotors.com/releases/2021/01/210119114332.htm Researchers have developed a way of combining a bone substitute and drugs to regenerate bone and heal severe fractures in the thigh or shin bone. The study was conducted on rats, but the researchers think that the method in various combinations will soon be commonplace in clinical settings. Tue, 19 Jan 2021 11:43:32 EST //www.koonmotors.com/releases/2021/01/210119114332.htm //www.koonmotors.com/releases/2021/01/210112110053.htm Gut microbes passed from female mice to their offspring, or shared between mice that live together, may influence the animals' bone mass. Tue, 12 Jan 2021 11:00:53 EST //www.koonmotors.com/releases/2021/01/210112110053.htm //www.koonmotors.com/releases/2021/01/210106115727.htm 一个多学科的研究小组ered several genetic markers associated with bone mineral accrual, which could ultimately help identify causes of eventual osteoporosis earlier in life through genetic testing. Wed, 06 Jan 2021 11:57:27 EST //www.koonmotors.com/releases/2021/01/210106115727.htm //www.koonmotors.com/releases/2021/01/210106082807.htm Innovators have developed a stabilized form of human calcitonin, which is a peptide drug already used for people with osteoporosis. Researchers created a prodrug form of the peptide hormone to increase its effectiveness as an osteoporosis treatment. Wed, 06 Jan 2021 08:28:07 EST //www.koonmotors.com/releases/2021/01/210106082807.htm //www.koonmotors.com/releases/2020/12/201224113116.htm By transferring mouse aged hematopoietic stem cells (aged HSCs) to the environment of young mice (bone marrow niche), it was demonstrated that the pattern of stem cell gene expression was rejuvenated to that of young hematopoietic stem cells. Thu, 24 Dec 2020 11:31:16 EST //www.koonmotors.com/releases/2020/12/201224113116.htm //www.koonmotors.com/releases/2020/12/201209094236.htm Although weight loss surgery is a highly effective treatment for obesity, it can be detrimental to bone health. A new study suggests that exercise may help address this shortcoming. Wed, 09 Dec 2020 09:42:36 EST //www.koonmotors.com/releases/2020/12/201209094236.htm //www.koonmotors.com/releases/2020/12/201203144112.htm A new article describes for the first time how minerals come together at the molecular level to form bones and other hard tissues, like teeth and enamel. Thu, 03 Dec 2020 14:41:12 EST //www.koonmotors.com/releases/2020/12/201203144112.htm //www.koonmotors.com/releases/2020/12/201201171732.htm A new study has discovered that vitamin D regulates calcium in a section of the intestine that previously was thought not to have played a key role. The findings have important implications on how bowel disease, including ulcerative colitis and Crohn's disease, may disrupt calcium regulation. Tue, 01 Dec 2020 17:17:32 EST //www.koonmotors.com/releases/2020/12/201201171732.htm //www.koonmotors.com/releases/2020/11/201124092157.htm A common weight loss surgery for adolescents with obesity called sleeve gastrectomy has harmful effects on bones, according to a new study. Tue, 24 Nov 2020 09:21:57 EST //www.koonmotors.com/releases/2020/11/201124092157.htm //www.koonmotors.com/releases/2020/11/201120132606.htm By disabling a function of a set of cells in mice, researchers appear to have halted the process that breaks down bone, a potential boon for osteoporosis treatment. Fri, 20 Nov 2020 13:26:06 EST //www.koonmotors.com/releases/2020/11/201120132606.htm //www.koonmotors.com/releases/2020/10/201020190126.htm Taking steroid inhalers or tablets to treat asthma or control flare-ups is linked to a heightened risk of brittle bones (osteoporosis) and increased vulnerability to broken bones (fragility fractures), finds new research. Tue, 20 Oct 2020 19:01:26 EDT //www.koonmotors.com/releases/2020/10/201020190126.htm //www.koonmotors.com/releases/2020/10/201019103501.htm Not too little, not too much - Goldilocks' 'just right' approach can now assess children's daily activities as new research confirms the best make up of a child's day to maximize bone health and function in children. Mon, 19 Oct 2020 10:35:01 EDT //www.koonmotors.com/releases/2020/10/201019103501.htm //www.koonmotors.com/releases/2020/10/201009094952.htm Bone marrow cancer is currently an incurable disease that affects about 400 people in Norway every year. One Norwegian researcher has now found an important reason for bone destruction in people with this disease. Fri, 09 Oct 2020 09:49:52 EDT //www.koonmotors.com/releases/2020/10/201009094952.htm //www.koonmotors.com/releases/2020/10/201008104243.htm Researchers showed that laser ablation of bone inhibits expression of the osteogenesis inhibitor protein sclerostin without causing inflammation, unlike the conventional bur-drilling technique. Further investigations confirmed that this beneficial bio-stimulation works by inducing mechanical stress. These findings help advance research into the treatment of osteoporosis as well as specific enhancement of bone regrowth in orthopedic and dental surgery. Thu, 08 Oct 2020 10:42:43 EDT //www.koonmotors.com/releases/2020/10/201008104243.htm //www.koonmotors.com/releases/2020/10/201001090139.htm A research team has revealed that narrow-range ultraviolet (UV) irradiation using light emitting diodes (LEDs) safely increases serum vitamin D levels in aging mice and thereby prevents the loss of their bone and muscle mass. Thu, 01 Oct 2020 09:01:39 EDT //www.koonmotors.com/releases/2020/10/201001090139.htm //www.koonmotors.com/releases/2020/09/200915090132.htm Researchers showed that the slow release of soy-based chemical compounds from a 3D-printed bone-like scaffold resulted in a reduction in bone cancer cells while building up healthy cells and reducing harmful inflammation. Tue, 15 Sep 2020 09:01:32 EDT //www.koonmotors.com/releases/2020/09/200915090132.htm //www.koonmotors.com/releases/2020/09/200914131910.htm Botox injections to manage jaw and facial pain do not result in clinically significant changes in jaw bone when used short term and in low doses, according to researchers. However, they found evidence of bone loss when higher doses were used. Mon, 14 Sep 2020 13:19:10 EDT //www.koonmotors.com/releases/2020/09/200914131910.htm //www.koonmotors.com/releases/2020/09/200911093027.htm Osteoporosis is characterized by a deterioration of the bones and an increased risk of fractures. With one third of postmenopausal women affected, it is a major public health problem. A research team has observed that exposure to warmer ambient temperatures increases bone strength and prevents the loss of bone density. This phenomenon is linked to a change in the composition of gut microbiota and makes hopes for osteoporosis treatments. Fri, 11 Sep 2020 09:30:27 EDT //www.koonmotors.com/releases/2020/09/200911093027.htm //www.koonmotors.com/releases/2020/08/200826083012.htm New research has highlighted a preventative treatment gap in patients prone to bone fractures who are otherwise healthy. Wed, 26 Aug 2020 08:30:12 EDT //www.koonmotors.com/releases/2020/08/200826083012.htm //www.koonmotors.com/releases/2020/08/200818103810.htm High intensity physical activity in early life might help maximise peak hip strength and prevent osteoporosis in later life, according to a new study. Tue, 18 Aug 2020 10:38:10 EDT //www.koonmotors.com/releases/2020/08/200818103810.htm //www.koonmotors.com/releases/2020/08/200805102032.htm An international research team has found a new approach that may be able to reduce bone loss in osteoporosis and maintain bone health. Wed, 05 Aug 2020 10:20:32 EDT //www.koonmotors.com/releases/2020/08/200805102032.htm //www.koonmotors.com/releases/2020/05/200506104506.htm A new study found that organic nitrates do not have clinically relevant effects on bone mineral density or bone turnover in postmenopausal women, and the medications caused significant side effects. Wed, 06 May 2020 10:45:06 EDT //www.koonmotors.com/releases/2020/05/200506104506.htm