//www.koonmotors.com/news/health_medicine/multiple_sclerosis/ Information on multiple sclerosis. Read current research articles and learn about multiple sclerosis diagnosis, symptoms as well as the latest MS treatment options. en-us Wed, 06 Sep 2023 14:46:10 EDT Wed, 06 Sep 2023 14:46:10 EDT 60 //www.koonmotors.com/images/scidaily-logo-rss.png//www.koonmotors.com/news/health_medicine/multiple_sclerosis/ For more science news, visit ScienceDaily. //www.koonmotors.com/releases/2023/08/230808110850.htm It has been known for several years that the diagnosis 'multiple sclerosis' conceals a whole range of different illnesses, each requiring customized treatment. Researchers have now described a possible new MS-like disease and explained how to diagnose it. Tue, 08 Aug 2023 11:08:50 EDT //www.koonmotors.com/releases/2023/08/230808110850.htm //www.koonmotors.com/releases/2023/07/230719221515.htm People who start taking medication soon after the first signs of multiple sclerosis (MS) may have a lower risk of disability later, according to a new study. Wed, 19 Jul 2023 22:15:15 EDT //www.koonmotors.com/releases/2023/07/230719221515.htm //www.koonmotors.com/releases/2023/07/230712165200.htm Two injectable therapies accounted for nearly 100 percent of medications for patients in 2001, but by 2020 that decreased to about 25 percent. Wed, 12 Jul 2023 16:52:00 EDT //www.koonmotors.com/releases/2023/07/230712165200.htm //www.koonmotors.com/releases/2023/07/230706124618.htm A study has demonstrated for the first time that diagnosis of multiple sclerosis (MS) can be significantly improved by additionally measuring the thickness of retinal layers in the eye. Use of the procedure helps to detect the condition at an earlier stage and predict its progression more accurately. This can lead to a decisive increase in the chance of improved patient outcomes. Thu, 06 Jul 2023 12:46:18 EDT //www.koonmotors.com/releases/2023/07/230706124618.htm //www.koonmotors.com/releases/2023/06/230628130340.htm 的研究与多个年代超过22000人clerosis (MS) has for the first time identified a genetic variant associated with faster progression of the disease, an accumulation of disability that can rob patients of their mobility and independence over time. Multiple sclerosis begins as an autoimmune disease where the immune system attacks the brain and the spinal cord, resulting in symptom flares, called relapses, as well as longer-term degeneration known as progression. Despite the development of effective treatments for the inflammatory autoimmune disease, none can prevent increased disability during the neurodegenerative phase of the disease. Wed, 28 Jun 2023 13:03:40 EDT //www.koonmotors.com/releases/2023/06/230628130340.htm //www.koonmotors.com/releases/2023/06/230628130323.htm Scientists identify the first genetic marker for MS severity, opening the door to preventing long-term disability. Wed, 28 Jun 2023 13:03:23 EDT //www.koonmotors.com/releases/2023/06/230628130323.htm //www.koonmotors.com/releases/2023/06/230615183107.htm A new study has identified a treatment that could repair myelin in the cortex, undoing some of the damage caused by MS. Thu, 15 Jun 2023 18:31:07 EDT //www.koonmotors.com/releases/2023/06/230615183107.htm //www.koonmotors.com/releases/2023/06/230612200436.htm A decade after scientists identified an over-the-counter antihistamine as a treatment for multiple sclerosis, researchers have developed an approach to measure the drug's effectiveness in repairing the brain, making it possible to also assess future therapies for the devastating disorder. Mon, 12 Jun 2023 20:04:36 EDT //www.koonmotors.com/releases/2023/06/230612200436.htm //www.koonmotors.com/releases/2023/03/230316124440.htm Criteria used by neurologists to assess for multiple sclerosis (MS) in adults may fail to identify the illness in children with imaging suspicious for the disease, an oversight that could delay treatment of the disease at its earliest stages, according to a new study. Thu, 16 Mar 2023 12:44:40 EDT //www.koonmotors.com/releases/2023/03/230316124440.htm //www.koonmotors.com/releases/2023/03/230308084337.htm A pilot trial tested the nasal administration of the drug Foralumab, an anti-CD3 monoclonal antibody. Investigators found evidence that the drug dampened the inflammatory T cell response and decreased lung inflammation in patients with COVID-19. Further analysis showed the same gene expression modulation in patients with multiple sclerosis, who experienced decreased brain inflammation, suggesting that Foralumab could be used to treat other diseases. Wed, 08 Mar 2023 08:43:37 EST //www.koonmotors.com/releases/2023/03/230308084337.htm //www.koonmotors.com/releases/2023/03/230306163014.htm Scientists have uncovered a chemical compound that holds potential as a therapeutic for various autoimmune diseases, and they've used it to treat mice. Mon, 06 Mar 2023 16:30:14 EST //www.koonmotors.com/releases/2023/03/230306163014.htm //www.koonmotors.com/releases/2023/02/230201134234.htm A researcher is one step closer to demonstrating the potential of a brain molecule called fractalkine to halt and even reverse the effects of multiple sclerosis and other neurodegenerative diseases. Researchers injected fractalkine into mice with chemically induced MS. They found the treatment increased the number of new oligodendrocytes -- vital brain and spinal cord cells that produce myelin in both embryonic and adult brains -- which are damaged during the MS autoimmune attack. Wed, 01 Feb 2023 13:42:34 EST //www.koonmotors.com/releases/2023/02/230201134234.htm //www.koonmotors.com/releases/2022/12/221221165109.htm In people with active secondary progressive multiple sclerosis (MS), hematopoietic stem cell transplants may delay disability longer than some other MS medications, according to a new study. The study involved autologous hematopoietic stem cell transplants, which use healthy blood stem cells from a person's own body to replace diseased cells. Wed, 21 Dec 2022 16:51:09 EST //www.koonmotors.com/releases/2022/12/221221165109.htm //www.koonmotors.com/releases/2022/12/221212140501.htm Multiple Sclerosis (MS) is almost always accompanied by fatigue, a massive tiredness that is described by the vast majority of patients as the most distressing symptom. In a recent scientific study, a research group identified light therapy as a promising non-drug treatment option: patients included in the study showed a measurable improvement after just 14 days of use. Mon, 12 Dec 2022 14:05:01 EST //www.koonmotors.com/releases/2022/12/221212140501.htm //www.koonmotors.com/releases/2022/11/221118144113.htm A study has found that anti-hyperglycemic medications used to treat Type 2 diabetes resulted in an increased risk of multiple sclerosis for people older than 45, particularly among women. Fri, 18 Nov 2022 14:41:13 EST //www.koonmotors.com/releases/2022/11/221118144113.htm //www.koonmotors.com/releases/2022/11/221110101820.htm Blood stem cell transplantation is a radical but highly effective therapy for multiple sclerosis. A study has now examined in detail the way in which the treatment curbs the autoimmune disease and how the immune system regenerates afterwards. A better understanding of these mechanisms should help the treatment approach, currently approved in only a few countries, to gain wider acceptance. Thu, 10 Nov 2022 10:18:20 EST //www.koonmotors.com/releases/2022/11/221110101820.htm //www.koonmotors.com/releases/2022/11/221104100245.htm Sex differences in the aging brain may offer an enticing clue for developing more effective neuroprotective treatments, according to a new research strategy. Fri, 04 Nov 2022 10:02:45 EDT //www.koonmotors.com/releases/2022/11/221104100245.htm //www.koonmotors.com/releases/2022/10/221006162830.htm The drug tofacitinib was well tolerated among patients with early scleroderma, primarily affecting the protein interferon both in fibroblasts and keratinocytes. Researchers say the drug is safe and can possibly be repurposed for systemic sclerosis treatment. Thu, 06 Oct 2022 16:28:30 EDT //www.koonmotors.com/releases/2022/10/221006162830.htm //www.koonmotors.com/releases/2022/10/221001104312.htm Researchers demonstrate the relationship between the rate of cognitive fatigue in MS and microstructural brain changes. The findings promise to advance development of clinical interventions for disabling fatigue. Sat, 01 Oct 2022 10:43:12 EDT //www.koonmotors.com/releases/2022/10/221001104312.htm //www.koonmotors.com/releases/2022/09/220920141424.htm The zebrafish serves as a model organism for researchers around the world: it can be used to study important physiological processes that also take place in a similar form in the human body. It is therefore routinely used in the search for possible active substances against diseases. Researchers have now described an innovative way to do this. In this process, the larvae fish are made a bit more 'human-like'. This humanization could make the search for active pharmaceutical substances much more efficient. Tue, 20 Sep 2022 14:14:24 EDT //www.koonmotors.com/releases/2022/09/220920141424.htm //www.koonmotors.com/releases/2022/09/220901135813.htm A new study suggests a simple blood test -- administered before CAR-T cell treatment is initiated -- may identify which patients are predisposed to developing neurotoxic side effects in the days and weeks after CAR-T cell therapy. Thu, 01 Sep 2022 13:58:13 EDT //www.koonmotors.com/releases/2022/09/220901135813.htm //www.koonmotors.com/releases/2022/08/220824170142.htm Researchers have known people who live farther from the equator are more likely to develop multiple sclerosis (MS) and have often attributed that to vitamin D exposure. But countries farther from the equator are also more likely to be wealthier than countries nearer to the equator. A new analysis shows that the amount a country spends on health care may help explain the link between MS and latitude. Wed, 24 Aug 2022 17:01:42 EDT //www.koonmotors.com/releases/2022/08/220824170142.htm //www.koonmotors.com/releases/2022/08/220810161158.htm Quality of life is a measure of a person's level of comfort, health and happiness. For people with multiple sclerosis (MS), a new study has found there are specific factors that may affect a person's physical and mental quality of life. Wed, 10 Aug 2022 16:11:58 EDT //www.koonmotors.com/releases/2022/08/220810161158.htm //www.koonmotors.com/releases/2022/08/220810105209.htm Drugs called interferon betas are common treatments for multiple sclerosis (MS), reducing relapses and slowing motor function decline. Interferon beta, a protein known to contain a zinc binding pocket, is thought to reduce proinflammatory molecules and even increase production of anti-inflammatory species in MS patients. But researchers now report that the molecule reduces the binding of three components -- zinc, C-peptide and albumin -- to red blood cells. Wed, 10 Aug 2022 10:52:09 EDT //www.koonmotors.com/releases/2022/08/220810105209.htm //www.koonmotors.com/releases/2022/06/220630142201.htm By increasing sensory input and promoting multisensory processing, virtual reality may increase the effectiveness of traditional cognitive rehabilitation and exercise training in individuals with MS, according to researchers. Thu, 30 Jun 2022 14:22:01 EDT //www.koonmotors.com/releases/2022/06/220630142201.htm //www.koonmotors.com/releases/2022/05/220526112749.htm Researchers have designed a targeted therapeutic treatment that restricts brain inflammation. The effectiveness of this approach in improving outcomes was demonstrated following brain injury, stroke or multiple sclerosis in mice. The system increases the number of regulatory T cells, mediators of the immune system's anti-inflammatory response, in the brain. By boosting the number of T regulatory cells in the brain, the researchers were able to prevent the death of brain tissue in mice following injury and the mice performed better in cognitive tests. The treatment has a high potential for use in patients with traumatic brain injury, with few alternatives currently available to prevent harmful neuroinflammation. Thu, 26 May 2022 11:27:49 EDT //www.koonmotors.com/releases/2022/05/220526112749.htm //www.koonmotors.com/releases/2022/05/220520101349.htm A research team has mapped out the development and genetic trajectory of previously understudied macrophages associated with the central nervous system. Among other things, the team found that meningeal macrophages are formed during gestation and develop in the same way as microglia, while perivascular macrophages develop after birth. Their new insights could pave the way for better understanding the origins and mechanisms behind leading brain-related pathologies such as Alzheimer's disease. Fri, 20 May 2022 10:13:49 EDT //www.koonmotors.com/releases/2022/05/220520101349.htm //www.koonmotors.com/releases/2022/05/220511123608.htm For patients suffering from multiple sclerosis (MS), becoming a mother is fraught with difficult questions: is it acceptable to continue disease modifying treatment during pregnancy and breastfeeding to keep the disease at bay, or does this put the child at risk? A study on the drug glatiramer acetate can relieve mothers of this concern during the breastfeeding period. A comparative study between children whose mothers had taken the drug while breastfeeding and those who hadn't revealed no significant differences in several infant health outcomes during the first 18 months of life. Wed, 11 May 2022 12:36:08 EDT //www.koonmotors.com/releases/2022/05/220511123608.htm //www.koonmotors.com/releases/2022/04/220427140615.htm Currently available therapies to treat multiple sclerosis (MS) lack precision and can lead to serious side effects. Researchers have now developed a method for identifying the immune cells involved in autoimmune diseases, and have identified four new target molecules of potential significance for future personalized treatment of MS. Wed, 27 Apr 2022 14:06:15 EDT //www.koonmotors.com/releases/2022/04/220427140615.htm //www.koonmotors.com/releases/2022/04/220426101648.htm Researchers managed to reduce chronic inflammation associated with multiple sclerosis in mice thanks to the administration of a type of lipid that mediates inflammation. Tue, 26 Apr 2022 10:16:48 EDT //www.koonmotors.com/releases/2022/04/220426101648.htm //www.koonmotors.com/releases/2022/04/220414110850.htm Researchers have found a way to supercharge immune cells that could enable them to clear disease and infections faster Thu, 14 Apr 2022 11:08:50 EDT //www.koonmotors.com/releases/2022/04/220414110850.htm //www.koonmotors.com/releases/2022/04/220413161815.htm 多发性硬化(MS)的估计成本管理计划hed $85.4 billion in 2019 in the United States, according to a new report. In addition, when researchers compared people with MS to people without MS they found that excess medical costs represent 74% of the overall economic burden of MS. The excess medical cost per person was $65,612 that year. Wed, 13 Apr 2022 16:18:15 EDT //www.koonmotors.com/releases/2022/04/220413161815.htm //www.koonmotors.com/releases/2022/04/220412141049.htm 最近的一项研究表明b的功效ehavioral intervention, EMOPRINT, for treating deficits of facial recognition in individuals with multiple sclerosis (MS). The study provides Class I evidence supporting the efficacy of an intervention to treat these deficits in MS. Tue, 12 Apr 2022 14:10:49 EDT //www.koonmotors.com/releases/2022/04/220412141049.htm //www.koonmotors.com/releases/2022/03/220324122612.htm Researchers have validated a new antibody test to diagnose multiple sclerosis (MS), a potentially disabling disease of the brain and spinal cord. Thu, 24 Mar 2022 12:26:12 EDT //www.koonmotors.com/releases/2022/03/220324122612.htm //www.koonmotors.com/releases/2022/03/220322151022.htm Multiple sclerosis is a chronic disease that damages neurons. New research looks at the role that a protein, STAT5, plays in the development of MS. Tue, 22 Mar 2022 15:10:22 EDT //www.koonmotors.com/releases/2022/03/220322151022.htm //www.koonmotors.com/releases/2022/03/220304182954.htm Investigators have discovered how a drug for multiple sclerosis interacts with its targets, a finding that may pave the way for better treatments. Fri, 04 Mar 2022 18:29:54 EST //www.koonmotors.com/releases/2022/03/220304182954.htm //www.koonmotors.com/releases/2022/03/220301131110.htm Multiple sclerosis sufferers often complain of more severe disease symptoms after consuming dairy products. Researchers have now found a possible cause for this. According to the study, a protein in cow's milk can trigger inflammation that targets the 'insulating layer' around nerve cells. The study was able to demonstrate this link in mice, but also found evidence of a similar mechanism in humans. The researchers therefore recommend that certain groups of sufferers avoid dairy products. Tue, 01 Mar 2022 13:11:10 EST //www.koonmotors.com/releases/2022/03/220301131110.htm //www.koonmotors.com/releases/2022/02/220218100650.htm Researchers shed new light on how myelin loss might underpin aberrant brain activity which have been observed in people with multiple sclerosis. The study suggests that myelination, however patchy on specific interneurons, is required to reach their full inhibitory potential. Fri, 18 Feb 2022 10:06:50 EST //www.koonmotors.com/releases/2022/02/220218100650.htm //www.koonmotors.com/releases/2022/02/220216112303.htm Researchers have studied the immune system of pairs of monozygotic twins to identify the influence of the environment and of genetics in cases of multiple sclerosis. In the process, they may have discovered precursor cells of the disease-causing T cells. Wed, 16 Feb 2022 11:23:03 EST //www.koonmotors.com/releases/2022/02/220216112303.htm //www.koonmotors.com/releases/2022/01/220128141316.htm An international team of researchers has discovered that a cell type in the central nervous system known as oligodendrocytes might have a different role in the development of multiple sclerosis (MS) than previously thought. The findings could open for new therapeutical approaches to MS. Fri, 28 Jan 2022 14:13:16 EST //www.koonmotors.com/releases/2022/01/220128141316.htm //www.koonmotors.com/releases/2022/01/220127104246.htm Eating more meat, having less of certain bacteria in the gut, and more of certain immune cells in the blood, all link with multiple sclerosis, reports a team of researchers. The work teased out subtle connections that could lead to a better understanding of the causes of the disease. Thu, 27 Jan 2022 10:42:46 EST //www.koonmotors.com/releases/2022/01/220127104246.htm //www.koonmotors.com/releases/2022/01/220118104107.htm It is important that multiple sclerosis (MS) is diagnosed and treated as early as possible in order to delay progression of the disease. The technique of magnetic resonance imaging (MRI) plays a key role in this process. A new MRI technique could pave the way to quicker assessment of disease activity in MS. Tue, 18 Jan 2022 10:41:07 EST //www.koonmotors.com/releases/2022/01/220118104107.htm //www.koonmotors.com/releases/2022/01/220113151342.htm A new study provides compelling evidence of causality between Epstein-Barr virus and multiple sclerosis. It suggests that most MS cases could be prevented by stopping EBV infection, and that targeting EBV could lead to the discovery of a cure for MS. Thu, 13 Jan 2022 15:13:42 EST //www.koonmotors.com/releases/2022/01/220113151342.htm //www.koonmotors.com/releases/2022/01/220110145312.htm Scientists have developed an innovative technique using small wearable sensors to gather data on how people -- who have suffered from a traumatic hand amputation -- use a prosthesis versus a transplanted hand in everyday life. So far, the data shows people with a transplanted hand demonstrate a more balanced use of their hands than those who use a prosthesis. Mon, 10 Jan 2022 14:53:12 EST //www.koonmotors.com/releases/2022/01/220110145312.htm //www.koonmotors.com/releases/2022/01/220106111546.htm Researchers analyzed thousands of microglia from different brain regions of deceased patients who had been diagnosed with a variety of neuropsychiatric and neurodegenerative disorders. Their results support the idea that microglia may play critical roles in some cases of brain disease while also providing a potentially valuable guide for future studies. Thu, 06 Jan 2022 11:15:46 EST //www.koonmotors.com/releases/2022/01/220106111546.htm //www.koonmotors.com/releases/2021/12/211220190638.htm A New York-based, multi-institutional research team has found high levels of three toxic metabolites produced by gut bacteria in the cerebrospinal fluid and plasma samples of multiple sclerosis (MS) patients. The important findings further scientists' understanding of how gut bacteria can impact the course of neurological diseases by producing compounds that are toxic to nerve cells. Mon, 20 Dec 2021 19:06:38 EST //www.koonmotors.com/releases/2021/12/211220190638.htm //www.koonmotors.com/releases/2021/12/211208161146.htm Living in sunny locations and spending time outdoors may raise the risk for skin cancer, but a new study shows that in children and young adults, sun exposure may protect against multiple sclerosis. The study follows previous work by other researchers that has demonstrated an association between increased ultraviolet exposure in childhood and lower odds of adult MS. Wed, 08 Dec 2021 16:11:46 EST //www.koonmotors.com/releases/2021/12/211208161146.htm //www.koonmotors.com/releases/2021/11/211130174008.htm A phase 3 clinical trial tested the safety and efficacy of teriflunomide, an oral immunomodulatory drug, in children with multiple sclerosis. Although the medication did not prevent disease relapses to a greater extent than placebo, the option for some patients to switch from placebo to teriflunomide before the end of the trial likely biased the results against treatment efficacy. The drug appeared to reduce the number of new or enlarged lesions that are detected through MRI. Tue, 30 Nov 2021 17:40:08 EST //www.koonmotors.com/releases/2021/11/211130174008.htm //www.koonmotors.com/releases/2021/11/211105150501.htm Researchers found that glatiramer acetate, a prescription drug currently used to treat patients with multiple sclerosis, improved memory in a mouse model of Alzheimer's disease. Fri, 05 Nov 2021 15:05:01 EDT //www.koonmotors.com/releases/2021/11/211105150501.htm //www.koonmotors.com/releases/2021/11/211104140127.htm 研究人员致力于确定振动training -- an intervention used to improve physical function for people with multiple sclerosis -- could also improve patients' cognitive function and quality of life. Thu, 04 Nov 2021 14:01:27 EDT //www.koonmotors.com/releases/2021/11/211104140127.htm //www.koonmotors.com/releases/2021/10/211018183349.htm A clinical trial has found that treatment with the immunomodulator interferon beta-1a plus the antiviral remdesivir was not superior to treatment with remdesivir alone in hospitalized adults with COVID-19 pneumonia. In addition, in a subgroup of patients who required high-flow oxygen, investigators found that interferon beta-1a was associated with more adverse events and worse outcomes. Mon, 18 Oct 2021 18:33:49 EDT //www.koonmotors.com/releases/2021/10/211018183349.htm //www.koonmotors.com/releases/2021/09/210930082358.htm Reactive electrophilic drugs like Tecfidera, approved for the treatment of relapsing multiple sclerosis, show a lot of potential but are also mystery. Scientists have now used an innovative chemical method to uncover the biological mechanisms of Tecfidera, providing a powerful tool for exploring other reactive electrophilic drugs. Thu, 30 Sep 2021 08:23:58 EDT //www.koonmotors.com/releases/2021/09/210930082358.htm //www.koonmotors.com/releases/2021/09/210922181518.htm A surprising discovery may offer a promising new direction in the study of multiple sclerosis and other diseases of hypomyelination -- when axons of neurons are not covered sufficiently in fatty sheaths (myelin), which disrupts communication between nerve cells. Wed, 22 Sep 2021 18:15:18 EDT //www.koonmotors.com/releases/2021/09/210922181518.htm //www.koonmotors.com/releases/2021/09/210909141304.htm An immunological molecule called fractalkine can boost the production of brain cells that produce myelin, a key factor in diseases such as multiple sclerosis, according to recent research. Thu, 09 Sep 2021 14:13:04 EDT //www.koonmotors.com/releases/2021/09/210909141304.htm //www.koonmotors.com/releases/2021/08/210819195038.htm Experts in MS research suggest that cognitive rehabilitation is an effective approach to improving MS-related cognitive impairment. Thu, 19 Aug 2021 19:50:38 EDT //www.koonmotors.com/releases/2021/08/210819195038.htm //www.koonmotors.com/releases/2021/08/210812092728.htm Researchers have for the first time demonstrated it's possible to use a synthetic thyroid hormone to regulate a gene implicated in neurodegenerative diseases like Alzheimer's, Parkinson's and multiple sclerosis. Thu, 12 Aug 2021 09:27:28 EDT //www.koonmotors.com/releases/2021/08/210812092728.htm //www.koonmotors.com/releases/2021/07/210713110811.htm A new study shows that a diet rich in isoflavone, a phytoestrogen or plant-based compound that resembles estrogen, protects against multiple sclerosis-like symptoms in a mouse model of the disease. Importantly, the isoflavone diet was only protective when the mice had gut microbes capable of breaking down the isoflavones. Tue, 13 Jul 2021 11:08:11 EDT //www.koonmotors.com/releases/2021/07/210713110811.htm //www.koonmotors.com/releases/2021/06/210616143159.htm 研究人员发现炎症molec的增加ules in serum and cerebrospinal fluid of C90RF72 patients, informing future anti-inflammatory therapies. Wed, 16 Jun 2021 14:31:59 EDT //www.koonmotors.com/releases/2021/06/210616143159.htm //www.koonmotors.com/releases/2021/06/210607084633.htm A new study has identified a molecule called ten-eleven-translocation 1 (TET1) as a necessary component in the repair of myelin, which protects nerves and facilitates accurate transmission of electrical signals. The discovery could have important implications in treating neurodegenerative diseases and for molecular rejuvenation of aging brains in healthy individuals. Mon, 07 Jun 2021 08:46:33 EDT //www.koonmotors.com/releases/2021/06/210607084633.htm //www.koonmotors.com/releases/2021/06/210603171058.htm Researchers have discovered that the immune cells that protect the brain and spinal cord come primarily from the skull. The finding opens up the possibility of developing therapies to target such cells as a way to prevent or treat brain conditions. Thu, 03 Jun 2021 17:10:58 EDT //www.koonmotors.com/releases/2021/06/210603171058.htm