//www.koonmotors.com/news/health_medicine/multiple_myeloma/ Read the latest news and information about multiple myeloma and related conditions, including potential symptoms, causes and treatments of the disease. en-us Wed, 06 Sep 2023 14:45:34 EDT Wed, 06 Sep 2023 14:45:34 EDT 60 //www.koonmotors.com/images/scidaily-logo-rss.png//www.koonmotors.com/news/health_medicine/multiple_myeloma/ For more science news, visit ScienceDaily. //www.koonmotors.com/releases/2023/01/230126124425.htm Chemists designed a bottlebrush-shaped nanoparticle that can be loaded with multiple drugs, in ratios that can be easily controlled. Using these particles, the researchers calculated and delivered the optimal ratio of three cancer drugs used to treat multiple myeloma. Thu, 26 Jan 2023 12:44:25 EST //www.koonmotors.com/releases/2023/01/230126124425.htm //www.koonmotors.com/releases/2022/12/221222123117.htm Researchers have demonstrated that people suffering from blood cancer have a good immune response to COVID-19 vaccinations. Vaccination protects patients with B-cell lymphoma and multiple myeloma against severe illness from COVID-19. Some patients even form highly potent antibodies. Thu, 22 Dec 2022 12:31:17 EST //www.koonmotors.com/releases/2022/12/221222123117.htm //www.koonmotors.com/releases/2022/12/221220113003.htm In our bones, specialized cells called osteoblasts are responsible for building up bone substance. A team of researchers has now identified an enzyme that controls the activity of osteoblasts. An agent that inhibits the activity of this enzyme reduced cancer-related bone loss and the number of bone metastases in multiple myeloma and in lung and breast cancer models in mice. Tue, 20 Dec 2022 11:30:03 EST //www.koonmotors.com/releases/2022/12/221220113003.htm //www.koonmotors.com/releases/2022/12/221211082744.htm A new therapy that makes the immune system kill bone marrow cancer cells was successful in as many as 73 percent of patients in two clinical trials. Sun, 11 Dec 2022 08:27:44 EST //www.koonmotors.com/releases/2022/12/221211082744.htm //www.koonmotors.com/releases/2022/11/221104100247.htm Researchers have identified therapies that can help patients with the blood cancer multiple myeloma who try an immunotherapy known as CAR-T only to find their cancer coming back afterwards. Fri, 04 Nov 2022 10:02:47 EDT //www.koonmotors.com/releases/2022/11/221104100247.htm //www.koonmotors.com/releases/2022/09/220906102025.htm New CT technology paired with artificial intelligence (AI)-based noise reduction offers superior detection of bone disease associated with multiple myeloma at lower radiation doses than conventional CT, according to a new study. Tue, 06 Sep 2022 10:20:25 EDT //www.koonmotors.com/releases/2022/09/220906102025.htm //www.koonmotors.com/releases/2022/09/220901135951.htm Researchers have published results that show encouraging therapeutic options for patients with the blood cancer multiple myeloma after first-line treatment with bispecific antibodies fails. Bispecific antibodies are a type of antibody that can bind to two different antigens at the same time -- they are meant to enhance the immune system's destruction of tumor cells. Thu, 01 Sep 2022 13:59:51 EDT //www.koonmotors.com/releases/2022/09/220901135951.htm //www.koonmotors.com/releases/2022/06/220605130404.htm Patients with multiple myeloma who have been treated with a three-drug combination therapy have a growing number of choices for subsequent treatment. Results of a new study can help patients and their physicians weigh benefits and risks of each option. Sun, 05 Jun 2022 13:04:04 EDT //www.koonmotors.com/releases/2022/06/220605130404.htm //www.koonmotors.com/releases/2022/05/220519081112.htm A test for the common blood cancer multiple myeloma also holds clear clues that the patient has one of the most uncommon and deadly forms of this cancer, investigators say. Thu, 19 May 2022 08:11:12 EDT //www.koonmotors.com/releases/2022/05/220519081112.htm //www.koonmotors.com/releases/2022/04/220407101045.htm 在大多数multip发现染色体异常le myeloma (MM) patients. While myeloma patients have generally benefited from the advancement of treatment modalities over the years, the treatment outcome for patients having two or more high-risk prognostic events remains poor. In a novel step forward, a research team has embarked on a study which aims to address the unmet clinical need in this group of patients. Thu, 07 Apr 2022 10:10:45 EDT //www.koonmotors.com/releases/2022/04/220407101045.htm //www.koonmotors.com/releases/2022/04/220406132351.htm Most immunocompromised people with a blood cancer called multiple myeloma benefited from a third dose of COVID-19 vaccines, a promising sign after it was shown that two doses tended to not be sufficient for them. However, some people with multiple myeloma still remained vulnerable and may need a fourth dose or antibody treatments as restrictions lift and new variants emerge, according to a new study. Wed, 06 Apr 2022 13:23:51 EDT //www.koonmotors.com/releases/2022/04/220406132351.htm //www.koonmotors.com/releases/2022/03/220301131117.htm Multiple myeloma, the most common type of bone marrow cancer in Germany, almost always returns, even after initial treatment success. In the majority of cases, the reasons behind this treatment resistance (e.g., genetic mutations) and the subsequent return of the disease, remain unknown. According to new research, it is the increased production of a specific protein which diminishes the cancer's sensitivity to treatment. Tue, 01 Mar 2022 13:11:17 EST //www.koonmotors.com/releases/2022/03/220301131117.htm //www.koonmotors.com/releases/2022/01/220112105637.htm Multiple myeloma is a cancer of the bone marrow, with a life expectancy of less than 5 years post-diagnosis. Proteasome inhibitors, the therapeutic backbone of current treatments, are very effective in treating newly diagnosed cancers but resistance or intolerance to these molecules inevitably develop, leading to relapses. While studying a neglected tropical disease , Buruli ulcer, researchers discovered a novel therapeutic target for multiple myeloma that could allow to bypass this resistance. Wed, 12 Jan 2022 10:56:37 EST //www.koonmotors.com/releases/2022/01/220112105637.htm //www.koonmotors.com/releases/2021/10/211012102700.htm A researcher has discovered an enzyme that plays a key role in the ability of cancer cells to resist drug treatment. Tue, 12 Oct 2021 10:27:00 EDT //www.koonmotors.com/releases/2021/10/211012102700.htm //www.koonmotors.com/releases/2021/06/210625173204.htm Researchers are studying a potential new chimeric antigen receptor-T cell therapy (CAR-T cell therapy) treatment for multiple myeloma. Fri, 25 Jun 2021 17:32:04 EDT //www.koonmotors.com/releases/2021/06/210625173204.htm //www.koonmotors.com/releases/2021/05/210517102627.htm An international team of researchers has analyzed the function of the histone demethylase KDM5A in multiple myeloma, one of the three major hematological cancers, and clarified the mechanism by which it promotes myeloma cell proliferation. They also developed a novel KDM5 inhibitor and showed that it inhibits cancer cell growth in a myeloma mouse model. The researchers expect that new therapies targeting KDM5A will be developed in the future. Mon, 17 May 2021 10:26:27 EDT //www.koonmotors.com/releases/2021/05/210517102627.htm //www.koonmotors.com/releases/2021/04/210411114056.htm A personalized cancer vaccine raised no safety concerns and showed potential benefit in patients with different cancers, including lung and bladder, that have a high risk of recurrence, according to results from an investigator-initiated phase I clinical trial. Sun, 11 Apr 2021 11:40:56 EDT //www.koonmotors.com/releases/2021/04/210411114056.htm //www.koonmotors.com/releases/2021/03/210308111949.htm 一种新型的汽车超过三元组t细胞疗法the expected length of remission for multiple myeloma patients who have relapsed several times, according to an international clinical trial. Mon, 08 Mar 2021 11:19:49 EST //www.koonmotors.com/releases/2021/03/210308111949.htm //www.koonmotors.com/releases/2021/02/210201144922.htm Restoring an enzyme that maintains the way chromosomes are packed inside cells may lead to new therapies for some blood cancers, according to a new study. Mon, 01 Feb 2021 14:49:22 EST //www.koonmotors.com/releases/2021/02/210201144922.htm //www.koonmotors.com/releases/2021/01/210120122453.htm A new study supports launch of Phase I clinical trial to test a designer DNA agent -- an antisense oligonucleotide that targets a gene called IRF4 -- in patients with multiple myeloma. Wed, 20 Jan 2021 12:24:53 EST //www.koonmotors.com/releases/2021/01/210120122453.htm //www.koonmotors.com/releases/2020/12/201205143408.htm A subcutaneous injection of the immune-boosting drug teclistamab was found to be safe and elicit responses in a majority of patients with relapsed or refractory multiple myeloma. Sat, 05 Dec 2020 14:34:08 EST //www.koonmotors.com/releases/2020/12/201205143408.htm //www.koonmotors.com/releases/2020/04/200403124931.htm A case study of a patient in Wuhan, China, suggests that the immunosuppressant tocilizumab may be an effective COVID-19 treatment for very ill patients who also have multiple myeloma and other blood cancers. The report also suggests that blood cancer patients may have atypical COVID-19 symptoms. Fri, 03 Apr 2020 12:49:31 EDT //www.koonmotors.com/releases/2020/04/200403124931.htm //www.koonmotors.com/releases/2020/03/200319103221.htm A revolutionary new technology has been applied to reveal the inner workings of individual cancer cells - potentially identifying more effective treatment combinations for people with cancer. Thu, 19 Mar 2020 10:32:21 EDT //www.koonmotors.com/releases/2020/03/200319103221.htm //www.koonmotors.com/releases/2019/10/191028104212.htm The largest randomized trial in asymptomatic patients with smoldering multiple myeloma suggests that lenalidomide, a cancer drug, may delay the onset of bone and other myeloma-related organ damage. Mon, 28 Oct 2019 10:42:12 EDT //www.koonmotors.com/releases/2019/10/191028104212.htm //www.koonmotors.com/releases/2019/08/190821173707.htm Researchers have found a new type of therapy to be effective for patients with a particular type of bone marrow cancer that is resistant to several standard therapies. Wed, 21 Aug 2019 17:37:07 EDT //www.koonmotors.com/releases/2019/08/190821173707.htm //www.koonmotors.com/releases/2019/06/190613104536.htm More than half of patients with relapsed multiple myeloma treated with carfilzomib experienced cardiac issues during treatment, according to a multi-institutional study. The study recommends that patients undergo a detailed cardiovascular history before being prescribed carfilzomib and then be monitored with natriuretic peptide testing, an indicator for heart failure. Thu, 13 Jun 2019 10:45:36 EDT //www.koonmotors.com/releases/2019/06/190613104536.htm //www.koonmotors.com/releases/2019/04/190425160843.htm Researchers have identified what keeps some cancer cells dormant -- a finding which could uncover new approaches to preventing the spread of cancer. Thu, 25 Apr 2019 16:08:43 EDT //www.koonmotors.com/releases/2019/04/190425160843.htm //www.koonmotors.com/releases/2019/04/190423133659.htm In multiple myeloma, Ig lambda translocations may indicate poor outcomes and resistance to immunomodulatory drugs such as lenalidomide. Tue, 23 Apr 2019 13:36:59 EDT //www.koonmotors.com/releases/2019/04/190423133659.htm //www.koonmotors.com/releases/2019/04/190408113957.htm When our plasma cells start producing a single cancer-causing protein rather than an array of antibody-like proteins to protect us, it's one of two arms of the Y-shaped protein that's likely to blame. Mon, 08 Apr 2019 11:39:57 EDT //www.koonmotors.com/releases/2019/04/190408113957.htm //www.koonmotors.com/releases/2019/03/190313080439.htm Our bodies are continuously concocting specific antibodies to thwart invaders like a virus or even pollen, and scientists have new information about how the essential production gets fired up and keeps up. Wed, 13 Mar 2019 08:04:39 EDT //www.koonmotors.com/releases/2019/03/190313080439.htm //www.koonmotors.com/releases/2018/12/181215141345.htm Hope has emerged for patients with a serious type of bone marrow cancer as new research into a therapeutic drug has revealed improved outcomes and survival rates. Sat, 15 Dec 2018 14:13:45 EST //www.koonmotors.com/releases/2018/12/181215141345.htm //www.koonmotors.com/releases/2018/12/181206114815.htm Israeli scientists and physicians develop a new technology for profiling the unique genetic makeup of myeloma tumor cells that will allow better diagnosis and treatment. Thu, 06 Dec 2018 11:48:15 EST //www.koonmotors.com/releases/2018/12/181206114815.htm //www.koonmotors.com/releases/2018/11/181101133950.htm 研究人员发现了一种联系RNA abnormalities and multiple myeloma progression. The findings offer novel insights for new, effective therapeutic strategies to be developed. Thu, 01 Nov 2018 13:39:50 EDT //www.koonmotors.com/releases/2018/11/181101133950.htm //www.koonmotors.com/releases/2018/08/180814101412.htm A pioneering study into myeloma, a rare cancer, could lead to GPs using simple blood tests to improve early diagnosis. Tue, 14 Aug 2018 10:14:12 EDT //www.koonmotors.com/releases/2018/08/180814101412.htm //www.koonmotors.com/releases/2018/07/180713093520.htm When it comes to diagnosing a condition in which the plasma cells that normally make antibodies to protect us instead become cancerous, it may be better to look at the urine as well as the serum of our blood for answers, pathologists say. Fri, 13 Jul 2018 09:35:20 EDT //www.koonmotors.com/releases/2018/07/180713093520.htm //www.koonmotors.com/releases/2018/07/180709161543.htm Through x-ray crystallography and kinase-inhibitor specificity profiling, researchers reveal that curcumin, a natural occurring chemical compound found in the spice turmeric, binds to the kinase enzyme dual-specificity tyrosine-regulated kinase 2 (DYRK2) at the atomic level. This previously unreported biochemical interaction of curcumin leads to inhibition of DYRK2 that impairs cell proliferation and reduces cancer burden. Mon, 09 Jul 2018 16:15:43 EDT //www.koonmotors.com/releases/2018/07/180709161543.htm //www.koonmotors.com/releases/2018/04/180426141507.htm A new study reports that New York City firefighters exposed to the 9/11 World Trade Center disaster site face an increased risk for developing myeloma precursor disease (MGUS), which can lead to the blood cancer multiple myeloma. Thu, 26 Apr 2018 14:15:07 EDT //www.koonmotors.com/releases/2018/04/180426141507.htm //www.koonmotors.com/releases/2018/04/180419141538.htm A new research effort has resulted in a low-cost, reliable blood test that uses a small plastic chip about the size of a credit card that can deliver the same diagnostic information as a bone biopsy -- but using a simple blood draw instead. 星期四,2018年4月19日14:15:38 EDT //www.koonmotors.com/releases/2018/04/180419141538.htm //www.koonmotors.com/releases/2018/02/180201142859.htm Researchers have identified two gene regions that contribute to multiple myeloma, an inherited cancer that occurs in bone marrow, through a new method that makes use of human disease pedigrees. Thu, 01 Feb 2018 14:28:59 EST //www.koonmotors.com/releases/2018/02/180201142859.htm //www.koonmotors.com/releases/2018/01/180129145742.htm A new anti-cancer strategy wields light as a precision weapon. Unlike traditional light therapy -- which is limited to the skin and areas accessible with an endoscope -- this technique can target and attack cancer cells that have spread deep inside the body. Mon, 29 Jan 2018 14:57:42 EST //www.koonmotors.com/releases/2018/01/180129145742.htm //www.koonmotors.com/releases/2018/01/180118084552.htm Patients with monoclonal gammopathy of undetermined significance are at risk of progressing to multiple myeloma or a related cancer even after 30 years of stability. Thu, 18 Jan 2018 08:45:52 EST //www.koonmotors.com/releases/2018/01/180118084552.htm //www.koonmotors.com/releases/2017/12/171228132029.htm The proteasome inhibitor carfilzomib has taken on an increasing role in the treatment of multiple myeloma, but new research shows the therapy comes with the risk of cardiovascular problems in a higher than expected percentage of patients. Thu, 28 Dec 2017 13:20:29 EST //www.koonmotors.com/releases/2017/12/171228132029.htm //www.koonmotors.com/releases/2017/12/171214101215.htm An international team has discovered the world's oldest known cases of breast cancer and multiple myeloma (a type of bone marrow cancer). The discoveries were made by conducting CT scans of two mummies found in the pharaonic necropolis of Qubbet el-Hawa in Aswan, Egypt. Thu, 14 Dec 2017 10:12:15 EST //www.koonmotors.com/releases/2017/12/171214101215.htm //www.koonmotors.com/releases/2017/12/171205144814.htm Using a database of multiple myeloma patient samples and information, researchers found that high ADAR1 levels correlate with reduced survival rates. They also determined that blocking the enzyme reduces multiple myeloma regeneration in experimental models derived from patient cancer cells. 星期二,2017年12月05 14:48:14 EST //www.koonmotors.com/releases/2017/12/171205144814.htm //www.koonmotors.com/releases/2017/11/171122151032.htm 尽管非裔美国人的三倍ikely to be diagnosed with a blood cancer called multiple myeloma, most scientific research on the disease has been based on people of European descent. That trend is problematic considering that African-Americans -- the most at-risk population for multiple myeloma -- have different genetics that can affect how this type of cancer progresses and what kind of targeted therapies are most effective. Wed, 22 Nov 2017 15:10:32 EST //www.koonmotors.com/releases/2017/11/171122151032.htm //www.koonmotors.com/releases/2017/11/171120085434.htm Researchers can use a new type of measurement to predict how drugs will affect cancer cells taken from multiple myeloma patients. Their predictions correlated with how those patients actually fared when treated with those drugs. Mon, 20 Nov 2017 08:54:34 EST //www.koonmotors.com/releases/2017/11/171120085434.htm //www.koonmotors.com/releases/2017/08/170810105002.htm 这是癌症的浆细胞,正常make an array of antibodies that protect us from infection. With multiple myeloma, the cells start primarily producing instead a singular product, called a monoclonal antibody that leaves patients vulnerable for serious infections, like pneumonia, and can even eat away at their bones. Sophisticated lab tests used to both diagnose the disease then follow treatment response, can send confusing messages to patients and their physicians. A new study is highlighting reasons for potential confusion. Thu, 10 Aug 2017 10:50:02 EDT //www.koonmotors.com/releases/2017/08/170810105002.htm //www.koonmotors.com/releases/2017/06/170629101650.htm A new type of therapeutic could greatly reduce bone disease in patients with the bone cancer, multiple myeloma. Multiple myeloma is a cancer that develops in bone, causing progressive bone destruction, bone fractures, and often devastating pain. Unlike existing treatments, this new approach rebuilds bone tissue, making it more resistant to fractures. This treatment could greatly reduce the debilitating pain of bone damage, transforming the prognosis for myeloma patients. Thu, 29 Jun 2017 10:16:50 EDT //www.koonmotors.com/releases/2017/06/170629101650.htm //www.koonmotors.com/releases/2017/06/170605110056.htm In an early clinical trial, 33 out of 35 (94 percent) patients had clinical remission of multiple myeloma upon receiving a new type of immunotherapy -- chimeric antigen receptor (CAR) T cells targeting B-cell maturation protein or BCMA. Most patients had only mild side effects. Mon, 05 Jun 2017 11:00:56 EDT //www.koonmotors.com/releases/2017/06/170605110056.htm //www.koonmotors.com/releases/2017/03/170308114625.htm An experimental drug, LCL161, stimulates the immune system, leading to tumor shrinkage in patients affected by multiple myeloma, report scientists. Wed, 08 Mar 2017 11:46:25 EST //www.koonmotors.com/releases/2017/03/170308114625.htm //www.koonmotors.com/releases/2017/02/170221161529.htm Treating multiple myeloma (MM) with myxoma virus (MYXV) eliminated a majority of malignant cells in preclinical studies, report investigators. Furthermore, introduction of MYXV had no impact on the bone marrow compartment and elicited a strong immune response that eradicated disease in some animals. Tue, 21 Feb 2017 16:15:29 EST //www.koonmotors.com/releases/2017/02/170221161529.htm //www.koonmotors.com/releases/2017/02/170206130350.htm A team of engineers say a compound found in green tea could have lifesaving potential for patients with multiple myeloma and amyloidosis, who face often-fatal medical complications associated with bone-marrow disorders. Mon, 06 Feb 2017 13:03:50 EST //www.koonmotors.com/releases/2017/02/170206130350.htm //www.koonmotors.com/releases/2017/01/170112110836.htm In a new study, researchers in Sweden show how the protein EZH2 affects the development of multiple myeloma, and that inhibition of EZH2 could be used as a new strategy to treat the disease. The tumor form multiple myeloma is today incurable and it has been challenging to improve therapy. Thu, 12 Jan 2017 11:08:36 EST //www.koonmotors.com/releases/2017/01/170112110836.htm //www.koonmotors.com/releases/2016/12/161209144721.htm 20 to 40 percent of the patients with multiple myeloma -- a type of leukemia -- have a defect in the ribosome, the protein factory of the cell. These patients have a poorer prognosis than patients with intact ribosomes. At the same time, they respond better to a drug that already exists, report investigators. Fri, 09 Dec 2016 14:47:21 EST //www.koonmotors.com/releases/2016/12/161209144721.htm //www.koonmotors.com/releases/2016/11/161118130235.htm Carrying extra weight increases a person's risk that a benign blood disorder will develop into multiple myeloma, a blood cancer. This is particularly true for older, African-American men, say researchers. Fri, 18 Nov 2016 13:02:35 EST //www.koonmotors.com/releases/2016/11/161118130235.htm //www.koonmotors.com/releases/2016/10/161026165835.htm People diagnosed with multiple myeloma are more likely to live longer if they are treated at a medical center that sees many patients with this blood cancer, researchers conclude. Wed, 26 Oct 2016 16:58:35 EDT //www.koonmotors.com/releases/2016/10/161026165835.htm //www.koonmotors.com/releases/2016/10/161012132041.htm To develop new approaches to cancer prevention, scientists have attempted to grow tumor cells from precursor states in animal models. Wed, 12 Oct 2016 13:20:41 EDT //www.koonmotors.com/releases/2016/10/161012132041.htm //www.koonmotors.com/releases/2016/10/161005151023.htm Findings by cancer researchers shed light on why treated cancers recur. The discovery could provide the key for reducing recurrence, and allow anti-cancer drugs to do their intended work. Wed, 05 Oct 2016 15:10:23 EDT //www.koonmotors.com/releases/2016/10/161005151023.htm //www.koonmotors.com/releases/2016/09/160919104426.htm A new study examines the assessment of minimal residual disease in patients newly treated for multiple myeloma as a factor in survival outcomes. Mon, 19 Sep 2016 10:44:26 EDT //www.koonmotors.com/releases/2016/09/160919104426.htm //www.koonmotors.com/releases/2016/08/160822083402.htm Advances in the treatment of multiple myeloma, a cancer that forms in a type of white blood cell, have led to improved survival predominantly among young and white patients, with less of an increase in survival observed in patients of other ethnicities. A new study indicates that this gap is mostly due to socioeconomic differences between whites and ethnic minorities, not race itself. Mon, 22 Aug 2016 08:34:02 EDT //www.koonmotors.com/releases/2016/08/160822083402.htm