https: //www.koonmotors.com/news/health_medicine/lupus/ Lupus News. Read the latest research on lupus and related autoimmune diseases, including new experimental treatments. en-us Mon, 16 Oct 2023 11:46:38 EDT Mon, 16 Oct 2023 11:46:38 EDT 60 https: //www.koonmotors.com/images/scidaily-logo-rss.pnghttps: //www.koonmotors.com/news/health_medicine/lupus/ 更多的科学新闻,科学日报的访问。 https: //www.koonmotors.com/releases/2023/06/230627225150.htm Recurrent bouts of systemic lupus erythematosus, marked by the body's immune system attack of its own tissues, closely tracked with measureable upticks in growth in the gut of a certain species of bacteria. Tue, 27 Jun 2023 22:51:50 EDT https: //www.koonmotors.com/releases/2023/06/230627225150.htm https: //www.koonmotors.com/releases/2023/03/230308112118.htm Scientists have made an important breakthrough in understanding what goes wrong in our bodies during the progression of inflammatory diseases and -- in doing so -- unearthed a potential new therapeutic target. The scientists have found that an enzyme called fumarate hydratase is repressed in macrophages, a frontline inflammatory cell type implicated in a range of diseases including lupus, arthritis, sepsis and COVID-19. Wed, 08 Mar 2023 11:21:18 EST https: //www.koonmotors.com/releases/2023/03/230308112118.htm https: //www.koonmotors.com/releases/2023/02/230201195336.htm A pair of researchers reports the success of their new, at-home method for early diagnosis and monitoring of lupus nephritis. or inflammation of the kidneys, one of the most severe complications for patients with systemic lupus erythematosus, known as lupus. Wed, 01 Feb 2023 19:53:36 EST https: //www.koonmotors.com/releases/2023/02/230201195336.htm https: //www.koonmotors.com/releases/2023/01/230126100201.htm Scientists have discovered the role of microRNA on inflammation in lupus disease. They identified the microRNAs that are downregulated in the disease and how they converge to cause the disease. Thu, 26 Jan 2023 10:02:01 EST https: //www.koonmotors.com/releases/2023/01/230126100201.htm https: //www.koonmotors.com/releases/2023/01/230113145351.htm Targeting iron metabolism in immune system cells may offer a new approach for treating systemic lupus erythematosus (SLE) -- the most common form of the chronic autoimmune disease lupus. A multidisciplinary team of investigators has discovered that blocking an iron uptake receptor reduces disease pathology and promotes the activity of anti-inflammatory regulatory T cells in a mouse model of SLE. Fri, 13 Jan 2023 14:53:51 EST https: //www.koonmotors.com/releases/2023/01/230113145351.htm https: //www.koonmotors.com/releases/2022/11/221123125121.htm Investigators have reported highly promising early results for CAR T therapy in a small set of patients with the autoimmune disease lupus. Wed, 23 Nov 2022 12:51:21 EST https: //www.koonmotors.com/releases/2022/11/221123125121.htm https: //www.koonmotors.com/releases/2022/11/221103140801.htm 一些基因变异可能使人们在非盟的风险toimmune diseases while conferring protection against the outcome of viral infection. A new study suggests that genetic predisposition for systemic lupus erythematosus (SLE) may be protective against severe COVID-19 infection. Thu, 03 Nov 2022 14:08:01 EDT https: //www.koonmotors.com/releases/2022/11/221103140801.htm https: //www.koonmotors.com/releases/2022/09/220908112326.htm A team of engineers and doctors has designed a unique 3D-printed light-sensing medical device that could help millions of people worldwide with lupus and other light-sensitive diseases. Thu, 08 Sep 2022 11:23:26 EDT https: //www.koonmotors.com/releases/2022/09/220908112326.htm https: //www.koonmotors.com/releases/2022/08/220828150105.htm An international research team presents the outcome of a thorough epidemiological investigation into possible links between nineteen of the most common autoimmune disorders and cardiovascular disease. The results of the study show that patients with autoimmune disease have a substantially higher risk (between 1.4 and 3.6 times depending on which autoimmune condition) of developing cardiovascular disease than people without an autoimmune disorder. Sun, 28 Aug 2022 15:01:05 EDT https: //www.koonmotors.com/releases/2022/08/220828150105.htm https: //www.koonmotors.com/releases/2022/07/220714103012.htm A new study finds that technology through video game-based cognitive therapy improves attention and executive functioning in patients with systemic lupus erythematosus (SLE). Thu, 14 Jul 2022 10:30:12 EDT https: //www.koonmotors.com/releases/2022/07/220714103012.htm https: //www.koonmotors.com/releases/2022/07/220713152900.htm People with systemic lupus erythematosus, or SLE, who received a 'booster' dose of SARS-CoV-2 vaccine after full vaccination are roughly half as likely to have a subsequent 'breakthrough' COVID-19 infection, a new study shows. Wed, 13 Jul 2022 15:29:00 EDT https: //www.koonmotors.com/releases/2022/07/220713152900.htm https: //www.koonmotors.com/releases/2022/07/220711111834.htm A novel molecular pathway involving cell signalling proteins in the brain may explain how stress affects neuropsychiatric lupus with diffuse neuropsychological manifestations. Mon, 11 Jul 2022 11:18:34 EDT https: //www.koonmotors.com/releases/2022/07/220711111834.htm https: //www.koonmotors.com/releases/2022/06/220602121433.htm A national expert in systemic lupus erythematosus, or lupus, has identified biomarkers for heart disease and for children with lupus nephritis. Thu, 02 Jun 2022 12:14:33 EDT https: //www.koonmotors.com/releases/2022/06/220602121433.htm https: //www.koonmotors.com/releases/2022/05/220503083003.htm A new study finds that the normal-appearing skin of lupus patients contains the same inflammatory signals that are detected when the skin develops a rash, sometimes at even higher levels. Researchers say immune cells undergo an inflammatory transformation that primes the skin without rashes for disease flares. Tue, 03 May 2022 08:30:03 EDT https: //www.koonmotors.com/releases/2022/05/220503083003.htm https: //www.koonmotors.com/releases/2022/04/220427115727.htm An international team of researchers has identified DNA mutations in a gene that senses viral RNA, as a cause of the autoimmune disease lupus, with the finding paving the way for the development of new treatments. Wed, 27 Apr 2022 11:57:27 EDT https: //www.koonmotors.com/releases/2022/04/220427115727.htm https: //www.koonmotors.com/releases/2022/03/220322111239.htm Antiphospholipid syndrome (APS) is rare in children and known to cause inflammation and recurring, potentially fatal, blood clots. Researchers found that two-thirds of children with the autoimmune disease experienced additional symptoms not formally associated with APS, including low platelet counts, hemolytic anemia and livedo reticularis, a rash indicating abnormal blood flow to the skin. Investigators say the findings underscore the importance of creating pediatric-specific criteria for the diagnosis of APS. Tue, 22 Mar 2022 11:12:39 EDT https: //www.koonmotors.com/releases/2022/03/220322111239.htm https: //www.koonmotors.com/releases/2022/02/220209155008.htm An expert in autoimmune diseases and systemic lupus erythematosus has identified potential biomarkers for neuropsychiatric symptoms of lupus after conducting a large-scale protein study. Wed, 09 Feb 2022 15:50:08 EST https: //www.koonmotors.com/releases/2022/02/220209155008.htm https: //www.koonmotors.com/releases/2021/12/211208094926.htm Lupus, an autoimmune disease, and macular degeneration, a leading cause of vision loss, share a common contributor to harmful inflammation, researchers found. Wed, 08 Dec 2021 09:49:26 EST https: //www.koonmotors.com/releases/2021/12/211208094926.htm https: //www.koonmotors.com/releases/2021/10/211015133229.htm Researchers can find signs of whether a person is on the way to developing the disease Lupus -- or is already ill. The revolutionary technique can be an important tool for diagnosing more autoimmune diseases. Fri, 15 Oct 2021 13:32:29 EDT https: //www.koonmotors.com/releases/2021/10/211015133229.htm https: //www.koonmotors.com/releases/2021/09/210927132044.htm Complex autoimmune diseases affecting various organ systems remain one of the greatest medical challenges in spite of immense advances in treatment. In particular, the diffuse symptoms at the early stage of complex autoimmune diseases make it hard to diagnose the condition early on, which in turn delays treatment. A team of researchers has now demonstrated that treatment can be extremely effective if autoimmune diseases are treated as early as possible, even before the first clinical symptoms appear. Mon, 27 Sep 2021 13:20:44 EDT https: //www.koonmotors.com/releases/2021/09/210927132044.htm https: //www.koonmotors.com/releases/2021/09/210917161206.htm Researchers attempted to unravel such mechanisms by adopting non-invasive diffusion magnetic resonance imaging (MRI) to study the brains of SLE patients, particularly the white matter, coupled with computerized neuropsychological assessment. White matter lies beneath the grey matter cortex in the human brain and comprises millions of bundles of nerve fibers that transmit signals to different brain regions. Fri, 17 Sep 2021 16:12:06 EDT https: //www.koonmotors.com/releases/2021/09/210917161206.htm https: //www.koonmotors.com/releases/2021/08/210816161346.htm 一个潜在生物标志物预测心脏的严重性disease in African American lupus patients was identified in a study conducted by a team of researchers. Mon, 16 Aug 2021 16:13:46 EDT https: //www.koonmotors.com/releases/2021/08/210816161346.htm https: //www.koonmotors.com/releases/2021/08/210812135922.htm The autoimmune disease lupus may be triggered by a defective process in the development of red blood cells (RBCs), according to a new study. The discovery could lead to new methods for classifying and treating patients with this disease. Thu, 12 Aug 2021 13:59:22 EDT https: //www.koonmotors.com/releases/2021/08/210812135922.htm https: //www.koonmotors.com/releases/2021/02/210202113903.htm Autoimmune diseases, in which the body's own immune system attacks healthy tissue, can be life-threatening and can impact all organs. A research team has now found a possible cause for these self-destructive immune system attacks: a hyperactive RANK protein on the surface of B cells. The research opens the door to new therapeutic possibilities. Tue, 02 Feb 2021 11:39:03 EST https: //www.koonmotors.com/releases/2021/02/210202113903.htm https: //www.koonmotors.com/releases/2021/01/210121163132.htm A new collaborative study reveals unexpected insights into how skin exposure to ultraviolet light can worsen clinical symptoms in autoimmune diseases such as lupus. Thu, 21 Jan 2021 16:31:32 EST https: //www.koonmotors.com/releases/2021/01/210121163132.htm https: //www.koonmotors.com/releases/2021/01/210106133030.htm The main bioactive compound of ginger root lowers autoantibody production and helps halt disease progression in mice with antiphospholipid syndrome and lupus. Wed, 06 Jan 2021 13:30:30 EST https: //www.koonmotors.com/releases/2021/01/210106133030.htm https: //www.koonmotors.com/releases/2020/12/201203200603.htm A new study has shown that people with rare autoimmune rheumatic diseases are at a greater risk of dying at a younger age during the COVID-19 pandemic. Thu, 03 Dec 2020 20:06:03 EST https: //www.koonmotors.com/releases/2020/12/201203200603.htm https: //www.koonmotors.com/releases/2020/12/201203144217.htm A new study suggests that even low doses of glucocorticoid may increase the risk of cardiovascular diseases. Thu, 03 Dec 2020 14:42:17 EST https: //www.koonmotors.com/releases/2020/12/201203144217.htm https: //www.koonmotors.com/releases/2020/11/201106103103.htm A new study shows that patients with rheumatic diseases across Africa, Southeast Asia, the Americas and Europe had trouble filling their prescriptions of antimalarial drugs, including hydroxychloroquine, during the 2020 global coronavirus pandemic, when antimalarials were touted as a possible COVID-19 treatment. Patients who could not access their antimalarial drugs faced worse physical and mental health outcomes as a result. Fri, 06 Nov 2020 10:31:03 EST https: //www.koonmotors.com/releases/2020/11/201106103103.htm https: //www.koonmotors.com/releases/2020/11/201106095654.htm New research shows that use of hydroxychloroquine, a generic drug, does not cause any significant differences in QTc length or prolonged QTc, key measures of heart rate, in people with rheumatoid arthritis (RA) or systemic lupus erythematosus. Fri, 06 Nov 2020 09:56:54 EST https: //www.koonmotors.com/releases/2020/11/201106095654.htm https: //www.koonmotors.com/releases/2020/10/201009162428.htm In severe cases of COVID-19, activation patterns of B cells resemble those seen in systemic lupus erythematosus, an autoimmune disease. Emory researchers want to see how far that resemblance extends. Fri, 09 Oct 2020 16:24:28 EDT https: //www.koonmotors.com/releases/2020/10/201009162428.htm https: //www.koonmotors.com/releases/2020/09/200922102422.htm Researchers have successfully treated two patients with the autoimmune disease systemic lupus erythematosus. Using daratumumab, a monoclonal antibody which targets specific immune cells known as plasma cells, the researchers were able to modulate the abnormal immunological memory processes found in these patients. Treatment induced sustainable clinical responses and resulted in a reduction in systemic inflammation. Tue, 22 Sep 2020 10:24:22 EDT https: //www.koonmotors.com/releases/2020/09/200922102422.htm https: //www.koonmotors.com/releases/2020/08/200825110548.htm Most adults with systemic lupus erythematosus (SLE) are not at increased risk of hospitalization from COVID-19 due to medications used to dampen their altered immune system, the cause of their disease. Tue, 25 Aug 2020 11:05:48 EDT https: //www.koonmotors.com/releases/2020/08/200825110548.htm https: //www.koonmotors.com/releases/2020/08/200817124914.htm Researchers have added to the growing body of understanding about how hydroxychloroquine (HCQ) is not a possible defense against COVID-19. Mon, 17 Aug 2020 12:49:14 EDT https: //www.koonmotors.com/releases/2020/08/200817124914.htm https: //www.koonmotors.com/releases/2020/07/200702113705.htm Researchers have identified the epigenetic proteins Tet2 and Tet3 as key regulators of B cell function. They showed that these proteins suppress B cell function and conversely, that Tet2/Tet3 knockout mice develop a mild form of systemic lupus erythematosus due to hyperactivation of T cells. These findings could help develop a novel treatment for autoimmune diseases. Thu, 02 Jul 2020 11:37:05 EDT https: //www.koonmotors.com/releases/2020/07/200702113705.htm https: //www.koonmotors.com/releases/2020/06/200601072953.htm Researchers have developed a new method to measure levels of the medication hydroxychloroquine in patients with the rheumatic disease systemic lupus erythematosus (SLE). The analysis method may also be useful in other areas, such as in the treatment of COVID-19. Mon, 01 Jun 2020 07:29:53 EDT https: //www.koonmotors.com/releases/2020/06/200601072953.htm https: //www.koonmotors.com/releases/2020/05/200513121637.htm Scientists have identified a new key element of the multi-component machinery responsible for sorting out the nature and severity of the pathogen challenge. The new protein, named TASL, is indispensable for the signaling of so-called Toll-like receptors (TLR) in the endosomes leading to activation of the gene-activator IRF5 in certain immune cells. Wed, 13 May 2020 12:16:37 EDT https: //www.koonmotors.com/releases/2020/05/200513121637.htm https: //www.koonmotors.com/releases/2020/05/200511112602.htm Study offers molecular explanation for long-standing observation that certain diseases occur more often or more severely in different sexes. Complement component 4 (C4) genes protect against the autoimmune disorders lupus and Sjögren's syndrome while raising risk of severe schizophrenia. Mon, 11 May 2020 11:26:02 EDT https: //www.koonmotors.com/releases/2020/05/200511112602.htm https: //www.koonmotors.com/releases/2020/04/200408142738.htm A drug used for cancer therapy has shown promise in reversing kidney damage caused by systemic lupus erythematosus (SLE, or lupus), according to a Yale-led study published April 8 in the journal Science Translational Medicine. Wed, 08 Apr 2020 14:27:38 EDT https: //www.koonmotors.com/releases/2020/04/200408142738.htm https: //www.koonmotors.com/releases/2020/03/200324131823.htm Patients with autoimmune diseases often have an illness experience riddled with symptom ambiguities and shifting diagnoses. A new study found that one way patients and physicians can work through the difficulty and frustration of communicating about these conditions is to use both broad diagnostic terms, like 'autoimmune disease,' as well as narrow ones, such as 'lupus or MS.' Tue, 24 Mar 2020 13:18:23 EDT https: //www.koonmotors.com/releases/2020/03/200324131823.htm https: //www.koonmotors.com/releases/2020/02/200213135800.htm Breakthrough cellular genomics technology has allowed researchers to reveal genetic mutations causing rogue behavior in the cells that cause autoimmune disease. Thu, 13 Feb 2020 13:58:00 EST https: //www.koonmotors.com/releases/2020/02/200213135800.htm https: //www.koonmotors.com/releases/2019/12/191218173930.htm Researchers offer the first real hope for the treatment of lupus, a disease which affects 1.5 million people in the US and more than 5 million globally, 90% women and for which there is no cure. Wed, 18 Dec 2019 17:39:30 EST https: //www.koonmotors.com/releases/2019/12/191218173930.htm https: //www.koonmotors.com/releases/2019/12/191211171150.htm In the last decade, scientists discovered that blocking a key regulator of the immune system helped unleash the body's natural defenses against several forms of cancer, opening up a new era of cancer immunotherapy. Now scientists have essentially flipped this script and found that when impaired a molecularly similar regulator can cause the damaging immune system attacks on skin and organs that are the hallmark of the autoimmune disease lupus. Wed, 11 Dec 2019 17:11:50 EST https: //www.koonmotors.com/releases/2019/12/191211171150.htm https: //www.koonmotors.com/releases/2019/11/191120070706.htm A discovery about how the immune system responds to malaria infection could lead to better treatments for hepatitis C, HIV and lupus, say researchers. The research team showed, in laboratory models, that strong inflammatory signals caused by malaria infection activate molecules that trigger the production of highly potent antibodies to fight the disease. Wed, 20 Nov 2019 07:07:06 EST https: //www.koonmotors.com/releases/2019/11/191120070706.htm https: //www.koonmotors.com/releases/2019/09/190913153155.htm A preclinical study shows how the interplay of two interleukin signaling proteins, IL-6 and IL-2, affects the development of T follicular helper cells and germinal centers. This interplay may either maintain or disrupt the balancing act of the immune system between attacking infections and benign surveillance of the body's own cells. Thus, the research may help guide future disease treatment for autoimmune diseases like lupus. Fri, 13 Sep 2019 15:31:55 EDT https: //www.koonmotors.com/releases/2019/09/190913153155.htm https: //www.koonmotors.com/releases/2019/09/190913143044.htm A highly gender-biased disease, lupus afflicts females some nine times more than males. Because of the disease's unpredictable turns and debilitating flares -- the risks of which are elevated in postpartum women -- females with the disease are often advised to avoid pregnancy altogether. Fri, 13 Sep 2019 14:30:44 EDT https: //www.koonmotors.com/releases/2019/09/190913143044.htm https: //www.koonmotors.com/releases/2019/08/190812140348.htm 一项突破性的研究已经确定了一个特定的蚂蚁ibody target implicated in neuropsychiatric symptoms of lupus. These symptoms, including cognitive impairment, mood disorders, seizures, headaches and psychosis, are among the most prevalent manifestations of the disease and occur in as many as 80% of adults and 95% of children with lupus. Mon, 12 Aug 2019 14:03:48 EDT https: //www.koonmotors.com/releases/2019/08/190812140348.htm https: //www.koonmotors.com/releases/2019/08/190807190831.htm Biomedical engineers have discovered blood clotting proteins in the urine of patients with Lupus Nephritis which is the leading cause of death in lupus patients. The new biomarker discovery could lead to better clinical disease monitoring. Wed, 07 Aug 2019 19:08:31 EDT https: //www.koonmotors.com/releases/2019/08/190807190831.htm https: //www.koonmotors.com/releases/2019/07/190703121457.htm Scientists could discern that in people with SLE, signals driving expansion and activation are present at an earlier stage of B cell differentiation than previously appreciated. Wed, 03 Jul 2019 12:14:57 EDT https: //www.koonmotors.com/releases/2019/07/190703121457.htm https: //www.koonmotors.com/releases/2019/05/190529131219.htm BRCA dna修复蛋白分子相互作用complex that is also responsible for regulating the immune system. When certain players in this pathway go awry, autoimmune disorders arise. An international team has deciphered the structure of the complex and have found new molecular targets for fighting autoimmunity. Wed, 29 May 2019 13:12:19 EDT https: //www.koonmotors.com/releases/2019/05/190529131219.htm https: //www.koonmotors.com/releases/2019/05/190528193024.htm In autoimmune disorders, the body's defense system erroneously attacks normal cells, leading to serious health problems. Researchers have developed new molecules that potentially could be used to treat many of these conditions. Tue, 28 May 2019 19:30:24 EDT https: //www.koonmotors.com/releases/2019/05/190528193024.htm https: //www.koonmotors.com/releases/2019/04/190419103713.htm New evidence points to a key role for a molecular switch called VGLL3 in autoimmune diseases, and the major gap in incidence between women and men. Building on past research showing that women have more VGLL3 in their skin cells than men, a team studied it further in mice. They show that having too much VGLL3 in skin cells pushes the immune system into overdrive, leading to an autoimmune response and symptoms similar to lupus. Fri, 19 Apr 2019 10:37:13 EDT https: //www.koonmotors.com/releases/2019/04/190419103713.htm https: //www.koonmotors.com/releases/2019/04/190408161701.htm Women who have healthy pregnancies tend to show distinct changes in the activities of immune genes starting early in pregnancy, while women who have complicated pregnancies tend to show clear departures from that pattern, according to a new study. Mon, 08 Apr 2019 16:17:01 EDT https: //www.koonmotors.com/releases/2019/04/190408161701.htm https: //www.koonmotors.com/releases/2019/03/190325163016.htm Patients with lupus are at increased risk of heart disease. Exposing endothelial cells -- known to protect against heart disease, in part by producing nitric oxide -- to the serum of patients with lupus decreased nitric oxide production. Administering L-sepiapterin restored that production. Mon, 25 Mar 2019 16:30:16 EDT https: //www.koonmotors.com/releases/2019/03/190325163016.htm https: //www.koonmotors.com/releases/2019/02/190226112246.htm Examining the autoimmune disease at the molecular level led researchers to a specific molecule that could be contributing to the disease progression in patients. Tue, 26 Feb 2019 11:22:46 EST https: //www.koonmotors.com/releases/2019/02/190226112246.htm https: //www.koonmotors.com/releases/2019/02/190219080742.htm The disease systemic lupus erythematosus (SLE) -- marked by the attack on joints, skin, and kidneys by the body's immune system -- is linked to an abnormal mix of bacteria in the gut. Tue, 19 Feb 2019 08:07:42 EST https: //www.koonmotors.com/releases/2019/02/190219080742.htm https: //www.koonmotors.com/releases/2018/12/181220111821.htm Could a change in diet be beneficial to people with autoimmune diseases such as lupus? Researchers have revealed how a dietary intervention can help prevent the development of this autoimmune disease in susceptible mice. Thu, 20 Dec 2018 11:18:21 EST https: //www.koonmotors.com/releases/2018/12/181220111821.htm https: //www.koonmotors.com/releases/2018/11/181108130543.htm 自身免疫性疾病如牛皮癣、红斑狼疮和rheumatoid arthritis more than double the risk of cardiovascular disease. A new study shows that immune cells that arise during autoimmune disease cause cholesterol to become trapped inside blood vessels. Thu, 08 Nov 2018 13:05:43 EST https: //www.koonmotors.com/releases/2018/11/181108130543.htm https: //www.koonmotors.com/releases/2018/09/180924160937.htm Findings from mouse study suggest organs affected by autoimmune disease suppress immune cells using methods similar to those used by cancer cells to evade detection. Mon, 24 Sep 2018 16:09:37 EDT https: //www.koonmotors.com/releases/2018/09/180924160937.htm https: //www.koonmotors.com/releases/2018/09/180920101101.htm The STING protein is normally an important part of our immune system, but in some autoimmune diseases it is itself the source of the disease. The pharmaceutical industry is therefore engaged in a race to find a drug that can inhibit STING. Now, researchers may have found it. Thu, 20 Sep 2018 10:11:01 EDT https: //www.koonmotors.com/releases/2018/09/180920101101.htm