//www.koonmotors.com/news/health_medicine/liver_disease/ Read the latest medical research on liver disease. What diets are best? Learn to recognize the symptoms of liver disease, including hepatitis, cirrhosis, and liver cancer. en-us Wed, 06 Sep 2023 14:46:48 EDT Wed, 06 Sep 2023 14:46:48 EDT 60 //www.koonmotors.com/images/scidaily-logo-rss.png//www.koonmotors.com/news/health_medicine/liver_disease/ For more science news, visit ScienceDaily. //www.koonmotors.com/releases/2023/09/230906112407.htm The liver produces bile, which the intestine uses for digestion. For the transport of bile, the liver relies on a network of microscopic tubings, known as bile canaliculi, formed by liver cells called hepatocytes. When the outflow of bile to the intestine is blocked, it collects in the liver and can lead to serious liver disease. Researchers found that high pressure in the bile canaliculi alters the structure of the liver tissue. They found that elevated pressure leads to the obviation of apical bulkheads, structures known to reinforce the canaliculi. Subsequently, bile canaliculi enlarge into liver cell rosettes that are observed in many liver diseases. This study identifies pressure to be a potential common cause of various liver diseases with biliary obstruction and thus contributes to a better understanding of liver diseases. Wed, 06 Sep 2023 11:24:07 EDT //www.koonmotors.com/releases/2023/09/230906112407.htm //www.koonmotors.com/releases/2023/09/230905124907.htm Resistant starch is a nondigestible fiber that ferments in the large intestine, and consumption of it has previously been shown to have a positive effect on metabolism in animal studies. Now, a 4-month randomized controlled trial in people with non-alcoholic fatty liver disease (NAFLD) indicates that daily intake of resistant starch can alter gut bacteria composition and lower liver triglycerides and liver enzymes associated with liver injury and inflammation. Tue, 05 Sep 2023 12:49:07 EDT //www.koonmotors.com/releases/2023/09/230905124907.htm //www.koonmotors.com/releases/2023/08/230824111908.htm Gene therapy with microRNA-22 produced better survival outcomes than the current FDA-approved drug for liver cancer and without noticeable toxicity in new mouse study. Thu, 24 Aug 2023 11:19:08 EDT //www.koonmotors.com/releases/2023/08/230824111908.htm //www.koonmotors.com/releases/2023/08/230809125629.htm Researchers have created a functional 'humanized' liver in living mice that will help scientists find human-specific mechanisms for regulating cholesterol levels and potentially for treating chronic liver diseases afflicting tens of millions of people in the United States. Wed, 09 Aug 2023 12:56:29 EDT //www.koonmotors.com/releases/2023/08/230809125629.htm //www.koonmotors.com/releases/2023/08/230808110942.htm Approximately 65% of adults in the United States consume sugar sweetened beverages daily. Chronic liver disease is a major cause of morbidity and mortality worldwide and can result in liver cancer and liver disease-related mortality. Researchers looked at the association between intake of sugar-sweetened beverages, artificially sweetened beverages, and incidence of liver cancer and chronic liver disease mortality. Tue, 08 Aug 2023 11:09:42 EDT //www.koonmotors.com/releases/2023/08/230808110942.htm //www.koonmotors.com/releases/2023/07/230718225646.htm Omega-3 lysolipids are important for protecting the liver from dietary fat, according to researchers. Tue, 18 Jul 2023 22:56:46 EDT //www.koonmotors.com/releases/2023/07/230718225646.htm //www.koonmotors.com/releases/2023/07/230705115127.htm With a new method for examining virus samples researchers have solved an old riddle about how Hepatitis C virus avoids the human body's immune defenses. The result may have an impact on how we track and treat viral diseases in general. Wed, 05 Jul 2023 11:51:27 EDT //www.koonmotors.com/releases/2023/07/230705115127.htm //www.koonmotors.com/releases/2023/03/230320143823.htm In 2020, bulevirtide (BLV) was conditionally approved for treating chronic hepatitis delta (CHD), an inflammation of the liver caused by hepatitis D virus (HDV). Now real-world studies of patients treated outside of clinical trials confirm that long-term suppressive therapy with BLV monotherapy has the potential to reduce viral replication and improve liver tests of these difficult-to-treat patients for the first time in 45 years, report investigators. Mon, 20 Mar 2023 14:38:23 EDT //www.koonmotors.com/releases/2023/03/230320143823.htm //www.koonmotors.com/releases/2023/03/230315132445.htm New research has established a link between western diets high in fat and sugar and the development of non-alcoholic fatty liver disease, the leading cause of chronic liver disease. Wed, 15 Mar 2023 13:24:45 EDT //www.koonmotors.com/releases/2023/03/230315132445.htm //www.koonmotors.com/releases/2023/02/230201134213.htm Scientists have identified a previously unknown species of circovirus, provisionally named human circovirus 1 (HCirV-1). Circoviruses are a family of small, highly resistant DNA viruses that were initially identified in 1974 in various animal species, where they can cause respiratory, renal, dermatological and reproductive problems. HCirV-1 is a novel virus that is distant from known animal circoviruses. It was shown to be implicated in damage to the liver of a patient undergoing immunosuppressive treatment. Wed, 01 Feb 2023 13:42:13 EST //www.koonmotors.com/releases/2023/02/230201134213.htm //www.koonmotors.com/releases/2023/01/230110103508.htm A new study found that eating fast food is associated with nonalcoholic fatty liver disease, a potentially life-threatening condition in which fat builds up in the liver. Tue, 10 Jan 2023 10:35:08 EST //www.koonmotors.com/releases/2023/01/230110103508.htm //www.koonmotors.com/releases/2023/01/230105083044.htm Research has shown for the first time that the effects of Alagille syndrome, an incurable genetic disorder that affects the liver, could be reversed with a single drug. The study has the potential to transform treatment for this rare disease and may also have implications for more common diseases. Thu, 05 Jan 2023 08:30:44 EST //www.koonmotors.com/releases/2023/01/230105083044.htm //www.koonmotors.com/releases/2023/01/230104154258.htm Using the latest technologies --i ncluding both single-nuclear sequencing of mice and human liver tissue and advanced 3D glass imaging of mice to characterize key scar-producing liver cells -- researchers have uncovered novel candidate drug targets for non-alcoholic fatty liver disease (NAFLD). Wed, 04 Jan 2023 15:42:58 EST //www.koonmotors.com/releases/2023/01/230104154258.htm //www.koonmotors.com/releases/2022/12/221208174301.htm Investigators have found that even subtle forms of liver disease directly impact heart health. The findings help further clarify the relationship between liver disease and heart disease beyond their shared risk factors. Thu, 08 Dec 2022 17:43:01 EST //www.koonmotors.com/releases/2022/12/221208174301.htm //www.koonmotors.com/releases/2022/12/221201123028.htm A new analysis showed that early signs of liver damage from high-dose green tea extract were somewhat predicted by one variation in a genotype and strongly predicted by another variation. Thu, 01 Dec 2022 12:30:28 EST //www.koonmotors.com/releases/2022/12/221201123028.htm //www.koonmotors.com/releases/2022/11/221118114845.htm A novel artificial intelligence blood testing technology has been used to successfully detect lung cancer in a 2021 study has now detected more than 80% of liver cancers in a new study of 724 people. Fri, 18 Nov 2022 11:48:45 EST //www.koonmotors.com/releases/2022/11/221118114845.htm //www.koonmotors.com/releases/2022/11/221103140806.htm 研究人员发表新的研究发现establish rationale for the use of a class of drugs known as MDA-9 inhibitors as a potential treatment option for aggressive liver cancer. Thu, 03 Nov 2022 14:08:06 EDT //www.koonmotors.com/releases/2022/11/221103140806.htm //www.koonmotors.com/releases/2022/11/221103104952.htm Even after chronic hepatitis C has been cured, portal hypertension remains the major factor driving the development of complications in advanced liver disease. Researchers have shown that the non-invasive tests explored in their earlier studies accurately estimate the probability of sequelae. Thu, 03 Nov 2022 10:49:52 EDT //www.koonmotors.com/releases/2022/11/221103104952.htm //www.koonmotors.com/releases/2022/10/221019172245.htm Results of a retrospective study of 26,000 patients show that receiving a third dose of the vaccine was associated with 80% reduction in overall COVID-19 and 100% reduction in severe course of the infection or death. Wed, 19 Oct 2022 17:22:45 EDT //www.koonmotors.com/releases/2022/10/221019172245.htm //www.koonmotors.com/releases/2022/10/221006121205.htm Researchers have revealed that common liver diseases are not driven by inflammatory cell death as previously thought, resolving a long-standing controversy in gastroenterology and pointing to a new direction for treatment. Thu, 06 Oct 2022 12:12:05 EDT //www.koonmotors.com/releases/2022/10/221006121205.htm //www.koonmotors.com/releases/2022/10/221005151830.htm A study provides compelling evidence of the important role of hepatocyte adenosine kinase in the progression of nonalcoholic fatty liver disease, NAFLD. Wed, 05 Oct 2022 15:18:30 EDT //www.koonmotors.com/releases/2022/10/221005151830.htm //www.koonmotors.com/releases/2022/10/221004105003.htm The hepatitis B virus (HBV) is responsible for one of the most serious and common infectious diseases. Transmitted through biological fluids, it attacks the liver cells. The chronic form of the disease can lead to serious complications, including cirrhosis and liver cancer. There is no effective treatment for the chronic form of the disease, which can only be prevented by vaccination. After identifying a key protein complex that is active when our body is infected by the virus, a team has deciphered the precise functioning of this protective mechanism, opening the way to new therapeutic targets. Tue, 04 Oct 2022 10:50:03 EDT //www.koonmotors.com/releases/2022/10/221004105003.htm //www.koonmotors.com/releases/2022/10/221004104959.htm 转移——当癌症扩散形成新的余脉rs -- causes approximately 90% of cancer-related deaths. Because metastatic cancer cells circulate in the blood, the liver -- which filters the blood -- is considered the most vulnerable organ, so treatments that prevent liver metastasis are urgently needed. A team of researchers discovered a mechanism that allows metastatic cancer cells to infiltrate the liver, and how that infiltration can be blocked by inhibiting a related protein. Tue, 04 Oct 2022 10:49:59 EDT //www.koonmotors.com/releases/2022/10/221004104959.htm //www.koonmotors.com/releases/2022/09/220926200715.htm A study identifies a molecule behind the runaway growth of bile duct cells inside the liver, which underlies many liver diseases. Mon, 26 Sep 2022 20:07:15 EDT //www.koonmotors.com/releases/2022/09/220926200715.htm //www.koonmotors.com/releases/2022/09/220925185054.htm Demand for donor livers for transplant patients outstrips supply with over 15% of waitlist patients dying after a year. A new international study offers support for increasing the use of living donor liver transplantation (LDLT) in Western countries and reducing the imbalance between organ supply and demand. Sun, 25 Sep 2022 18:50:54 EDT //www.koonmotors.com/releases/2022/09/220925185054.htm //www.koonmotors.com/releases/2022/09/220915104824.htm What happens when people unknowingly eat, drink or inhale nearly invisible pieces of plastic? Although it's unclear what impact this really has on humans, researchers have now taken a step toward answering that question. A team now reports laboratory results indicating that tiny plastic particles could enter liver and lung cells and disrupt their regular processes, potentially causing adverse health outcomes. Thu, 15 Sep 2022 10:48:24 EDT //www.koonmotors.com/releases/2022/09/220915104824.htm //www.koonmotors.com/releases/2022/08/220826113326.htm A new immunological treatment against hepatitis B and D viruses, both of which can cause liver cancer, shows promising results in animal models. Fri, 26 Aug 2022 11:33:26 EDT //www.koonmotors.com/releases/2022/08/220826113326.htm //www.koonmotors.com/releases/2022/08/220815112828.htm A hormone secreted by fat cells can restrain the growth of liver tumors in mice, according to a new study. Mon, 15 Aug 2022 11:28:28 EDT //www.koonmotors.com/releases/2022/08/220815112828.htm //www.koonmotors.com/releases/2022/08/220811135321.htm In mouse studies, researchers find that excess alcohol consumption alters gut microbiome but latter is not directly or significantly linked to liver disease. Thu, 11 Aug 2022 13:53:21 EDT //www.koonmotors.com/releases/2022/08/220811135321.htm //www.koonmotors.com/releases/2022/08/220805091251.htm Scientists have found that elevated blood levels of an amino acid called homocysteine correlate strongly with the severity of an advanced form of non-alcoholic fatty liver disease. They also found vitamin B12 and folic acid could be used to prevent and/or delay disease progression. Fri, 05 Aug 2022 09:12:51 EDT //www.koonmotors.com/releases/2022/08/220805091251.htm //www.koonmotors.com/releases/2022/08/220801102958.htm New findings have uncovered how essential the FOCAD gene is for maintaining a healthy liver, especially in children. Scientists have found that children carrying loss-of-function mutations in FOCAD are presented with an early onset, paediatric form of liver cirrhosis that can be life-threatening. Mon, 01 Aug 2022 10:29:58 EDT //www.koonmotors.com/releases/2022/08/220801102958.htm //www.koonmotors.com/releases/2022/07/220728091037.htm People with sedentary lifestyles and unhealthy sleep behaviors could develop fatty liver disease, according to new research. Thu, 28 Jul 2022 09:10:37 EDT //www.koonmotors.com/releases/2022/07/220728091037.htm //www.koonmotors.com/releases/2022/07/220727153638.htm In mouse studies, researchers report that lactating mothers expose their feeding pups to triclosan, an antimicrobial commonly used in consumer products, resulting in early signs of liver damage. Wed, 27 Jul 2022 15:36:38 EDT //www.koonmotors.com/releases/2022/07/220727153638.htm //www.koonmotors.com/releases/2022/07/220714095151.htm Researchers have created a liquid biopsy test, which uses two circulating proteins, to test for major liver diseases. The test was found to be highly accurate, sensitive, and specific for both NASH and liver fibrosis. Thu, 14 Jul 2022 09:51:51 EDT //www.koonmotors.com/releases/2022/07/220714095151.htm //www.koonmotors.com/releases/2022/07/220712102714.htm Researchers identified a novel mechanism by which expression of the tumor suppressor p53 paradoxically promotes liver cancer development in patients with chronic liver disease. By generating a mouse model with constant p53 expression in its liver cells, the team observed increased numbers of hepatic progenitor cells (HPCs) and liver cancer incidence. These HPCs could induce cancer when injected into certain mice. This did not occur with p53 deleted, demonstrating its critical significance. Tue, 12 Jul 2022 10:27:14 EDT //www.koonmotors.com/releases/2022/07/220712102714.htm //www.koonmotors.com/releases/2022/07/220706133250.htm The growing incidence of a potentially cancer-causing liver disease in children is associated with prenatal exposure to several endocrine-disrupting chemicals, researchers report. Wed, 06 Jul 2022 13:32:50 EDT //www.koonmotors.com/releases/2022/07/220706133250.htm //www.koonmotors.com/releases/2022/06/220627165957.htm Engineers have created a new liver tissue model that allows them to trace the steps involved in liver regeneration more precisely than has been possible before. Mon, 27 Jun 2022 16:59:57 EDT //www.koonmotors.com/releases/2022/06/220627165957.htm //www.koonmotors.com/releases/2022/06/220627141400.htm In a pair of studies, scientists have deepened investigations into the genetic origins of nonalcoholic fatty liver disease in children, describing multiple gene variants that contribute to disease risk. Mon, 27 Jun 2022 14:14:00 EDT //www.koonmotors.com/releases/2022/06/220627141400.htm //www.koonmotors.com/releases/2022/06/220622164531.htm An estimated one-quarter of adults in the U.S. have nonalcoholic fatty liver disease (NAFLD), an excess of fat in liver cells that can cause chronic inflammation and liver damage, increasing the risk of liver cancer. Now researchers have developed a simple blood test to predict which NAFLD patients are most likely to develop liver cancer. Wed, 22 Jun 2022 16:45:31 EDT //www.koonmotors.com/releases/2022/06/220622164531.htm //www.koonmotors.com/releases/2022/05/220527121413.htm Machine learning is playing an ever-increasing role in biomedical research. Scientists have now developed a new method of using molecular data to extract subtypes of illnesses. In the future, this method can help to support the study of larger patient groups. Fri, 27 May 2022 12:14:13 EDT //www.koonmotors.com/releases/2022/05/220527121413.htm //www.koonmotors.com/releases/2022/04/220420092147.htm New research has identified a crucial link between arthritis and the risk of serious liver disease in people with hemochromatosis. Wed, 20 Apr 2022 09:21:47 EDT //www.koonmotors.com/releases/2022/04/220420092147.htm //www.koonmotors.com/releases/2022/04/220419103243.htm Non-alcoholic fatty liver disease (NAFLD), commonly known as fatty liver disease, is a prevalent disease frequently seen in obese people. Having high fat content in the liver is detrimental as it is strongly associated with severe health problems like diabetes, high blood pressure, and liver cancer. A research team uncovers a new protective mechanism against this disorder. Tue, 19 Apr 2022 10:32:43 EDT //www.koonmotors.com/releases/2022/04/220419103243.htm //www.koonmotors.com/releases/2022/04/220414110821.htm It is estimated that about one in four adults worldwide has an abnormal build-up of fat in the liver, called non-alcoholic fatty liver disease (NAFLD). NAFLD can lead to permanent liver damage, and heart disease is the leading cause of death in people with fatty liver disease. Because NAFLD is often missed in routine medical screening, the new scientific statement raises awareness and understanding about its link to heart disease and to outline how to prevent and diagnose the condition. Thu, 14 Apr 2022 11:08:21 EDT //www.koonmotors.com/releases/2022/04/220414110821.htm //www.koonmotors.com/releases/2022/04/220413141540.htm Scientists have significantly boosted the effectiveness of a therapeutic vaccine designed to control chronic hepatitis B (HBV) infection, after uncovering and thwarting 'the enemy within'. Wed, 13 Apr 2022 14:15:40 EDT //www.koonmotors.com/releases/2022/04/220413141540.htm //www.koonmotors.com/releases/2022/04/220407161952.htm A hormone that triggers puberty and controls fertility in humans might be developed as a treatment for non-alcoholic fatty liver disease, according to new research. Thu, 07 Apr 2022 16:19:52 EDT //www.koonmotors.com/releases/2022/04/220407161952.htm //www.koonmotors.com/releases/2022/03/220330121407.htm A study is the first in North America to demonstrate that living-donor liver transplant is a viable option for patients who have systemically controlled colorectal cancer and liver tumors that cannot be surgically removed. Wed, 30 Mar 2022 12:14:07 EDT //www.koonmotors.com/releases/2022/03/220330121407.htm //www.koonmotors.com/releases/2022/03/220329090741.htm Infections with hepatitis C and E are so common that, going only by statistics, many people should be infected with both viruses at the same time. However, only very few such cases have been reported. A research team has a guess as to why this is the case: The researchers found that the viruses inhibit each other when they infect at the same time. Tue, 29 Mar 2022 09:07:41 EDT //www.koonmotors.com/releases/2022/03/220329090741.htm //www.koonmotors.com/releases/2022/03/220323101257.htm Researchers have discovered in mice an additional use of globins as an intravenous drug that can delay liver fibrosis progression. Wed, 23 Mar 2022 10:12:57 EDT //www.koonmotors.com/releases/2022/03/220323101257.htm //www.koonmotors.com/releases/2022/03/220317120405.htm 非酒精性脂肪肝病(NAFLD)是其中之一the leading causes of death worldwide. However, why premenopausal women are more resistant to NAFLD than men is currently unknown. Now, scientists demonstrate, through sex-balanced experiments on mice, that the female liver produces higher levels of a protein that has a protective effect against NAFLD. Their findings could lead to new therapeutic strategies for treating NAFLD. Thu, 17 Mar 2022 12:04:05 EDT //www.koonmotors.com/releases/2022/03/220317120405.htm //www.koonmotors.com/releases/2022/03/220304112024.htm A high-fat diet is not enough to cause short-term fatty liver disease. However, if this diet is combined with the intake of beverages sweetened with liquid fructose, the accumulation of fats in the liver accelerates and hypertriglyceridemia -- a cardiovascular risk factor -- can appear, according to researchers. Fri, 04 Mar 2022 11:20:24 EST //www.koonmotors.com/releases/2022/03/220304112024.htm //www.koonmotors.com/releases/2022/03/220302110636.htm As of today, there is no vaccine against hepatitis C. To improve the search for it, researchers are looking for a so-called surrogate model: an animal that can also suffer from viral hepatitis and whose course of infection allows conclusions about the behavior of the hepatitis C virus in humans. They found what they were looking for in the horse. Wed, 02 Mar 2022 11:06:36 EST //www.koonmotors.com/releases/2022/03/220302110636.htm //www.koonmotors.com/releases/2022/02/220218172310.htm Researchers report that patients with chronic hepatitis C who are treated with direct-acting antiviral medicines are less likely to be hospitalized or seek emergency care for liver and non-liver related health issues. The study underscores the extraordinary effect of these newer antivirals, which have been shown to cure hepatitis C in 98 percent of patients who take them. Fri, 18 Feb 2022 17:23:10 EST //www.koonmotors.com/releases/2022/02/220218172310.htm //www.koonmotors.com/releases/2022/02/220214144025.htm Researchers have uncovered a new pathway that helps explain how consuming too much alcohol causes damage to the liver, specifically mitochondrial dysfunction in alcohol-associated liver disease. Mon, 14 Feb 2022 14:40:25 EST //www.koonmotors.com/releases/2022/02/220214144025.htm //www.koonmotors.com/releases/2022/01/220118104131.htm A new study identifies two genes, previously reported to be involved in cancer, as regulators of the metabolic state of the liver. Alterations in these genes influence the likelihood of developing fatty liver disease. Tue, 18 Jan 2022 10:41:31 EST //www.koonmotors.com/releases/2022/01/220118104131.htm //www.koonmotors.com/releases/2021/12/211220190708.htm A one-year increase in alcohol consumption in the U.S. during the COVID-19 pandemic is estimated to cause 8,000 additional deaths from alcohol-related liver disease, 18,700 cases of liver failure, and 1,000 cases of liver cancer by 2040. A sustained increase in alcohol consumption for more than one year could result in 19-35 percent additional mortality. Mon, 20 Dec 2021 19:07:08 EST //www.koonmotors.com/releases/2021/12/211220190708.htm //www.koonmotors.com/releases/2021/12/211220120641.htm Exercise not only trains the muscles but can also prevent the development of fatty liver. A new study shows which molecular adaptations, in particular of the liver mitochondria, can be observed in this process. Mon, 20 Dec 2021 12:06:41 EST //www.koonmotors.com/releases/2021/12/211220120641.htm //www.koonmotors.com/releases/2021/12/211206113023.htm Researchers have demonstrated that microgravity and other environmental factors in space play different roles in inducing oxidative stress, which, in turn, alters the metabolism of sulfur-containing compounds in the liver of mice. The study highlighted steps that can be taken, such as boosting antioxidant capacity with dietary supplements, to safeguard astronaut health. Mon, 06 Dec 2021 11:30:23 EST //www.koonmotors.com/releases/2021/12/211206113023.htm //www.koonmotors.com/releases/2021/11/211110145455.htm Researchers have shown that albino mice of the C57BL/6 line are highly susceptible to developing the inflammatory liver condition non-alcoholic steatohepatitis (NASH) when fed a high cholesterol diet. The albino mice carry a mutation in the tyrosinase gene leading to a deficiency of melanin synthesis. NASH is a serious illness in humans, and the identification of the involvement of tyrosinase in NASH development will guide future research into this condition. Wed, 10 Nov 2021 14:54:55 EST //www.koonmotors.com/releases/2021/11/211110145455.htm //www.koonmotors.com/releases/2021/10/211013122736.htm Mutations linking liver disease with obesity and diabetes have been identified, leading to new understanding about how systemic diseases interact. Wed, 13 Oct 2021 12:27:36 EDT //www.koonmotors.com/releases/2021/10/211013122736.htm //www.koonmotors.com/releases/2021/09/210921125116.htm Scientists describe the structure of a key protein on the surface of the hepatitis C virus (HCV) and how it interacts with its receptor found on some human cells. The findings provide new leads for developing an HCV vaccine. Tue, 21 Sep 2021 12:51:16 EDT //www.koonmotors.com/releases/2021/09/210921125116.htm