//www.koonmotors.com/news/health_medicine/leukemia/ Read the latest medical research and information on leukemia. Learn about the symptoms and diagnosis of chronic myeloid leukemia (CML) and other leukemia types. What new leukemia treatments are under development? en-us Mon, 16 Oct 2023 22:46:43 EDT Mon, 16 Oct 2023 22:46:43 EDT 60 //www.koonmotors.com/images/scidaily-logo-rss.png//www.koonmotors.com/news/health_medicine/leukemia/ For more science news, visit ScienceDaily. //www.koonmotors.com/releases/2023/08/230831142858.htm A broad new strategy could hold hope for treating virtually all blood cancers with CAR T cell therapy, which is currently approved for five subtypes of blood cancer. Scientists have demonstrated the potential efficacy of this approach a preclinical study. Thu, 31 Aug 2023 14:28:58 EDT //www.koonmotors.com/releases/2023/08/230831142858.htm //www.koonmotors.com/releases/2023/08/230829125932.htm Early laboratory results in mice show the drug PXS-5505 increases survival when combined with chemotherapy in the treatment of pancreatic ductal adenocarcinomas. Tue, 29 Aug 2023 12:59:32 EDT //www.koonmotors.com/releases/2023/08/230829125932.htm //www.koonmotors.com/releases/2023/08/230817164043.htm Scientists have identified how low levels of the TET2 gene fuel the rapid growth of acute myeloid leukemia in animal models. Thu, 17 Aug 2023 16:40:43 EDT //www.koonmotors.com/releases/2023/08/230817164043.htm //www.koonmotors.com/releases/2023/08/230811115507.htm Researchers have developed a new form of gene therapy that can stop cell division in fusion-driven cancer. Fri, 11 Aug 2023 11:55:07 EDT //www.koonmotors.com/releases/2023/08/230811115507.htm //www.koonmotors.com/releases/2023/08/230809164732.htm 一项研究表明getti新的步骤更多的病人ng gene therapy. Wed, 09 Aug 2023 16:47:32 EDT //www.koonmotors.com/releases/2023/08/230809164732.htm //www.koonmotors.com/releases/2023/07/230706124523.htm A new study has demonstrated the safety of using microbiota transplant therapy (MTT) in patients with acute myeloid leukemia (AML) -- a type of blood cancer -- and recipients of hematopoietic cell transplantation (HCT). Thu, 06 Jul 2023 12:45:23 EDT //www.koonmotors.com/releases/2023/07/230706124523.htm //www.koonmotors.com/releases/2023/06/230622142348.htm Clinicians have a new standard for graft-versus-host disease (GVHD) prevention after allogeneic hematopoietic stem cell transplantation, according to results from a phase III study. The new standard is more effective at preventing GVHD and came with less side effects, compared with the current gold standard. Thu, 22 Jun 2023 14:23:48 EDT //www.koonmotors.com/releases/2023/06/230622142348.htm //www.koonmotors.com/releases/2023/06/230614220519.htm Three young patients with relapsed T-cell leukemia have now been treated with base-edited T-cells. Wed, 14 Jun 2023 22:05:19 EDT //www.koonmotors.com/releases/2023/06/230614220519.htm //www.koonmotors.com/releases/2023/06/230608120903.htm Cancer researchers have made an important new connection between a person's cancer risk and the activity of circular RNAs, a poorly understood family of genetic fragments present in the body. A new study finds that specific circular RNAs within many of us can stick to the DNA in our cells and cause DNA mutations which result in cancer -- the so-called oncogenes. Thu, 08 Jun 2023 12:09:03 EDT //www.koonmotors.com/releases/2023/06/230608120903.htm //www.koonmotors.com/releases/2023/04/230424103345.htm Despite the promise of new medications that promote cancer cell death in people with acute myeloid leukemia, leukemic cells often adopt features that let them evade the drugs' effects within a year. Mon, 24 Apr 2023 10:33:45 EDT //www.koonmotors.com/releases/2023/04/230424103345.htm //www.koonmotors.com/releases/2023/03/230323135506.htm Scientists have discovered a mechanism that linked a leukemic mutation to varying potentials for disease development -- a discovery which could eventually lead to a way to identify patients with the mutation who are most at risk. The mutation is in a gene called TET2, which is prevalent in patients with myeloid leukemia. The scientists labeled and tracked individual blood stem cells in mice with the mutation and found that a subset of blood stem cells and their progeny -- known as clones -- made an outsized contribution to the overall population of blood and immune cells. The over-contributing clones tended to produce a lot of 'myeloid' cells including immune cells called granulocytes, which may potentially lead to myeloid leukemia. Thu, 23 Mar 2023 13:55:06 EDT //www.koonmotors.com/releases/2023/03/230323135506.htm //www.koonmotors.com/releases/2023/03/230321112619.htm Researchers have determined a novel mechanism linking the metabolism of ribonucleic acids, RNA, to the development of leukemia in myelodysplastic syndrome patients, MDS. They explain what makes hematopoietic stem cells acquire malignant traits in cancer. Tue, 21 Mar 2023 11:26:19 EDT //www.koonmotors.com/releases/2023/03/230321112619.htm //www.koonmotors.com/releases/2023/03/230315132419.htm A new targeted drug has not only sparked remissions in patients with a common form of leukemia but also induced the cancer cells to reveal one of their schemes for resisting the drug, investigators report in a new pair of studies. Wed, 15 Mar 2023 13:24:19 EDT //www.koonmotors.com/releases/2023/03/230315132419.htm //www.koonmotors.com/releases/2023/03/230310103508.htm People with a third copy of chromosome 21, known as trisomy 21, are at high risk of developing acute myeloid leukemia (AML), an aggressive form of blood cancer. Scientists have now identified the cause: although the additional chromosome 21 leads to increased gene dosage of many genes, it is above all the perturbation of the RUNX1 gene -- a gene that regulates many other genes -- that seems to be responsible for AML pathogenesis. Targeting the perturbed regulator could pave the way for new therapies. Fri, 10 Mar 2023 10:35:08 EST //www.koonmotors.com/releases/2023/03/230310103508.htm //www.koonmotors.com/releases/2023/03/230308112159.htm Researchers identify potential therapeutic for acute myeloid leukemia that targets a DNA repair protein. Wed, 08 Mar 2023 11:21:59 EST //www.koonmotors.com/releases/2023/03/230308112159.htm //www.koonmotors.com/releases/2023/02/230223132919.htm Researchers have identified a possible new targeted drug for treating acute myeloid leukemia. In the future, the discovery may help patients with certain rare subtypes of the disease. Thu, 23 Feb 2023 13:29:19 EST //www.koonmotors.com/releases/2023/02/230223132919.htm //www.koonmotors.com/releases/2023/02/230223132816.htm A new study shows fasting can trigger a negative effect on fighting infection on a cellular level in mouse models. Thu, 23 Feb 2023 13:28:16 EST //www.koonmotors.com/releases/2023/02/230223132816.htm //www.koonmotors.com/releases/2023/01/230129193412.htm Patients with myelofibrosis had clinically significant improvement in disease-related symptoms, including anemia and spleen enlargement, when treated with the targeted therapy momelotinib, according to new results. Sun, 29 Jan 2023 19:34:12 EST //www.koonmotors.com/releases/2023/01/230129193412.htm //www.koonmotors.com/releases/2023/01/230124101558.htm The value of chemotherapy delivery at specific times of the day to optimize efficacy and minimize adverse effects in hematologic malignancy remains unknown. An interdisciplinary research team discovers its benefit by analyzing cohorts of diffuse large B cell lymphoma (DLBCL)* patients: Chemotherapy in the afternoon significantly improves treatment outcomes of female patients while there is no difference depending on treatment time in male patients. Tue, 24 Jan 2023 10:15:58 EST //www.koonmotors.com/releases/2023/01/230124101558.htm //www.koonmotors.com/releases/2023/01/230117192909.htm Researchers find that an antimicrobial molecule modifies T-cell-signalling and thus attenuates overshooting immune reactions. Tue, 17 Jan 2023 19:29:09 EST //www.koonmotors.com/releases/2023/01/230117192909.htm //www.koonmotors.com/releases/2023/01/230117083220.htm Technology that enables an unprecedented, high-resolution look for all structural variants in our genes that are known to cause cancer can outperform standard tests used today for common blood cancers like leukemia, researchers report. Tue, 17 Jan 2023 08:32:20 EST //www.koonmotors.com/releases/2023/01/230117083220.htm //www.koonmotors.com/releases/2023/01/230111083504.htm Severe inflammation weakens the body's ability to kill cancerous blood cells in people with acute myeloid leukemia (AML), a new study shows. Wed, 11 Jan 2023 08:35:04 EST //www.koonmotors.com/releases/2023/01/230111083504.htm //www.koonmotors.com/releases/2023/01/230110103405.htm Researchers have found a new method that within hours can predict if certain cancer patients will survive after chemotherapy. Tue, 10 Jan 2023 10:34:05 EST //www.koonmotors.com/releases/2023/01/230110103405.htm //www.koonmotors.com/releases/2023/01/230105151327.htm Scientists have performed the largest study yet examining drug sensitivity in childhood acute lymphoblastic leukemia across genomic subtypes and its association with treatment response. Thu, 05 Jan 2023 15:13:27 EST //www.koonmotors.com/releases/2023/01/230105151327.htm //www.koonmotors.com/releases/2022/12/221222101019.htm Researchers describe the impact of epigenetics on cancer treatment and how it has become a crucial tool to improve early detection, predict disease progression and become a target for new treatments. Thu, 22 Dec 2022 10:10:19 EST //www.koonmotors.com/releases/2022/12/221222101019.htm //www.koonmotors.com/releases/2022/12/221220113003.htm In our bones, specialized cells called osteoblasts are responsible for building up bone substance. A team of researchers has now identified an enzyme that controls the activity of osteoblasts. An agent that inhibits the activity of this enzyme reduced cancer-related bone loss and the number of bone metastases in multiple myeloma and in lung and breast cancer models in mice. Tue, 20 Dec 2022 11:30:03 EST //www.koonmotors.com/releases/2022/12/221220113003.htm //www.koonmotors.com/releases/2022/11/221121215746.htm Intestinal bacteria composition is crucial to driving the recovery of neutrophils counts in the blood of mice following treatments such as stem cell transplants or chemotherapy. Mon, 21 Nov 2022 21:57:46 EST //www.koonmotors.com/releases/2022/11/221121215746.htm //www.koonmotors.com/releases/2022/11/221115114019.htm Scientists have made bone marrow 'organoids' that capture the key features of human bone marrow. Tue, 15 Nov 2022 11:40:19 EST //www.koonmotors.com/releases/2022/11/221115114019.htm //www.koonmotors.com/releases/2022/11/221110114240.htm Researchers discovered that by blocking the production of an enzyme called DHODH, they were able to halt the growth of MYC gene-amplified medulloblastoma in mouse models, the most aggressive subtype of this cancer. Thu, 10 Nov 2022 11:42:40 EST //www.koonmotors.com/releases/2022/11/221110114240.htm //www.koonmotors.com/releases/2022/10/221027150338.htm Researchers have used CRISPR/Cas9 technology to engineer donor T cells to try to treat seriously ill children with resistant leukemia, who had otherwise exhausted all available therapies. Thu, 27 Oct 2022 15:03:38 EDT //www.koonmotors.com/releases/2022/10/221027150338.htm //www.koonmotors.com/releases/2022/10/221027124037.htm A prodrug form of curcumin, TBP1901, has shown anti-tumor effects without toxicities. The enzyme GUSB was identified for its key role in TBP1901 conversion to curcumin, which also has essential therapeutic targets. Thu, 27 Oct 2022 12:40:37 EDT //www.koonmotors.com/releases/2022/10/221027124037.htm //www.koonmotors.com/releases/2022/10/221025153406.htm Researchers have set their sights on a new therapeutic target for an aggressive form of breast cancer with limited treatment options. Through a comprehensive and cutting-edge genomic screening method known as CRISPR/CAS9 screening, scientists were able to identify a specific enzyme called UBA1 that revealed itself as an ideal therapeutic target. Using a novel UBA-inhibiting drug called TAK-243, they blocked the cellular function of UBA1 and effectively killed cancer cells in patient-derived breast tumors in mice. Tue, 25 Oct 2022 15:34:06 EDT //www.koonmotors.com/releases/2022/10/221025153406.htm //www.koonmotors.com/releases/2022/10/221019111412.htm Endothelial cells -- the cells that line blood vessels -- grown alongside leukemia cells become corrupted and rescue the cancer cells from many chemotherapy drugs, a study found. Wed, 19 Oct 2022 11:14:12 EDT //www.koonmotors.com/releases/2022/10/221019111412.htm //www.koonmotors.com/releases/2022/10/221017142455.htm Among patients with kidney cancer, the activity of four specific genes in the cancer cells seems to be able to predict the risk of the tumor spreading and the patient's chances of survival. Mon, 17 Oct 2022 14:24:55 EDT //www.koonmotors.com/releases/2022/10/221017142455.htm //www.koonmotors.com/releases/2022/09/220920103425.htm Scientists have shown that high-fat diets can cause rapid changes in the bone marrow of mice, driving the production of inflammatory immune cells, according to new findings. Tue, 20 Sep 2022 10:34:25 EDT //www.koonmotors.com/releases/2022/09/220920103425.htm //www.koonmotors.com/releases/2022/09/220901135805.htm 科学家们创造了一个路线图的基因mutations present in the most common childhood cancer, acute lymphoblastic leukemia (ALL). The study supplies a comprehensive view of the genomics of all subtypes of ALL. Thu, 01 Sep 2022 13:58:05 EDT //www.koonmotors.com/releases/2022/09/220901135805.htm //www.koonmotors.com/releases/2022/08/220824152322.htm Chemotherapy sucks. The treatments generally have awful side effects, and it's no secret that the drugs involved are often toxic to the patient as well as their cancer. The idea is that, since cancers grow so quickly, chemotherapy will kill off the disease before its side effects kill the patient. That's why scientists and doctors are constantly searching for more effective therapies. Wed, 24 Aug 2022 15:23:22 EDT //www.koonmotors.com/releases/2022/08/220824152322.htm //www.koonmotors.com/releases/2022/08/220801111124.htm All human tumors originating from various tissues share a series of properties that define them, including the ability to prevent cell death. Instead, healthy organs induce programmed cell death or apoptosis to balance their size and eliminate damaged cells. There is a specific and physiological cell death called ferroptosis that occurs induced by the oxidation of fat mediated by iron content. Mon, 01 Aug 2022 11:11:24 EDT //www.koonmotors.com/releases/2022/08/220801111124.htm //www.koonmotors.com/releases/2022/07/220718154258.htm The potentially lifesaving act of gifting bone marrow can be accompanied by uncomfortable side effects to the donor, making it a truly selfless expression of kindness. Recognizing this good will and wanting to improve the donor experience, clinical researchers recently described a pain control method for bone marrow harvest that has revolutionized the experience for donors and slashed the need for opioids. Mon, 18 Jul 2022 15:42:58 EDT //www.koonmotors.com/releases/2022/07/220718154258.htm //www.koonmotors.com/releases/2022/06/220630160035.htm Researchers have discovered potential new drugs that target mitochondria in cancer cells. Their study in the journal Leukemia describes the compounds' potential for killing leukemia cells when administered by themselves or in combination with other chemotherapies. Thu, 30 Jun 2022 16:00:35 EDT //www.koonmotors.com/releases/2022/06/220630160035.htm //www.koonmotors.com/releases/2022/06/220620100825.htm Acute lymphoblastic leukemia (ALL) is the most common cancer affecting children. The T-ALL form of leukemia that emerges from early T lineage cells has a poorer prognosis than B-lineage ALL. The prognosis for relapsed T-ALL is very poor and new therapies are sorely needed. Medical researchers have discovered a new combination of drugs that is effective against T-ALL. Mon, 20 Jun 2022 10:08:25 EDT //www.koonmotors.com/releases/2022/06/220620100825.htm //www.koonmotors.com/releases/2022/06/220609155731.htm 研究人员已经确定了记录的作用ion factors Runx1 and Runx2 in the inhibition of fibrosis, the abnormal build-up of connective tissue with severe hematopoietic defects, in the bone marrow. Mice lacking both Runx1 and Runx2 in CAR cells, a major component of the hematopoietic stem cell niche, demonstrated severe myelofibrosis and defects in the production of blood cells. Runx1 and Runx2 may act as potential targets in the diagnosis and treatment of myelofibrosis. Thu, 09 Jun 2022 15:57:31 EDT //www.koonmotors.com/releases/2022/06/220609155731.htm //www.koonmotors.com/releases/2022/06/220605130404.htm 多发性骨髓瘤患者治疗ed with a three-drug combination therapy have a growing number of choices for subsequent treatment. Results of a new study can help patients and their physicians weigh benefits and risks of each option. Sun, 05 Jun 2022 13:04:04 EDT //www.koonmotors.com/releases/2022/06/220605130404.htm //www.koonmotors.com/releases/2022/06/220602121428.htm Genetically engineered immune cells successfully target the specific cancer cells that may be responsible for relapse of acute myeloid leukemia (AML), a type of blood cancer, and proved effective in animal models of the disease, according to a preclinical study. The new cell therapy, now being tested in phase 1 clinical trials, may ultimately help patients with AML to remain cancer-free. Thu, 02 Jun 2022 12:14:28 EDT //www.koonmotors.com/releases/2022/06/220602121428.htm //www.koonmotors.com/releases/2022/05/220510102932.htm Scientists have pinpointed a possible new target for treating patients with the blood cancer juvenile myelomonocytic leukaemia (JMML), according to a new study. Tue, 10 May 2022 10:29:32 EDT //www.koonmotors.com/releases/2022/05/220510102932.htm //www.koonmotors.com/releases/2022/05/220509100940.htm Acute myeloid leukaemia is a rare and devastating blood cancer that is highly resistant to treatment. Now, scientists have discovered a way to suppress a specific protein that promotes drug resistance. Mon, 09 May 2022 10:09:40 EDT //www.koonmotors.com/releases/2022/05/220509100940.htm //www.koonmotors.com/releases/2022/04/220428125358.htm impr调查人员设计了一种新颖的方法oving CAR T therapy through a drug combination and cellular engineering that improves the strength and durability of the tumor-killing effect of a CAR T directed against acute myeloid leukemia. Thu, 28 Apr 2022 12:53:58 EDT //www.koonmotors.com/releases/2022/04/220428125358.htm //www.koonmotors.com/releases/2022/04/220420200213.htm A discovery has the potential to benefit leukemia patients by opening up new treatment strategies for treating the disease. Wed, 20 Apr 2022 20:02:13 EDT //www.koonmotors.com/releases/2022/04/220420200213.htm //www.koonmotors.com/releases/2022/04/220420170450.htm Researchers have found that the KLF4 gene is reprogrammed at the onset of acute promyelocytic leukaemia (APL), an aggressive type of blood cancer that is responsible for 5-15% of all types of leukemia. Overexpressing KLF4 suppressed the self-renewal traits of cancerous cells and reversed the effects caused by the actions of oncofusion events that cause the disease. The findings pave the way for the development of drugs that boost the expression of the gene at the earliest stages of cancer formation, intercepting the disease before it becomes uncontrollable. Wed, 20 Apr 2022 17:04:50 EDT //www.koonmotors.com/releases/2022/04/220420170450.htm //www.koonmotors.com/releases/2022/04/220411101305.htm An international study demonstrates that the body's immune system attacks itself in a rare type of blood cancer. Consequently, treatment should be targeted at the immune system as well, not only the cancer cells. Mon, 11 Apr 2022 10:13:05 EDT //www.koonmotors.com/releases/2022/04/220411101305.htm //www.koonmotors.com/releases/2022/04/220405084604.htm Although clinical labs have known for almost a century that a oddly shaped nucleus resembling pince-nez glasses in blood cells could indicate leukemia, the cause of this anomaly remained unknown. Scientists have now discovered that loss of nuclear Lamin B1 induces defects in the nuclear morphology and in human hematopoietic [blood-forming] stem cells associated with malignancy. The scientists went on to detail that lamin B1 deficiency alters genome organization. This in turn causes expansion of blood-forming stem cells, a bias towards their becoming myeloids, genome instability due to defective DNA damage repair and other problems that set the stage for cancer. Tue, 05 Apr 2022 08:46:04 EDT //www.koonmotors.com/releases/2022/04/220405084604.htm //www.koonmotors.com/releases/2022/03/220329142518.htm Ten-second videos of white blood cell motion in the skin's microvasculature greatly improved the prediction of which stem cell and bone marrow transplant patients would have a relapse of their blood cancer. Tue, 29 Mar 2022 14:25:18 EDT //www.koonmotors.com/releases/2022/03/220329142518.htm //www.koonmotors.com/releases/2022/03/220317172451.htm New research finds that patients with ASXL1-mutant chronic myelomonocytic leukemia -- an uncommon type of cancer of the bone marrow -- have distinctive epigenetic changes that can activate harmful genes and cause the cancer to grow faster. The ASXL1 genetic mutation also can transform the disease into the more aggressive acute myeloid leukemia. Thu, 17 Mar 2022 17:24:51 EDT //www.koonmotors.com/releases/2022/03/220317172451.htm //www.koonmotors.com/releases/2022/03/220314120649.htm New research has begun to unravel the mystery of why a particular form of leukaemia in infants has defied efforts to improve outcomes, despite significant improvements in treating older children. Scientists have now found subtle differences in the cell type that causes B acute lymphoblastic leukaemia (B-ALL) that may help to explain why some cases are more severe than others. Mon, 14 Mar 2022 12:06:49 EDT //www.koonmotors.com/releases/2022/03/220314120649.htm //www.koonmotors.com/releases/2022/03/220307113104.htm Researchers have discovered the first proteomic subtype of an aggressive blood cancer by using mass spectrometry technology. Mon, 07 Mar 2022 11:31:04 EST //www.koonmotors.com/releases/2022/03/220307113104.htm //www.koonmotors.com/releases/2022/02/220228190958.htm New research reveals how our immune system can be triggered to attack cancer cells. The research could help develop new approaches to treating people with leukemia. The team studied acute myeloid leukaemia - a blood cancer which is very difficult to treat. The study identified a process of activating the immune system to fight the leukaemia cells. Mon, 28 Feb 2022 19:09:58 EST //www.koonmotors.com/releases/2022/02/220228190958.htm //www.koonmotors.com/releases/2022/02/220224125207.htm Researchers have uncovered a new role of a chromatin-modulatory enzyme, termed EZH2, during cancer development. They then designed a new small-molecule, MS177, based on the proteolysis-targeting chimera (PROTAC) technology, that targets both EZH2 and cMyc and thus inhibits cancer growth. Thu, 24 Feb 2022 12:52:07 EST //www.koonmotors.com/releases/2022/02/220224125207.htm //www.koonmotors.com/releases/2022/02/220223104941.htm Some genetic mutations linked to leukemia are less than useful guides to making treatment decisions for patients. A new study suggests a group of clinical signs that can be paired with genetic testing to better inform the timing of more aggressive treatment. Wed, 23 Feb 2022 10:49:41 EST //www.koonmotors.com/releases/2022/02/220223104941.htm //www.koonmotors.com/releases/2022/02/220217102047.htm Scientists have found a previously overlooked mutation in a subtype of pediatric leukemia that has implications for identifying high-risk patients. Thu, 17 Feb 2022 10:20:47 EST //www.koonmotors.com/releases/2022/02/220217102047.htm //www.koonmotors.com/releases/2022/02/220217102036.htm Acute myeloid leukemia, which affects blood and bone marrow cells, is a particularly dangerous form of cancer. More than half of patients under the age of 60 die. This proportion rises to 85% for patients over 60. A team has now identified a previously unknown mechanism that could lead to the development of new therapies. The selective activation of AMPK, a key enzyme in the energy balance of tumor cells, would indeed lead to their death by triggering the cells stress response. Moreover, the scientists have successfully exploited this energy gap in an animal model of the disease: a combination of two drugs -- one of which is already on the market -- has indeed shown promise. However, their effectiveness has yet to be confirmed on leukaemia stem cells, which have the ability to escape many treatments to restart tumor growth. Thu, 17 Feb 2022 10:20:36 EST //www.koonmotors.com/releases/2022/02/220217102036.htm