//www.koonmotors.com/news/health_medicine/immune_system/ 免疫和免疫系统。阅读最新的我dical research on immune response, immune deficiency, immune system diseases and immune system boosters. en-us Wed, 06 Sep 2023 14:48:00 EDT Wed, 06 Sep 2023 14:48:00 EDT 60 //www.koonmotors.com/images/scidaily-logo-rss.png//www.koonmotors.com/news/health_medicine/immune_system/ For more science news, visit ScienceDaily. //www.koonmotors.com/releases/2023/09/230906115607.htm A groundbreaking study has shed new light on the genetic underpinnings of Alzheimer's disease. Wed, 06 Sep 2023 11:56:07 EDT //www.koonmotors.com/releases/2023/09/230906115607.htm //www.koonmotors.com/releases/2023/09/230906115505.htm New 'hypervirulent' strains of the bacterium Klebsiella pneumoniae have emerged in healthy people in community settings, prompting a research group to investigate how the human immune system defends against infection. After exposing the strains to components of the human immune system in a laboratory 'test tube' setting, scientists found that some strains were more likely to survive in blood and serum than others, and that neutrophils (white blood cells) are more likely to ingest and kill some strains than others. Wed, 06 Sep 2023 11:55:05 EDT //www.koonmotors.com/releases/2023/09/230906115505.htm //www.koonmotors.com/releases/2023/09/230906112446.htm A recent study has introduced a groundbreaking milestone in tissue regeneration by developing a technology that utilizes autologous blood to produce three-dimensional microvascular implants. Wed, 06 Sep 2023 11:24:46 EDT //www.koonmotors.com/releases/2023/09/230906112446.htm //www.koonmotors.com/releases/2023/09/230906112440.htm Human immune cells are capable of coordinating their own movement more independently than previously thought. Researchers discovered that immune cells do not just passively follow the chemical cues in their environment. Quite the contrary, they can also shape these cues and navigate in complex environments in a self-organized manner. Wed, 06 Sep 2023 11:24:40 EDT //www.koonmotors.com/releases/2023/09/230906112440.htm //www.koonmotors.com/releases/2023/09/230905155717.htm Researchers have discovered a new avenue of cell death in Alzheimer's disease and vascular dementia. The study reveals for the first time that a form of cell death known as ferroptosis -- caused by a buildup of iron in cells -- destroys microglia cells in cases of Alzheimer's and vascular dementia. Tue, 05 Sep 2023 15:57:17 EDT //www.koonmotors.com/releases/2023/09/230905155717.htm //www.koonmotors.com/releases/2023/09/230901143610.htm When fighting disease, our immune cells need to reach their target quickly. Researchers have now discovered that immune cells actively generate their own guidance system to navigate through complex environments. This challenges earlier notions about these movements. The researchers' findings enhance our knowledge of the immune system and offer potential new approaches to improve human immune response. Fri, 01 Sep 2023 14:36:10 EDT //www.koonmotors.com/releases/2023/09/230901143610.htm //www.koonmotors.com/releases/2023/09/230901124042.htm A study sheds new light on why tumors that have spread to the brain from other parts of the body respond to immunotherapy while glioblastoma, an aggressive cancer that originates in the brain, does not. Fri, 01 Sep 2023 12:40:42 EDT //www.koonmotors.com/releases/2023/09/230901124042.htm //www.koonmotors.com/releases/2023/08/230831164439.htm Researchers have determined how Leishmaniasis vaccine candidates, created using mutated disease-causing parasites, prompt molecular-level changes in host cells that have specific roles in helping generate the immune response. Thu, 31 Aug 2023 16:44:39 EDT //www.koonmotors.com/releases/2023/08/230831164439.htm //www.koonmotors.com/releases/2023/08/230831164228.htm Researchers have discovered some new and surprising ways that viral RNA and influenza virus are detected by human lung cells, which has potential implications for treating people affected by such viruses. Thu, 31 Aug 2023 16:42:28 EDT //www.koonmotors.com/releases/2023/08/230831164228.htm //www.koonmotors.com/releases/2023/08/230831142858.htm A broad new strategy could hold hope for treating virtually all blood cancers with CAR T cell therapy, which is currently approved for five subtypes of blood cancer. Scientists have demonstrated the potential efficacy of this approach a preclinical study. Thu, 31 Aug 2023 14:28:58 EDT //www.koonmotors.com/releases/2023/08/230831142858.htm //www.koonmotors.com/releases/2023/08/230830131948.htm When an immunocompromised person's system begins to recover and produce more white blood cells, it's usually a good thing -- unless they develop C-IRIS, a potentially deadly inflammatory condition. New research has found that the pulmonary distress often associated with C-IRIS is caused not by damage to the lungs, but by newly populated T-cells infiltrating the brain. Knowing this mechanism of action can help researchers and physicians better understand the illness and provide new treatment targets. Wed, 30 Aug 2023 13:19:48 EDT //www.koonmotors.com/releases/2023/08/230830131948.htm //www.koonmotors.com/releases/2023/08/230830131855.htm Fresh discoveries about a type of immune cells could give lung cancer patients a more accurate prognosis and better identify who will benefit from immunotherapies. Researchers found that the location in and around tumours of cytotoxic T cells, which play a key role in fighting cancer, may help predict patient survival and indicate whether or not treatments will work. Wed, 30 Aug 2023 13:18:55 EDT //www.koonmotors.com/releases/2023/08/230830131855.htm //www.koonmotors.com/releases/2023/08/230830131718.htm The human immune system is adaptive, remembering past infections and training itself to guard against future similar infections. But what happens when people have compromised immune systems due to chronic conditions, aging, or medications that decrease immunity as a side effect? In such cases, people can get opportunistic infections, so called because the germs causing illness would have been eradicated by a fully healthy immune system. Conditions and medicines causing immune suppression are on the rise, and so are patients experiencing opportunistic infection. Now, researchers have uncovered a sex-based variance in the trained immune memory response to infection in mice that might translate to humans. Wed, 30 Aug 2023 13:17:18 EDT //www.koonmotors.com/releases/2023/08/230830131718.htm //www.koonmotors.com/releases/2023/08/230830131658.htm Immunologists have uncovered new approaches to enhance protection from tumors and infections. They have revealed new insights into the metabolism of specialized cells of the immune system known as tissue-resident CD8 T cells and how they could be enhanced as immune defense weapons against tumors. Wed, 30 Aug 2023 13:16:58 EDT //www.koonmotors.com/releases/2023/08/230830131658.htm //www.koonmotors.com/releases/2023/08/230830131653.htm Researchers have identified stem cells in the human thymus for the first time. These cells represent a potential new target to understand immune diseases and cancer and how to boost the immune system. Wed, 30 Aug 2023 13:16:53 EDT //www.koonmotors.com/releases/2023/08/230830131653.htm //www.koonmotors.com/releases/2023/08/230829125956.htm Selective targeting of cancerous cells poses major clinical challenges during cancer therapy. However, this limitation can be overcome by using bioengineered bacteria with highly optimized chemical modifications. A recent study demonstrates the use of chemically modified purple photosynthetic bacteria for the successful detection and elimination of colon cancer cells in a mouse model. The study also sheds light on the underlying mechanism of action. Tue, 29 Aug 2023 12:59:56 EDT //www.koonmotors.com/releases/2023/08/230829125956.htm //www.koonmotors.com/releases/2023/08/230829125942.htm Scientists are working on a new approach to treating kidney failure that could one day free people from needing dialysis or having to take harsh drugs to suppress their immune system after a transplant. Tue, 29 Aug 2023 12:59:42 EDT //www.koonmotors.com/releases/2023/08/230829125942.htm //www.koonmotors.com/releases/2023/08/230825140329.htm A new study has examined how T cells of the immune system are affected by weightlessness. The results could explain why astronauts' T cells become less active and less effective at fighting infection. Fri, 25 Aug 2023 14:03:29 EDT //www.koonmotors.com/releases/2023/08/230825140329.htm //www.koonmotors.com/releases/2023/08/230825122006.htm In the new study, the team used the model to demonstrate that as Alzheimer's pathology accumulates in the brain, specific types of immune cells called CT8+ T Cells surge into the brain and amplify the destruction caused by neuroinflammation. Fri, 25 Aug 2023 12:20:06 EDT //www.koonmotors.com/releases/2023/08/230825122006.htm //www.koonmotors.com/releases/2023/08/230824111920.htm Researchers have uncovered a functional role for KRAS mutations in pancreatic cancer and rapidly translated these findings into a novel therapeutic approach combining a KRAS G12D inhibitor with immune checkpoint inhibitors for early- and late-stage KRAS G12D-mutant pancreatic cancer. The combination therapy led to durable tumor elimination and significantly improved survival outcomes in preclinical models, leading to the launch of a Phase I clinical trial. Thu, 24 Aug 2023 11:19:20 EDT //www.koonmotors.com/releases/2023/08/230824111920.htm //www.koonmotors.com/releases/2023/08/230823122619.htm Immunotherapies for cancer aim to induce the immune system to combat cancer cells more effectively. A research team has now described a new, modular strategy for T-cell-based immunotherapy that manages to work without complex genetic modifications. Modulation of cell-cell communications through an ingenious regulatory circuit using various small, specially folded DNA molecules (aptamers) causes cancer cells to directly activate their mortal enemies, T cells. Wed, 23 Aug 2023 12:26:19 EDT //www.koonmotors.com/releases/2023/08/230823122619.htm //www.koonmotors.com/releases/2023/08/230823122523.htm A study has discovered a new relationship between cancer cells and the immune system, and shows how cancer can selfishly hijack a normally helpful immune pathway. Wed, 23 Aug 2023 12:25:23 EDT //www.koonmotors.com/releases/2023/08/230823122523.htm //www.koonmotors.com/releases/2023/08/230823122517.htm T cell bispecific antibodies (TCBs) are an emerging class of immunotherapeutics with several TCBs approved by the FDA for the treatment of leukemias, lymphomas, and myelomas. TCBs label tumor cells with one of their ends, and attract immune cells with another end to coerce them into tumor cell killing. However, one major challenge in the development of TCBs are 'on-target, off-tumor' toxicities at sites in the body that also express TCB-targeted antigens. Scientists have now created an immune-infiltrated human kidney organoid-on-chip model that allows kidney toxicity of TCBs. Wed, 23 Aug 2023 12:25:17 EDT //www.koonmotors.com/releases/2023/08/230823122517.htm //www.koonmotors.com/releases/2023/08/230822151748.htm Many researchers believe that the neurodegenerative disorder gets started in the gut. Research now suggests that an autoimmune reaction may be driving those early events. Tue, 22 Aug 2023 15:17:48 EDT //www.koonmotors.com/releases/2023/08/230822151748.htm //www.koonmotors.com/releases/2023/08/230821174259.htm The rate at which additional COVID-19 boosters are needed for cancer patients depends on the treatment they are receiving, researchers say. Mon, 21 Aug 2023 17:42:59 EDT //www.koonmotors.com/releases/2023/08/230821174259.htm //www.koonmotors.com/releases/2023/08/230821114358.htm Anti-estrogenic therapies can suppress the growth of cancer that does not express estrogen receptors; when combined with immune checkpoint inhibitor therapies, they halt tumor progression in mice models. Mon, 21 Aug 2023 11:43:58 EDT //www.koonmotors.com/releases/2023/08/230821114358.htm //www.koonmotors.com/releases/2023/08/230817163908.htm Scientists found that immune cells present in individuals long before influenza infection predict whether the illness is symptomatic. Thu, 17 Aug 2023 16:39:08 EDT //www.koonmotors.com/releases/2023/08/230817163908.htm //www.koonmotors.com/releases/2023/08/230816114227.htm Researchers have found that molecules in vegetables like broccoli or cauliflower help to maintain a healthy barrier in the lung and ease infection. Wed, 16 Aug 2023 11:42:27 EDT //www.koonmotors.com/releases/2023/08/230816114227.htm //www.koonmotors.com/releases/2023/08/230816114136.htm Teeth could be capable of preserving antibodies for hundreds of years, allowing scientists to investigate the history of infectious human diseases, a new study has found. Wed, 16 Aug 2023 11:41:36 EDT //www.koonmotors.com/releases/2023/08/230816114136.htm //www.koonmotors.com/releases/2023/08/230816114132.htm A psychological study suggests our brain can assess the state of our own health more precisely than we think -- and it is probably even able to correctly evaluate the state of our immune system. Wed, 16 Aug 2023 11:41:32 EDT //www.koonmotors.com/releases/2023/08/230816114132.htm //www.koonmotors.com/releases/2023/08/230815131506.htm Nanovesicles can be bioengineered to target cancer cells and deliver treatments directly, according to new research. Tue, 15 Aug 2023 13:15:06 EDT //www.koonmotors.com/releases/2023/08/230815131506.htm //www.koonmotors.com/releases/2023/08/230814174537.htm 装备cancer-infecting、溶瘤细胞的病毒with tumor-inhibiting genetic cargo stimulates the immune system and helps immunotherapy to shrink or completely clear aggressive tumors in mice, according to a new study. The results pave the way for clinical trials combining oncolytic viruses with immunotherapy. Mon, 14 Aug 2023 17:45:37 EDT //www.koonmotors.com/releases/2023/08/230814174537.htm //www.koonmotors.com/releases/2023/08/230811115448.htm Researchers have created a panel of genetically diverse mice that accurately model the highly variable human response to SARS-CoV-2 infection. The team uncovered differences in the innate immune and regulated proinflammatory responses, the timing and strength of which are associated with disease severity. Fri, 11 Aug 2023 11:54:48 EDT //www.koonmotors.com/releases/2023/08/230811115448.htm //www.koonmotors.com/releases/2023/08/230811115433.htm An experimental malaria vaccine appears safe and promotes an immune response in African infants, one of the groups most vulnerable to severe malaria disease. There is currently only one malaria vaccine, 'RTS,S' that is approved by the World Health Organization and offers partial disease protection. However, in the results of the early-stage phase Ib trial, researchers find that targeting RH5 -- a protein that the malaria pathogen Plasmodium falciparum uses to invade red blood cells -- can generate a promising immune response that is most pronounced in an infant cohort. Fri, 11 Aug 2023 11:54:33 EDT //www.koonmotors.com/releases/2023/08/230811115433.htm //www.koonmotors.com/releases/2023/08/230811115425.htm Scientists discovered that anti-CTLA-4 immunotherapy extended the lives of mice with glioblastoma by causing specialized CD4+ T immune cells to 1) infiltrate the brain and 2) tell brain-resident immune cells called microglia to destroy tumor cells. Their findings show the benefit of harnessing the body's own immune cells to fight brain cancer and could lead to more effective immunotherapies. Fri, 11 Aug 2023 11:54:25 EDT //www.koonmotors.com/releases/2023/08/230811115425.htm //www.koonmotors.com/releases/2023/08/230810141015.htm Scientists can finally hunt down a harmful kind of human T cell. Immune cells called ex-T regulatory cells (exTregs) tend to be rare in the body and, so far, impossible to detect in human samples. A new study gives scientists a reliable way to find human exTregs and provides a window into how exTregs contribute to inflammation and cardiovascular disease. Thu, 10 Aug 2023 14:10:15 EDT //www.koonmotors.com/releases/2023/08/230810141015.htm //www.koonmotors.com/releases/2023/08/230810110353.htm Nano-sized particles released by red blood cells reduce inflammation and fat deposition in immune cells, potentially paving the way for new methods of treating atherosclerosis. Thu, 10 Aug 2023 11:03:53 EDT //www.koonmotors.com/releases/2023/08/230810110353.htm //www.koonmotors.com/releases/2023/08/230809164732.htm A study shows new steps toward more patients getting gene therapy. Wed, 09 Aug 2023 16:47:32 EDT //www.koonmotors.com/releases/2023/08/230809164732.htm //www.koonmotors.com/releases/2023/08/230809164724.htm Promising preclinical results show hematopoietic stem cell therapy was effective in rescuing memory loss, neuroinflammation and beta amyloid build-up in a mouse model of Alzheimer's disease. Wed, 09 Aug 2023 16:47:24 EDT //www.koonmotors.com/releases/2023/08/230809164724.htm //www.koonmotors.com/releases/2023/08/230809164716.htm In Parkinson's disease, growing evidence targets neuroinflammation as essential for brain pathogenesis. But which group of immune cells that reside in the brain direct this inflammatory response? Scientists used a mouse model of Parkinson's disease to show that border-associated macrophages -- not microglia -- mediate the neuroinflammatory response in the brain. Wed, 09 Aug 2023 16:47:16 EDT //www.koonmotors.com/releases/2023/08/230809164716.htm //www.koonmotors.com/releases/2023/08/230809130650.htm Scientists have shown that immunotherapy after stem cell transplantation effectively combats certain nerve tumors in children. Crucially, stem cells from a parent provide children with a new immune system that responds much better to immunotherapies. Wed, 09 Aug 2023 13:06:50 EDT //www.koonmotors.com/releases/2023/08/230809130650.htm //www.koonmotors.com/releases/2023/08/230809130628.htm Alzheimer's, stroke, multiple sclerosis and other neurological diseases cause severe damage due to neuroinflammation mediated by immune cells. Managing this inflammation poses a significant medical challenge because the brain is protected by the skull and additional surrounding membranes that make the brain less accessible for treatment approaches. Scientists had previously discovered pathways going from the bone marrow of the skull towards the brain, allowing immune cell movement. Now, new research revealed that cells in the skull's bone marrow are unique in their composition and in their disease response. These findings offer new possibilities for the diagnosis and treatment of neurological diseases and revolutionize brain health monitoring in the future with non-invasive skull imaging. Wed, 09 Aug 2023 13:06:28 EDT //www.koonmotors.com/releases/2023/08/230809130628.htm //www.koonmotors.com/releases/2023/08/230809130602.htm Researchers have designed a probiotic to suppress autoimmunity in the brain, which occurs when the immune system attacks the cells of the central nervous system. Wed, 09 Aug 2023 13:06:02 EDT //www.koonmotors.com/releases/2023/08/230809130602.htm //www.koonmotors.com/releases/2023/08/230808110925.htm Researchers have found wheat gluten causes brain inflammation in mice. Tue, 08 Aug 2023 11:09:25 EDT //www.koonmotors.com/releases/2023/08/230808110925.htm //www.koonmotors.com/releases/2023/08/230808110836.htm 一些hiv - 1航空公司获得了早期的蚂蚁iretroviral treatment during several years are able to control the virus for a long term after treatment interruption. However, the mechanisms enabling this post-treatment control have not been fully elucidated. Scientists have now investigated and revealed how neutralizing antibodies, including those described as broadly neutralizing, contribute to virus control. A clinical trial involving the use of broadly neutralizing antibodies should begin in France before the end of 2023. Tue, 08 Aug 2023 11:08:36 EDT //www.koonmotors.com/releases/2023/08/230808110836.htm //www.koonmotors.com/releases/2023/08/230807152150.htm Researchers discovered an entirely new and unexpected mechanism by which the immune system can get rid of cells lacking molecules that identify them as part of the self in mice. The finding has possible implications for cancer treatment. Mon, 07 Aug 2023 15:21:50 EDT //www.koonmotors.com/releases/2023/08/230807152150.htm //www.koonmotors.com/releases/2023/08/230803213832.htm A new study has identified a pair of genes whose expression by a type of immune cell within tumors is predictive of outcomes for cancer patients and is linked to a vast network of gene expression programs, engaged by multiple cell types in the tumor microenvironment, that control human cancers. Thu, 03 Aug 2023 21:38:32 EDT //www.koonmotors.com/releases/2023/08/230803213832.htm //www.koonmotors.com/releases/2023/08/230803141711.htm CAR-T immune therapies could be effective against solid tumors if the right targets are identified, a new study suggests. The researchers successfully deployed CAR-T in a mouse model of ovarian cancer, a type of aggressive, solid-tumor cancer that has eluded such therapies until now. Thu, 03 Aug 2023 14:17:11 EDT //www.koonmotors.com/releases/2023/08/230803141711.htm //www.koonmotors.com/releases/2023/08/230803112958.htm 免疫system T cells that should be able to kill cancer cells become dysfunctional or 'exhausted' within hours of encountering a tumor, according to a new study. Thu, 03 Aug 2023 11:29:58 EDT //www.koonmotors.com/releases/2023/08/230803112958.htm //www.koonmotors.com/releases/2023/08/230803112925.htm A research team has published rigorous new research that advances a quest to understand a puzzling -- and heartbreaking -- ultra-rare disease that's found almost exclusively in boys. Thu, 03 Aug 2023 11:29:25 EDT //www.koonmotors.com/releases/2023/08/230803112925.htm //www.koonmotors.com/releases/2023/08/230802235458.htm New research has uncovered evidence that the thymus is in fact critical for adult health generally and for preventing cancer and perhaps autoimmune disease. Wed, 02 Aug 2023 23:54:58 EDT //www.koonmotors.com/releases/2023/08/230802235458.htm //www.koonmotors.com/releases/2023/08/230802132023.htm Researchers have found that a specific immune signaling pathway drives ageing-related inflammation and neurodegeneration. The work can help us understand the mechanisms behind ageing-associated impairment and disease. Wed, 02 Aug 2023 13:20:23 EDT //www.koonmotors.com/releases/2023/08/230802132023.htm //www.koonmotors.com/releases/2023/08/230802132005.htm A study on almost four thousand people of African descent has identified a gene that acts as natural defense against HIV by limiting its replication in certain white blood cells. This research paves the way for new treatment strategies and underscores the importance of studying diverse ancestral populations to better address their specific medical needs and global health disparities. Wed, 02 Aug 2023 13:20:05 EDT //www.koonmotors.com/releases/2023/08/230802132005.htm //www.koonmotors.com/releases/2023/08/230801152848.htm New research reveals a type of monoclonal antibody already tested in certain forms of cancer may be a promising treatment in stopping the progression of amyotrophic lateral sclerosis, or ALS, a fatal neurodegenerative disease. Tue, 01 Aug 2023 15:28:48 EDT //www.koonmotors.com/releases/2023/08/230801152848.htm //www.koonmotors.com/releases/2023/07/230731110747.htm Scientists have identified a protein that plays a pivotal role in the action of several emerging cancer therapies. The researchers say the discovery will likely aid efforts to fine-tune the use of immunotherapies against several challenging cancers. Mon, 31 Jul 2023 11:07:47 EDT //www.koonmotors.com/releases/2023/07/230731110747.htm //www.koonmotors.com/releases/2023/07/230731110737.htm Researchers have uncovered why some intestinal worm infections become chronic in animal models, which could eventually lead to human vaccines and improved treatments. Parasitic worms, also called helminths, usually infect the host by living in the gut. About a quarter of the world population is afflicted with helminth infections. Mon, 31 Jul 2023 11:07:37 EDT //www.koonmotors.com/releases/2023/07/230731110737.htm //www.koonmotors.com/releases/2023/07/230731110713.htm Eosiniphilic esophagitis occurs more frequently in children and can prevent food from being swallowed, potentially leading to malnutrition, weight loss and poor growth. A new study has identified the pathway that causes the chronic immune system disease and a novel treatment strategy. Mon, 31 Jul 2023 11:07:13 EDT //www.koonmotors.com/releases/2023/07/230731110713.htm //www.koonmotors.com/releases/2023/07/230728113401.htm A metabolic by-product that is more prevalent during fasting may supercharge immune cells as they fight infection and disease, reports an early stage study. The findings may pave the way for future personalized dietary recommendations to augment treatments for infection, cancer and other diseases. Fri, 28 Jul 2023 11:34:01 EDT //www.koonmotors.com/releases/2023/07/230728113401.htm //www.koonmotors.com/releases/2023/07/230727144130.htm Investigators have designed an innovative RNA-based strategy to activate dendritic cells--which play a key role in immune response -- that eradicated tumors and prevented their recurrence in mouse models of melanoma. The findings suggest that the approach has the potential to be effective against tumors that have already spread to other parts of the body and against different cancer types. Cancer cells employ strategies to switch off various stages of the cancer-immunity cycle, the process by which dendritic cells educate T cells to kill cancer cells. This immunosuppressive environment that impedes activation of cancer-killing T cells allows tumors to grow, say the researchers. Thu, 27 Jul 2023 14:41:30 EDT //www.koonmotors.com/releases/2023/07/230727144130.htm //www.koonmotors.com/releases/2023/07/230727143941.htm In a promising form of immunotherapy known as CAR T-cell (chimeric antigen receptor) therapy, the patient's T cells are engineered to better recognize and attack antigens on the surface of cancer cells. In treatments currently approved for use in battling lymphoma and leukemia, however, the therapy has a drawback: Amidst the cancer-killing frenzy, many engineered T cells become tainted with the remnants of cancer antigens, which causes them to turn on other T cells. This eventually depletes the body of cancer-fighting cells and opens the door for a recurrence of cancer. A new study, however, has identified a way to tame the self-destructive tendencies of these killer T cells. Thu, 27 Jul 2023 14:39:41 EDT //www.koonmotors.com/releases/2023/07/230727143941.htm