//www.koonmotors.com/news/health_medicine/hiv_and_aids/ HIV and AIDS information and facts. Read latest medical articles and view educational videos on AIDS and HIV symptoms and treatments. Stay informed about new developments on the AIDS/HIV front. en-us Fri, 08 Sep 2023 08:16:27 EDT Fri, 08 Sep 2023 08:16:27 EDT 60 //www.koonmotors.com/images/scidaily-logo-rss.png//www.koonmotors.com/news/health_medicine/hiv_and_aids/ For more science news, visit ScienceDaily. //www.koonmotors.com/releases/2023/09/230905124929.htm A new international study has shown mpox (formerly known as monkeypox) infections to be less severe among those who are vaccinated or had a previous infection in 2022, underlining the importance and effectiveness of vaccination. Tue, 05 Sep 2023 12:49:29 EDT //www.koonmotors.com/releases/2023/09/230905124929.htm //www.koonmotors.com/releases/2023/08/230830131950.htm Australian researchers have found an existing blood cancer drug can kill 'silent' HIV cells and delay reinfections -- a significant pre-clinical discovery that could lead to a future cure for the disease. Wed, 30 Aug 2023 13:19:50 EDT //www.koonmotors.com/releases/2023/08/230830131950.htm //www.koonmotors.com/releases/2023/08/230830131948.htm When an immunocompromised person's system begins to recover and produce more white blood cells, it's usually a good thing -- unless they develop C-IRIS, a potentially deadly inflammatory condition. New research has found that the pulmonary distress often associated with C-IRIS is caused not by damage to the lungs, but by newly populated T-cells infiltrating the brain. Knowing this mechanism of action can help researchers and physicians better understand the illness and provide new treatment targets. Wed, 30 Aug 2023 13:19:48 EDT //www.koonmotors.com/releases/2023/08/230830131948.htm //www.koonmotors.com/releases/2023/08/230822111628.htm A team of researchers successfully tested a new antifungal therapy to treat fungal meningitis. Tue, 22 Aug 2023 11:16:28 EDT //www.koonmotors.com/releases/2023/08/230822111628.htm //www.koonmotors.com/releases/2023/08/230817164016.htm A single injection of a novel CRISPR gene-editing treatment safely and efficiently removes SIV -- a virus related to the AIDS-causing agent HIV -- from the genomes of non-human primates, scientists now report. The groundbreaking work complements previous experiments as the basis for the first-ever clinical trial of an HIV gene-editing technology in human patients, which was authorized by the Food and Drug Administration (FDA) in 2022. Thu, 17 Aug 2023 16:40:16 EDT //www.koonmotors.com/releases/2023/08/230817164016.htm //www.koonmotors.com/releases/2023/08/230810110414.htm Researchers created a germ-free mouse model to evaluate the role of the microbiome in the infection, replication, and pathogenesis of HIV and the Epstein-Barr virus, the virus that can cause mononucleosis and other serious diseases. Thu, 10 Aug 2023 11:04:14 EDT //www.koonmotors.com/releases/2023/08/230810110414.htm //www.koonmotors.com/releases/2023/08/230810110313.htm A study has identified a new pathway that human immune deficiency virus (HIV) uses to enter the nucleus of a healthy cell, where it can then replicate and go on to invade other cells. Thu, 10 Aug 2023 11:03:13 EDT //www.koonmotors.com/releases/2023/08/230810110313.htm //www.koonmotors.com/releases/2023/08/230808110836.htm 一些hiv - 1航空公司获得了早期的蚂蚁iretroviral treatment during several years are able to control the virus for a long term after treatment interruption. However, the mechanisms enabling this post-treatment control have not been fully elucidated. Scientists have now investigated and revealed how neutralizing antibodies, including those described as broadly neutralizing, contribute to virus control. A clinical trial involving the use of broadly neutralizing antibodies should begin in France before the end of 2023. Tue, 08 Aug 2023 11:08:36 EDT //www.koonmotors.com/releases/2023/08/230808110836.htm //www.koonmotors.com/releases/2023/08/230802132005.htm A study on almost four thousand people of African descent has identified a gene that acts as natural defense against HIV by limiting its replication in certain white blood cells. This research paves the way for new treatment strategies and underscores the importance of studying diverse ancestral populations to better address their specific medical needs and global health disparities. Wed, 02 Aug 2023 13:20:05 EDT //www.koonmotors.com/releases/2023/08/230802132005.htm //www.koonmotors.com/releases/2023/07/230728113448.htm Scientists appear to have discovered a way to produce a true structure of the rare but naturally-occurring anti-HIV compound Lancilactone C from start to finish. The domino-like reaction enables the total synthesis of lancilactones and related compounds. Its non-cytotoxicity in mammals could potentially make this triterpenoid an ideal candidate for treating AIDS. Fri, 28 Jul 2023 11:34:48 EDT //www.koonmotors.com/releases/2023/07/230728113448.htm //www.koonmotors.com/releases/2023/07/230726113046.htm The results of a novel study has revealed exciting findings in the pursuit of an HIV cure. Wed, 26 Jul 2023 11:30:46 EDT //www.koonmotors.com/releases/2023/07/230726113046.htm //www.koonmotors.com/releases/2023/07/230722004700.htm Researchers have discovered the molecular mechanisms by which the human immunodeficiency virus (HIV) becomes resistant to Dolutegravir, one of the most effective, clinically used antiviral drugs for treating HIV. Their findings reveal how changes to the 3D structures of integrase, an HIV protein, can lead to Dolutegravir resistance and how other compounds may be able to overcome this resistance. Sat, 22 Jul 2023 00:47:00 EDT //www.koonmotors.com/releases/2023/07/230722004700.htm //www.koonmotors.com/releases/2023/07/230704110913.htm Global efforts to reduce infectious disease rates must have a greater focus on older children and adolescents after a shift in disease burden onto this demographic, according to a new study. Tue, 04 Jul 2023 11:09:13 EDT //www.koonmotors.com/releases/2023/07/230704110913.htm //www.koonmotors.com/releases/2023/06/230627123000.htm A milliliter of blood contains about 15 individual drops. For a person with human immunodeficiency virus (HIV), each drop of blood could contain anywhere from fewer than 20 copies of the virus to more than 500,000 copies. Called the viral load, this is what is measured to allow clinicians to understand how patients are responding to anti-viral medications and monitor potential progression. The time-consuming viral load testing needs to be repeated several times as a patient undergoes treatment. Now, a research team has developed a time and cost-efficient digital assay that can directly measure the presence of HIV in single drop of blood. Tue, 27 Jun 2023 12:30:00 EDT //www.koonmotors.com/releases/2023/06/230627123000.htm //www.koonmotors.com/releases/2023/06/230622182820.htm Just as space holds infinite mysteries, when we zoom in at the level of biomolecules (one trillion times smaller than a meter), there is still so much to learn. Scientists are studying the conformational landscapes of biomolecules and how they modulate cell function. When biomolecules receive certain inputs, it can cause the atoms to rearrange and the biomolecule to change shape. This change in shape affects their function in cells, so understanding conformational dynamics is critical for drug development. Thu, 22 Jun 2023 18:28:20 EDT //www.koonmotors.com/releases/2023/06/230622182820.htm //www.koonmotors.com/releases/2023/05/230530174312.htm Scientists have spent years trying to develop an effective HIV vaccine, but none have proven successful. Based on findings from a recently published study, a research team may have put science one step closer to that goal. Tue, 30 May 2023 17:43:12 EDT //www.koonmotors.com/releases/2023/05/230530174312.htm //www.koonmotors.com/releases/2023/05/230525141517.htm New animal research is helping explain why at least five people have become HIV-free after receiving a stem cell transplant, and may bring scientists closer to developing what they hope will be a widespread cure for the virus that causes AIDS. A new study describes how two nonhuman primates were cured of the monkey form of HIV after receiving a stem cell transplant. It also reveals that two circumstances must co-exist for a cure to occur and documents the order in which HIV is cleared from the body. Thu, 25 May 2023 14:15:17 EDT //www.koonmotors.com/releases/2023/05/230525141517.htm //www.koonmotors.com/releases/2023/05/230509122018.htm New research found that people living with HIV that have had pulmonary tuberculosis had broader and more potent HIV antibody responses and differences in HIV sequences predicted to be antibody resistant as compared to those without suspected or documented tuberculosis. Tue, 09 May 2023 12:20:18 EDT //www.koonmotors.com/releases/2023/05/230509122018.htm //www.koonmotors.com/releases/2023/05/230502155419.htm Gene-editing therapy aimed at two targets -- HIV-1, the virus that causes AIDS, and CCR5, the co-receptor that helps the virus get into cells -- can effectively eliminate HIV infection, new research shows. The study combines a dual gene-editing strategy with antiretroviral drugs to cure animals of HIV-1. Tue, 02 May 2023 15:54:19 EDT //www.koonmotors.com/releases/2023/05/230502155419.htm //www.koonmotors.com/releases/2023/03/230327114935.htm To develop treatments that may one day entirely rid the body of HIV infection, scientists have long sought to identify all of the places that the virus can hide its genetic code. Now, in a study using blood samples from men and women with HIV on long-term suppressive therapy, a team of scientists reports new evidence that one such stable reservoir of HIV genomes can be found in circulating white blood cells called monocytes. Mon, 27 Mar 2023 11:49:35 EDT //www.koonmotors.com/releases/2023/03/230327114935.htm //www.koonmotors.com/releases/2023/03/230324093449.htm MitoQ, a mitochondrial antioxidant that is available to the public as a diet supplement, was found in a mouse study to reverse the detrimental effects that HIV and antiretroviral therapy (ART) have on mitochondria in the brain, heart, aorta, lungs, kidney and liver. Fri, 24 Mar 2023 09:34:49 EDT //www.koonmotors.com/releases/2023/03/230324093449.htm //www.koonmotors.com/releases/2023/03/230316114046.htm The human immunodeficiency virus HIV-1 is able to infect various tissues in humans. Once inside the cells, the virus integrates its genome into the cellular genome and establishes persistent infections. The role of the structure and organization of the host genome in HIV-1 infection is not well understood. Using a cell culture model based on brain immune microglia cells, an international research team has now defined the insertion patterns of HIV-1 in the genome of microglia cells. Thu, 16 Mar 2023 11:40:46 EDT //www.koonmotors.com/releases/2023/03/230316114046.htm //www.koonmotors.com/releases/2023/03/230309164655.htm Researchers have examined how patient characteristics and COVID-19 infection may affect the antibody responses of people with HIV -- including responses against SARS-CoV-2 proteins as well as proteins from other viruses. Thu, 09 Mar 2023 16:46:55 EST //www.koonmotors.com/releases/2023/03/230309164655.htm //www.koonmotors.com/releases/2023/02/230228113747.htm A research team has shown that, as early as the first days of infection, HIV is able to create reservoirs where it will hide and persist during antiretroviral therapy. Tue, 28 Feb 2023 11:37:47 EST //www.koonmotors.com/releases/2023/02/230228113747.htm //www.koonmotors.com/releases/2023/02/230224165409.htm Haematopoietic stem cell transplantation for the treatment of severe blood cancers is the only medical intervention that has cured two people living with HIV in the past. An international group of physicians and researchers has now identified another case in which HIV infection has been shown to be cured in the same way. The successful healing process of this third patient was for the first time characterized in great detail virologically and immunologically over a time span of ten years. Fri, 24 Feb 2023 16:54:09 EST //www.koonmotors.com/releases/2023/02/230224165409.htm //www.koonmotors.com/releases/2023/01/230131124430.htm A new vaccine could be the first clinically approved immunization to protect against invasive fungal infections, a growing concern as antifungal drug resistance increases. Fungal infections cause more than 1.5 million deaths worldwide each year and cost billions. They also double hospitalization costs, double the length of hospital stays and double the risk of death in hospitalized patients, according to a previous recent study. Tue, 31 Jan 2023 12:44:30 EST //www.koonmotors.com/releases/2023/01/230131124430.htm //www.koonmotors.com/releases/2023/01/230130130459.htm By repurposing one of the human body's natural cargo transports, a research team has developed a vaccine platform that could curb certain engineering challenges, storage demands and side effects of vaccines that combat HIV epidemics and the COVID-19 pandemic. Mon, 30 Jan 2023 13:04:59 EST //www.koonmotors.com/releases/2023/01/230130130459.htm //www.koonmotors.com/releases/2023/01/230118134000.htm An investigational HIV vaccine regimen tested among men who have sex with men (MSM) and transgender people was safe but did not provide protection against HIV acquisition, an independent data and safety monitoring board (DSMB) has determined. The HPX3002/HVTN 706, or 'Mosaico,' Phase 3 clinical trial began in 2019 and involved 3,900 volunteers ages 18 to 60 years in Europe, North America and South America. Based on the DSMB's recommendation, the study will be discontinued. Wed, 18 Jan 2023 13:40:00 EST //www.koonmotors.com/releases/2023/01/230118134000.htm //www.koonmotors.com/releases/2023/01/230117133654.htm A diverse immune response hinges on naive B cells mingling with high affinity ones in the late-stage germinal center. Whether that helps or hinders, however, depends on the virus. Tue, 17 Jan 2023 13:36:54 EST //www.koonmotors.com/releases/2023/01/230117133654.htm //www.koonmotors.com/releases/2023/01/230110151022.htm In a rigorous new study virologists are describing an against-the-grain discovery that is a potential game changer in the field. It has the potential to show the way forward for HIV cure research. Tue, 10 Jan 2023 15:10:22 EST //www.koonmotors.com/releases/2023/01/230110151022.htm //www.koonmotors.com/releases/2023/01/230102114536.htm Vaccination and boosting, especially when recent, helped to limit the spread of COVID-19 in California prisons during the first Omicron wave, according to an analysis that examined transmission between people living in the same cell. Mon, 02 Jan 2023 11:45:36 EST //www.koonmotors.com/releases/2023/01/230102114536.htm //www.koonmotors.com/releases/2022/12/221209094801.htm Researchers have found that people infected with HIV who receive antiretroviral therapy form antibodies against Sars-Cov-2 after being vaccinated against COVID with mRNA vaccines. Their immune response to the vaccination is, however, less strong than that of healthy people. A third vaccination reduces this gap. Fri, 09 Dec 2022 09:48:01 EST //www.koonmotors.com/releases/2022/12/221209094801.htm //www.koonmotors.com/releases/2022/12/221206204921.htm People who receive monoclonal antibodies before vaccines may benefit from increased coverage, due to antibody feedback inhibition, according to new research. Tue, 06 Dec 2022 20:49:21 EST //www.koonmotors.com/releases/2022/12/221206204921.htm //www.koonmotors.com/releases/2022/12/221202124838.htm While scientists have struggled in the past to create an effective vaccine against HIV, a novel vaccine design strategy being pursued by a team of researchers. The teams work shows new promise, according to data from a first-in-human clinical trial. Fri, 02 Dec 2022 12:48:38 EST //www.koonmotors.com/releases/2022/12/221202124838.htm //www.koonmotors.com/releases/2022/11/221128201747.htm Researchers found that across the U.S., anal cancer incidence and mortality rates increased 1.5-fold in men and women over 50 years old. However, the most prominent increase -- more than two-fold -- occurred among people over 50 years of age living in the Midwestern and Southeastern states. Mon, 28 Nov 2022 20:17:47 EST //www.koonmotors.com/releases/2022/11/221128201747.htm //www.koonmotors.com/releases/2022/11/221122111356.htm Though antiretroviral therapy has made HIV a manageable disease, people living with HIV often suffer from chronic inflammation. This can put them at an increased risk of developing comorbidities such as cardiovascular disease and neurocognitive dysfunction, impacting the longevity and quality of their lives. Now, a new study explains why chronic inflammation may be happening and how suppression or even eradication of HIV in the body may not resolve it. Tue, 22 Nov 2022 11:13:56 EST //www.koonmotors.com/releases/2022/11/221122111356.htm //www.koonmotors.com/releases/2022/11/221114190621.htm An immune response that likely evolved to help fight infections appears to be the mechanism that drives human immunodeficiency virus (HIV) into a latent state, lurking in cells only to erupt anew, researchers report. Mon, 14 Nov 2022 19:06:21 EST //www.koonmotors.com/releases/2022/11/221114190621.htm //www.koonmotors.com/releases/2022/11/221110144027.htm People living with HIV have a significantly delayed internal body clock, consistent with the symptoms of jet lag, according to new findings. Thu, 10 Nov 2022 14:40:27 EST //www.koonmotors.com/releases/2022/11/221110144027.htm //www.koonmotors.com/releases/2022/11/221108120517.htm The type of virus used as a model to study the efficacy of non-neutralizing antibodies against the virus responsible for AIDS has a crucial role to play, according to a new study. Tue, 08 Nov 2022 12:05:17 EST //www.koonmotors.com/releases/2022/11/221108120517.htm //www.koonmotors.com/releases/2022/11/221107192300.htm Researchers have identified how a specific protein in SARS-CoV-2, the virus responsible for COVID-19, damages heart tissue. They then used a drug to reverse the toxic effects of that protein on the heart. Mon, 07 Nov 2022 19:23:00 EST //www.koonmotors.com/releases/2022/11/221107192300.htm //www.koonmotors.com/releases/2022/11/221107114454.htm Investigators analyzed longitudinal samples of cervical and serum biomarker levels for immune activation, before and after subjects acquired HSV-2. They found that altered levels of specific biomarkers in the mucosa and serum were associated with HSV-2 acquisition only, while others overlapped with biomarkers and combinations predictive of HIV-1 acquisition. Mon, 07 Nov 2022 11:44:54 EST //www.koonmotors.com/releases/2022/11/221107114454.htm //www.koonmotors.com/releases/2022/11/221104093259.htm Researchers have identified the specific mutations in the monkeypox virus that contribute to its continued infectiousness. The findings could lead to several outcomes: modified versions of existing drugs used to treat people suffering from monkeypox or the development of new drugs that account for the current mutations to increase their effectiveness at reducing symptoms and the spread of the virus. Fri, 04 Nov 2022 09:32:59 EDT //www.koonmotors.com/releases/2022/11/221104093259.htm //www.koonmotors.com/releases/2022/11/221101100733.htm In the tough war against glioblastoma, scientists are taking a cue from viruses on how to make the aggressive cancer more vulnerable to treatment. Their target is SAMHD1, a protein which can protect us from viral infections by destroying an essential building block of DNA that viruses and cancer need to replicate. Tue, 01 Nov 2022 10:07:33 EDT //www.koonmotors.com/releases/2022/11/221101100733.htm //www.koonmotors.com/releases/2022/10/221028111654.htm The parasite Toxoplasma is carried by a large portion of the global human population. Now a study shows how this microscopic parasite so successfully spreads in the body, for example to the brain. The parasite infects immune cells and hijacks their identity. Fri, 28 Oct 2022 11:16:54 EDT //www.koonmotors.com/releases/2022/10/221028111654.htm //www.koonmotors.com/releases/2022/10/221025090452.htm A big group of bacteria found in our soil, our water and our shower heads are harmless for most of us, but a new study indicates they are associated with an increased risk of dying in individuals whose kidneys have failed. Tue, 25 Oct 2022 09:04:52 EDT //www.koonmotors.com/releases/2022/10/221025090452.htm //www.koonmotors.com/releases/2022/10/221021132741.htm Starting antiretroviral treatment (ART) early in the course of HIV infection when the immune system is stronger results in better long-term health outcomes compared with delaying ART, according to new findings. Fri, 21 Oct 2022 13:27:41 EDT //www.koonmotors.com/releases/2022/10/221021132741.htm //www.koonmotors.com/releases/2022/10/221021093746.htm A three-dose course of the hepatitis B vaccine HEPLISAV-B fully protected adults living with HIV who had never been vaccinated against or infected with the hepatitis B virus (HBV), according to new study. Fri, 21 Oct 2022 09:37:46 EDT //www.koonmotors.com/releases/2022/10/221021093746.htm //www.koonmotors.com/releases/2022/10/221017142435.htm While the standard treatment for HIV can hold the disease in check, a new study shows how experimental medicines can boost the body's own ability to suppress the virus. An important step towards a cure, say researchers behind the study. Mon, 17 Oct 2022 14:24:35 EDT //www.koonmotors.com/releases/2022/10/221017142435.htm //www.koonmotors.com/releases/2022/10/221013194117.htm People with HIV who have moderate immune suppression appear to be at greater risk of severe COVID-19 'breakthrough' infection after vaccination, according to a new study. Thu, 13 Oct 2022 19:41:17 EDT //www.koonmotors.com/releases/2022/10/221013194117.htm //www.koonmotors.com/releases/2022/10/221013101607.htm A study that analyzed genes in nasal swabs from asymptomatic people who tested positive for SARS-CoV-2 showed the results could be attributed to occupational exposure rather than infection. Thu, 13 Oct 2022 10:16:07 EDT //www.koonmotors.com/releases/2022/10/221013101607.htm //www.koonmotors.com/releases/2022/10/221012132533.htm New research in Zambia finds that children infected with HIV are significantly more likely to do worse in neurological assessments despite having well-controlled HIV disease, suggesting that they may struggle with cognitive and mental health issues. However, the research also indicates that early intervention -- in the form of better nutrition and antiretroviral therapies -- may help close the gap. Wed, 12 Oct 2022 13:25:33 EDT //www.koonmotors.com/releases/2022/10/221012132533.htm //www.koonmotors.com/releases/2022/10/221004105003.htm The hepatitis B virus (HBV) is responsible for one of the most serious and common infectious diseases. Transmitted through biological fluids, it attacks the liver cells. The chronic form of the disease can lead to serious complications, including cirrhosis and liver cancer. There is no effective treatment for the chronic form of the disease, which can only be prevented by vaccination. After identifying a key protein complex that is active when our body is infected by the virus, a team has deciphered the precise functioning of this protective mechanism, opening the way to new therapeutic targets. Tue, 04 Oct 2022 10:50:03 EDT //www.koonmotors.com/releases/2022/10/221004105003.htm //www.koonmotors.com/releases/2022/10/221003200156.htm Scientists have successfully modeled the formation of SARS-CoV-2, the virus that spreads COVID-19. The research offers an overall understanding of the assembly and formation of SARS-CoV-2 from its constituent components. Mon, 03 Oct 2022 20:01:56 EDT //www.koonmotors.com/releases/2022/10/221003200156.htm //www.koonmotors.com/releases/2022/10/221003141407.htm Two studies combine bioinformatics and other techniques to develop new vaccine candidates against HIV. Mon, 03 Oct 2022 14:14:07 EDT //www.koonmotors.com/releases/2022/10/221003141407.htm //www.koonmotors.com/releases/2022/09/220930112636.htm An obscure family of viruses, already endemic in wild African primates and known to cause fatal Ebola-like symptoms in some monkeys, is 'poised for spillover' to humans, according to new research. Fri, 30 Sep 2022 11:26:36 EDT //www.koonmotors.com/releases/2022/09/220930112636.htm //www.koonmotors.com/releases/2022/09/220930090841.htm Certain gut bacteria -- including one that is essential for a healthy gut microbiome -- differ between people who go on to acquire HIV infection compared to those who have not become infected. Fri, 30 Sep 2022 09:08:41 EDT //www.koonmotors.com/releases/2022/09/220930090841.htm //www.koonmotors.com/releases/2022/09/220929204048.htm Is it ethical to test possible HIV cures by having subjects stop taking antiretroviral therapy and then giving them placebos rather than the experimental treatment? The answer is often yes, according to a new paper. Thu, 29 Sep 2022 20:40:48 EDT //www.koonmotors.com/releases/2022/09/220929204048.htm //www.koonmotors.com/releases/2022/09/220926090211.htm A new study shows that two kidney transplant patients treated with immunosuppressive drugs, and who later had a lengthy COVID-19 infection, developed a version of the virus with a genetic change (mutation) that made it resistant to the antiviral therapy remdesivir. Mon, 26 Sep 2022 09:02:11 EDT //www.koonmotors.com/releases/2022/09/220926090211.htm //www.koonmotors.com/releases/2022/09/220923153040.htm Tiny nets woven from DNA strands can ensnare the spike protein of the virus that causes COVID-19, lighting up the virus for a fast-yet-sensitive diagnostic test -- and also impeding the virus from infecting cells, opening a new possible route to antiviral treatment, according to a new study. Fri, 23 Sep 2022 15:30:40 EDT //www.koonmotors.com/releases/2022/09/220923153040.htm //www.koonmotors.com/releases/2022/09/220921113124.htm Researchers have discovered how the immune system can transform into an antibody-making machine capable of neutralizing one of the most elusive viruses out there: HIV. This finding is an important step toward developing effective, long-lasting vaccines against pathogens such as HIV, influenza, malaria, and SARS-CoV-2. Wed, 21 Sep 2022 11:31:24 EDT //www.koonmotors.com/releases/2022/09/220921113124.htm