Genes News -- ScienceDaily //www.koonmotors.com/news/health_medicine/genes/ Genes and Genetics News. Read today's medical research in genetics including what can damage genes, what can protect them, and more. en-us Fri, 08 Sep 2023 22:47:43 EDT Fri, 08 Sep 2023 22:47:43 EDT 60 Genes News -- ScienceDaily //www.koonmotors.com/images/scidaily-logo-rss.png//www.koonmotors.com/news/health_medicine/genes/ For more science news, visit ScienceDaily. These worms have rhythm //www.koonmotors.com/releases/2023/09/230908161058.htm Researchers have developed a new imaging technique to observe active gene expression in real time. They found that four molecules work together to control the timing of each stage of the C. elegans worm's development. This timekeeping process could provide important clues about the natural rhythm of development in humans and other animals. Fri, 08 Sep 2023 16:10:58 EDT //www.koonmotors.com/releases/2023/09/230908161058.htm Study links epigenetic changes to historic trauma in Alaska Native communities //www.koonmotors.com/releases/2023/09/230907205950.htm Researchers investigated the relationship between historical traumatic events experienced by Alaska Native communities and epigenetic markers on genes that previous studies have linked to trauma. The new study found a similar pattern among Alaska Native participants, with specific epigenetic differences observed in those who reported experiencing the most intense symptoms of distress when reflecting on historic losses. Thu, 07 Sep 2023 20:59:50 EDT //www.koonmotors.com/releases/2023/09/230907205950.htm Engineers design more powerful RNA vaccines //www.koonmotors.com/releases/2023/09/230907130332.htm By adding synergistic self-adjuvanting properties to Covid-19 RNA vaccines, researchers showed they could significantly boost the immune response generated in mice. Thu, 07 Sep 2023 13:03:32 EDT //www.koonmotors.com/releases/2023/09/230907130332.htm Genetic study of blood glucose levels calls for stratified treatment with GLP-1R agonists in type 2 diabetes //www.koonmotors.com/releases/2023/09/230907130323.htm Researchers reveal for the first time that high blood sugar levels in type 2 diabetes can play a causal role in lung disorders. Thu, 07 Sep 2023 13:03:23 EDT //www.koonmotors.com/releases/2023/09/230907130323.htm Early findings suggest clinical and lab-based approach critical to tracking head and neck cancer recurrence //www.koonmotors.com/releases/2023/09/230907105810.htm Early findings of two studies shed light on new ways to anticipate recurrence in HPV-positive head and neck cancer sooner. Thu, 07 Sep 2023 10:58:10 EDT //www.koonmotors.com/releases/2023/09/230907105810.htm Study illuminates mechanism that annotates genetic information passed from fathers to offspring //www.koonmotors.com/releases/2023/09/230906161820.htm Scientists have identified a key part of a mechanism that annotates genetic information before it is passed from fathers to their offspring. The findings shed new light on genomic imprinting, a fundamental, biological process in which a gene from one parent is switched off while the copy from the other parent remains active. Errors in imprinting are linked to a host of diseases, such as the rare disease Silver-Russell syndrome along with certain cancers and diabetes. Wed, 06 Sep 2023 16:18:20 EDT //www.koonmotors.com/releases/2023/09/230906161820.htm How sleep deprivation can harm the brain //www.koonmotors.com/releases/2023/09/230906143429.htm Not only does a lack of sleep make you feel awful, research has shown it impairs the brain. What's more, sleep loss over long periods can even increase risk for Alzheimer's and other neurological diseases. Researchers want to understand how sleep deprivation causes this harm. In a new study, a team working with mice has identified a protective protein whose level declines with sleep deprivation, leading to neuronal death. Wed, 06 Sep 2023 14:34:29 EDT //www.koonmotors.com/releases/2023/09/230906143429.htm Researchers identify new gene mutation that alters Alzheimer's disease risk //www.koonmotors.com/releases/2023/09/230906115607.htm A groundbreaking study has shed new light on the genetic underpinnings of Alzheimer's disease. Wed, 06 Sep 2023 11:56:07 EDT //www.koonmotors.com/releases/2023/09/230906115607.htm 'Super-enhancer' super-charges pancreatic tumor growth //www.koonmotors.com/releases/2023/09/230906112428.htm Scientists identified new set of molecules that drive the growth of human pancreatic cancer cell lines, explaining how genetic mutations can activate genetic 'super-enhancers' that promote out-of-control pancreatic cancer growth. They show the efficacy of an experimental drug that targets a super-enhancer related protein, demonstrating the promise of therapeutics that block the effects of super-enhancers. Wed, 06 Sep 2023 11:24:28 EDT //www.koonmotors.com/releases/2023/09/230906112428.htm Rubber plumbing seals can leak additives into drinking water //www.koonmotors.com/releases/2023/09/230906112418.htm As drinking water flows through pipes and into a glass, it runs against the rubber seals inside some plumbing devices. These parts contain additives that contribute to their flexibility and durability, but these potentially harmful compounds can leak into drinking water, according to a small-scale study. The authors report that the released compounds, which are typically linked to tire pollution, also transformed into other unwanted byproducts. Wed, 06 Sep 2023 11:24:18 EDT //www.koonmotors.com/releases/2023/09/230906112418.htm Researchers to study Alzheimer's disease in marmosets //www.koonmotors.com/releases/2023/09/230906112412.htm Neuroscientists created the first non-human primate model of hereditary Alzheimer's in marmosets to accelerate the pace of drug discovery and rebuild the foundation for future translational studies. Wed, 06 Sep 2023 11:24:12 EDT //www.koonmotors.com/releases/2023/09/230906112412.htm 为什么米ale kidneys more vulnerable to disease than female kidneys? Mouse study points to testosterone //www.koonmotors.com/releases/2023/09/230905124856.htm 女性肾脏是已知的更有弹性isease and injury, but a new study may help researchers better understand how to address sex-related health disparities for patients with kidney diseases. The study describes not only how sex hormones drive differences in male and female mouse kidneys, but also how lowering testosterone can 'feminize' this organ and improve its resilience. Tue, 05 Sep 2023 12:48:56 EDT //www.koonmotors.com/releases/2023/09/230905124856.htm New genes and natural toxins offer hope for cancer patients unresponsive to chemotherapy //www.koonmotors.com/releases/2023/09/230904104625.htm Scientists have discovered two new genes that cause head and neck cancer patients to be resistant to chemotherapy, and that silencing either gene can make cancer cells previously unresponsive to chemotherapy subsequently respond to it. Mon, 04 Sep 2023 10:46:25 EDT //www.koonmotors.com/releases/2023/09/230904104625.htm First-in-class targeted microRNA therapy slows cancer tumor growth //www.koonmotors.com/releases/2023/09/230904104617.htm A new cancer therapy attacks tumors by tricking cancer cells into absorbing a snippet of RNA that naturally blocks cell division. Mon, 04 Sep 2023 10:46:17 EDT //www.koonmotors.com/releases/2023/09/230904104617.htm A new approach to stop cancer growth? //www.koonmotors.com/releases/2023/08/230831164436.htm 生化研究人员已经确定了一个新的函数tion of a key protein that leads to cancer -- a finding they believe could lead to more effective treatments for a range of cancers and other diseases. Thu, 31 Aug 2023 16:44:36 EDT //www.koonmotors.com/releases/2023/08/230831164436.htm Scientists unpick how lung cells induce immune response to influenza //www.koonmotors.com/releases/2023/08/230831164228.htm Researchers have discovered some new and surprising ways that viral RNA and influenza virus are detected by human lung cells, which has potential implications for treating people affected by such viruses. Thu, 31 Aug 2023 16:42:28 EDT //www.koonmotors.com/releases/2023/08/230831164228.htm Largest genetic study of epilepsy to date provides new insights on why epilepsy develops and potential treatments //www.koonmotors.com/releases/2023/08/230831142832.htm The largest genetic study of its kind has discovered specific changes in our DNA that increase the risk of developing epilepsy and may inform the development of new treatments. 星期四,2023年8月31日14:28:32美国东部时间 //www.koonmotors.com/releases/2023/08/230831142832.htm Unraveling the long history of breast cancer formation //www.koonmotors.com/releases/2023/08/230831121759.htm The mechanism by which breast cancer is formed in the cells of mammalian epithelium has been discovered. Although roughly 20 mutations accumulate annually in each epithelial cell until menopause, the mutation rate significantly decreases after menopause. Accumulation also decreased after childbirth, suggesting the effect of estrogen in mammary epithelium. Thu, 31 Aug 2023 12:17:59 EDT //www.koonmotors.com/releases/2023/08/230831121759.htm Burning candles and fumes from cooking is harmful for people with mild asthma //www.koonmotors.com/releases/2023/08/230831121728.htm A new study shows that young individuals with even mild asthma should remember to turn ventilation all the way up when cooking or burning candles. The fumes can cause irritation and inflammation in the body. Thu, 31 Aug 2023 12:17:28 EDT //www.koonmotors.com/releases/2023/08/230831121728.htm New blood test for noncoding RNA significantly improves cancer detection //www.koonmotors.com/releases/2023/08/230831121621.htm A lab is developing more accurate and powerful liquid biopsy technologies that take advantage of signals from RNA 'dark matter,' an understudied area of the genome. Thu, 31 Aug 2023 12:16:21 EDT //www.koonmotors.com/releases/2023/08/230831121621.htm Promising evidence for sickle cell gene therapy //www.koonmotors.com/releases/2023/08/230830195934.htm A clinical trial has tested a potentially curative stem cell gene therapy for sickle cell disease. The results were promising. Wed, 30 Aug 2023 19:59:34 EDT //www.koonmotors.com/releases/2023/08/230830195934.htm Genetic factor fends off Alzheimer's and Parkinson's //www.koonmotors.com/releases/2023/08/230830151801.htm A massive study of medical and genetic data shows that people with a particular version of a gene involved in immune response had a lower risk of Alzheimer's and Parkinson's disease. Wed, 30 Aug 2023 15:18:01 EDT //www.koonmotors.com/releases/2023/08/230830151801.htm New blood test detects a key indicator of Parkinson's disease //www.koonmotors.com/releases/2023/08/230830151742.htm Researchers have developed a blood test that detects Parkinson's disease, potentially establishing a way to help diagnose the condition before nervous system damage worsens. A new blood-based diagnostic test would be a major advancement for Parkinson's disease, which afflicts 10 million people worldwide and is the second-most common neurodegenerative disease after Alzheimer's. Wed, 30 Aug 2023 15:17:42 EDT //www.koonmotors.com/releases/2023/08/230830151742.htm Educational attainment protects against a genetic risk factor for Alzheimer's disease //www.koonmotors.com/releases/2023/08/230830133603.htm 一项新的研究进一步说明时to risk of Alzheimer's disease, even genetically determined forms of the disease, genetics is only one piece of the puzzle. Researchers investigated the influence of genetics and educational attainment on cognitive decline by studying data from 675 people who carry a mutation that predisposes them to early onset Alzheimer's disease. Carriers of this mutation -- known as PSEN1 E280A -- have a median age of 49 for onset of dementia. The team found that among carriers who also carried a second mutation that puts them at heightened risk -- APOE e4 -- had an accelerated age of onset of cognitive decline. Among carriers who had an APOE e2 mutation -- known to be protective -- age of onset was delayed. The team also assessed the effect of educational attainment on cognitive function among PSEN1 E280A mutation carriers, including those who carried different APOE genotypes. They found that higher educational attainment -- that is, more years of education -- was associated with preserved cognitive ability particularly for those at highest genetic risk. Wed, 30 Aug 2023 13:36:03 EDT //www.koonmotors.com/releases/2023/08/230830133603.htm Could a cancer drug hold the key to an HIV cure? //www.koonmotors.com/releases/2023/08/230830131950.htm Australian researchers have found an existing blood cancer drug can kill 'silent' HIV cells and delay reinfections -- a significant pre-clinical discovery that could lead to a future cure for the disease. Wed, 30 Aug 2023 13:19:50 EDT //www.koonmotors.com/releases/2023/08/230830131950.htm Newly engineered versions of bacterial enzyme reveal how antibiotics could be more potent //www.koonmotors.com/releases/2023/08/230830130846.htm Researchers applied a new technology to generate the full inventory of mutations in the bacterial species Escherichia coli where the antibiotic rifampicin attaches to and disables an essential bacterial enzyme known as RNA polymerase (RNAP). Wed, 30 Aug 2023 13:08:46 EDT //www.koonmotors.com/releases/2023/08/230830130846.htm Your genes influence whether depression leads to other diseases //www.koonmotors.com/releases/2023/08/230829125934.htm A new study shows that people suffering from hospital-treated depression may have a high risk of developing conditions such as substance abuse, bipolar disorder, schizophrenia and anxiety -- depending on their genetic predisposition to the individual disorder. Tue, 29 Aug 2023 12:59:34 EDT //www.koonmotors.com/releases/2023/08/230829125934.htm The physics of fat droplets reveal DNA danger //www.koonmotors.com/releases/2023/08/230828162352.htm Researchers have looked beyond biochemistry to publish groundbreaking work on the physics of fat droplets found inside many types of cells, revealing them to be a potential threat to a cell's nucleus.They have discovered fat-filled lipid droplets' surprising capability to indent and puncture the nucleus, the organelle which contains and regulates a cell's DNA. The stakes of their findings are high: a ruptured nucleus can lead to elevated DNA damage that is characteristic of many diseases, including cancer. Mon, 28 Aug 2023 16:23:52 EDT //www.koonmotors.com/releases/2023/08/230828162352.htm New approach to fighting malaria //www.koonmotors.com/releases/2023/08/230828162349.htm Findings can open up new avenues for targeted approaches toward therapeutic strategies against the malaria-causing P. falciparum that are aimed at stopping the parasite's life cycle progression and its sexual differentiation, thus blocking the transmission of the parasite into mosquitoes. Mon, 28 Aug 2023 16:23:49 EDT //www.koonmotors.com/releases/2023/08/230828162349.htm Rare disease shares mechanism with cystic fibrosis //www.koonmotors.com/releases/2023/08/230828162346.htm 研究人员发现,相同的细胞mechanism involved in a form of cystic fibrosis is also implicated in a form of a rare disease called cystinosis. The mechanism cleans up mutated proteins. In cystinosis, a genetic disease, this allows cystine crystals to build up in the cell. This disrupts the cell, and eventually, tissues and ultimately organs, particularly the kidneys and the eyes. Mon, 28 Aug 2023 16:23:46 EDT //www.koonmotors.com/releases/2023/08/230828162346.htm Unlocking the secrets of cell antennas //www.koonmotors.com/releases/2023/08/230825140357.htm The NSL (non-specific lethal) complex regulates thousands of genes in fruit flies and mammals. Silencing the NSL genes leads to the death of the organism, which gave the complex its curious name. Researchers have now discovered that the genes regulated by the NSL complex also include genes of the intraciliary transport system. This enables different cell types to form cilia on their surface, which are important for cell communication. The study shows that these genes are 'switched on' by the NSL complex, regardless of whether a particular cell has cilia or not. The researchers found that this class of cilia-associated genes is crucial for the function of podocytes. This is a highly specialized cell type of the kidney that, paradoxically, does not have cilia. These findings have important implications for ciliopathies and kidney disease. Fri, 25 Aug 2023 14:03:57 EDT //www.koonmotors.com/releases/2023/08/230825140357.htm How being in space impairs astronauts' immune system //www.koonmotors.com/releases/2023/08/230825140329.htm A new study has examined how T cells of the immune system are affected by weightlessness. The results could explain why astronauts' T cells become less active and less effective at fighting infection. Fri, 25 Aug 2023 14:03:29 EDT //www.koonmotors.com/releases/2023/08/230825140329.htm Pros and cons of ChatGPT plugin, Code Interpreter, in education, biology, health //www.koonmotors.com/releases/2023/08/230825122024.htm Researchers see potential in educational settings for the newest official ChatGPT plugin, called Code Interpreter, they've found limitations for its use by scientists who work with biological data utilizing computational methods to prioritize targeted treatment for cancer and genetic disorders. Fri, 25 Aug 2023 12:20:24 EDT //www.koonmotors.com/releases/2023/08/230825122024.htm Scientists discover a previously unknown way cells break down proteins //www.koonmotors.com/releases/2023/08/230824150719.htm Short-lived proteins control gene expression in cells to carry out a number of vital tasks, from helping the brain form connections to helping the body mount an immune defense. These proteins are made in the nucleus and are quickly destroyed once they've done their job. The mechanism degrades short-lived proteins that support brain and immune functions. Thu, 24 Aug 2023 15:07:19 EDT //www.koonmotors.com/releases/2023/08/230824150719.htm Study uncovers genetic risk factors for heart failure //www.koonmotors.com/releases/2023/08/230824120201.htm A global team of scientists conducted one of the largest genetic association studies on heart failure to date. Using genomic data from over 90,000 heart failure patients and more than a million controls, the team identified 39 genetic mutations associated with heart failure, 18 of which had not been reported previously. Thu, 24 Aug 2023 12:02:01 EDT //www.koonmotors.com/releases/2023/08/230824120201.htm Epigenetic mechanism that causes bitter taste distortion discovered //www.koonmotors.com/releases/2023/08/230824120153.htm A bitter taste in the mouth is often a symptom or side effect of illness, which may be the result of how the body reacts to pathogens. A new study sheds light on the mechanisms involved in the complex interplay between taste perception and immune function. Their work also highlights the potential of a sequencing tool for investigating epigenetic mechanisms that affect taste-cell gene expression. Thu, 24 Aug 2023 12:01:53 EDT //www.koonmotors.com/releases/2023/08/230824120153.htm Researchers describe rebuilding, regenerating lung cells //www.koonmotors.com/releases/2023/08/230824111925.htm Researchers have discovered a novel approach for engrafting engineered cells into injured lung tissue. These findings may lead to new ways for treating lung diseases, such as emphysema, pulmonary fibrosis and COVID-19. The two studies describe the methodologies for engineering lung stem cells and transplanting them into injured experimental lungs without immunosuppression. Thu, 24 Aug 2023 11:19:25 EDT //www.koonmotors.com/releases/2023/08/230824111925.htm CRISPR-Cas3 gene editing system restores dystrophin function in stem cells derived from patients with Duchenne muscular dystrophy //www.koonmotors.com/releases/2023/08/230824111922.htm Duchenne muscular dystrophy (DMD) is a muscle degeneration disorder caused by mutations affecting the dystrophin gene. Researchers show how a dual CRISPR RNA method restored dystrophin protein function in induced pluripotent stem cells derived from DMD patients. The approach worked by removing large sections of the dystrophin gene, allowing the cells to skip faulty or misaligned sections of the genetic code. This yields truncated but still functional proteins for a wide variety of mutation patterns associated with DMD. Thu, 24 Aug 2023 11:19:22 EDT //www.koonmotors.com/releases/2023/08/230824111922.htm Topography of the genome influences where cancer mutations thrive, study shows //www.koonmotors.com/releases/2023/08/230824111914.htm Researchers have uncovered a connection between the topography of the human genome and the presence of mutations in human cancer. Just as different terrains on Earth foster distinct ecosystems, certain regions in the genome seem to provide an environment for specific mutations to thrive. Thu, 24 Aug 2023 11:19:14 EDT //www.koonmotors.com/releases/2023/08/230824111914.htm Gene therapy study identifies potential new treatment for liver cancer //www.koonmotors.com/releases/2023/08/230824111908.htm Gene therapy with microRNA-22 produced better survival outcomes than the current FDA-approved drug for liver cancer and without noticeable toxicity in new mouse study. Thu, 24 Aug 2023 11:19:08 EDT //www.koonmotors.com/releases/2023/08/230824111908.htm Women more severely affected by chronic fatigue syndrome //www.koonmotors.com/releases/2023/08/230824111857.htm Women with ME/CFS tend to have more symptoms and co-occurring conditions than men, according to initial results from the world's largest study of the disease. It has long been known that women are more likely to have ME/CFS (myalgic encephalomyelitis/chronic fatigue syndrome) but the DecodeME study has shown for the first time how their experience differs from men. Thu, 24 Aug 2023 11:18:57 EDT //www.koonmotors.com/releases/2023/08/230824111857.htm Study IDs secret of stealthy invader essential to ruinous rice disease //www.koonmotors.com/releases/2023/08/230824111811.htm The virulence of a rice-wrecking fungus relies on genetic decoding quirks that could prove central to stopping it, says new research. The research team hopes that identifying an essential but formerly unknown stage in the fungal takeover of rice cells can accelerate the treatment or prevention of rice blast disease, which ruins up to 30% of global yields each year. Thu, 24 Aug 2023 11:18:11 EDT //www.koonmotors.com/releases/2023/08/230824111811.htm Could microplastics in soil introduce drug-resistant superbugs to the food supply? //www.koonmotors.com/releases/2023/08/230823192945.htm A new review argues ever-present microplastics could promote gene transfer among microbes, potentially resulting in greater antibiotic resistance. The review calls for more research on microplastic-microbe interactions where our food is grown. 结婚,2023年8月23日19:29:45美国东部时间 //www.koonmotors.com/releases/2023/08/230823192945.htm Insights from fully sequencing 43 human Y chromosomes //www.koonmotors.com/releases/2023/08/230823165531.htm Highly challenging to sequence and long overlooked, the human Y chromosome's contributions to health and disease remain largely unknown. A new paper that presents, for the first time, the complete sequences of multiple human Y chromosomes from lineages from around the globe provides an essential step forward in understanding the roles of the Y chromosome in human evolution and biology. Wed, 23 Aug 2023 16:55:31 EDT //www.koonmotors.com/releases/2023/08/230823165531.htm Longevity gene from naked mole rats extends lifespan of mice //www.koonmotors.com/releases/2023/08/230823165402.htm In a groundbreaking endeavor, researchers have successfully transferred a longevity gene from naked mole rats to mice, resulting in improved health and an extension of the mouse's lifespan. The research opens exciting possibilities for unlocking the secrets of aging and extending human lifespan. Wed, 23 Aug 2023 16:54:02 EDT //www.koonmotors.com/releases/2023/08/230823165402.htm New approach to nongenetic T-cell-based immunotherapy //www.koonmotors.com/releases/2023/08/230823122619.htm Immunotherapies for cancer aim to induce the immune system to combat cancer cells more effectively. A research team has now described a new, modular strategy for T-cell-based immunotherapy that manages to work without complex genetic modifications. Modulation of cell-cell communications through an ingenious regulatory circuit using various small, specially folded DNA molecules (aptamers) causes cancer cells to directly activate their mortal enemies, T cells. Wed, 23 Aug 2023 12:26:19 EDT //www.koonmotors.com/releases/2023/08/230823122619.htm Study connects neural gene expression differences to functional distinctions //www.koonmotors.com/releases/2023/08/230823122606.htm Researchers compared a pair of superficially similar motor neurons in fruit flies to examine how their differing use of the same genome produced distinctions in form and function. Wed, 23 Aug 2023 12:26:06 EDT //www.koonmotors.com/releases/2023/08/230823122606.htm Researchers fully sequence the Y chromosome for the first time //www.koonmotors.com/releases/2023/08/230823122524.htm What was once the final frontier of the human genome -- the Y chromosome -- has just been mapped out in its entirety. Scientists used advanced sequencing technologies to read out the full DNA sequence of the Y chromosome -- a region of the genome that typically drives male reproductive development. The results demonstrate that this advance improves DNA sequencing accuracy for the chromosome, which could help identify certain genetic disorders and potentially uncover the genetic roots of others. Wed, 23 Aug 2023 12:25:24 EDT //www.koonmotors.com/releases/2023/08/230823122524.htm New research shows how cancer rewires a key immune pathway to spread //www.koonmotors.com/releases/2023/08/230823122523.htm A study has discovered a new relationship between cancer cells and the immune system, and shows how cancer can selfishly hijack a normally helpful immune pathway. Wed, 23 Aug 2023 12:25:23 EDT //www.koonmotors.com/releases/2023/08/230823122523.htm Researchers discover potential target for gastric cancers associated with Epstein-Barr virus //www.koonmotors.com/releases/2023/08/230822151743.htm Scientists have discovered a potential target for gastric cancers associated with Epstein-Barr Virus. Tue, 22 Aug 2023 15:17:43 EDT //www.koonmotors.com/releases/2023/08/230822151743.htm 细菌是如何通过细胞冲浪货物吗 //www.koonmotors.com/releases/2023/08/230822151740.htm Researchers found some bacteria ship cellular cargo by 'surfing' along proteins called ParA/MinD ATPases. Tue, 22 Aug 2023 15:17:40 EDT //www.koonmotors.com/releases/2023/08/230822151740.htm Neuroscientists create new resource to improve Alzheimer's disease research models //www.koonmotors.com/releases/2023/08/230822151729.htm 一项新的研究使用铁道部e genetically diverse mouse models to study the accumulation and spread of abnormal tau protein deposits in the brain -- a known sign of Alzheimer's disease and several other neurodegenerative diseases. Tue, 22 Aug 2023 15:17:29 EDT //www.koonmotors.com/releases/2023/08/230822151729.htm High-fat diets alter gut bacteria, boosting colorectal cancer risk in mice //www.koonmotors.com/releases/2023/08/230822111728.htm Researchers have discovered how high-fat diets can change gut bacteria and alter digestive molecules called bile acids that are modified by those bacteria, predisposing mice to colorectal cancer. The findings bring scientists closer to understanding the causes of and how to prevent colorectal cancer. Tue, 22 Aug 2023 11:17:28 EDT //www.koonmotors.com/releases/2023/08/230822111728.htm A new DNA drug to fight blood clots //www.koonmotors.com/releases/2023/08/230821114401.htm Various medical circumstances, including heart attacks and extreme cases of COVID-19, necessitate the use of anticoagulants, medicines that prevent blood clots. But the most commonly used, heparin, can induce potentially fatal side effects by making the blood clots worse rather than better. This only happens in a minority of patients so effective treatments are not commonly explored. Researchers have now proposed a side effect-free anticoagulating treatment that has so far proved effective in test mice and could be ready for human trials in just a few years. Mon, 21 Aug 2023 11:44:01 EDT //www.koonmotors.com/releases/2023/08/230821114401.htm Time is right to develop a consensus Human Skin Cell Atlas, according to leading dermatology experts //www.koonmotors.com/releases/2023/08/230821114347.htm As a single organ, our skin is able to perform a broad repertoire of vital functions. Dermatology experts call for a reference guide to single-cell composition of normal human skin, which is still lacking. A grassroots movement to establish a Human Skin Cell Atlas is taking shape, as reported in a recent review. A global team of experts has outlined a roadmap as a first step towards creating a comprehensive and inclusive reference work on this important topic. Mon, 21 Aug 2023 11:43:47 EDT //www.koonmotors.com/releases/2023/08/230821114347.htm 'Viral relicts' in the genome could fuel neurodegeneration //www.koonmotors.com/releases/2023/08/230821114333.htm Genetic remnants of viruses that are naturally present in the human genome could affect the development of neurodegenerative diseases. Researchers come to this conclusion on the basis of studies on cell cultures. Mon, 21 Aug 2023 11:43:33 EDT //www.koonmotors.com/releases/2023/08/230821114333.htm New research has major implications for controlling t cell activity //www.koonmotors.com/releases/2023/08/230818134137.htm According to new research, T cells have a nuclear receptor doing something very odd—but very important—to help them fight pathogens and destroy cancer cells. This receptor, called retinoic acid receptor alpha, is known to control gene expression programs in the nucleus, but it also now appears to operate outside the cell nucleus to coordinate the early events triggered at the cell surface that lead to T cell activation. Fri, 18 Aug 2023 13:41:37 EDT //www.koonmotors.com/releases/2023/08/230818134137.htm How TET2 gene deficiency fuels development of acute myeloid leukemia //www.koonmotors.com/releases/2023/08/230817164043.htm Scientists have identified how low levels of the TET2 gene fuel the rapid growth of acute myeloid leukemia in animal models. Thu, 17 Aug 2023 16:40:43 EDT //www.koonmotors.com/releases/2023/08/230817164043.htm 小说治疗基地d on gene editing safely and effectively removes HIV-like virus from genomes of non-human primates //www.koonmotors.com/releases/2023/08/230817164016.htm A single injection of a novel CRISPR gene-editing treatment safely and efficiently removes SIV -- a virus related to the AIDS-causing agent HIV -- from the genomes of non-human primates, scientists now report. The groundbreaking work complements previous experiments as the basis for the first-ever clinical trial of an HIV gene-editing technology in human patients, which was authorized by the Food and Drug Administration (FDA) in 2022. Thu, 17 Aug 2023 16:40:16 EDT //www.koonmotors.com/releases/2023/08/230817164016.htm Data researchers connect diet to changes in the microbiome //www.koonmotors.com/releases/2023/08/230817163903.htm New research shows that intermittent fasting and calorie restriction change the microbiome composition in the gut, which could affect other functions in the body. Thu, 17 Aug 2023 16:39:03 EDT //www.koonmotors.com/releases/2023/08/230817163903.htm