//www.koonmotors.com/news/health_medicine/epigenetics/ Read the latest research news on epigenetics, epigenetic influences on disease risk and gene silencing. en-us Mon, 16 Oct 2023 18:17:56 EDT Mon, 16 Oct 2023 18:17:56 EDT 60 //www.koonmotors.com/images/scidaily-logo-rss.png//www.koonmotors.com/news/health_medicine/epigenetics/ For more science news, visit ScienceDaily. //www.koonmotors.com/releases/2023/10/231009191631.htm Researchers have unveiled a new mechanism for regulating mitochondrial function. The findings reveal the critical role played by the enzymatic activity of the lysine acetyltransferase MOF in maintaining mitochondrial integrity and function through acetylation of mitochondrial electron transport chain component COX17. Cells lacking MOF-mediated COX17 acetylation exhibit dramatic mitochondrial defects and impaired ability to produce energy. Underscoring the clinical relevance of these findings, the team also showed that cells from human patients with a developmental disorder caused by mutations in MOF also exhibited respiratory defects that could be ameliorated by interventions such as acetylation-mimetic COX17 or mitochondrially targeted MOF. Mon, 09 Oct 2023 19:16:31 EDT //www.koonmotors.com/releases/2023/10/231009191631.htm //www.koonmotors.com/releases/2023/09/230906161820.htm Scientists have identified a key part of a mechanism that annotates genetic information before it is passed from fathers to their offspring. The findings shed new light on genomic imprinting, a fundamental, biological process in which a gene from one parent is switched off while the copy from the other parent remains active. Errors in imprinting are linked to a host of diseases, such as the rare disease Silver-Russell syndrome along with certain cancers and diabetes. Wed, 06 Sep 2023 16:18:20 EDT //www.koonmotors.com/releases/2023/09/230906161820.htm //www.koonmotors.com/releases/2023/08/230824120153.htm A bitter taste in the mouth is often a symptom or side effect of illness, which may be the result of how the body reacts to pathogens. A new study sheds light on the mechanisms involved in the complex interplay between taste perception and immune function. Their work also highlights the potential of a sequencing tool for investigating epigenetic mechanisms that affect taste-cell gene expression. Thu, 24 Aug 2023 12:01:53 EDT //www.koonmotors.com/releases/2023/08/230824120153.htm //www.koonmotors.com/releases/2023/08/230822151743.htm Scientists have discovered a potential target for gastric cancers associated with Epstein-Barr Virus. Tue, 22 Aug 2023 15:17:43 EDT //www.koonmotors.com/releases/2023/08/230822151743.htm //www.koonmotors.com/releases/2023/07/230711133218.htm A team of researchers has discovered that the memory of the immune system relies on characteristic epigenetic features and a specific 3D arrangement of the DNA in the nucleus of memory cells, allowing for a fast activation of these cells. These features are altered in chronic inflammation diseases like asthma and could be important in autoimmune diseases and cancer. Tue, 11 Jul 2023 13:32:18 EDT //www.koonmotors.com/releases/2023/07/230711133218.htm //www.koonmotors.com/releases/2023/06/230607215842.htm New research finds an unexpected link between chromosomal instability and epigenetic alternations, both of which are hallmarks of cancer -- especially advanced, drug-resistant cancers. Wed, 07 Jun 2023 21:58:42 EDT //www.koonmotors.com/releases/2023/06/230607215842.htm //www.koonmotors.com/releases/2023/05/230524182037.htm Scientists studied how the epigenetic landscape influences the binding of pioneer transcription factors, affecting access to DNA. Wed, 24 May 2023 18:20:37 EDT //www.koonmotors.com/releases/2023/05/230524182037.htm //www.koonmotors.com/releases/2023/04/230420110138.htm New research examines the impact that maternal stress during pregnancy has on the neuro-development of babies. Thu, 20 Apr 2023 11:01:38 EDT //www.koonmotors.com/releases/2023/04/230420110138.htm //www.koonmotors.com/releases/2023/03/230328145211.htm A team of scientists has identified two distinct subtypes of insulin-producing beta cells, or ß cells, each with crucial characteristics that may be leveraged to better understand and treat Type 1 and Type 2 diabetes. Tue, 28 Mar 2023 14:52:11 EDT //www.koonmotors.com/releases/2023/03/230328145211.htm //www.koonmotors.com/releases/2023/03/230302073244.htm Adding evidence to the importance of early development, a new study links neutral maternal behavior toward infants with an epigenetic change in children related to stress response. Epigenetics are molecular processes independent of DNA that influence gene behavior. In this study, researchers found that neutral or awkward behavior of mothers with their babies at 12 months correlated with an epigenetic change called methylation, or the addition of methane and carbon molecules, on a gene called NR3C1 when the children were 7 years old. This gene has been associated with regulating the body's response to stress. Thu, 02 Mar 2023 07:32:44 EST //www.koonmotors.com/releases/2023/03/230302073244.htm //www.koonmotors.com/releases/2023/03/230301120825.htm A major new study reveals a 'traffic light' mechanism controlling genetic activity within cells -- a system which could potentially be targeted by cancer drugs already in development. The research describes how 'epigenetic' changes to the structure of DNA can act as a stop-go signal in determining whether a gene should be read. Unlike our genetic make-up, which is well understood, the world of epigenetics is still largely unexplored and referred to as the 'dark matter' of the genome. Wed, 01 Mar 2023 12:08:25 EST //www.koonmotors.com/releases/2023/03/230301120825.htm //www.koonmotors.com/releases/2023/01/230112113203.htm More than 2,500 genes exhibit significant sex differences in expression in mouse alveolar type II cells (AT2s), important for keeping the lungs functioning, potentially explaining sex biases in the prevalence and severity of lung diseases. In particular, very high numbers of X-linked genes escape transcriptional silencing in lung alveolar type 2 (AT2s) cells, researchers report. Thu, 12 Jan 2023 11:32:03 EST //www.koonmotors.com/releases/2023/01/230112113203.htm //www.koonmotors.com/releases/2022/12/221222101019.htm Researchers describe the impact of epigenetics on cancer treatment and how it has become a crucial tool to improve early detection, predict disease progression and become a target for new treatments. Thu, 22 Dec 2022 10:10:19 EST //www.koonmotors.com/releases/2022/12/221222101019.htm //www.koonmotors.com/releases/2022/12/221206083112.htm Consistent exercise can change not just waistlines but the very molecules in the human body that influence how genes behave, a new study of twins indicates. The study found that the more physically active siblings in identical twin pairs had lower signs of metabolic disease, measured by waist size and body mass index. This also correlated with differences in their epigenomes, the molecular processes that are around DNA and independent of DNA sequence, but influence gene expression. The more active twins had epigenetic marks linked to lowered metabolic syndrome, a condition that can lead to heart disease, stroke and type 2 diabetes. Since the identical twins have the same genetics, the study suggests that markers of metabolic disease are strongly influenced by how a person interacts with their environment as opposed to just their inherited genetics. Tue, 06 Dec 2022 08:31:12 EST //www.koonmotors.com/releases/2022/12/221206083112.htm //www.koonmotors.com/releases/2022/11/221104165402.htm The gene-silencing complex HUSH might be involved in complex disorders affecting the brain and neurons. However, its mechanism of action remains unclear. Researchers now uncover the in vivo targets and physiological functions of a component of the HUSH gene-silencing complex and one of its associated proteins. The work, conducted in laboratory mouse models and human brain organoids, links the HUSH complex to normal brain development, neuronal individuality and connectivity, as well as mouse behavior. Fri, 04 Nov 2022 16:54:02 EDT //www.koonmotors.com/releases/2022/11/221104165402.htm //www.koonmotors.com/releases/2022/11/221102110319.htm Toxicologists have found that the protein p53 continuously protects our cells from tumorigenesis by coordinating important metabolic processes that stabilize their genomes. Wed, 02 Nov 2022 11:03:19 EDT //www.koonmotors.com/releases/2022/11/221102110319.htm //www.koonmotors.com/releases/2022/10/221004134356.htm Researchers describe how different types of repetitive DNA elements are controlled by the same silencing mechanism in fruit fly ovaries. Central to their findings is an uncharacterized protein that the researchers named 'Kipferl', which ensures the effective control of jumping genes. The findings suggest that different selfish elements compete for the host genome defense system and that Kipferl might be the first of a series of similarly acting molecules yet to be uncovered. Tue, 04 Oct 2022 13:43:56 EDT //www.koonmotors.com/releases/2022/10/221004134356.htm //www.koonmotors.com/releases/2022/10/221003110230.htm New epigenetic biomarkers to predict more aggressive forms of prostate cancer have been discovered. Mon, 03 Oct 2022 11:02:30 EDT //www.koonmotors.com/releases/2022/10/221003110230.htm //www.koonmotors.com/releases/2022/09/220929133422.htm A team of researchers reports that molecular mechanisms of brain development during early life are likely a major determinant of obesity risk. Thu, 29 Sep 2022 13:34:22 EDT //www.koonmotors.com/releases/2022/09/220929133422.htm //www.koonmotors.com/releases/2022/09/220926200451.htm Changing the epigenetic marks on chromosomes leads to altered gene expression in offspring and in grandoffspring, demonstrating 'transgenerational epigenetic inheritance.' Without altering the genetic code in the DNA, epigenetic modifications can change how genes are expressed, affecting an organism's health and development. The once radical idea that such changes in gene expression can be inherited now has a growing body of evidence behind it, but the mechanisms involved remain poorly understood. Mon, 26 Sep 2022 20:04:51 EDT //www.koonmotors.com/releases/2022/09/220926200451.htm //www.koonmotors.com/releases/2022/09/220912105413.htm A new rodent study shows that even small quantities of alcohol can trigger epigenomic and transciptomic changes in brain circuitry in an area that is crucial in the development of addiction. Mon, 12 Sep 2022 10:54:13 EDT //www.koonmotors.com/releases/2022/09/220912105413.htm //www.koonmotors.com/releases/2022/08/220831095004.htm Changes known as epigenetic modifications play an important role in cancer development, among other things. Being able to analyze them quickly and reliably could, for example, contribute significantly to the further development of personalized therapy. A research team has now succeeded in characterizing the chemical changes in proteins that are typical for epigenetic modifications using nanopore analysis. Wed, 31 Aug 2022 09:50:04 EDT //www.koonmotors.com/releases/2022/08/220831095004.htm //www.koonmotors.com/releases/2022/08/220811142958.htm A fundamental discovery about a driver of healthy development in embryos could rewrite our understanding of what can be inherited from our parents and how their life experiences may shape us. Thu, 11 Aug 2022 14:29:58 EDT //www.koonmotors.com/releases/2022/08/220811142958.htm //www.koonmotors.com/releases/2022/07/220701143124.htm Researchers report the development of a chemical-based sequencing method to quantify different epigenetic markers simultaneously. Their method, called NT-seq, short for nitrite treatment followed by next-generation sequencing, is a sequencing method for detecting multiple types of DNA methylation genome-wide. Fri, 01 Jul 2022 14:31:24 EDT //www.koonmotors.com/releases/2022/07/220701143124.htm //www.koonmotors.com/releases/2022/05/220525102934.htm A new study supports the notion that patients with type 2 diabetes patient should be divided into subgroups and given individualized treatment. The study demonstrates that there are distinct epigenetic differences between different groups of patients with type 2 diabetes. The epigenetic markers are also associated with different risks of developing common complications in type 2 diabetes, such as stroke, heart attack and kidney disease. Wed, 25 May 2022 10:29:34 EDT //www.koonmotors.com/releases/2022/05/220525102934.htm //www.koonmotors.com/releases/2022/05/220519115328.htm In most mammals, females have two X chromosomes and males have one X and one Y chromosome in each of their cells. To avoid a double dose of X-linked genes in females, one of the Xs is silenced early in the developmental process. This silencing is critical, yet how it happens has been relatively mysterious. Two new studies reveal more about this silencing process and insights that could improve stem cell research. Thu, 19 May 2022 11:53:28 EDT //www.koonmotors.com/releases/2022/05/220519115328.htm //www.koonmotors.com/releases/2022/04/220427171428.htm Researchers have discovered a gene responsible for prenatal death when critical epigenetic instructions are missing from egg cells. The study shows that in mice, failed epigenetic suppression of an X-chromosome gene called Xist leads to miscarriage and developmental abnormalities. Forced suppression of maternal Xist rescued the failed miscarriages. Wed, 27 Apr 2022 17:14:28 EDT //www.koonmotors.com/releases/2022/04/220427171428.htm //www.koonmotors.com/releases/2022/04/220418094008.htm Researchers have found that heterozygous loss of the methyl-CpG binding protein Zbtb38 downregulated the expression of the transcription factors Nanog and Sox2, as well as genes involved in epiblast proliferation, differentiation, and viability. This finding highlights the methyl-CpG binding protein's physiological significance throughout embryonic development. Mon, 18 Apr 2022 09:40:08 EDT //www.koonmotors.com/releases/2022/04/220418094008.htm //www.koonmotors.com/releases/2022/04/220412161556.htm Cellular biologists discover why some patients become resistant to standard treatments for nonsmall cell lung cancer. Tue, 12 Apr 2022 16:15:56 EDT //www.koonmotors.com/releases/2022/04/220412161556.htm //www.koonmotors.com/releases/2022/04/220411113725.htm Though chemotherapies are effective in some patients, tumour cells may acquire tolerance to these treatments. In other words, cells adapt to chemotherapy so they can survive. A new study delivers promising results on epigenetic mechanisms that regulate gene expression. Mon, 11 Apr 2022 11:37:25 EDT //www.koonmotors.com/releases/2022/04/220411113725.htm //www.koonmotors.com/releases/2022/04/220405084554.htm Researchers have revealed how an 'accordion effect' is critical to switching off genes, in a study that transforms the fundamentals of what we know about gene silencing. The finding expands our understanding of how we switch genes on and off to make the different cell types in our bodies, as we develop in the womb. Tue, 05 Apr 2022 08:45:54 EDT //www.koonmotors.com/releases/2022/04/220405084554.htm //www.koonmotors.com/releases/2022/04/220404105714.htm A new study identifies associations between DNA methylation patterns and gene expression levels in blood samples from children. The findings provide researchers with a powerful tool to better understand the association between early environmental exposures, epigenetic changes and disease. Mon, 04 Apr 2022 10:57:14 EDT //www.koonmotors.com/releases/2022/04/220404105714.htm //www.koonmotors.com/releases/2022/04/220401122200.htm How is the activity of genes regulated by the packaging of DNA? To answer this question, researchers developed a technique to measure both gene expression and DNA packaging at the same time. Fri, 01 Apr 2022 12:22:00 EDT //www.koonmotors.com/releases/2022/04/220401122200.htm //www.koonmotors.com/releases/2022/03/220329114747.htm Scientists have shown how accelerated biological aging measured by an epigenetic clock may increase the risk of bowel cancer, according to a new report. Tue, 29 Mar 2022 11:47:47 EDT //www.koonmotors.com/releases/2022/03/220329114747.htm //www.koonmotors.com/releases/2022/03/220317172451.htm New research finds that patients with ASXL1-mutant chronic myelomonocytic leukemia -- an uncommon type of cancer of the bone marrow -- have distinctive epigenetic changes that can activate harmful genes and cause the cancer to grow faster. The ASXL1 genetic mutation also can transform the disease into the more aggressive acute myeloid leukemia. Thu, 17 Mar 2022 17:24:51 EDT //www.koonmotors.com/releases/2022/03/220317172451.htm //www.koonmotors.com/releases/2022/02/220228150628.htm A multidisciplinary team has devised a new approach to 3D imaging that captures DNA methylation, a key epigenetic change associated with learning in the brain. The scientists say their proof-of-concept study in pigs will easily translate to humans, as the new method relies on standard MRI technology and biological markers already in use in human medicine. Mon, 28 Feb 2022 15:06:28 EST //www.koonmotors.com/releases/2022/02/220228150628.htm //www.koonmotors.com/releases/2022/02/220208113905.htm Researchers discover a 'switch' specific to transcription factors that induce the genes essential for blood vessel development in postnatal periods. Mouse models further showed that the modifiers responsible for the switch are critical for postnatal angiogenesis. Tue, 08 Feb 2022 11:39:05 EST //www.koonmotors.com/releases/2022/02/220208113905.htm //www.koonmotors.com/releases/2022/01/220124103901.htm A newly developed test to screen for three rare genetic disorders simultaneously in newborns was feasible, reliable and scalable, according to a new study. Mon, 24 Jan 2022 10:39:01 EST //www.koonmotors.com/releases/2022/01/220124103901.htm //www.koonmotors.com/releases/2022/01/220120135128.htm New research shows that specific enzymes can remove lactic acid marks. This finding may increase our understanding of cancer medicine and how physical exercise, among other things, can affect human epigenetics. Thu, 20 Jan 2022 13:51:28 EST //www.koonmotors.com/releases/2022/01/220120135128.htm //www.koonmotors.com/releases/2022/01/220112121540.htm Hereditary diseases as well as cancers and cardiovascular diseases may be associated with a phenomenon known as genomic imprinting, in which only the maternally or paternally inherited gene is active. An international research team has now investigated the mechanisms responsible for the deactivation of the genes. Wed, 12 Jan 2022 12:15:40 EST //www.koonmotors.com/releases/2022/01/220112121540.htm //www.koonmotors.com/releases/2022/01/220111112012.htm Scientists have taken a significant step in providing the people of Rwanda the scientific tools they need to help address mental health issues that stemmed from the 1994 genocides of the Tutsi ethnic group. Tue, 11 Jan 2022 11:20:12 EST //www.koonmotors.com/releases/2022/01/220111112012.htm //www.koonmotors.com/releases/2022/01/220105103131.htm The researchers showed for the first time that the DNA methylome of these brain tumors can be reprogrammed. The study said that this is the first time DNA methylome reprogramming has occurred with any solid human tumor. Wed, 05 Jan 2022 10:31:31 EST //www.koonmotors.com/releases/2022/01/220105103131.htm //www.koonmotors.com/releases/2022/01/220104095557.htm Researchers generated mice with a specific DNA sequence inverted to determine if orientation affects expression of a gene called H19. Expression can also be impacted if the surrounding DNA is altered by a process called methylation. Interestingly, methylation was only relevant when the inverted sequence was inherited from the father. When inherited from the mother, the inversion had the opposite effect on H19 expression, suggesting a more complex mechanism is at play. Tue, 04 Jan 2022 09:55:57 EST //www.koonmotors.com/releases/2022/01/220104095557.htm //www.koonmotors.com/releases/2021/11/211122135504.htm 同卵双胞胎具有相同的基因,但双can suffer from type 2 diabetes while the other twin does not develop the disease. Researchers have now discovered that there are differences in gene activity in twins where only one sibling had developed the disease. The discovery could contribute to the development of new treatment methods. Mon, 22 Nov 2021 13:55:04 EST //www.koonmotors.com/releases/2021/11/211122135504.htm //www.koonmotors.com/releases/2021/09/210930104846.htm Many people are confronted with chronic pain that can last for months or even years. How to best treat chronic pain? First, pain must be categorized for the right treatment to be prescribed. However, is that it is very challenging for patients to define their pain, its intensity or even its location using questionnaires. To overcome this difficulty, scientists have carried out a complete epigenomic analysis of patients, making it possible to find the epigenetic signatures specific to each pain category. Thu, 30 Sep 2021 10:48:46 EDT //www.koonmotors.com/releases/2021/09/210930104846.htm //www.koonmotors.com/releases/2021/09/210915085842.htm Researchers have discovered that the FDA-approved anti-fungal drug, sulconazole, exhibits anti-cancer properties towards glioblastoma cells. An in-depth investigation of this compound revealed that it competes with biotin (Vitamin H), an important co-factor for metabolic enzymes and modifier of histones, allowing it to inhibit the normal function of biotin-dependent metabolic enzymes and specific histone modification-associated gene expression. Wed, 15 Sep 2021 08:58:42 EDT //www.koonmotors.com/releases/2021/09/210915085842.htm //www.koonmotors.com/releases/2021/08/210825143100.htm A new study analyzes the association between more than 100 environmental exposures and the 'epigenetic clock' of over 1,000 children in six European countries. Wed, 25 Aug 2021 14:31:00 EDT //www.koonmotors.com/releases/2021/08/210825143100.htm //www.koonmotors.com/releases/2021/08/210819102747.htm A CRISPR screening tool identified a new therapeutic target to treat acute myeloid leukemia (AML) that has the potential to leave patients with fewer side effects than current approaches. Thu, 19 Aug 2021 10:27:47 EDT //www.koonmotors.com/releases/2021/08/210819102747.htm //www.koonmotors.com/releases/2021/08/210810104643.htm Periconceptional conditions are known to influence the later health of individuals. Fetal growth and development set the framework for future health, but recently it has also been suggested that the individual is epigenetically prepared for the conditions in which he or she will be born. If food or nutrient intake is scarce during pregnancy, the emerging individual seems to be better prepared to absorb energy and nutrients than a similar individual whose developmental conditions have been more favorable. Tue, 10 Aug 2021 10:46:43 EDT //www.koonmotors.com/releases/2021/08/210810104643.htm //www.koonmotors.com/releases/2021/08/210803105532.htm 一个创新的策略,分析t的一个地区he genome offers the possibility of early diagnosis of schizophrenia. Tue, 03 Aug 2021 10:55:32 EDT //www.koonmotors.com/releases/2021/08/210803105532.htm //www.koonmotors.com/releases/2021/07/210709094505.htm A new study provides a potential tool for unraveling the mystery of how experiences can cause inheritable changes to an animal's biology. By mating nematode worms, they produced permanent epigenetic changes that lasted for more than 300 generations. Fri, 09 Jul 2021 09:45:05 EDT //www.koonmotors.com/releases/2021/07/210709094505.htm //www.koonmotors.com/releases/2021/06/210628170610.htm Researchers noted a significant difference in mice from mothers that were fed a diet rich in canola oil, compared with mothers fed a diet rich in corn oil. A maternal Omega 3-rich diet affected genome-wide epigenetic landscape changes in offspring and potentially modulated gene expression patterns. Mon, 28 Jun 2021 17:06:10 EDT //www.koonmotors.com/releases/2021/06/210628170610.htm //www.koonmotors.com/releases/2021/06/210621123819.htm Biologists have discovered 71 new 'imprinted' genes in the mouse genome, a finding that takes them a step closer to unravelling some of the mysteries of epigenetics - an area of science that describes how genes are switched on (and off) in different cells, at different stages in development and adulthood. Mon, 21 Jun 2021 12:38:19 EDT //www.koonmotors.com/releases/2021/06/210621123819.htm //www.koonmotors.com/releases/2021/06/210610091050.htm The team looked in different regions of the brain, which are affected in Alzheimer's disease before looking for common changes across these cortical regions. They identified 220 sites in the genome, including 84 new genes, which showed different levels of DNA methylation in the cortex in individuals with more severe Alzheimer's disease, which weren't seen in the cerebellum. Thu, 10 Jun 2021 09:10:50 EDT //www.koonmotors.com/releases/2021/06/210610091050.htm //www.koonmotors.com/releases/2021/06/210607161237.htm Computer simulations visualize in atomic detail how DNA opens while wrapped around proteins. Mon, 07 Jun 2021 16:12:37 EDT //www.koonmotors.com/releases/2021/06/210607161237.htm //www.koonmotors.com/releases/2021/05/210521171112.htm The human body is constantly exposed to various environmental actors, from viruses to bacteria to fungi, but most of these microbial organisms provoke little or no response from our skin, which is charged with monitoring and protecting from external dangers. Fri, 21 May 2021 17:11:12 EDT //www.koonmotors.com/releases/2021/05/210521171112.htm //www.koonmotors.com/releases/2021/05/210519120815.htm This is the first evidence that secondhand smoke during pregnancy correlates with changes in disease-related gene regulation in babies. These findings support the idea that many adult diseases have their origins in environmental exposures, such as stress, poor nutrition, pollution or tobacco smoke, during early development. Wed, 19 May 2021 12:08:15 EDT //www.koonmotors.com/releases/2021/05/210519120815.htm //www.koonmotors.com/releases/2021/05/210513173539.htm B细胞是免疫细胞负责创造ing antibodies, and most produce antibodies in response to a pathogen or a vaccine. A small subset of B cells instead spontaneously make antibodies that perform vital housekeeping functions. Understanding how epigenetics spur these differences in such similar cells is an important fundamental question in immunology. Thu, 13 May 2021 17:35:39 EDT //www.koonmotors.com/releases/2021/05/210513173539.htm //www.koonmotors.com/releases/2021/04/210423130134.htm People with type 2 diabetes tend to have poorer muscle function than others. Now a research team has discovered that in type 2 diabetes, a specific gene is of great importance for the ability of muscle stem cells to create new mature muscle cells. Fri, 23 Apr 2021 13:01:34 EDT //www.koonmotors.com/releases/2021/04/210423130134.htm //www.koonmotors.com/releases/2021/04/210420131103.htm Using a widely known field of mathematics designed mainly to study how digital and other forms of information are measured, stored and shared, scientists say they have uncovered a likely key genetic culprit in the development of acute lymphoblastic leukemia (ALL). Tue, 20 Apr 2021 13:11:03 EDT //www.koonmotors.com/releases/2021/04/210420131103.htm