Cystic Fibrosis News -- ScienceDaily
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Cystic Fibrosis (CF) Research News. Read the latest advances in treatment of cystic fibrosis.
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Wed, 06 Sep 2023 14:46:04 EDT
Wed, 06 Sep 2023 14:46:04 EDT
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Cystic Fibrosis News -- ScienceDaily
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For more science news, visit ScienceDaily.
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Connections between drinking water quality and increased lung infections in people with cystic fibrosis
//www.koonmotors.com/releases/2023/08/230825122019.htm
High levels of some minerals and metals in environmental water supplies may increase the risk of nontuberculous mycobacteria (NTM) pulmonary infections in people with cystic fibrosis, according to a new study. The study found the presence of the metals molybdenum and vanadium along with sulfate -- a collection of mineral salts -- in the U.S. municipal water system was associated with an increased incidence of NTM pulmonary infections, the leading cause of drinking-water associated illnesses.
Fri, 25 Aug 2023 12:20:19 EDT
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Triple combination therapy brings lasting improvement in cystic fibrosis
//www.koonmotors.com/releases/2023/07/230707111622.htm
The mucus in the airways is not as sticky, inflammation in the lungs significantly reduced: Triple combination therapy can achieve these positive, lasting effects in patients with cystic fibrosis (CF). According to new research, this form of medication improves the symptoms of CF in many patients.
Fri, 07 Jul 2023 11:16:22 EDT
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综合结构生物学提供了新的线索爱博网投领导者or cystic fibrosis treatment
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The cystic fibrosis transmembrane conductance regulator has been studied for years but the new efforts have yielded important insights.
Wed, 22 Mar 2023 19:09:31 EDT
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Cystic fibrosis drug could help treat pneumonia
//www.koonmotors.com/releases/2022/12/221222101017.htm
Pathogens such as SARS-CoV-2 and pneumococcus can cause severe pneumonia. If the airways then fill with fluid, the patient risks developing acute respiratory distress syndrome. Researchers have now discovered the molecular mechanisms that trigger fluid accumulation in the lungs. This also led them to discover a potential new therapy: A cystic fibrosis drug proved effective in their laboratory experiments, raising hope that this could be used to treat pneumonia regardless of the pathogen that caused it.
Thu, 22 Dec 2022 10:10:17 EST
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New test can help patients with cystic fibrosis
//www.koonmotors.com/releases/2022/11/221114095312.htm
Researchers have developed a simple urine test to measure the severity of the serious disease cystic fibrosis and assess the effect of new treatments.
Mon, 14 Nov 2022 09:53:12 EST
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Researchers take key step toward improving treatment of cystic fibrosis
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Researchers have taken a key step toward improving and lengthening the lives of cystic fibrosis patients, who experience chronically clogged airways and a dramatically shortened life expectancy.
Wed, 26 Oct 2022 19:35:25 EDT
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Non-white newborns with cystic fibrosis more likely to be missed in screening
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Cystic fibrosis is missed more often in newborn screenings for non-white than white babies, creating higher risk for irreversible lung damage and other serious outcomes in Black, Hispanic, Asian, American Indian and Alaska Native newborns, a new study finds.
Tue, 25 Oct 2022 15:02:24 EDT
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Cystic fibrosis patients can benefit from vitamin supplements, research shows
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Cystic fibrosis patients who supplement their diet with vitamin C can also derive greater benefit from another antioxidant, vitamin E, resulting in a reduction in damaging inflammation, a study suggests.
Thu, 29 Sep 2022 13:34:37 EDT
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Manuka honey could help clear deadly drug-resistant lung infection, research finds
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A potential new treatment combining natural manuka honey with a widely used drug has been developed by scientists to treat a potentially lethal lung infection and greatly reduce side effects of one of the current drugs used for its treatment.
Wed, 07 Sep 2022 19:25:41 EDT
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Immune cell model paves way for new treatments targeting common infection amongst immunocompromised children
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Researchers have successfully engineered human immune cells to model an infection common among immunocompromised people in a breakthrough discovery, paving the way for new drug testing and treatments.
Thu, 18 Aug 2022 12:23:43 EDT
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Cystic fibrosis: Causal treatment suitable from childhood
//www.koonmotors.com/releases/2022/08/220808161831.htm
Cystic fibrosis remains an incurable genetic disorder which impairs lung function and significantly reduces life expectancy. A new combination drug therapy which addresses the disorder's underlying defects offers a promising new treatment approach. The use of this therapy had previously been limited to adolescents and adults. Designed to meet the highest standards of clinical practice, a study has now confirmed that this combination therapy regimen is also beneficial to primary school-aged children. Earlier treatment means disease progression is likely to be significantly slowed.
Mon, 08 Aug 2022 16:18:31 EDT
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Using iPSCs, researchers create cells that represent the airways of cystic fibrosis patients
//www.koonmotors.com/releases/2022/08/220801133122.htm
Cystic fibrosis (CF) is caused by a mutation of the CFTR gene. While there are many hundreds of known mutations, not all of them are currently treatable which means a significant number of CF patients lack targeted therapies. In an effort to identify new treatments for these patients, researchers from Boston University School of Medicine (BUSM) set out to use blood cells from individuals with CF to make patient-specific induced pluripotent stem cells (iPSCs) and generate lung epithelial cells in the lab. These lung cells are functional and highly similar to the lung cells of the patient. Using these 'lung cells in a dish,' they have created a novel platform to discover effective drugs for those patients who currently don't have any treatment options.
Mon, 01 Aug 2022 13:31:22 EDT
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Study finds delays in initial cystic fibrosis evaluation in infants of color
//www.koonmotors.com/releases/2022/07/220727163104.htm
Infants from minoritized racial and ethnic backgrounds who have positive newborn screening tests for cystic fibrosis received their diagnostic follow-up for the disease later than recommended and later than white, non-Hispanic infants, according to a new study.
Wed, 27 Jul 2022 16:31:04 EDT
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A new treatment approach for cystic fibrosis
//www.koonmotors.com/releases/2022/07/220714165803.htm
Antisense oligonucleotides, or ASOs, are molecules that can be used to control protein levels in cells. Scientists have discovered a new way ASOs may help cells produce a protein missing in cystic fibrosis (CF) patients. The discovery sets the stage for a new therapeutic approach that may help reduce CF symptoms and improve patients' quality of life.
Thu, 14 Jul 2022 16:58:03 EDT
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Drilling for rare disease therapeutics
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A drug discovery approach developed -- in part inspired by oil companies -- revealed why drugs for cystic fibrosis fall short.
Thu, 16 Jun 2022 13:52:26 EDT
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Cystic fibrosis: Restoring airway integrity
//www.koonmotors.com/releases/2022/05/220524100524.htm
Cystic fibrosis is a rare genetic disease which can cause very serious symptoms. In particular, patients suffer from chronic bacterial infections that can lead to respiratory failure. It is caused by mutations in the CFTR gene, which regulates water movement across the cell membrane. Consequently, mucus quality is altered, it is no longer capable of capturing undesirable bacteria and expelling them. Using a model reproducing a respiratory epithelium -- a protective tissue composed of a monolayer of cells -- scientists have discovered that a simple film of liquid is sufficient to restore the airways' seal and reduce the risk of bacterial infection.
Tue, 24 May 2022 10:05:24 EDT
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Researchers find trove of proteins that may influence cystic fibrosis
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Researchers have identified hundreds of new proteins that could play a role in cystic fibrosis, and which may shed light on why some patients respond better than others to current therapies.
Mon, 14 Feb 2022 09:57:49 EST
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Insights into a cystic fibrosis treatment may herald a novel class of drugs
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Protein folding diseases, from Alzheimer's to Gaucher's, may one day be treated by a unique class of protein corrector molecules that are already helping manage cystic fibrosis.
Mon, 24 Jan 2022 11:50:56 EST
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Cystic fibrosis faithfully modeled in a human Lung Airway Chip
//www.koonmotors.com/releases/2021/11/211119155230.htm
Despite advances in patient screenings and breakthrough therapies that allow CF patients now to live into their mid- to late 30s or 40s, sometimes even longer, all patients are plagued by bacteria settling in their mucus, which causes inflammation in their lungs, and eventually causes their respiratory systems to fail. A major barrier to developing new and urgently needed treatments is the lack of human in vitro models that recapitulate the CF disease's pathology.
Fri, 19 Nov 2021 15:52:30 EST
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Lower airways are distinct in cystic fibrosis even at younger ages
//www.koonmotors.com/releases/2021/10/211021175118.htm
In the largest study of its kind, researchers found that the lower airways in children with cystic fibrosis (CF) have a higher burden of infection, more inflammation and lower diversity of microorganisms, compared to children with other illnesses who also have lung issues. They noted a clear divergence in these bacterial communities in toddlers, which is typically before progressive lung disease takes hold in patients with CF. Their findings could help providers target specific pathogens earlier, treat them and potentially prevent more severe lung disease.
Thu, 21 Oct 2021 17:51:18 EDT
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Bacterial infections in sinuses of cystic fibrosis patients share surprising similarities
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A dogma-challenging discovery reveals that highly adapted bacterial communities in the sinuses of people with cystic fibrosis become more fragmented and experience mutations that erode their genomes. So rather than targeting red herring mutations, researchers suggest paying attention to patterns of genomic adaptation versus erosion, which might better indicate a viable path towards the more effective therapeutics for cystic fibrosis.
Tue, 19 Oct 2021 12:01:17 EDT
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Better understanding of cystic fibrosis
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New understanding of cellular defects related to Cystic Fibrosis (CF) could help pave the way for treatment.
Wed, 06 Oct 2021 16:01:06 EDT
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New CRISPR/Cas9 technique corrects cystic fibrosis in cultured human stem cells
//www.koonmotors.com/releases/2021/08/210809105908.htm
研究人员纠正突变,导致囊性fibrosis in cultured human stem cells. They used a technique called prime editing to replace the 'faulty' piece of DNA with a healthy piece. The study shows that prime editing is safer than the conventional CRISPR/Cas9 technique.
Mon, 09 Aug 2021 10:59:08 EDT
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A small molecule induces readthrough of cystic fibrosis CFTR nonsense mutations
//www.koonmotors.com/releases/2021/07/210719110521.htm
An experimental drug suggests that a 'path is clearly achievable' to treat currently untreatable cases of cystic fibrosis disease caused by nonsense mutations. This includes about 11 percent of cystic fibrosis patients, as well as patients with other genetic diseases.
Mon, 19 Jul 2021 11:05:21 EDT
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Scientists demonstrate promising new approach for treating cystic fibrosis
//www.koonmotors.com/releases/2021/06/210616121545.htm
A new CF treatment strategy involves small, nucleic acid molecules called oligonucleotides that can correct some of the gene defects that underlie CF but are not addressed by existing modulator therapies. The researchers used a new delivery method that overcomes traditional obstacles of getting oligonucleotides into lung cells.
Wed, 16 Jun 2021 12:15:45 EDT
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Novel nanotech improves cystic fibrosis antibiotic by 100,000-fold, research shows
//www.koonmotors.com/releases/2021/05/210513095958.htm
New nanotechnology could change the lives of thousands of people living with cystic fibrosis (CF) as groundbreaking research shows it can improve the effectiveness of the CF antibiotic Tobramycin, increasing its efficacy by up to 100,000-fold.
Thu, 13 May 2021 09:59:58 EDT
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Molecular analysis identifies key differences in lungs of cystic fibrosis patients
//www.koonmotors.com/releases/2021/05/210506163621.htm
A team of researchers has developed a molecular catalog of cells in healthy lungs and the lungs of people with cystic fibrosis.
Thu, 06 May 2021 16:36:21 EDT
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Multi-drug resistant infection about to evolve within cystic fibrosis patients
//www.koonmotors.com/releases/2021/04/210429142629.htm
Scientists have been able to track how a multi-drug resistant organism is able to evolve and spread widely among cystic fibrosis patients - showing that it can evolve rapidly within an individual during chronic infection. The researchers say their findings highlight the need to treat patients with Mycobacterium abscessus infection immediately, counter to current medical practice.
Thu, 29 Apr 2021 14:26:29 EDT
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How bacteria defeat drugs that fight cystic fibrosis
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Researchers and their partners have discovered a slimy strategy used by bacteria to defeat antibiotics and other drugs used to combat infections afflicting people with cystic fibrosis.
Sat, 27 Feb 2021 08:33:02 EST
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Scientists reverse deadly impacts of asthma in mice
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Excess mucus in the lungs can be fatal for asthma patients, but scientists have broken up those secretions at the molecular level and reversed their often deadly impacts.
Wed, 13 Jan 2021 10:08:33 EST
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抗真菌药物改善关键的囊性纤维化生物量rkers in clinical study
//www.koonmotors.com/releases/2020/12/201217135247.htm
A drug widely used to treat fungal infections improved key biomarkers in lung tissue cultures as well as in the noses of patients with cystic fibrosis, a clinical study found.
Thu, 17 Dec 2020 13:52:47 EST
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Understanding lung infections in patients with cystic fibrosis
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For young people with cystic fibrosis, lung infection with Staphylococcus aureus, MRSA, is common and is treated with antibiotics in the hope that this will prevent a decline in lung function. However there has recently been debate over the role S. aureus plays in CF lung disease. Researchers have used a new model of CF lungs which could be used to make better decisions about future use of antibiotics.
Thu, 19 Nov 2020 13:10:30 EST
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Genetic mutation could worsen heart function in Duchenne muscular dystrophy patients
//www.koonmotors.com/releases/2020/11/201104085145.htm
A mutation in the gene that causes cystic fibrosis may accelerate heart function decline in those with Duchenne muscular dystrophy (DMD), a new study suggests. The findings could help doctors develop new strategies to preserve heart function in this population, potentially extending patients' lives.
Wed, 04 Nov 2020 08:51:45 EST
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Mechanics of mucus in cystic fibrosis patients
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New research examines the properties of the mucus of cystic fibrosis (CF) patients and the role it plays in a pathogens' ability to survive. The new information could have important implications for CF treatment.
Wed, 28 Oct 2020 12:45:24 EDT
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Cystic fibrosis: Why so many respiratory complications?
//www.koonmotors.com/releases/2020/07/200713120024.htm
Cystic fibrosis causes severe respiratory and digestive disorders. Despite considerable therapeutic advances, this disease still reduces life expectancy, in particular due to life-threatening respiratory infections. Scientists have now discovered the reason for this large number of lung infections: a protein, Vav3.
Mon, 13 Jul 2020 12:00:24 EDT
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A newly discovered disease may lead to better treatment of cystic fibrosis
//www.koonmotors.com/releases/2020/06/200605140505.htm
认为囊胞性纤维症是最常见的严重的继承ted disorder worldwide. Researchers have now discovered a novel disease that might lead to a better understanding of cystic fibrosis and new treatment options in the future.
Fri, 05 Jun 2020 14:05:05 EDT
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Mucus breakthrough could help patients breathe easy
//www.koonmotors.com/releases/2020/05/200513081757.htm
New insights into the molecular mechanisms driving mucus viscosity were have been discovered. A discovery about how mucus thickness is regulated could help to improve airway-clearing treatment options for people with chronic respiratory conditions such as asthma, cystic fibrosis and chronic obstructive pulmonary disease (COPD).
Wed, 13 May 2020 08:17:57 EDT
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Curing genetic disease in human cells
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Scientists show for the first time that a newer type of CRISPR, called base-editing, can safely cure cystic fibrosis in stem cells derived from patients.
Thu, 20 Feb 2020 14:17:40 EST
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Plant-based relatives of cholesterol could give boost to gene therapy
//www.koonmotors.com/releases/2020/02/200220091538.htm
Gene-infused nanoparticles used for combating disease work better when they include plant-based relatives of cholesterol because their shape and structure help the genes get where they need to be inside cells.
Thu, 20 Feb 2020 09:15:38 EST
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New treatment kills off infection that can be deadly to cystic fibrosis patients
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Scientists have combined doses of three antibiotics -- amoxicillin and imipenem-relebactam and found it was 100% effective in killing off the infection which is usually extremely difficult to treat in patients with cystic fibrosis. The infection results in severe decline in lung function and sometimes death.
Mon, 27 Jan 2020 07:52:47 EST
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Dangerous bacteria communicate to avoid antibiotics
//www.koonmotors.com/releases/2019/11/191122113311.htm
Researchers have found a new survival mechanism for a commonly known type of bacteria. It can send out warning signals and thus make sure that other bacteria escape 'dangers' such as antibiotics. The researchers hope that the new knowledge can be utilized to make antibiotic treatment more effective.
Fri, 22 Nov 2019 11:33:11 EST
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Study reveals 'bug wars' that take place in cystic fibrosis
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Scientists have revealed how common respiratory bugs that cause serious infections in people with cystic fibrosis interact together, according to a new study.
Tue, 12 Nov 2019 14:29:28 EST
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Three-drug combo improves lung function in most common genetic form of cystic fibrosis
//www.koonmotors.com/releases/2019/10/191031174701.htm
A phase three clinical trial determined that a 3-drug combination improved lung function and reduced symptoms in cystic fibrosis (CF) patients who have a single copy of the most common genetic mutation for the disease.
Thu, 31 Oct 2019 17:47:01 EDT
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Disease-causing protein in cystic fibrosis has ancient roots in sea lamprey
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The oldest known ortholog of the ion channel that is defective in patients with cystic fibrosis arose approximately 450 million years ago in the sea lamprey, researchers report. Many differences between lamprey and jawed vertebrate orthologs of this protein, called the cystic fibrosis transmembrane conductance regulator, are vestiges of the evolutionary transition from a transporter to a specialized chloride and bicarbonate channel.
Thu, 31 Oct 2019 11:25:34 EDT
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Cystic fibrosis carriers at increased risk of digestive symptoms
//www.koonmotors.com/releases/2019/10/191017135743.htm
Researchers have found that carriers of the most common genetic variant that causes cystic fibrosis experience some symptoms similar to those of people with cystic fibrosis. These findings were enabled by large-scale genomic data made available just a few years ago.
Thu, 17 Oct 2019 13:57:43 EDT
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In cystic fibrosis, lungs feed deadly bacteria
//www.koonmotors.com/releases/2019/08/190821124357.htm
A steady supply of its favorite food helps a deadly bacterium thrive in the lungs of people with cystic fibrosis, according to a new study.
Wed, 21 Aug 2019 12:43:57 EDT
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New intra-nasal imaging to study airways in patients with cystic fibrosis
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Researchers describe minimally invasive new tool for viewing differences in the nasal airways of cystic fibrosis patients in vivo at a cellular level.
Wed, 07 Aug 2019 14:22:45 EDT
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Human pancreas on a chip opens new possibilities for studying disease
//www.koonmotors.com/releases/2019/07/190716073722.htm
Scientists created human pancreas on a chip that allowed them to identify the possible cause of a frequent and deadly complication of cystic fibrosis (CF) called CF-Related Diabetes, or CFRD. It may be feasible to also use the small two-chambered device, which features bioengineered human pancreatic organoids to study the causes of non-CF-related conditions such as type 1 and 2 diabetes.
Tue, 16 Jul 2019 07:37:22 EDT
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Hinge-like protein may open new doors in cystic fibrosis treatment
//www.koonmotors.com/releases/2019/07/190709153612.htm
Drugs known as potentiators alleviate some symptoms of cystic fibrosis. Researchers recently figured out how these compounds work--a finding that may lead to better drugs that patients can more easily afford.
Tue, 09 Jul 2019 15:36:12 EDT
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Manuka honey to kill drug-resistant bacteria found in cystic fibrosis infections
//www.koonmotors.com/releases/2019/05/190529131142.htm
Manuka honey could provide the key to a breakthrough treatment for cystic fibrosis patients following preliminary work.
Wed, 29 May 2019 13:11:42 EDT
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Discovery shows how mucus build-up, not infections, triggers cystic fibrosis lung damage
//www.koonmotors.com/releases/2019/04/190403155413.htm
The build-up of abnormally thick mucus and the associated inflammation appear to be the initiating cause of damage to the lungs of children with cystic fibrosis (CF), rather than bacterial infections, according to a new study.
Wed, 03 Apr 2019 15:54:13 EDT
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Potential cystic fibrosis treatment uses 'molecular prosthetic' for missing lung protein
//www.koonmotors.com/releases/2019/03/190313143248.htm
An approved drug normally used to treat fungal infections could also do the job of a protein channel that is missing or dysfunctional in the lungs of people with cystic fibrosis, operating as a prosthesis on the molecular scale, says new research.
Wed, 13 Mar 2019 14:32:48 EDT
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Determining what binds to mucus
//www.koonmotors.com/releases/2019/03/190313114744.htm
The human body is full of mucus. This viscous goo isn't just a nuisance that gets coughed up or sneezed out -- it can bind to drugs, toxins or microbes, potentially impacting human health. However, relatively little is known about such interactions. Now, researchers say they have developed a new way of analyzing mucus binding that could lead to better drug development.
Wed, 13 Mar 2019 11:47:44 EDT
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Bacterial immunity and infectious disease
//www.koonmotors.com/releases/2019/01/190108125458.htm
Patients with cystic fibrosis are often infected by pseudomonas aeruginosa, a bacterium that infects the lungs and prevents breathing, often causing death. P. aeruginosa itself can also be infected by viruses, which can affect the clinical outcomes of cystic fibrosis patients. Researchers have now used P. aeruginosa as a kind of 'model system' for understanding how bacteria's interactions with viruses may affect human health.
Tue, 08 Jan 2019 12:54:58 EST
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Experimental findings support a connection between mucins in the lung and pulmonary fibrosis
//www.koonmotors.com/releases/2018/12/181218093004.htm
A team of investigators has identified a connection between mucus in the small airways and pulmonary fibrosis.
Tue, 18 Dec 2018 09:30:04 EST
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Blood test could lead to cystic fibrosis treatment tailored to each patient
//www.koonmotors.com/releases/2018/12/181212200803.htm
Researchers have used a blood test and microarray technology to identify distinct molecular signatures in children with cystic fibrosis. These patterns of gene expression ultimately could help predict disease severity and treatment response, and lead to therapies tailored to each patient's precise biology.
Wed, 12 Dec 2018 20:08:03 EST
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Towards a treatment for gluten intolerance
//www.koonmotors.com/releases/2018/11/181130111601.htm
乳糜泻是一种严重的自身免疫性疾病the intestine. It occurs when people develop sensitivity to gluten, a substance found in wheat, rye, and barley. Medical researchers have now uncovered a new molecular player in the development of gluten intolerance. Their discovery suggests potential targets for the development of therapeutic approaches for the disease.
Fri, 30 Nov 2018 11:16:01 EST
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Can scientists change mucus to make it easier to clear, limiting harm to lungs?
//www.koonmotors.com/releases/2018/11/181112191914.htm
For people with conditions such as cystic fibrosis and COPD, mucus can get too thick and sticky; coughing alone can't clear it. Infections develop, leading to severe chronic disease and early death. Now, for the first time, scientists have shown why coughing often cannot tear mucus apart and away from the airway lining. And they showed how to make mucus thinner and less sticky so coughing can become a therapeutic aid.
Mon, 12 Nov 2018 19:19:14 EST
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Hypertonic saline may help babies with cystic fibrosis breathe better
//www.koonmotors.com/releases/2018/11/181109073059.htm
Babies with cystic fibrosis may breathe better by inhaling hypertonic saline, according to a randomized controlled trial conducted in Germany.
Fri, 09 Nov 2018 07:30:59 EST
//www.koonmotors.com/releases/2018/11/181109073059.htm
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Mucus, cough and chronic lung disease
//www.koonmotors.com/releases/2018/10/181024095338.htm
As a cold ends, a severe mucus cough starts. Sound familiar? Two studies now give explanations: First, crucial mechanisms of the mucus in both diseased and healthy airways; second, what happens in such chronic lung diseases as cystic fibrosis and chronic obstructive pulmonary disease (COPD).
Wed, 24 Oct 2018 09:53:38 EDT
//www.koonmotors.com/releases/2018/10/181024095338.htm