//www.koonmotors.com/news/health_medicine/bladder_cancer/ Bladder cancer. Read about the latest medical research on bladder cancer and related topics. en-us Wed, 06 Sep 2023 14:45:33 EDT Wed, 06 Sep 2023 14:45:33 EDT 60 //www.koonmotors.com/images/scidaily-logo-rss.png//www.koonmotors.com/news/health_medicine/bladder_cancer/ For more science news, visit ScienceDaily. //www.koonmotors.com/releases/2023/07/230712124705.htm Prostate cancer is a leading cause of death among American men, and it's resistant to one of the most powerful chemotherapy medications -- cisplatin. Now, researchers have developed the first therapy of its kind that disrupts prostate cancer cells' metabolism and releases cisplatin into the weakened cells, causing them to die. In mouse models, an orally administered version shrunk tumors substantially. Wed, 12 Jul 2023 12:47:05 EDT //www.koonmotors.com/releases/2023/07/230712124705.htm //www.koonmotors.com/releases/2023/06/230621121032.htm As men age, some of their cells lose the very thing that makes them biological males -- the Y chromosome -- and this loss hampers the body's ability to fight cancer, according to new research. The study found that loss of the Y chromosome helps cancer cells evade the body's immune system. This common impact of the aging process in men results in aggressive bladder cancer, but somehow also renders the disease more vulnerable -- and responsive -- to a standard treatment called immune checkpoint inhibitors. Wed, 21 Jun 2023 12:10:32 EDT //www.koonmotors.com/releases/2023/06/230621121032.htm //www.koonmotors.com/releases/2023/03/230315132413.htm A new study represents a first step towards generating highly detailed 3-dimensional maps of lung tumors using genetically engineered mouse models. Wed, 15 Mar 2023 13:24:13 EDT //www.koonmotors.com/releases/2023/03/230315132413.htm //www.koonmotors.com/releases/2022/12/221228130358.htm An enzyme that defends human cells against viruses can help drive cancer evolution towards greater malignancy by causing myriad mutations in cancer cells, according to a new study. The finding suggests that the enzyme may be a potential target for future cancer treatments. Wed, 28 Dec 2022 13:03:58 EST //www.koonmotors.com/releases/2022/12/221228130358.htm //www.koonmotors.com/releases/2022/10/221005141743.htm An epigenetics drug currently being used for the treatment of blood cancers and rare sarcomas can stop the growth of bladder cancer by activating the immune system, reports a new study in mice. The drug is now being tested in a national clinical trial for patients with late-stage bladder cancer. Wed, 05 Oct 2022 14:17:43 EDT //www.koonmotors.com/releases/2022/10/221005141743.htm //www.koonmotors.com/releases/2022/09/220912112430.htm Researchers have made two important discoveries about the mechanism by which bladder cancer cells foil attacks from the immune system. The research could lead to a new therapeutic option for patients with these types of tumors. Mon, 12 Sep 2022 11:24:30 EDT //www.koonmotors.com/releases/2022/09/220912112430.htm //www.koonmotors.com/releases/2022/08/220822174822.htm Many bladder cancer patients cannot tolerate the strong side effects of the gold standard treatment. Researchers have found a way to minimize those side effects and are poised to move into clinical trials. Mon, 22 Aug 2022 17:48:22 EDT //www.koonmotors.com/releases/2022/08/220822174822.htm //www.koonmotors.com/releases/2022/08/220804130616.htm Investigators have identified genetic signatures that could predict whether tumors in patients with bladder and other cancers will respond to immunotherapy. Thu, 04 Aug 2022 13:06:16 EDT //www.koonmotors.com/releases/2022/08/220804130616.htm //www.koonmotors.com/releases/2022/07/220712102724.htm Development of a precision medicine technology based on artificial intelligence that predicts immunotherapy response in cancer patients. Tue, 12 Jul 2022 10:27:24 EDT //www.koonmotors.com/releases/2022/07/220712102724.htm //www.koonmotors.com/releases/2022/06/220609195008.htm Male sex hormones interfere with the body's ability to fight bladder cancer, likely explaining why males experience higher cancer rates and more deadly disease, according to a new study. Thu, 09 Jun 2022 19:50:08 EDT //www.koonmotors.com/releases/2022/06/220609195008.htm //www.koonmotors.com/releases/2022/05/220509171056.htm Researchers describe a novel form of gene regulation that is altered in bladder cancer, leading to the boosting of a gene pathway that helps the cancer cells survive during rapid growth. The work focuses on a 22-base fragment of transfer RNA, tRF-3b, which is modified by the enzyme complex TRMT6/61A. In bladder cancer, the levels of TRMT6/61A -- a methyltransferase -- are elevated. The methylation modification prevents tRF-3bs from silencing the expression of various genes in the unfolded protein response pathway in the cancer cells. Mon, 09 May 2022 17:10:56 EDT //www.koonmotors.com/releases/2022/05/220509171056.htm //www.koonmotors.com/releases/2022/05/220504110424.htm Researchers share the identification of a new potential target for CAR T cells called OR2H1 that they have demonstrated inhibits growth in lung and ovarian tumors. Wed, 04 May 2022 11:04:24 EDT //www.koonmotors.com/releases/2022/05/220504110424.htm //www.koonmotors.com/releases/2022/04/220422094310.htm In a small but multi-institutional study, an artificial intelligence-based system improved providers' assessments of whether patients with bladder cancer had complete response to chemotherapy before a radical cystectomy (bladder removal surgery). Fri, 22 Apr 2022 09:43:10 EDT //www.koonmotors.com/releases/2022/04/220422094310.htm //www.koonmotors.com/releases/2022/03/220330111401.htm Researchers have found that treatment with miR-634 reduces the resistance of oral squamous cell carcinoma cells to cisplatin, resulting in increased tumor cell killing. An ointment containing miR-634 had a similar effect in mice, suggesting that this simple topical treatment could be used to improve the prognosis of patients with advanced oral cancer. Wed, 30 Mar 2022 11:14:01 EDT //www.koonmotors.com/releases/2022/03/220330111401.htm //www.koonmotors.com/releases/2022/03/220328090017.htm Adding an anti-inflammatory medication to immunotherapy and standard chemotherapy drugs may provide long-term suppression of aggressive bladder tumor growth, according to a proof-of-concept study. Mon, 28 Mar 2022 09:00:17 EDT //www.koonmotors.com/releases/2022/03/220328090017.htm //www.koonmotors.com/releases/2022/02/220211102631.htm Researchers discovered how ovarian cancer hides from the body's immune system. The findings will help develop novel precision therapies for ovarian cancer, a common and aggressive cancer type. Fri, 11 Feb 2022 10:26:31 EST //www.koonmotors.com/releases/2022/02/220211102631.htm //www.koonmotors.com/releases/2021/10/211019120103.htm Identifying the dynamic events occurring during urinary tract infections (UTI) has revealed a new potential strategy to combat this condition, considered the most common type of infection. Tue, 19 Oct 2021 12:01:03 EDT //www.koonmotors.com/releases/2021/10/211019120103.htm //www.koonmotors.com/releases/2021/10/211001130256.htm More than half of U.S. women will experience at least one urinary tract infection (UTI) in their lifetimes, while a quarter will have a subsequent infection. Recurrent urinary tract infections are defined as two or more infections in six months or three or more in a year. Fri, 01 Oct 2021 13:02:56 EDT //www.koonmotors.com/releases/2021/10/211001130256.htm //www.koonmotors.com/releases/2021/09/210901100326.htm Two recent studies describe the potential of liquid biopsies to identify and track tumor growth in two very different cancers: bladder cancer and peripheral nerve tumors. Despite the differences between these cancers and their associated biopsies, the studies demonstrate the possible benefits of this relatively new tool in the fight against cancer. Wed, 01 Sep 2021 10:03:26 EDT //www.koonmotors.com/releases/2021/09/210901100326.htm //www.koonmotors.com/releases/2021/08/210816125723.htm Researchers have found adding the experimental drug entinostat to an immunotherapy-like treatment substantially boosted cancer remission in mice. This approach shows such promise that it's already being tested in an ongoing clinical trial in people with advanced bladder cancer. Mon, 16 Aug 2021 12:57:23 EDT //www.koonmotors.com/releases/2021/08/210816125723.htm //www.koonmotors.com/releases/2021/08/210802160627.htm A new treatment for advanced urothelial cancer was effective with tolerable side effects in an international, multi-center phase 2 clinical trial. The trial results prompted a U.S. Food and Drug Administration (FDA) accelerated approval of the treatment on April 13, giving patients with this very aggressive type of cancer a new therapeutic option. Mon, 02 Aug 2021 16:06:27 EDT //www.koonmotors.com/releases/2021/08/210802160627.htm //www.koonmotors.com/releases/2021/07/210722194950.htm Researchers report a study has demonstrated that patients with advanced bladder cancers whose tumors have a mutated FGFR3 gene respond to immunotherapy in a manner that is similar to patients without that mutation. This discovery runs counter to previous research that suggested FGFR3-mutated bladder cancers should not be treated with immunotherapy. Thu, 22 Jul 2021 19:49:50 EDT //www.koonmotors.com/releases/2021/07/210722194950.htm //www.koonmotors.com/releases/2021/06/210621123721.htm A blood test that can detect tiny amounts of circulating cancer DNA may be able to identify risk of cancer recurrence and guide precision treatment in bladder cancer following surgery, according to a clinical study. Mon, 21 Jun 2021 12:37:21 EDT //www.koonmotors.com/releases/2021/06/210621123721.htm //www.koonmotors.com/releases/2021/03/210318085615.htm Scientists have demonstrated that blocking 'cell drinking,' or macropinocytosis, in the thick tissue surrounding a pancreatic tumor slowed tumor growth--providing more evidence that macropinocytosis is a driver of pancreatic cancer growth and is an important therapeutic target. Thu, 18 Mar 2021 08:56:15 EDT //www.koonmotors.com/releases/2021/03/210318085615.htm //www.koonmotors.com/releases/2021/03/210301151532.htm Researchers describe a new vaccination strategy that they think could re-program the body to fight off the bacteria that cause urinary tract infections. Mon, 01 Mar 2021 15:15:32 EST //www.koonmotors.com/releases/2021/03/210301151532.htm //www.koonmotors.com/releases/2021/01/210114164011.htm Why do some hosts' immune systems reject tumors easily, while others have a harder time doing so? It depends on the types of the immune cells known as CD8 T cells and how a host's specific T cells match up with the neoantigens present in the tumor. Thu, 14 Jan 2021 16:40:11 EST //www.koonmotors.com/releases/2021/01/210114164011.htm //www.koonmotors.com/releases/2021/01/210107135655.htm Improving imaging processes will lead to more successful treatments and help reduce morbidity in men with the disease. Thu, 07 Jan 2021 13:56:55 EST //www.koonmotors.com/releases/2021/01/210107135655.htm //www.koonmotors.com/releases/2020/10/201014140958.htm Scientists have found that the main sensor protein enabling our sense of touch also underlies the feeling of having a full bladder and makes normal bladder function possible. The discovery marks a key advance in basic neurobiology and may also lead to better treatments for bladder control and urination problems, which are common especially among the elderly. Wed, 14 Oct 2020 14:09:58 EDT //www.koonmotors.com/releases/2020/10/201014140958.htm //www.koonmotors.com/releases/2020/09/200902182436.htm Researchers studying two forms of skin cancer identified a long-overlooked factor determining why some tumors are more likely to metastasize than others: the physical properties of the tissue in which the cancer originates. The findings might set the stage for new ways to monitor and treat the diseases in the future. Wed, 02 Sep 2020 18:24:36 EDT //www.koonmotors.com/releases/2020/09/200902182436.htm //www.koonmotors.com/releases/2020/08/200828081024.htm 研究已经发现了一个小分子化合物that can activate the Wnt pathway in non-Wnt subtypes of medulloblastoma, making these aggressive forms of cancer more responsive to therapies. The work also found the Wnt pathway, which has historically been considered cancer-promoting, to function as a cancer inhibitor in certain contexts. Fri, 28 Aug 2020 08:10:24 EDT //www.koonmotors.com/releases/2020/08/200828081024.htm //www.koonmotors.com/releases/2020/08/200813144920.htm 研究人员发现,肠道细菌帮助p our immune system battle cancerous tumors and how they do it. The discovery may provide a new understanding of why immunotherapy, a treatment for cancer that helps amplify immune response, works in some cases, but not others. The findings show combining immunotherapy with specific microbial therapy helps the immune system to recognize and attack cancer cells in three forms of cancer. Thu, 13 Aug 2020 14:49:20 EDT //www.koonmotors.com/releases/2020/08/200813144920.htm //www.koonmotors.com/releases/2020/05/200505105333.htm Researchers have developed a new device that can monitor bladder volume in real-time and effectively empty the bladder. Tue, 05 May 2020 10:53:33 EDT //www.koonmotors.com/releases/2020/05/200505105333.htm //www.koonmotors.com/releases/2020/04/200428225426.htm Researchers have recreated how toxins from smoking cause unique patterns of DNA damage. The discovery could help scientists better understand the cause of bladder cancer and the link to smoking. The causes of bladder cancer remain largely unknown, however smoking is seen as the main risk factor for the disease. Tue, 28 Apr 2020 22:54:26 EDT //www.koonmotors.com/releases/2020/04/200428225426.htm //www.koonmotors.com/releases/2020/01/200129131529.htm The fight against Urinary Tract Infection pain, discomfort and a constant urge to urinate has taken a step forward with scientists identifying how the immune systems defence against bladder infection causes nerves to magnify sensations felt by patients. Flinders University researchers at SAHMRI in collaboration with Griffith University on the Gold Coast, have analysed how the immune system responds to urinary tract infections and the direct link this response has to magnifying bladder pain. Wed, 29 Jan 2020 13:15:29 EST //www.koonmotors.com/releases/2020/01/200129131529.htm //www.koonmotors.com/releases/2019/12/191218153437.htm Saccharin received a bad rap after studies in the 1970s linked consumption of large amounts of the artificial sweetener to bladder cancer in laboratory rats. Later, research revealed that these findings were not relevant to people. And in a complete turnabout, recent studies indicate that saccharin can actually kill human cancer cells. Now, researchers have made artificial sweetener derivatives that show improved activity against two tumor-associated enzymes. Wed, 18 Dec 2019 15:34:37 EST //www.koonmotors.com/releases/2019/12/191218153437.htm //www.koonmotors.com/releases/2019/12/191213115401.htm While trying to develop a comparatively easy, inexpensive way to give physicians and their patients with bladder cancer a better idea of likely outcome and best treatment options, scientists found that sophisticated new subtyping techniques designed to do this provide no better information than long-standing pathology tests. Fri, 13 Dec 2019 11:54:01 EST //www.koonmotors.com/releases/2019/12/191213115401.htm //www.koonmotors.com/releases/2019/12/191211145602.htm Patients with well-supported immune cells in their tumors are more likely to control their cancers' growth for a longer time, an observation that could guide treatment decisions after surgery for kidney cancer. In addition, the findings could help researchers expand the dramatic but sparse benefits of cancer immunotherapy to more people. Wed, 11 Dec 2019 14:56:02 EST //www.koonmotors.com/releases/2019/12/191211145602.htm //www.koonmotors.com/releases/2019/11/191112095747.htm Researchers have come up with a way to combine the anthrax toxin with a growth factor to kill bladder cancer cells and tumors. Tue, 12 Nov 2019 09:57:47 EST //www.koonmotors.com/releases/2019/11/191112095747.htm //www.koonmotors.com/releases/2019/08/190819093001.htm A new study shows that tumor cells depleted of ARID1A -- a protein that acts as a cancer suppressor -- become highly sensitive to anticancer poly ADP ribose polymerase (PARP) inhibitor drugs after radiation treatment. The research could advance efforts to treat many human cancers with loss of ARID1A that are resistant to current standard treatments, the study team suggests. Mon, 19 Aug 2019 09:30:01 EDT //www.koonmotors.com/releases/2019/08/190819093001.htm //www.koonmotors.com/releases/2019/08/190814130731.htm Metastasis, in which cancer cells break free from the primary tumor and form tumors at other sites, worsens the prognosis for many cancer patients. The lymph nodes -- glands of the immune system located throughout the body -- are typically the traveling cells' first destination. Now, researchers have developed a strategy to target metastases in lymph nodes for destruction, before they can cause cancer at other locations. Wed, 14 Aug 2019 13:07:31 EDT //www.koonmotors.com/releases/2019/08/190814130731.htm //www.koonmotors.com/releases/2019/08/190805155916.htm Researchers have opened up a possible avenue for new cancer therapies that don't have the side effects that oftentimes accompany many current cancer treatments by identifying a protein modification that specifically supports survival of tumor cells. Mon, 05 Aug 2019 15:59:16 EDT //www.koonmotors.com/releases/2019/08/190805155916.htm //www.koonmotors.com/releases/2019/07/190725130817.htm Researchers have devised a very promising non-invasive and individualized technique for detecting and treating bladder cancer. The method uses a 'liquid biopsy' -- a urine specimen -- instead of the invasive tumor sampling needed today, and a method to culture cancer cells that can reveal the molecular underpinnings of each patient's unique bladder cancer. Thu, 25 Jul 2019 13:08:17 EDT //www.koonmotors.com/releases/2019/07/190725130817.htm //www.koonmotors.com/releases/2019/07/190708112441.htm Researchers demonstrate the role of an oncogene in altering the immediate environment of tumors. Mon, 08 Jul 2019 11:24:41 EDT //www.koonmotors.com/releases/2019/07/190708112441.htm //www.koonmotors.com/releases/2019/07/190704191431.htm A strain of the common cold virus has been found to potentially target, infect and destroy cancer cells in patients with bladder cancer, a new study reports. No trace of the cancer was found in one patient following treatment with the virus. Thu, 04 Jul 2019 19:14:31 EDT //www.koonmotors.com/releases/2019/07/190704191431.htm //www.koonmotors.com/releases/2019/06/190627114002.htm Desperate for nutrients, rapidly growing pancreatic tumors resort to scavenging 'fuel' through an alternative supply route, called macropinocytosis. Blocking this process, often described as 'cellular drinking,' could lead to tumor-starving drugs. Now, scientists have identified a signaling pathway that regulates macropinocytosis, the nutritional cue that triggers the process and key metabolic differences between tumors -- revealing new directions for drug development and patient treatment. Thu, 27 Jun 2019 11:40:02 EDT //www.koonmotors.com/releases/2019/06/190627114002.htm //www.koonmotors.com/releases/2019/02/190207132420.htm A therapy derived from the eggs of parasitic worms helps to protect against one of chemotherapy's debilitating side effects by significantly downregulating major proinflammatory pathways, reducing inflammation. Thu, 07 Feb 2019 13:24:20 EST //www.koonmotors.com/releases/2019/02/190207132420.htm //www.koonmotors.com/releases/2018/11/181114132000.htm Cancer scientists have combined 'liquid biopsy,' epigenetic alterations and machine learning to develop a blood test to detect and classify cancer at its earliest stages. Wed, 14 Nov 2018 13:20:00 EST //www.koonmotors.com/releases/2018/11/181114132000.htm //www.koonmotors.com/releases/2018/10/181019120736.htm Overactive bladder (OAB) is a common form of urinary incontinence that is widely treated with pelvic floor muscle (PFM) training. A new laboratory study lends insights into how PFM training works: by reducing contractions of the detrusor muscle of the bladder. Fri, 19 Oct 2018 12:07:36 EDT //www.koonmotors.com/releases/2018/10/181019120736.htm //www.koonmotors.com/releases/2018/10/181009115033.htm Researchers have uncovered a tumor cell population responsible for resistance to therapy and tumor relapse in the most frequent human cancer. They also identify a novel therapeutic strategy that target this resisting tumor population and prevents tumor relapse. Tue, 09 Oct 2018 11:50:33 EDT //www.koonmotors.com/releases/2018/10/181009115033.htm //www.koonmotors.com/releases/2018/10/181004155432.htm 研究人员发现在一个共同的过程e development of late-stage, small cell cancers of the prostate and lung. These shared molecular mechanisms could lead to the development of drugs to treat not just prostate and lung cancers, but small cell cancers of almost any organ. Thu, 04 Oct 2018 15:54:32 EDT //www.koonmotors.com/releases/2018/10/181004155432.htm //www.koonmotors.com/releases/2018/08/180831110408.htm Patients with muscle-invasive bladder cancer have been shown to benefit from chemotherapy prior to surgical removal of the bladder. But which type of chemotherapy leads to the best outcomes in terms of complete response rates or cancer control? Researchers examined data from more than 800 surgical patients with advanced bladder cancer. Fri, 31 Aug 2018 11:04:08 EDT //www.koonmotors.com/releases/2018/08/180831110408.htm //www.koonmotors.com/releases/2018/08/180829081336.htm This study reveals how some tumors fuel their own growth and how stopping this vicious cycle could lead to new treatments. Wed, 29 Aug 2018 08:13:36 EDT //www.koonmotors.com/releases/2018/08/180829081336.htm //www.koonmotors.com/releases/2018/08/180824135010.htm Researchers bioprint complex tubular tissues to replace dysfunctional vessels and ducts in the body. Fri, 24 Aug 2018 13:50:10 EDT //www.koonmotors.com/releases/2018/08/180824135010.htm //www.koonmotors.com/releases/2018/08/180813143805.htm Medical researchers are calling for the word 'cancer' to be dropped from some doctor-patient conversations in a bid to reduce patient anxiety and harm from over treatment. The appeal follows mounting evidence that patients who are told they have 'cancer' for low risk conditions more often choose surgery than those whose condition is described with terms such as 'lesions' or 'abnormal cells'. Mon, 13 Aug 2018 14:38:05 EDT //www.koonmotors.com/releases/2018/08/180813143805.htm //www.koonmotors.com/releases/2018/07/180713220137.htm A class of molecules formed when the body metabolizes omega-3 fatty acids could inhibit cancer's growth and spread, researchers report in a new study in mice. In mice with tumors of osteosarcoma - a bone cancer that is notoriously painful and difficult to treat -- endocannabinoids slowed the growth of tumors and blood vessels, inhibited the cancer cells from migrating and caused cancer cell death. Fri, 13 Jul 2018 22:01:37 EDT //www.koonmotors.com/releases/2018/07/180713220137.htm //www.koonmotors.com/releases/2018/07/180710110845.htm An amino acid transporter named xCT may affect the growth and progression of non-small cell lung cancer, a discovery that may predict the five-year survival rate of patients suffering from this cancer, now at 16 percent, researchers have concluded. Tue, 10 Jul 2018 11:08:45 EDT //www.koonmotors.com/releases/2018/07/180710110845.htm //www.koonmotors.com/releases/2018/06/180627160219.htm A new study has found that the female bladder not only contains bacteria, but the microbes are similar to those found in the vagina. The finding could lead to improved diagnostic tests and treatments for urinary tract infections and other urinary tract disorders. Wed, 27 Jun 2018 16:02:19 EDT //www.koonmotors.com/releases/2018/06/180627160219.htm //www.koonmotors.com/releases/2018/06/180615185418.htm Using a targeted therapy to block a protein that suppresses T cell activity could improve cancer treatment with immune checkpoint inhibitors, researchers report. Fri, 15 Jun 2018 18:54:18 EDT //www.koonmotors.com/releases/2018/06/180615185418.htm //www.koonmotors.com/releases/2018/06/180604172645.htm An experimental drug that blocks abnormal neural communication after spinal cord injury could one day be the key to improving quality of life by improving bladder function, new research suggests. Mon, 04 Jun 2018 17:26:45 EDT //www.koonmotors.com/releases/2018/06/180604172645.htm //www.koonmotors.com/releases/2018/05/180529132047.htm Researchers have detected an olfactory receptor in the human bladder that might prove useful for bladder cancer therapy and diagnosis. Tue, 29 May 2018 13:20:47 EDT //www.koonmotors.com/releases/2018/05/180529132047.htm