//www.koonmotors.com/news/health_medicine/anemia/ Anemia and related blood disorders. Read the latest medical research including new experimental treatments. en-us Mon, 16 Oct 2023 17:46:32 EDT Mon, 16 Oct 2023 17:46:32 EDT 60 //www.koonmotors.com/images/scidaily-logo-rss.png//www.koonmotors.com/news/health_medicine/anemia/ For more science news, visit ScienceDaily. //www.koonmotors.com/releases/2023/01/230129193412.htm Patients with myelofibrosis had clinically significant improvement in disease-related symptoms, including anemia and spleen enlargement, when treated with the targeted therapy momelotinib, according to new results. Sun, 29 Jan 2023 19:34:12 EST //www.koonmotors.com/releases/2023/01/230129193412.htm //www.koonmotors.com/releases/2022/11/221101111548.htm The destruction of red blood cells, or mechanical hemolysis, is an inevitable complication of interventional devices, so scientists want to gain a better understanding of the phenomenon. Researchers develop a red blood cell destruction model based on simulations of dissipative particle dynamics within a high shear flow. The team discovered that acceleration during shearing is a major factor in red blood cell destruction, beyond exposure time and shear stress. They recommend adding a flow buffer structure to the structural design of ventricular assist devices to reduce part of the hemolysis caused by shear acceleration. Tue, 01 Nov 2022 11:15:48 EDT //www.koonmotors.com/releases/2022/11/221101111548.htm //www.koonmotors.com/releases/2022/10/221012132603.htm Scientists found the cellular response to low oxygen also increases fetal hemoglobin expression in adults, which could lead to novel treatments for some common genetic anemias. Wed, 12 Oct 2022 13:26:03 EDT //www.koonmotors.com/releases/2022/10/221012132603.htm //www.koonmotors.com/releases/2022/10/221006121158.htm Two proteins ensure that cells can take up iron when needed. If both control proteins are switched off in mice, the animals develop severe anemia, as expected. Surprisingly, at the same time a cell type of the innate immune defense, the neutrophils, also dramatically decreases. Iron deficiency, a known defense mechanism against infectious pathogens, is a double edged sword, as it simultaneously curbs the defensive power of an important arm of the innate immune system. Thu, 06 Oct 2022 12:11:58 EDT //www.koonmotors.com/releases/2022/10/221006121158.htm //www.koonmotors.com/releases/2022/04/220414110900.htm Results from a phase 3 clinical indicate that the oral drug mitapivat is safe and effective for treating adults with pyruvate kinase deficiency, a genetic condition that causes red blood cell destruction. The trial's results led to the drug's approval by the U.S. Food and Drug Administration in February. Thu, 14 Apr 2022 11:09:00 EDT //www.koonmotors.com/releases/2022/04/220414110900.htm //www.koonmotors.com/releases/2022/01/220114115708.htm A world-first study has revealed how space travel can cause lower red blood cell counts, known as space anemia. Analysis of 14 astronauts showed their bodies destroyed 54 percent more red blood cells in space than they normally would on Earth, according to a new study. Fri, 14 Jan 2022 11:57:08 EST //www.koonmotors.com/releases/2022/01/220114115708.htm //www.koonmotors.com/releases/2021/10/211020150401.htm Researchers uncover the mechanism of how red blood cells detect and bind DNA, opening the door to a new area of research for the treatment of inflammatory diseases. Wed, 20 Oct 2021 15:04:01 EDT //www.koonmotors.com/releases/2021/10/211020150401.htm //www.koonmotors.com/releases/2021/10/211019110513.htm A mathematical model of the body's interacting physiological and biochemical processes shows that it may be more effective to replace red blood cell transfusion with transfusion of other fluids that are far less in demand. Tue, 19 Oct 2021 11:05:13 EDT //www.koonmotors.com/releases/2021/10/211019110513.htm //www.koonmotors.com/releases/2021/10/211012150042.htm New research shows how anemia can generate different immune responses in males versus females. Tue, 12 Oct 2021 15:00:42 EDT //www.koonmotors.com/releases/2021/10/211012150042.htm //www.koonmotors.com/releases/2021/08/210830104917.htm Half of pregnant women who had a simple blood test to check their iron stores had low iron levels, and one in four had severe iron deficiency, according to a new article. But despite how common iron deficiency is, 40% of pregnant women in this large regional study never had their iron levels checked, and women of lower socioeconomic status were less likely to get tested. Researchers said the findings underscore the need to revisit clinical guidelines to ensure that ferritin testing, the standard measure of iron deficiency, is included as a routine part of maternal care and pregnancy health screenings. Mon, 30 Aug 2021 10:49:17 EDT //www.koonmotors.com/releases/2021/08/210830104917.htm //www.koonmotors.com/releases/2021/08/210806171916.htm 池3期临床试验的结果恶魔trate that roxadustat is efficacious and may be comparable to placebo in studies done to date for treating anemia in patients with chronic kidney disease who do not require dialysis. Fri, 06 Aug 2021 17:19:16 EDT //www.koonmotors.com/releases/2021/08/210806171916.htm //www.koonmotors.com/releases/2021/06/210601135730.htm Researchers have developed a proof-of-concept treatment for blood disorders like sickle cell disease and beta-thalassemia that could raise hemoglobin levels by activating production of both fetal and adult hemoglobin. Using a viral vector engineered to reactivate fetal hemoglobin production, suppress mutant hemoglobin, and supply functional adult hemoglobin, the researchers developed an approach that could produce more hemoglobin through a single vector. Tue, 01 Jun 2021 13:57:30 EDT //www.koonmotors.com/releases/2021/06/210601135730.htm //www.koonmotors.com/releases/2021/04/210409093609.htm For those who have sickle cell disease, there are only a few treatment options, which include bone marrow transplants, gene therapy or other treatments that address a subset of symptoms. Now, researchers report discovery of a small molecule that could treat sickle cell disease by boosting levels of fetal hemoglobin, a healthy form that adults normally do not make. Fri, 09 Apr 2021 09:36:09 EDT //www.koonmotors.com/releases/2021/04/210409093609.htm //www.koonmotors.com/releases/2020/12/201231091046.htm A randomized clinical trial is the largest study to-date to compare thresholds for blood transfusions in premature babies, offers guidance for health care providers. Thu, 31 Dec 2020 09:10:46 EST //www.koonmotors.com/releases/2020/12/201231091046.htm //www.koonmotors.com/releases/2020/11/201110133148.htm New research shows that the lowest risk for autism spectrum disorder is associated with mid-levels of an immune marker measured at birth -- whereas too much or not enough were linked to increased risk. Tue, 10 Nov 2020 13:31:48 EST //www.koonmotors.com/releases/2020/11/201110133148.htm //www.koonmotors.com/releases/2020/09/200930085153.htm A recently developed UM171 molecule was used in a blood transplant by a medical team on a young man suffering from severe aplastic anemia, an autoimmune disease. Wed, 30 Sep 2020 08:51:53 EDT //www.koonmotors.com/releases/2020/09/200930085153.htm //www.koonmotors.com/releases/2020/08/200814131012.htm Pregnant women from sub-Saharan Africa with malaria and human immunodeficiency virus (HIV) have a higher prevalence of anemia than pregnant women without infections, according to researchers. The findings may have implications for reducing the risk of death in pregnant women and preventing low birth weights and neurocognitive impairment in their children as a result of anemia. Fri, 14 Aug 2020 13:10:12 EDT //www.koonmotors.com/releases/2020/08/200814131012.htm //www.koonmotors.com/releases/2020/05/200520151253.htm In the bone marrow, blood stem cells via precursor cells give rise to a variety of blood cell types with various functions: white blood cells, red blood cells, or blood platelets. In which cell type a cell develops depends on various factors. The correct dosage of the enzyme MOF at the right time triggers developmental programs in blood stem cells and precursor cells, and the cells differentiate into red blood cells. Wed, 20 May 2020 15:12:53 EDT //www.koonmotors.com/releases/2020/05/200520151253.htm //www.koonmotors.com/releases/2020/04/200423130510.htm High-altitude adaptations in the Himalayas may lower risk for some chronic diseases, according to researchers. Thu, 23 Apr 2020 13:05:10 EDT //www.koonmotors.com/releases/2020/04/200423130510.htm //www.koonmotors.com/releases/2019/11/191112110200.htm An autoimmune attack on uninfected red blood cells likely contributes to anemia -- a shortage of red blood cells -- in people with malaria. Tue, 12 Nov 2019 11:02:00 EST //www.koonmotors.com/releases/2019/11/191112110200.htm //www.koonmotors.com/releases/2019/10/191022174405.htm Patients who survive a cerebral hemorrhage may suffer delayed severe brain damage caused by free hemoglobin, which comes from red blood cells and damages neurons. Researchers have now discovered a protective protein in the body called haptoglobin, which prevents this effect. Tue, 22 Oct 2019 17:44:05 EDT //www.koonmotors.com/releases/2019/10/191022174405.htm //www.koonmotors.com/releases/2019/08/190820154250.htm Iron deficiency in pregnancy is a common problem that often goes unrecognized and untreated due to a lack of knowledge of its implications and competing clinical priorities. To enhance screening and management of iron deficiency in pregnancy, a research team has developed a quality improvement toolkit, called IRON MOM. The implementation of IRON MOM resulted in increased rates of ferritin testing and decreased rates of anemia. Tue, 20 Aug 2019 15:42:50 EDT //www.koonmotors.com/releases/2019/08/190820154250.htm //www.koonmotors.com/releases/2019/07/190702112908.htm Chemists are reporting a new finding on how sickle cells are formed, which may lead not only to stopping their formation, but to new avenues for making uniformly-sized nanoparticles for industry. Tue, 02 Jul 2019 11:29:08 EDT //www.koonmotors.com/releases/2019/07/190702112908.htm //www.koonmotors.com/releases/2019/02/190219080748.htm Female adolescent blood donors are more likely to have low iron stores and iron deficiency anemia than adult female blood donors and nondonors, which could have significant negative consequences on their developing brains, a new study suggests. Tue, 19 Feb 2019 08:07:48 EST //www.koonmotors.com/releases/2019/02/190219080748.htm //www.koonmotors.com/releases/2019/02/190206115626.htm Silent strokes are a common symptom of sickle cell disease, though they can be debilitating. Researchers recently showed that silent strokes may be caused by decreased oxygen delivery to a part of the brain called the white matter. Wed, 06 Feb 2019 11:56:26 EST //www.koonmotors.com/releases/2019/02/190206115626.htm //www.koonmotors.com/releases/2018/12/181217101745.htm In a first-in-human clinical trial, the investigational drug sutimlimab appeared to be effective in treating cold agglutinin disease, a rare chronic blood disorder for which there are currently no approved treatments. Mon, 17 Dec 2018 10:17:45 EST //www.koonmotors.com/releases/2018/12/181217101745.htm //www.koonmotors.com/releases/2018/10/181009115001.htm Pediatric researchers studying the life-threatening blood disorder Fanconi anemia have devised a method to block the abnormal biological signals that drive the disease. This proof-of-concept finding in animals and stem cells from human cord blood may lay the foundation for better treatments for children with the rare, frequently fatal disease. Tue, 09 Oct 2018 11:50:01 EDT //www.koonmotors.com/releases/2018/10/181009115001.htm //www.koonmotors.com/releases/2018/09/180926110637.htm Japanese scientists have revealed a biological 'switch' that influences whether an immature blood cell would develop into a red blood cell or a subtype of white blood cell called myeloid cells in response to infection or inflammation within the body. Wed, 26 Sep 2018 11:06:37 EDT //www.koonmotors.com/releases/2018/09/180926110637.htm //www.koonmotors.com/releases/2018/09/180903152916.htm A new study describes how sickled red blood cells get stuck in tiny blood vessels of patients with sickle-cell disease. The findings may help researchers predict more accurately when such a vaso-occlusive pain crisis might occur. Mon, 03 Sep 2018 15:29:16 EDT //www.koonmotors.com/releases/2018/09/180903152916.htm //www.koonmotors.com/releases/2018/08/180802115657.htm Researchers have found how hypoxia (a low concentration of oxygen) decreases Protein S, a natural anticoagulant, resulting in an increased risk for the development of potentially life-threatening blood clots (thrombosis). Although hypoxia has been associated with an increased risk for thrombosis, this research showed for the first time a molecular cause. Thu, 02 Aug 2018 11:56:57 EDT //www.koonmotors.com/releases/2018/08/180802115657.htm //www.koonmotors.com/releases/2018/04/180404133505.htm Every day, stem cells in our bone marrow produce billions of new red blood cells. Any disruption in this process can result in serious disease. Researchers have succeeded in furthering our understanding of how blood cells are formed. Their insights into the molecular foundations of this process may help break new ground in the treatment of certain types of anemia. Wed, 04 Apr 2018 13:35:05 EDT //www.koonmotors.com/releases/2018/04/180404133505.htm //www.koonmotors.com/releases/2018/04/180404125813.htm Researchers report that a protein called myosin IIA contracts to give red blood cells their distinctive shape. The findings could shed light on sickle cell diseases and other disorders where red blood cells are deformed. Wed, 04 Apr 2018 12:58:13 EDT //www.koonmotors.com/releases/2018/04/180404125813.htm //www.koonmotors.com/releases/2018/03/180322140449.htm In hookworms that infect and feed on the blood of mice, scientists have discovered a key step in blood digestion that can be targeted to disrupt the parasite's development and survival. Thu, 22 Mar 2018 14:04:49 EDT //www.koonmotors.com/releases/2018/03/180322140449.htm //www.koonmotors.com/releases/2018/03/180321092634.htm Pregnant women with anemia are twice as likely to die during or shortly after pregnancy compared to those without the condition, according to a major international study. Wed, 21 Mar 2018 09:26:34 EDT //www.koonmotors.com/releases/2018/03/180321092634.htm //www.koonmotors.com/releases/2018/03/180319120102.htm For the first time, cellular machines called ribosomes -- which create proteins in every cell of the body -- have been linked to blood stem cell differentiation. The findings have revealed a potential new therapeutic pathway to treat Diamond-Blackfan anemia. Mon, 19 Mar 2018 12:01:02 EDT //www.koonmotors.com/releases/2018/03/180319120102.htm //www.koonmotors.com/releases/2018/02/180201173408.htm Researchers have discovered the contribution of a specific gene in the proper development of blood cells that give rise to hematopoietic stem cells. The findings identify a potential target for the development of treatments for some types of leukemia, anemia and other blood disorders. Thu, 01 Feb 2018 17:34:08 EST //www.koonmotors.com/releases/2018/02/180201173408.htm //www.koonmotors.com/releases/2018/01/180122110806.htm Researchers have discovered an unknown biological process that controls the production of vital cells that carry oxygen throughout the body. The discovery could help doctors develop new treatments for anemias that affect millions of people. Mon, 22 Jan 2018 11:08:06 EST //www.koonmotors.com/releases/2018/01/180122110806.htm //www.koonmotors.com/releases/2017/12/171205130108.htm Engineers and nutritionists have created a swift solution for a challenging global health problem: a low-cost, rapid test to detect iron and vitamin A deficiencies at the point of care. Tue, 05 Dec 2017 13:01:08 EST //www.koonmotors.com/releases/2017/12/171205130108.htm //www.koonmotors.com/releases/2017/11/171113123624.htm Lower thresholds for blood transfusions during cardiac surgery have proven to be safe and provide good patient outcomes compared to traditional thresholds, according to the largest research study ever performed in this area. Mon, 13 Nov 2017 12:36:24 EST //www.koonmotors.com/releases/2017/11/171113123624.htm //www.koonmotors.com/releases/2017/10/171003133200.htm To reduce the burden of anemia, health officials need a better picture of the disease's global impact, an understanding made viable by a portable and affordable way to analyze blood. Researchers have now developed a device smaller than a toaster that can detect the level of hemoglobin in whole blood samples using optical absorbance. Tue, 03 Oct 2017 13:32:00 EDT //www.koonmotors.com/releases/2017/10/171003133200.htm //www.koonmotors.com/releases/2017/09/170920131704.htm Researchers found a high rate of anemia 10 years after patients received Roux-en-Y gastric bypass, suggesting that long-term follow-up with a bariatric specialist is important to lessen the risk for anemia, according to a new study. Wed, 20 Sep 2017 13:17:04 EDT //www.koonmotors.com/releases/2017/09/170920131704.htm //www.koonmotors.com/releases/2017/09/170912093045.htm Space flight anemia -- the reduction of circulating red blood cells during time spent in space -- is an established phenomenon, but it may not be a major concern during long-duration space missions, according to a study. Tue, 12 Sep 2017 09:30:45 EDT //www.koonmotors.com/releases/2017/09/170912093045.htm //www.koonmotors.com/releases/2017/08/170818123537.htm Researchers have identified the mechanism behind red blood cell specialization and revealed that it is controlled by an enzyme called UBE2O. This finding could spark the development of new treatments for blood disorders and cancers. Fri, 18 Aug 2017 12:35:37 EDT //www.koonmotors.com/releases/2017/08/170818123537.htm //www.koonmotors.com/releases/2017/07/170710161001.htm Fanconi贫血症是一种罕见的遗传性疾病的性格ized by hematologic symptoms and high cancer risk. Mutations in nearly 20 different genes have been identified in patients with Fanconi anemia. Medical researchers now reveal a new Fanconi anemia gene, RFWD3, that is involved in complex DNA repair processes and may also play a relevant role in cancer risk. Mon, 10 Jul 2017 16:10:01 EDT //www.koonmotors.com/releases/2017/07/170710161001.htm //www.koonmotors.com/releases/2017/07/170705164538.htm Researchers have adapted an existing diagnostic test for malaria to predict the dangerous complications that sometimes arise after the parasite is eradicated from patients' blood. Wed, 05 Jul 2017 16:45:38 EDT //www.koonmotors.com/releases/2017/07/170705164538.htm //www.koonmotors.com/releases/2017/06/170626093507.htm Individuals who do not produce enough iron are anemic, and often experience fatigue. One common remedy is for physicians to prescribe an iron infusion to their anemic patients. This makes sense, but can lead to unexpected consequences like increasing the risk of food poisons such as Salmonella. These types of poisons depend on abundant access to iron. Physicians should be attuned to this dynamic when determining the strength of iron infusions for their anemic patients. Mon, 26 Jun 2017 09:35:07 EDT //www.koonmotors.com/releases/2017/06/170626093507.htm //www.koonmotors.com/releases/2017/06/170613111709.htm A clinical trial compared new and traditional treatments for iron-deficiency anemia and determined that the traditional treatment, ferrous sulfate, can more effectively treat the anemia in young children. Tue, 13 Jun 2017 11:17:09 EDT //www.koonmotors.com/releases/2017/06/170613111709.htm //www.koonmotors.com/releases/2017/06/170608145509.htm An estimated 1 billion people in the world live without access to any type of sanitation facility, such as a toilet or latrine. Sanitation access is known to be associated with the risk of transmitting certain diseases, including parasitic worms. But the impacts don't stop there. For children, living in a community with poor levels of sanitation access increases their odds of stunted growth, anemia, and diarrhea, even if their household has access to a sanitation facility. Thu, 08 Jun 2017 14:55:09 EDT //www.koonmotors.com/releases/2017/06/170608145509.htm //www.koonmotors.com/releases/2017/05/170518104116.htm One in three patients hospitalized for medical problems experienced a drop in their red blood cell count due to the hospitalization -- a concept called hospital-acquired anemia, new research showed. Thu, 18 May 2017 10:41:16 EDT //www.koonmotors.com/releases/2017/05/170518104116.htm //www.koonmotors.com/releases/2017/05/170511142017.htm 研究人员已经证明,一个小molecule can transport iron in human cells and live animals when proteins that normally do the same job are missing, a condition that often causes severe anemia in patients. Such 'molecular prosthetics' might treat a host of incurable diseases caused by protein deficiencies, such as anemias, cystic fibrosis or certain types of heart disease. Thu, 11 May 2017 14:20:17 EDT //www.koonmotors.com/releases/2017/05/170511142017.htm //www.koonmotors.com/releases/2017/05/170511141946.htm Investigators describe a compound known as Hinokitiol which can correct iron-delivery defects in preclinical models. Their study lays the groundwork for investigating Hinkitiol's full potential beyond cellular and model organisms. Thu, 11 May 2017 14:19:46 EDT //www.koonmotors.com/releases/2017/05/170511141946.htm //www.koonmotors.com/releases/2017/02/170223101837.htm Our blood stem cells generate around a thousand billion new blood cells every day. But the blood stem cells’ capacity to produce blood changes as we age. This leads to older people being more susceptible to anemia, lowered immunity and a greater risk of developing certain kinds of blood cancer. Now for the first time, a research team has succeeded in rejuvenating blood stem cells with established reduced function in aging mice. Thu, 23 Feb 2017 10:18:37 EST //www.koonmotors.com/releases/2017/02/170223101837.htm //www.koonmotors.com/releases/2017/02/170221130722.htm Testosterone treatment improved bone density and anemia for men over 65 with unequivocally low testosterone, a new study has concluded. However, testosterone treatment did not improve cognitive function, and it increased the amount of plaque buildup in participants' coronary arteries. Tue, 21 Feb 2017 13:07:22 EST //www.koonmotors.com/releases/2017/02/170221130722.htm //www.koonmotors.com/releases/2017/02/170217012518.htm A mutation in the hemoglobin of a young woman in Germany was found to cause her mild anemia. But her father, who shared the mutation, did not develop anemia because his mutant hemoglobin was stabilized by carbon monoxide produced from his smoking. Fri, 17 Feb 2017 01:25:18 EST //www.koonmotors.com/releases/2017/02/170217012518.htm //www.koonmotors.com/releases/2017/01/170117135946.htm When clamping of the umbilical cord is delayed, iron deficiency up to six months of age can be prevented, according to a new study. Tue, 17 Jan 2017 13:59:46 EST //www.koonmotors.com/releases/2017/01/170117135946.htm //www.koonmotors.com/releases/2017/01/170112180936.htm In a phase 3 trial of patients with chronic kidney disease, 52.1% of patients receiving oral ferric citrate experienced a significant boost in hemoglobin levels (a reflection of red blood cell counts) compared with 19.1% of patients receiving placebo. A treatment effect was seen as early as 1-2 weeks after the start of treatment, and the response was durable. Thu, 12 Jan 2017 18:09:36 EST //www.koonmotors.com/releases/2017/01/170112180936.htm //www.koonmotors.com/releases/2017/01/170105160212.htm Iron deficiency anemia protects children against the blood-stage of Plasmodium falciparum malaria in Africa, and treating anemia with iron supplementation removes this protective effect, new research suggests. Thu, 05 Jan 2017 16:02:12 EST //www.koonmotors.com/releases/2017/01/170105160212.htm //www.koonmotors.com/releases/2016/12/161229113457.htm Medical researchers examined the association between sensorineural hearing loss and conductive hearing loss and iron deficiency anemia in adults ages 21 to 90 years in the United States. Thu, 29 Dec 2016 11:34:57 EST //www.koonmotors.com/releases/2016/12/161229113457.htm //www.koonmotors.com/releases/2016/12/161201172316.htm An important molecular link between a rare childhood genetic disease and a major cancer gene has been uncovered by scientists. The discovery could lead to improved treatment outcomes for some cancer patients, they say. Thu, 01 Dec 2016 17:23:16 EST //www.koonmotors.com/releases/2016/12/161201172316.htm //www.koonmotors.com/releases/2016/10/161026110544.htm A new gene editing strategy has been used to correct mutations that cause thalassemia, a form of anemia. Their gene editing technique provided corrections to the mutations and alleviated the disease in mice, the researchers said. The finding could lead to studies of a similar gene therapy to treat people with inherited blood disorders. Wed, 26 Oct 2016 11:05:44 EDT //www.koonmotors.com/releases/2016/10/161026110544.htm