//www.koonmotors.com/news/computers_math/computational_biology/ Computational biology and bioinformatics. Read the latest research from universities and research institutes around the world. Full text, images, free. en-us Wed, 06 Sep 2023 14:51:56 EDT Wed, 06 Sep 2023 14:51:56 EDT 60 //www.koonmotors.com/images/scidaily-logo-rss.png//www.koonmotors.com/news/computers_math/computational_biology/ For more science news, visit ScienceDaily. //www.koonmotors.com/releases/2023/08/230825122024.htm Researchers see potential in educational settings for the newest official ChatGPT plugin, called Code Interpreter, they've found limitations for its use by scientists who work with biological data utilizing computational methods to prioritize targeted treatment for cancer and genetic disorders. Fri, 25 Aug 2023 12:20:24 EDT //www.koonmotors.com/releases/2023/08/230825122024.htm //www.koonmotors.com/releases/2023/08/230814122339.htm A mathematical model provides new insights into the distribution of genetic information during bacterial cell division Mon, 14 Aug 2023 12:23:39 EDT //www.koonmotors.com/releases/2023/08/230814122339.htm //www.koonmotors.com/releases/2023/06/230605181331.htm Scientists using artificial intelligence technology may be inviting unwanted noise into their genome analyses. Now, researchers have created a computational correction that will allow them to see through the fog and find genuine DNA features that could signal breakthroughs in health and medicine. Mon, 05 Jun 2023 18:13:31 EDT //www.koonmotors.com/releases/2023/06/230605181331.htm //www.koonmotors.com/releases/2023/04/230414201831.htm Scientists have developed a software package to help answer key questions about genetic factors associated with shared characteristics among different species. Fri, 14 Apr 2023 20:18:31 EDT //www.koonmotors.com/releases/2023/04/230414201831.htm //www.koonmotors.com/releases/2023/03/230330172121.htm A new artificial intelligence tool can predict the functions of enzymes based on their amino acid sequences, even when the enzymes are unstudied or poorly understood. Researchers said the AI tool, dubbed CLEAN, outperforms the leading state-of-the-art tools in accuracy, reliability and sensitivity. Better understanding of enzymes and their functions would be a boon for research in genomics, chemistry, industrial materials, medicine, pharmaceuticals and more. Thu, 30 Mar 2023 17:21:21 EDT //www.koonmotors.com/releases/2023/03/230330172121.htm //www.koonmotors.com/releases/2023/03/230330122758.htm Researchers used computational modeling to reveal finer details surrounding the outer shell of the COVID-19 virus. The work expands the scientific community's understanding of SARS-COV-2, and could lead to more refined antiviral therapies and better vaccines. Thu, 30 Mar 2023 12:27:58 EDT //www.koonmotors.com/releases/2023/03/230330122758.htm //www.koonmotors.com/releases/2023/02/230216161928.htm Researchers have developed and released an innovative software tool to assemble truly complete (i.e., gapless) genome sequences from a variety of species. Thu, 16 Feb 2023 16:19:28 EST //www.koonmotors.com/releases/2023/02/230216161928.htm //www.koonmotors.com/releases/2023/02/230215143606.htm Researchers used computational modeling to uncover mutations in the human genome that likely influenced the evolution of human cognition. This groundbreaking research in human genomics could lead to a better understanding of human health and the discovery of novel treatments for complex brain disorders. The study is to be published in Science Advances. Wed, 15 Feb 2023 14:36:06 EST //www.koonmotors.com/releases/2023/02/230215143606.htm //www.koonmotors.com/releases/2023/01/230120131300.htm A researcher has created a computer reconstruction of a virus, including its complete native genome. Although other researchers have created similar reconstructions, this is believed to be the first to replicate the exact chemical and 3D structure of a 'live' virus. Fri, 20 Jan 2023 13:13:00 EST //www.koonmotors.com/releases/2023/01/230120131300.htm //www.koonmotors.com/releases/2023/01/230111193518.htm Combing computational physics with experimental data, researchers have developed computer models for determining a drug candidate's ability to target and bind to proteins within cells. Wed, 11 Jan 2023 19:35:18 EST //www.koonmotors.com/releases/2023/01/230111193518.htm //www.koonmotors.com/releases/2022/10/221004121940.htm A milestone report proposes a new technique for modeling molecular life with computers. The advance promises new insights into the fundamental biology of a cell, as well as faster and more precise treatment of human disease. Tue, 04 Oct 2022 12:19:40 EDT //www.koonmotors.com/releases/2022/10/221004121940.htm //www.koonmotors.com/releases/2022/09/220920100818.htm Researchers have developed a new mathematical technique to begin to understand how a cell's nucleus is organized. They hope this understanding will expose vulnerabilities that can be targeted to reprogram a cell to stop cancer or other diseases. Tue, 20 Sep 2022 10:08:18 EDT //www.koonmotors.com/releases/2022/09/220920100818.htm //www.koonmotors.com/releases/2022/08/220818122424.htm A Rutgers analysis of dozens of artificial intelligence (AI) software programs used in precision, or personalized, medicine to prevent, diagnose and treat disease found that no program exists that can be used for all treatments. Thu, 18 Aug 2022 12:24:24 EDT //www.koonmotors.com/releases/2022/08/220818122424.htm //www.koonmotors.com/releases/2022/08/220809141159.htm Investigators have created the most bio-realistic and complex computer models of individual brain cells -- in unparalleled quantity. Their research details how these models could one day answer questions about neurological disorders -- and even human intellect -- that aren't possible to explore through biological experiments. Tue, 09 Aug 2022 14:11:59 EDT //www.koonmotors.com/releases/2022/08/220809141159.htm //www.koonmotors.com/releases/2022/08/220808162144.htm A new study reveals a proof-of-concept model that uses artificial intelligence (AI) to combine multiple types of data from different sources to predict patient outcomes for 14 different types of cancer. Mon, 08 Aug 2022 16:21:44 EDT //www.koonmotors.com/releases/2022/08/220808162144.htm //www.koonmotors.com/releases/2022/08/220808162100.htm Newly developed artificial intelligence (AI) programs accurately predicted the role of DNA's regulatory elements and three-dimensional (3D) structure based solely on its raw sequence, according to recent studies. These tools could eventually shed new light on how genetic mutations lead to disease and could lead to new understanding of how genetic sequence influences the spatial organization and function of chromosomal DNA in the nucleus, according to researchers. Mon, 08 Aug 2022 16:21:00 EDT //www.koonmotors.com/releases/2022/08/220808162100.htm //www.koonmotors.com/releases/2022/07/220721131959.htm Despite existing tools that facilitate the sharing of genomic information with researchers, none of those options give Indigenous governments control over how these data are used. In a new article, authors propose a new blockchain model where researchers are only allowed to access the genomic data after the Indigenous entities have approved the research project. Thu, 21 Jul 2022 13:19:59 EDT //www.koonmotors.com/releases/2022/07/220721131959.htm //www.koonmotors.com/releases/2022/07/220708123638.htm Researchers develop user-friendly software system to optimize biological systems. Fri, 08 Jul 2022 12:36:38 EDT //www.koonmotors.com/releases/2022/07/220708123638.htm //www.koonmotors.com/releases/2022/06/220624105121.htm Automation in disease diagnosis is reliant on deep learning models that can accurately and efficiently identify measurements of tumors, tissue volume, or other sorts of abnormalities. Now, researchers have unveiled a new, resource-light model capable of identifying many common eye diseases. Fri, 24 Jun 2022 10:51:21 EDT //www.koonmotors.com/releases/2022/06/220624105121.htm //www.koonmotors.com/releases/2022/06/220616121630.htm 学者已经创建了一个新的全球存储库的linguistic data. The project is designed to facilitate new insights into the evolution of words and sounds of the languages spoken across the world today. The Lexibank database contains standardized lexical data for more than 2000 languages. It is the most extensive publicly available collection compiled so far. Thu, 16 Jun 2022 12:16:30 EDT //www.koonmotors.com/releases/2022/06/220616121630.htm //www.koonmotors.com/releases/2022/06/220613124544.htm Researchers have developed a mathematical tool to estimate tumor-specific RNA levels from tumor samples with mixed cell types. Using this technique on thousands of samples found that higher mRNA levels are correlated with shorter survival. Mon, 13 Jun 2022 12:45:44 EDT //www.koonmotors.com/releases/2022/06/220613124544.htm //www.koonmotors.com/releases/2022/06/220606145423.htm A new study examines mathematical models designed to draw inferences about how evolution operates at the level of populations of organisms. The study concludes that such models must be constructed with the greatest care, avoiding unwarranted initial assumptions, weighing the quality of existing knowledge and remaining open to alternate explanations. Mon, 06 Jun 2022 14:54:23 EDT //www.koonmotors.com/releases/2022/06/220606145423.htm //www.koonmotors.com/releases/2022/05/220517170255.htm Researchers have developed PlasmidMaker, a versatile automated platform for plasmid design & construction. These circular DNA molecules are used by scientists to introduce new genes into a target organism, and have extensive use in basic and applied biology. In particular, they have applications in the large-scale production of bioproducts. Tue, 17 May 2022 17:02:55 EDT //www.koonmotors.com/releases/2022/05/220517170255.htm //www.koonmotors.com/releases/2022/04/220412141041.htm Researchers have developed a new computational tool to select optimal combination therapies for patients with cancer based on the co-occurring alterations in a given tumor. Tue, 12 Apr 2022 14:10:41 EDT //www.koonmotors.com/releases/2022/04/220412141041.htm //www.koonmotors.com/releases/2022/03/220321132143.htm A new computational approach successfully combines data from parallel gene-expression profiling methods to create spatial maps of a given tissue at single-cell resolution. The resulting maps can provide unique biological insights into the cancer microenvironment and many other tissue types. Mon, 21 Mar 2022 13:21:43 EDT //www.koonmotors.com/releases/2022/03/220321132143.htm //www.koonmotors.com/releases/2022/02/220224140841.htm Researchers have taken a major step towards mapping the entirety of genetic relationships among humans: a single genealogy that traces the ancestry of all of us. Thu, 24 Feb 2022 14:08:41 EST //www.koonmotors.com/releases/2022/02/220224140841.htm //www.koonmotors.com/releases/2022/02/220220195404.htm A new accelerator chip called 'Hiddenite' that can achieve state-of-the-art accuracy in the calculation of sparse 'hidden neural networks' with lower computational burdens has now been developed. By employing the proposed on-chip model construction, which is the combination of weight generation and 'supermask' expansion, the Hiddenite chip drastically reduces external memory access for enhanced computational efficiency. Sun, 20 Feb 2022 19:54:04 EST //www.koonmotors.com/releases/2022/02/220220195404.htm //www.koonmotors.com/releases/2022/02/220217141336.htm Scientists have developed CROPSR, the first open-source software tool for genome-wide design and evaluation of guide RNA (gRNA) sequences for CRISPR/Cas9 experiments. This tool significantly shortens the time required to design a CRISPR experiment and reduces the challenge of working with complex crop genomes. It should accelerate bioenergy crop development as well as broader crop improvements and other gene-editing research. Thu, 17 Feb 2022 14:13:36 EST //www.koonmotors.com/releases/2022/02/220217141336.htm //www.koonmotors.com/releases/2022/02/220210114016.htm Rare genetic diseases can sometimes be recognized through facial features, such as characteristically shaped brows, nose or cheeks. Researchers have now trained software that uses portrait photos to better diagnose such diseases. The improved version "GestaltMatcher" can now also detect diseases that are not yet known to it. It also manages to diagnose known diseases with very small numbers of patients. Thu, 10 Feb 2022 11:40:16 EST //www.koonmotors.com/releases/2022/02/220210114016.htm //www.koonmotors.com/releases/2022/01/220127172646.htm Scientists have just launched GENIGMA, a videogame that enlists players to solve puzzles while generating real-world scientific data that can detect alterations in genomic sequences and ultimately advance breast cancer research. The game was created to boost worldwide research efforts that depend on cancer cell lines, a critical resource used by scientists to study cancer and test new drugs to treat the disease. One of the limitations of cancer cell lines are a lack of high-resolution genome reference maps, which are necessary to help researchers interpret their scientific results. Thu, 27 Jan 2022 17:26:46 EST //www.koonmotors.com/releases/2022/01/220127172646.htm //www.koonmotors.com/releases/2022/01/220112145118.htm Harnessing the power of genomics to find risk factors for major diseases or search for relatives relies on the costly and time-consuming ability to analyze huge numbers of genomes. Computer scientists have now leveled the playing field by creating a cloud-based platform that grants genomics researchers easy access to one of the world's largest genomics databases. Known as AnVIL (Genomic Data Science Analysis, Visualization, and Informatics Lab-space), the new platform gives any researcher with an Internet connection access to thousands of analysis tools, patient records, and more than 300,000 genomes. Wed, 12 Jan 2022 14:51:18 EST //www.koonmotors.com/releases/2022/01/220112145118.htm //www.koonmotors.com/releases/2022/01/220107101011.htm Researchers have developed a computational approach for simulating interactions between matter and light at the atomic scale. The team tested their method by modeling light -- matter interactions in a thin film of amorphous silicon dioxide, composed of more than 10,000 atoms, using the world's fastest supercomputer, Fugaku. The proposed approach is highly efficient and could be used to study a wide range of phenomena in nanoscale optics and photonics. Fri, 07 Jan 2022 10:10:11 EST //www.koonmotors.com/releases/2022/01/220107101011.htm //www.koonmotors.com/releases/2021/11/211111154306.htm A massive international research effort has led to development of a genetic model for the 'ultimate' chickpea, with the potential to lift crop yields by up to 12 per cent. Thu, 11 Nov 2021 15:43:06 EST //www.koonmotors.com/releases/2021/11/211111154306.htm //www.koonmotors.com/releases/2021/10/211014141916.htm A new computational analysis suggests that, beyond the initial effect of one infected person arriving and spreading disease to a previously uninfected population, the continuous arrival of more infected individuals has a significant influence on the evolution and severity of the local outbreak. Thu, 14 Oct 2021 14:19:16 EDT //www.koonmotors.com/releases/2021/10/211014141916.htm //www.koonmotors.com/releases/2021/10/211014100204.htm An artificial intelligence (AI)-based technology rapidly diagnoses rare disorders in critically ill children with high accuracy. The benchmark finding foreshadows the next phase of medicine, where technology helps clinicians quickly determine the root cause of disease so they can give patients the right treatment sooner. Thu, 14 Oct 2021 10:02:04 EDT //www.koonmotors.com/releases/2021/10/211014100204.htm //www.koonmotors.com/releases/2021/09/210920121741.htm Scientists have launched a unique software that is able to perform highly complex simulations of a variety of biological processes. Mon, 20 Sep 2021 12:17:41 EDT //www.koonmotors.com/releases/2021/09/210920121741.htm //www.koonmotors.com/releases/2021/08/210812123103.htm Engineers have created new dynamic DNA data structures able to store and recall information in an ordered way from DNA molecules. They also analyzed how these structures are able to be interfaced with external nucleic acid computing circuits. Thu, 12 Aug 2021 12:31:03 EDT //www.koonmotors.com/releases/2021/08/210812123103.htm //www.koonmotors.com/releases/2021/07/210721172645.htm A new method could lead to more accurate predictions of how new materials behave at the atomic scale. Wed, 21 Jul 2021 17:26:45 EDT //www.koonmotors.com/releases/2021/07/210721172645.htm //www.koonmotors.com/releases/2021/06/210628152920.htm Computer scientists are sending RAMBO to rescue genomic researchers who sometimes wait days or weeks for search results from enormous DNA databases. Mon, 28 Jun 2021 15:29:20 EDT //www.koonmotors.com/releases/2021/06/210628152920.htm //www.koonmotors.com/releases/2021/05/210527145312.htm New estimates suggest that mass gatherings during an election in the Malaysian state of Sabah directly caused 70 percent of COVID-19 cases detected in Sabah after the election, and indirectly caused 64.4 percent of cases elsewhere in Malaysia. Thu, 27 May 2021 14:53:12 EDT //www.koonmotors.com/releases/2021/05/210527145312.htm //www.koonmotors.com/releases/2021/05/210526093108.htm New approaches to battle cancer have already unearthed a treasure trove of useful data -- and they're now being made available for free. Wed, 26 May 2021 09:31:08 EDT //www.koonmotors.com/releases/2021/05/210526093108.htm //www.koonmotors.com/releases/2021/05/210524092005.htm Researchers have developed a new software tool to detect, evaluate and quantify off-target editing activity, including adverse translocation events that can cause cancer. The software is based on input taken from a standard measurement assay, involving multiplexed PCR amplification and Next-Generation Sequencing (NGS). Mon, 24 May 2021 09:20:05 EDT //www.koonmotors.com/releases/2021/05/210524092005.htm //www.koonmotors.com/releases/2021/03/210323131203.htm TACC's Frontera supercomputer aids in building infection models of COVID-19 variants. Tue, 23 Mar 2021 13:12:03 EDT //www.koonmotors.com/releases/2021/03/210323131203.htm //www.koonmotors.com/releases/2021/03/210312132631.htm Scientists have developed a computer-guided design tool called IRENE, which significantly helps increase the efficiency of cell conversions by predicting highly effective combinations of cell type-specific TFs. Fri, 12 Mar 2021 13:26:31 EST //www.koonmotors.com/releases/2021/03/210312132631.htm //www.koonmotors.com/releases/2021/03/210304144832.htm Researchers have proposed a new quantitative strategy for pooling COVID-19 tests in order to monitor spread and detect outbreaks early within closed communities, such as nursing homes or universities. Thu, 04 Mar 2021 14:48:32 EST //www.koonmotors.com/releases/2021/03/210304144832.htm //www.koonmotors.com/releases/2021/02/210223164437.htm A revolutionary machine-learning (ML) approach to simulate the motions of atoms in materials such as aluminum is described. Tue, 23 Feb 2021 16:44:37 EST //www.koonmotors.com/releases/2021/02/210223164437.htm //www.koonmotors.com/releases/2021/02/210218151102.htm Researchers have developed advanced explainable artificial intelligence (AI) in a technical tour de force to decipher regulatory instructions encoded in DNA. Thu, 18 Feb 2021 15:11:02 EST //www.koonmotors.com/releases/2021/02/210218151102.htm //www.koonmotors.com/releases/2021/02/210211144420.htm A new computational analysis suggests that people under the age of 20 are about half as susceptible to COVID-19 infection as adults, and they are less likely to infect others. Thu, 11 Feb 2021 14:44:20 EST //www.koonmotors.com/releases/2021/02/210211144420.htm //www.koonmotors.com/releases/2021/02/210210153312.htm An innovative partnership takes aim at medicine down to the individual level by applying state-of-the-art computation to medical care. Wed, 10 Feb 2021 15:33:12 EST //www.koonmotors.com/releases/2021/02/210210153312.htm //www.koonmotors.com/releases/2021/02/210209113914.htm Researchers have found that a computer algorithm developed using echocardiogram videos of the heart can predict mortality within a year. The algorithm -- an example of what is known as machine learning, or artificial intelligence (AI) -- outperformed other clinically used predictors, including pooled cohort equations and the Seattle Heart Failure score. Tue, 09 Feb 2021 11:39:14 EST //www.koonmotors.com/releases/2021/02/210209113914.htm //www.koonmotors.com/releases/2021/02/210202113722.htm Academics have established a method of turbocharging desktop PCs to give them the same capability as supercomputers worth tens of millions of pounds. Tue, 02 Feb 2021 11:37:22 EST //www.koonmotors.com/releases/2021/02/210202113722.htm //www.koonmotors.com/releases/2020/12/201231141456.htm A novel computational drug screening strategy combined with lab experiments suggest that pralatrexate, a chemotherapy medication originally developed to treat lymphoma, could potentially be repurposed to treat COVID-19. Thu, 31 Dec 2020 14:14:56 EST //www.koonmotors.com/releases/2020/12/201231141456.htm //www.koonmotors.com/releases/2020/12/201222104118.htm Atomic force microscopy (AFM) allows to obtain images and movies showing proteins at work, however with limited resolution. The developed BioAFMviewer software opens the opportunity to use the enormous amount of available high-resolution protein data to better understand experiments. Within an interactive interface with rich functionality, the BioAFMviewer computationally emulates tip-scanning of any biomolecular structure to generate simulated AFM graphics and movies. They greatly help in the interpretation of e.g., high-speed AFM observations. Tue, 22 Dec 2020 10:41:18 EST //www.koonmotors.com/releases/2020/12/201222104118.htm //www.koonmotors.com/releases/2020/10/201014114606.htm Scientist challenge scientific journals to hold computational researchers to higher standards of transparency, and call for their colleagues to share their code, models and computational environments in publications. Wed, 14 Oct 2020 11:46:06 EDT //www.koonmotors.com/releases/2020/10/201014114606.htm //www.koonmotors.com/releases/2020/10/201008142110.htm A new computational model suggests that certain mutations that block infection by the most dangerous species of malaria have not become widespread in people because of the parasite's effects on the immune system. Thu, 08 Oct 2020 14:21:10 EDT //www.koonmotors.com/releases/2020/10/201008142110.htm //www.koonmotors.com/releases/2020/09/200929123544.htm Researchers have developed the app 'Genopo' that can analyze the coronavirus genome on a portable Android device. Tue, 29 Sep 2020 12:35:44 EDT //www.koonmotors.com/releases/2020/09/200929123544.htm //www.koonmotors.com/releases/2020/09/200910150302.htm Geneticists could identify the causes of disorders that currently go undiagnosed if standard practices for collecting individual genetic information were expanded to capture more variants that researchers can now decipher, concludes new research. Thu, 10 Sep 2020 15:03:02 EDT //www.koonmotors.com/releases/2020/09/200910150302.htm //www.koonmotors.com/releases/2020/09/200908113231.htm A recent study has shed new light on the Minoan system of fractions, one of the outstanding enigmas tied to the ancient writing of numbers. Tue, 08 Sep 2020 11:32:31 EDT //www.koonmotors.com/releases/2020/09/200908113231.htm //www.koonmotors.com/releases/2020/08/200825160553.htm 一个新的文章看虚拟成像技术的使用trials in effective assessment and optimization of CT and radiography acquisitions and analysis tools to help manage the coronavirus disease (COVID-19) pandemic. Tue, 25 Aug 2020 16:05:53 EDT //www.koonmotors.com/releases/2020/08/200825160553.htm //www.koonmotors.com/releases/2020/08/200806122637.htm A team of researchers have developed an algorithm through machine learning that helps predict sites of DNA methylation - a process that can change the activity of DNA without changing its overall structure - and could identify disease-causing mechanisms that would otherwise be missed by conventional screening methods. Thu, 06 Aug 2020 12:26:37 EDT //www.koonmotors.com/releases/2020/08/200806122637.htm