advertisement
Science News
from research organizations

Microbial link between Western-style diet and incidence of colorectal cancer uncovered

Date:
June 27, 2022
Source:
Brigham and Women's Hospital
Summary:
New research builds the case that a Western-style diet -- rich in red and processed meat, sugar and refined grains/carbohydrates -- is tied to higher risk of colorectal cancer through the intestinal microbiota.
Share:
advertisement

FULL STORY

New research builds the case that a Western-style diet -- rich in red and processed meat, sugar and refined grains/carbohydrates -- is tied to higher risk of colorectal cancer through the intestinal microbiota.

Investigators from Brigham and Women's Hospital with collaborators looked at data from more than 134,000 participants from two U.S.-wide prospective cohort studies. The team analyzed dietary patterns as well as DNA fromEscherichia colistrains found in more than 1,000 colorectal tumors.

The team looked for bacterial strains carrying a distinct genetic island known aspolyketide synthase (pks). Pksencodes an enzyme that has been shown to cause mutations in human cells. Overall, the team found that Western diet was associated with colorectal tumors containing high amounts ofpks+ E. colibut not with tumors containing little to no amount ofpks+ E. coli.

"These findings support our hypothesis that Western-style diets increase colorectal cancer risk through its effect onpks+ E. coli," said corresponding author Shuji Ogino, MD, PhD, MS, of the Program in Molecular Pathological Epidemiology in the Department of Pathology at the Brigham. "This is the first study to link Western diet with specific pathogenic bacteria in cancer. Our next question is which component of western-style diet and lifestyle relates to colorectal cancer containing this bacterial species."

advertisement

Story Source:

Materialsprovided byBrigham and Women's Hospital.注意:内容可能被编辑风格d length.


Journal Reference:

  1. Kota Arima, Rong Zhong, Tomotaka Ugai, Melissa Zhao, Koichiro Haruki, Naohiko Akimoto, Mai Chan Lau, Kazuo Okadome, Raaj S. Mehta, Juha P. Väyrynen, Junko Kishikawa, Tyler S. Twombly, Shanshan Shi, Kenji Fujiyoshi, Keisuke Kosumi, Yoko Ogata, Hideo Baba, Fenglei Wang, Kana Wu, Mingyang Song, Xuehong Zhang, Charles S. Fuchs, Cynthia L. Sears, Walter C. Willett, Edward L. Giovannucci, Jeffrey A. Meyerhardt, Wendy S. Garrett, Curtis Huttenhower, Andrew T. Chan, Jonathan A. Nowak, Marios Giannakis, Shuji Ogino.Western-style Diet, pks Island-Carrying Escherichia coli, and Colorectal Cancer: Analyses from Two Large Prospective Cohort Studies.Gastroenterology, 2022; DOI:10.1053/j.gastro.2022.06.054

Cite This Page:

Brigham and Women's Hospital. "Microbial link between Western-style diet and incidence of colorectal cancer uncovered." ScienceDaily. ScienceDaily, 27 June 2022. .
Brigham and Women's Hospital. (2022, June 27). Microbial link between Western-style diet and incidence of colorectal cancer uncovered.ScienceDaily. Retrieved July 29, 2023 from www.koonmotors.com/releases/2022/06/220627124937.htm
Brigham and Women's Hospital. "Microbial link between Western-style diet and incidence of colorectal cancer uncovered." ScienceDaily. www.koonmotors.com/releases/2022/06/220627124937.htm (accessed July 29, 2023).

Explore More
from ScienceDaily

RELATED STORIES