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Novel AI algorithm for digital pathology analysis

The framework was able to accurately classify different lung tumors

Date:
May 23, 2022
Source:
Boston University School of Medicine
Summary:
Digital pathology is an emerging field which deals with mainly microscopy images that are derived from patient biopsies. Because of the high resolution, most of these whole slide images (WSI) have a large size, typically exceeding a gigabyte (Gb). Therefore, typical image analysis methods cannot efficiently handle them. Seeing a need, researchers developed a novel artificial intelligence (AI) algorithm based on a framework called representation learning to classify lung cancer subtype based on lung tissue images from resected tumors.
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Digital pathology is an emerging field which deals with mainly microscopy images that are derived from patient biopsies. Because of the high resolution, most of these whole slide images (WSI) have a large size, typically exceeding a gigabyte (Gb). Therefore, typical image analysis methods cannot efficiently handle them.

Seeing a need, researchers from Boston University School of Medicine (BUSM) have developed a novel artificial intelligence (AI) algorithm based on a framework called representation learning to classify lung cancer subtype based on lung tissue images from resected tumors.

"We are developing novel AI-based methods that can bring efficiency to assessing digital pathology data. Pathology practice is in the midst of a digital revolution. Computer-based methods are being developed to assist the expert pathologist. Also, in places where there is no expert, such methods and technologies can directly assist diagnosis," explains corresponding author Vijaya B. Kolachalama, PhD, FAHA, assistant professor of medicine and computer science at BUSM.

研究人员开发了一个基于视觉交易nsformer for digital pathology called Graph Transformer (GTP) that leverages a graph representation of pathology images and the computational efficiency of transformer architectures to perform analysis on the whole slide image.

"Translating the latest advances in computer science to digital pathology is not straightforward and there is a need to build AI methods that can exclusively tackle the problems in digital pathology," explains co-corresponding author Jennifer Beane, PhD, associate professor of medicine at BUSM.

Using whole slide images and clinical data from three publicly available national cohorts, they then developed a model that could distinguish between lung adenocarcinoma, lung squamous cell carcinoma, and adjacent non-cancerous tissue. Over a series of studies and sensitivity analyses, they showed that their GTP framework outperforms current state-of-the-art methods used for whole slide image classification.

They believe their machine learning framework has implications beyond digital pathology. "Researchers who are interested in the development of computer vision approaches for other real-world applications can also find our approach to be useful," they added.

These findings appear online in the journalIEEE Transactions on Medical Imaging.

Funding for this study was provided by grants from the National Institutes of Health (R21-CA253498, R01-HL159620), Johnson & Johnson Enterprise Innovation, Inc., the American Heart Association (20SFRN35460031), the Karen Toffler Charitable Trust, and the National Science Foundation (1551572, 1838193)

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Story Source:

Materialsprovided byBoston University School of Medicine.注意:内容可能被编辑风格d length.


Journal Reference:

  1. Yi Zheng, Rushin H. Gindra, Emily J. Green, Eric J. Burks, Margrit Betke, Jennifer E. Beane, Vijaya B. Kolachalama.A graph-transformer for whole slide image classification.IEEE Transactions on Medical Imaging, 2022; 1 DOI:10.1109/TMI.2022.3176598

Cite This Page:

Boston University School of Medicine. "Novel AI algorithm for digital pathology analysis: The framework was able to accurately classify different lung tumors." ScienceDaily. ScienceDaily, 23 May 2022. /releases/2022/05/220523115527.htm>.
Boston University School of Medicine. (2022, May 23). Novel AI algorithm for digital pathology analysis: The framework was able to accurately classify different lung tumors.ScienceDaily. Retrieved August 15, 2023 from www.koonmotors.com/releases/2022/05/220523115527.htm
Boston University School of Medicine. "Novel AI algorithm for digital pathology analysis: The framework was able to accurately classify different lung tumors." ScienceDaily. www.koonmotors.com/releases/2022/05/220523115527.htm (accessed August 15, 2023).

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