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Scientists use machine learning to identify antibiotic resistant bacteria that can spread between animals, humans and the environment

Date:
April 21, 2022
Source:
University of Nottingham
Summary:
Experts have developed a ground-breaking software, which combines DNA sequencing and machine learning to help them find where, and to what extent, antibiotic resistant bacteria is being transmitted between humans, animals and the environment.
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Experts from the University of Nottingham have developed a ground-breaking software, which combines DNA sequencing and machine learning to help them find where, and to what extent, antibiotic resistant bacteria is being transmitted between humans, animals and the environment.

The study, which is published inPLOS Computational Biology, was led by Dr Tania Dottorini from the School of Veterinary Medicine and Science at the University.

Anthropogenic environments (spaces created by humans), such as areas of intensive livestock farming, are seen as ideal breeding grounds for antimicrobial-resistant bacteria and antimicrobial resistant genes, which are capable of infecting humans and carrying resistance to drugs used in human medicine. This can have huge implications for how certain illnesses and infections can be treated effectively.

China has a large intensive livestock farming industry, poultry being the second most important source of meat in the country, and is the largest user of antibiotics for food production in the world.

In this new study, a team of experts looked at a large scale commercial poultry farm in China, and collected 154 samples from animals, carcasses, workers and their households and environments. From the samples, they isolated a specific bacteria calledEscherichia coli (E. coli).These bacteria can live quite harmlessly in a person's gut, but can also be pathogenic, and genome carry resistance genes against certain drugs, which can result in illness including severe stomach cramps, diarrhea and vomiting.

Researchers used a computational approach that integrates machine learning, whole genome sequencing, gene sharing networks and mobile genetic elements, to characterise the different types of pathogens found in the farm. They found that antimicrobial genes (genes conferring resistance to the antibiotics) were present in both pathogenic and non-pathogenic bacteria.

The new approach, using machine learning, enabled the team to uncover an entire network of genes associated with antimicrobial resistance, shared across animals, farm workers and the environment around them. Notably, this network included genes known to cause antibiotic resistance as well as yet unknown genes associated to antibiotic resistance.

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Dr Dottorini said: "We cannot say at this stage where the bacteria originated from, we can only say we found it and it has been shared between animals and humans. As we already know there has been sharing, this is worrying, because people can acquire resistances to drugs from two different ways -- from direct contact with an animal, or indirectly by eating contaminated meat. This could be a particular problem in poultry farming, as it is the most widely used meat in the world.

"The computational tools that we have developed will enable us to analyse large complex data from different sources, at the same time as identifying where hotspots for certain bacteria may be. They are fast, they are precise and they can be applied on large environments -- for instance -- multiple farms at the same time.

"There are many antimicrobial resistant genes we already know about, but how do we go beyond these and unravel new targets to design new drugs?

"Our approach, using machine learning, opens up new possibilities for the development of fast, affordable and effective computational methods that can provide new insights into the epidemiology of antimicrobial resistance in livestock farming."

这项研究是在与教授合作完成的sor Junshi Chen, Professor Fengqin Li and Professor Zixin Peng from China National Center for Food Safety Risk Assessment (CFSA).

Story Source:

Materialsprovided byUniversity of Nottingham.注意:内容可能被编辑风格d length.


Journal Reference:

  1. Zixin Peng, Alexandre Maciel-Guerra, Michelle Baker, Xibin Zhang, Yue Hu, Wei Wang, Jia Rong, Jing Zhang, Ning Xue, Paul Barrow, David Renney, Dov Stekel, Paul Williams, Longhai Liu, Junshi Chen, Fengqin Li, Tania Dottorini.Whole-genome sequencing and gene sharing network analysis powered by machine learning identifies antibiotic resistance sharing between animals, humans and environment in livestock farming.PLOS Computational Biology, 2022; 18 (3): e1010018 DOI:10.1371/journal.pcbi.1010018

Cite This Page:

University of Nottingham. "Scientists use machine learning to identify antibiotic resistant bacteria that can spread between animals, humans and the environment." ScienceDaily. ScienceDaily, 21 April 2022. /releases/2022/04/220421094046.htm>.
University of Nottingham. (2022, April 21). Scientists use machine learning to identify antibiotic resistant bacteria that can spread between animals, humans and the environment.ScienceDaily. Retrieved September 6, 2023 from www.koonmotors.com/releases/2022/04/220421094046.htm
University of Nottingham. "Scientists use machine learning to identify antibiotic resistant bacteria that can spread between animals, humans and the environment." ScienceDaily. www.koonmotors.com/releases/2022/04/220421094046.htm (accessed September 6, 2023).

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