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Cutibacterium acnes, a bacteria that is known to cause acne, is also widely spread on people with healthy skin. Recent advances in gene sequencing have shown that differences in the genetic background between strains of bacteria may lead to differing roles in the skin. A new study, done without animal (mammal) testing, shows that the nonpathogenic strain ofC. acnesimproves the skin's resistance against the infection-causing bacteriaStaphylococcus aureus.
The report appears inMicrobiology Spectrumof the American Society for Microbiology.
"It is likely thatC. acnesmaintains skin health by inhibiting common pathogens likeS. aureusfrom invading skin tissue," said lead author Ayano Tsuru, a graduate student at the Graduate School of Human Life Science, Osaka City University. "Instead of using mammals, we explored this withCaenorhabditis elegans,a 1mm nematode that has basic animal parts like a nervous system, muscles, and digestive tract, as well as a body surface barrier equivalent to human skin."
In this joint study between the Osaka City University and Okayama University, researchers usedC. elegansto investigate the biological effects of several strains ofC. acnesisolated from human skin.
Results showed that ribotype (RT) 4 and 8 strains, a classification of bacteria strains based on polymorphisms in rRNA, which are often detected in the skin of individuals suffering from acne, shortened the lifespan of the nematode, while RT6 strains that are often found in the skin of people without acne, did not.
"This means that," explains supporting author Yumi Hamazaki also a graduate student at the OCU Graduate School of Human Life Science, "ribotype strains ofC. acnesthat cause acne in humans correlated with virulence, or a shortening theC. eleganslifespan."
The team further clarified this finding by investigating the effect of healthy skin-associated strains ofC. acneson the nematode's susceptibility toS. aureus. Results showed the survival period of nematodes infected with the pathogen to be longer than the control group.
Also, RNA sequencing analysis of changes in the gene expression revealed that strains ofC. acnesbehind healthy skin activated a group of genes related to innate immunity and biological defense responses inC. elegans. "Further analysis of nematode gene mutants" states Professor Shuta Tomida of the Center for Comprehensive Genomic Medicine at Okayama University Hospital, "suggests this resistance toS. aureus是由TIR-1和p38 MAPK通路re responsible for innate immunity and not by suppressing the growth of theS. aureuspathogen.
The implications of this study are wide and exciting.
By focusing on ribotypes related to the absence of acne, this study revealed there are beneficial aspects of acne bacteria, which have had a generally negative image.
As advisor to the study, Eriko Kage-Nakadai, professor at the OCU Graduate School of Human Life Science puts it, "this reminds us that when evaluating the biological effects of certain bacteria, there is a need for a discussion at the strain level. Also," the professor continues, "the fact that we succeeded in detecting the effects of skin indigenous bacteria usingC. elegansillustrates the usefulness of this nematode as an alternative model in the field of epidemiology."
Lastly, in the landscape of probiotic research currently dominated by bifidobacteria and lactobacillus, the team is excited at the expectation that this study may lead to the application of healthy skin-related strains ofC. acnesas a "non-drinking probiotic."
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