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Microbes turn back the clock as research discovers their potential to reverse aging in the brain

Date:
August 9, 2021
Source:
University College Cork
Summary:
Research introduces a novel approach to reverse aspects of aging-related deterioration in the brain and cognitive function via the microbes in the gut.
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Research from APC Microbiome Ireland (APC) at University College Cork (UCC) published today in the leading international scientific journalNature Agingintroduces a novel approach to reverse aspects of aging-related deterioration in the brain and cognitive function via the microbes in the gut.

As our population ages one of the key global challenges is to develop strategies to maintain healthy brain function. This ground-breaking research opens up a potentially new therapeutic avenues in the form of microbial-based interventions to slow down brain aging and associated cognitive problems.

The work was carried out by researchers in the Brain-Gut-Microbiota lab in APC led by Prof John F. Cryan, Vice President for Research & Innovation, University College Cork as well as a Principal Investigator at APC Microbiome Ireland an SFI Research Centre, based in in University College Cork and Teagasc Moorepark.

There is a growing appreciation of the importance of the microbes in the gut on all aspects of physiology and medicine. In this latest mouse study the authors show that by transplanting microbes from young into old animals they could rejuvenate aspects of brain and immune function. Prof John F. Cryan, says "Previous research published by the APC and other groups internationally has shown that the gut microbiome plays a key role in aging and the aging process. This new research is a potential game changer , as we have established that the microbiome can be harnessed to reverse age-related brain deterioration. We also see evidence of improved learning ability and cognitive function." Although very exciting Cryan cautions that "it is still early days and much more work is needed to see how these findings could be translated in humans."

APC Director Prof Paul Ross stated that "This research of Prof. Cryan and colleagues further demonstrates the importance of the gut microbiome in many aspects of health, and particularly across across the brain/gut axis where brain functioning can be positively influenced. The study opens up possibilities in the future to modulate gut microbiota as a therapeutic target to influence brain health" The study was led by co-first authors Dr Marcus Boehme along with PhD students Katherine E. Guzzetta, and Thomaz Bastiaansen.

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Materialsprovided byUniversity College Cork.注意:内容可能被编辑风格d length.


Journal Reference:

  1. Marcus Boehme, Katherine E. Guzzetta, Thomaz F. S. Bastiaanssen, Marcel van de Wouw, Gerard M. Moloney, Andreu Gual-Grau, Simon Spichak, Loreto Olavarría-Ramírez, Patrick Fitzgerald, Enrique Morillas, Nathaniel L. Ritz, Minal Jaggar, Caitlin S. M. Cowan, Fiona Crispie, Francisco Donoso, Evelyn Halitzki, Marta C. Neto, Marzia Sichetti, Anna V. Golubeva, Rachel S. Fitzgerald, Marcus J. Claesson, Paul D. Cotter, Olivia F. O’Leary, Timothy G. Dinan, John F. Cryan.Microbiota from young mice counteracts selective age-associated behavioral deficits.Nature Aging, 2021; DOI:10.1038/s43587-021-00093-9

Cite This Page:

University College Cork. "Microbes turn back the clock as research discovers their potential to reverse aging in the brain." ScienceDaily. ScienceDaily, 9 August 2021. /releases/2021/08/210809122202.htm>.
University College Cork. (2021, August 9). Microbes turn back the clock as research discovers their potential to reverse aging in the brain.ScienceDaily. Retrieved August 19, 2023 from www.koonmotors.com/releases/2021/08/210809122202.htm
University College Cork. "Microbes turn back the clock as research discovers their potential to reverse aging in the brain." ScienceDaily. www.koonmotors.com/releases/2021/08/210809122202.htm (accessed August 19, 2023).

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