Published inEClinical Medicine, results from the first licenced English stool bank, which supplies FMT treatment to patients in the NHS, have shown that in 78% of cases the patient's diarrhea had stopped and had not returned in the 90 days after treatment.

Antibiotics can be effective in treating the first episode ofC.diff. However, 10-20% of patients don't respond and the infection then recurs. Success rates of antibiotics in relapsing infection can be as low as 30%.

C.diffinfections result from the good gut bacteria being killed by antibiotics given for other infections and causes severe diarrhea, abdominal pain and may be fatal in elderly patients.

During FMT, the good bacteria in the faeces of a healthy donor are transferred to the gut of a patient with the infection.

The Microbiome Treatment Centre at the University of Birmingham is the first in the UK to be licenced for FMT preparation by the Medicines and Healthcare products Regulatory Agency (MHRA), supplying NHS patients across the country.

Before the dedicated centre was set up, many patients across the UK were unable to access this treatment.

Scientific studies have demonstrated that FMT treatment is better than treatment with special expensive antibiotics forC.diffinfections, particularly when the patient's infection has come back again.

The development of a licenced FMT service at the University of Birmingham will widen the supply and improve equality of access to FMT treatment across the NHS. It will provide critical support for researchers both here in Birmingham and in other centres working on how FMT produces a cure not only inC.diffinfection but also conditions such as ulcerative colitis and other diseases which seem to be linked to the gut microbiome.

Lead author Dr Victoria McCune, Consultant Clinical Scientist in Microbiology at South Tees Hospital NHS Foundation Trust, said:

"Our research has successfully shown the benefits of treating recurrentC.diffpatients with FMT. Our standardised approach to making FMT will improve the quality and safety of this treatment for many more patients."

Professor Peter Hawkey, Professor of Clinical and Public Health Bacteriology at the University of Birmingham's Institute of Microbiology and Infection, said:

"This work has turned an unregulated potentially dangerous method of faecal transplantation into a national service providing rapid, safe regulated, life-saving treatment for a serious disease affecting thousands of patients in the UK."