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Insights on the effects of cannabidiol on severe form of epilepsy

Date:
November 7, 2019
Source:
Wiley
Summary:
New results may help explain why cannabidiol -- a chemical component of marijuana with no psychoactive properties -- reduces the frequency of seizures in patients with a severe form of epilepsy.
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完整的故事

Results from a study published in theBritish Journal of Clinical Pharmacologymay help explain why cannabidiol -- a chemical component of marijuana with no psychoactive properties -- reduces the frequency of seizures in patients with a severe form of epilepsy. The effect may be explained by a drug-drug interaction between cannabidiol and the anti-seizure medication clobazam.

The form of epilepsy examined in the study is called Lennox-Gastaut syndrome. Investigators conducted clinical trial simulations for the effect of 20 mg/kg/day cannabidiol on seizure frequency in patients with this syndrome.

"The effects of cannabidiol on seizure frequency in Lennox-Gastaut patients could be explained entirely through estimated elevations of blood levels of clobazam, which might mean that cannabidiol in itself may not have any, or at best limited, antiepileptic effects," said senior author Geert Jan Groeneveld, MD, PhD, of the Centre for Human Drug Research, in The Netherlands.

Dr. Groeneveld also co-authored an accompanying editorial that highlights some of the shortcomings of past clinical trial analyses on cannabidiol's effectiveness for reducing seizures.

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Story Source:

Materialsprovided byWiley.注意:内容可能被编辑风格d length.


Journal Reference:

  1. Kirsten Riber Bergmann, Karen Broekhuizen, Geert Jan Groeneveld.Clinical trial simulations of the interaction between cannabidiol and clobazam and effect on drop‐seizure frequency.British Journal of Clinical Pharmacology, 2019; DOI:10.1111/bcp.14158

Cite This Page:

Wiley. "Insights on the effects of cannabidiol on severe form of epilepsy." ScienceDaily. ScienceDaily, 7 November 2019. .
Wiley. (2019, November 7). Insights on the effects of cannabidiol on severe form of epilepsy.ScienceDaily. Retrieved June 29, 2023 from www.koonmotors.com/releases/2019/11/191107160632.htm
Wiley. "Insights on the effects of cannabidiol on severe form of epilepsy." ScienceDaily. www.koonmotors.com/releases/2019/11/191107160632.htm (accessed June 29, 2023).

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