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Young plasma restores aged livers

Date:
November 1, 2018
Source:
Federation of American Societies for Experimental Biology
Summary:
A recent study has examined the effect of young plasma on aged livers, and livers' sensitivity to ischemia reperfusion injury (IRI) in experimental animals. IRI occurs when blood flow to an organ is temporarily interrupted, and can be a serious postoperative complication of liver resection and transplantation, especially among elderly patients.
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A recent study published inThe FASEB Journalexamined the effect of young plasma on aged livers, and livers' sensitivity to ischemia reperfusion injury (IRI) in experimental animals. IRI occurs when blood flow to an organ is temporarily interrupted, and can be a serious postoperative complication of liver resection and transplantation, especially among elderly patients.

Recent studies suggest that blood from young animals has therapeutic potential to prevent age-related phenomena, including liver damage. To test this theory, Liu and colleagues examined three groups of rats.

The first was pretreated with injections of young animal-derived plasma, while the second was pretreated with plasma from old animals. The third group served as the control. The three groups were then exposed to ischemia reperfusion in the liver. The researchers observed less liver injury in the first group than the others, demonstrating that young plasma has a protective effect that reduces injury under ischemia reperfusion.

"Reducing IRI is of paramount importance, especially for older populations," stated Anding Liu, MD, PhD, a researcher at the Experimental Medicine Center, Tongji Hospital, Tongji Medical College, within the Huazhong University of Science and Technology in Wuhan, China. "This study suggests the exciting concept that rejuvenating factors in young plasma may be the key to maintaining long-lasting health."

"The notion of mammalian, age-dependent blood-borne factors that can confer trans-acting protections or ameliorations of various kinds is over a century old, and often controversial, but here we have a clear, welcome case," said Thoru Pederson, PhD, Editor-in-Chief of The FASEB Journal.

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Materials provided byFederation of American Societies for Experimental Biology.注意:内容可能被编辑风格d length.


Journal Reference:

  1. Anding Liu, Jiankun Yang, Qi Hu, Olaf Dirsch, Uta Dahmen, Cuntai Zhang, David A. Gewirtz, Haoshu Fang, Jian Sun.Young plasma attenuates age-dependent liver ischemia reperfusion injury.The FASEB Journal, 2018; fj.201801234R DOI:10.1096/fj.201801234R

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Federation of American Societies for Experimental Biology. "Young plasma restores aged livers." ScienceDaily. ScienceDaily, 1 November 2018. /releases/2018/11/181101142905.htm>.
Federation of American Societies for Experimental Biology. (2018, November 1). Young plasma restores aged livers.ScienceDaily. Retrieved September 6, 2023 from www.koonmotors.com/releases/2018/11/181101142905.htm
Federation of American Societies for Experimental Biology. "Young plasma restores aged livers." ScienceDaily. www.koonmotors.com/releases/2018/11/181101142905.htm (accessed September 6, 2023).

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