Researchers are increasingly exploring the effects of exercise in various clinical populations, but little attention is being focused on the neural mechanisms that underlie positive changes in mobility and cognition. Using this conceptual framework will enable scientists to systematically examine the effects of exercise on brain connectivity, brain structure, and molecular/cellular mechanisms in the population with MS, and develop new strategies for rehabilitative care.

"Many individuals with MS develop disabling deficits in mobility and cognition," said John DeLuca, PhD, senior VP of Research and Training at Kessler Foundation, and a co-author of the article. "Exercise is a low-cost, non-invasive modality that relieves both types of symptoms," noted Dr. DeLuca, "so we are very interested in learning more about how activity results in these improvements. Rethinking how we view exercise in our plans for the long-term management of people with MS and other neurological conditions is our first step. We anticipate that use of the PRIMERS framework will accelerate advances in treatment by integrating the contributions from neuroscience, neurophysiology, and neurorehabilitation," Dr. DeLuca concluded.