//www.koonmotors.com/news/plants_animals/epigenetics/ Read the latest research news on epigenetics, epigenetic influences on disease risk and gene silencing. en-us Sun, 22 Oct 2023 12:53:12 EDT Sun, 22 Oct 2023 12:53:12 EDT 60 //www.koonmotors.com/images/scidaily-logo-rss.png//www.koonmotors.com/news/plants_animals/epigenetics/ For more science news, visit ScienceDaily. //www.koonmotors.com/releases/2023/10/231009191631.htm Researchers have unveiled a new mechanism for regulating mitochondrial function. The findings reveal the critical role played by the enzymatic activity of the lysine acetyltransferase MOF in maintaining mitochondrial integrity and function through acetylation of mitochondrial electron transport chain component COX17. Cells lacking MOF-mediated COX17 acetylation exhibit dramatic mitochondrial defects and impaired ability to produce energy. Underscoring the clinical relevance of these findings, the team also showed that cells from human patients with a developmental disorder caused by mutations in MOF also exhibited respiratory defects that could be ameliorated by interventions such as acetylation-mimetic COX17 or mitochondrially targeted MOF. Mon, 09 Oct 2023 19:16:31 EDT //www.koonmotors.com/releases/2023/10/231009191631.htm //www.koonmotors.com/releases/2023/09/230929131649.htm Recent discoveries in the field of epigenetics, the study of inheritance of traits that occur without changing the DNA sequence, have shown that chronological age in mammals correlates with epigenetic changes that accumulate during the lifetime of an individual. In humans, this observation has led to the development of epigenetic clocks, which are now extensively used as biomarkers of aging. While these clocks work accurately from birth until death, they are set back to zero in each new generation. Now, an international team shows that epigenetic clocks not only exist in plants, but that these clocks keep ticking accurately over many generations. Fri, 29 Sep 2023 13:16:49 EDT //www.koonmotors.com/releases/2023/09/230929131649.htm //www.koonmotors.com/releases/2023/09/230906161820.htm Scientists have identified a key part of a mechanism that annotates genetic information before it is passed from fathers to their offspring. The findings shed new light on genomic imprinting, a fundamental, biological process in which a gene from one parent is switched off while the copy from the other parent remains active. Errors in imprinting are linked to a host of diseases, such as the rare disease Silver-Russell syndrome along with certain cancers and diabetes. Wed, 06 Sep 2023 16:18:20 EDT //www.koonmotors.com/releases/2023/09/230906161820.htm //www.koonmotors.com/releases/2023/08/230824120153.htm A bitter taste in the mouth is often a symptom or side effect of illness, which may be the result of how the body reacts to pathogens. A new study sheds light on the mechanisms involved in the complex interplay between taste perception and immune function. Their work also highlights the potential of a sequencing tool for investigating epigenetic mechanisms that affect taste-cell gene expression. Thu, 24 Aug 2023 12:01:53 EDT //www.koonmotors.com/releases/2023/08/230824120153.htm //www.koonmotors.com/releases/2023/08/230810141041.htm An international research team details changes in DNA that researchers found are shared by humans and other mammals throughout history and are associated with life span and numerous other traits. Thu, 10 Aug 2023 14:10:41 EDT //www.koonmotors.com/releases/2023/08/230810141041.htm //www.koonmotors.com/releases/2023/03/230301120825.htm A major new study reveals a 'traffic light' mechanism controlling genetic activity within cells -- a system which could potentially be targeted by cancer drugs already in development. The research describes how 'epigenetic' changes to the structure of DNA can act as a stop-go signal in determining whether a gene should be read. Unlike our genetic make-up, which is well understood, the world of epigenetics is still largely unexplored and referred to as the 'dark matter' of the genome. Wed, 01 Mar 2023 12:08:25 EST //www.koonmotors.com/releases/2023/03/230301120825.htm //www.koonmotors.com/releases/2023/01/230112113203.htm More than 2,500 genes exhibit significant sex differences in expression in mouse alveolar type II cells (AT2s), important for keeping the lungs functioning, potentially explaining sex biases in the prevalence and severity of lung diseases. In particular, very high numbers of X-linked genes escape transcriptional silencing in lung alveolar type 2 (AT2s) cells, researchers report. Thu, 12 Jan 2023 11:32:03 EST //www.koonmotors.com/releases/2023/01/230112113203.htm //www.koonmotors.com/releases/2022/11/221104165402.htm The gene-silencing complex HUSH might be involved in complex disorders affecting the brain and neurons. However, its mechanism of action remains unclear. Researchers now uncover the in vivo targets and physiological functions of a component of the HUSH gene-silencing complex and one of its associated proteins. The work, conducted in laboratory mouse models and human brain organoids, links the HUSH complex to normal brain development, neuronal individuality and connectivity, as well as mouse behavior. Fri, 04 Nov 2022 16:54:02 EDT //www.koonmotors.com/releases/2022/11/221104165402.htm //www.koonmotors.com/releases/2022/11/221102110319.htm Toxicologists have found that the protein p53 continuously protects our cells from tumorigenesis by coordinating important metabolic processes that stabilize their genomes. Wed, 02 Nov 2022 11:03:19 EDT //www.koonmotors.com/releases/2022/11/221102110319.htm //www.koonmotors.com/releases/2022/10/221004134356.htm Researchers describe how different types of repetitive DNA elements are controlled by the same silencing mechanism in fruit fly ovaries. Central to their findings is an uncharacterized protein that the researchers named 'Kipferl', which ensures the effective control of jumping genes. The findings suggest that different selfish elements compete for the host genome defense system and that Kipferl might be the first of a series of similarly acting molecules yet to be uncovered. Tue, 04 Oct 2022 13:43:56 EDT //www.koonmotors.com/releases/2022/10/221004134356.htm //www.koonmotors.com/releases/2022/09/220926200451.htm Changing the epigenetic marks on chromosomes leads to altered gene expression in offspring and in grandoffspring, demonstrating 'transgenerational epigenetic inheritance.' Without altering the genetic code in the DNA, epigenetic modifications can change how genes are expressed, affecting an organism's health and development. The once radical idea that such changes in gene expression can be inherited now has a growing body of evidence behind it, but the mechanisms involved remain poorly understood. Mon, 26 Sep 2022 20:04:51 EDT //www.koonmotors.com/releases/2022/09/220926200451.htm //www.koonmotors.com/releases/2022/08/220831095004.htm Changes known as epigenetic modifications play an important role in cancer development, among other things. Being able to analyze them quickly and reliably could, for example, contribute significantly to the further development of personalized therapy. A research team has now succeeded in characterizing the chemical changes in proteins that are typical for epigenetic modifications using nanopore analysis. Wed, 31 Aug 2022 09:50:04 EDT //www.koonmotors.com/releases/2022/08/220831095004.htm //www.koonmotors.com/releases/2022/08/220811142958.htm 一个基本发现司机的健康development in embryos could rewrite our understanding of what can be inherited from our parents and how their life experiences may shape us. Thu, 11 Aug 2022 14:29:58 EDT //www.koonmotors.com/releases/2022/08/220811142958.htm //www.koonmotors.com/releases/2022/05/220519115328.htm In most mammals, females have two X chromosomes and males have one X and one Y chromosome in each of their cells. To avoid a double dose of X-linked genes in females, one of the Xs is silenced early in the developmental process. This silencing is critical, yet how it happens has been relatively mysterious. Two new studies reveal more about this silencing process and insights that could improve stem cell research. Thu, 19 May 2022 11:53:28 EDT //www.koonmotors.com/releases/2022/05/220519115328.htm //www.koonmotors.com/releases/2022/05/220504153619.htm Gene editing may be a potential treatment for anxiety and alcohol use disorder in adults who were exposed to binge drinking in their adolescence, according to the results of an animal study. The researchers used a gene-editing tool called CRISPR-dCas9 in their experiments to manipulate the histone acetylation and methylation processes at the Arc gene in models of adult rats. Wed, 04 May 2022 15:36:19 EDT //www.koonmotors.com/releases/2022/05/220504153619.htm //www.koonmotors.com/releases/2022/04/220427171428.htm Researchers have discovered a gene responsible for prenatal death when critical epigenetic instructions are missing from egg cells. The study shows that in mice, failed epigenetic suppression of an X-chromosome gene called Xist leads to miscarriage and developmental abnormalities. Forced suppression of maternal Xist rescued the failed miscarriages. Wed, 27 Apr 2022 17:14:28 EDT //www.koonmotors.com/releases/2022/04/220427171428.htm //www.koonmotors.com/releases/2022/04/220418094008.htm Researchers have found that heterozygous loss of the methyl-CpG binding protein Zbtb38 downregulated the expression of the transcription factors Nanog and Sox2, as well as genes involved in epiblast proliferation, differentiation, and viability. This finding highlights the methyl-CpG binding protein's physiological significance throughout embryonic development. Mon, 18 Apr 2022 09:40:08 EDT //www.koonmotors.com/releases/2022/04/220418094008.htm //www.koonmotors.com/releases/2022/04/220405084554.htm Researchers have revealed how an 'accordion effect' is critical to switching off genes, in a study that transforms the fundamentals of what we know about gene silencing. The finding expands our understanding of how we switch genes on and off to make the different cell types in our bodies, as we develop in the womb. Tue, 05 Apr 2022 08:45:54 EDT //www.koonmotors.com/releases/2022/04/220405084554.htm //www.koonmotors.com/releases/2022/04/220401122200.htm How is the activity of genes regulated by the packaging of DNA? To answer this question, researchers developed a technique to measure both gene expression and DNA packaging at the same time. Fri, 01 Apr 2022 12:22:00 EDT //www.koonmotors.com/releases/2022/04/220401122200.htm //www.koonmotors.com/releases/2022/03/220310115124.htm Animals often use highly specific signals to warn their herd about approaching predators. Surprisingly, similar behaviors are also observed among plants. Shedding more light on this phenomenon, researchers have discovered one such mechanism. Using Arabidopsis thaliana as a model system, the researchers have shown that herbivore-damaged plants give off volatile chemical 'scents' that trigger epigenetic modifications in the defense genes of neighboring plants. These genes subsequently trigger anti-herbivore defense systems. Thu, 10 Mar 2022 11:51:24 EST //www.koonmotors.com/releases/2022/03/220310115124.htm //www.koonmotors.com/releases/2022/02/220228150628.htm A multidisciplinary team has devised a new approach to 3D imaging that captures DNA methylation, a key epigenetic change associated with learning in the brain. The scientists say their proof-of-concept study in pigs will easily translate to humans, as the new method relies on standard MRI technology and biological markers already in use in human medicine. Mon, 28 Feb 2022 15:06:28 EST //www.koonmotors.com/releases/2022/02/220228150628.htm //www.koonmotors.com/releases/2022/02/220228091140.htm 在人类和其他真核生物,两个主要epigenetic marks are known. A team has discovered a third, novel epigenetic mark -- one formerly known only in bacteria -- in bdelloid rotifers, small freshwater animals. Epigenetic marks are modifications to DNA bases that don't change the underlying genetic code, but 'write' extra information on top of it that can be inherited along with your genome. Mon, 28 Feb 2022 09:11:40 EST //www.koonmotors.com/releases/2022/02/220228091140.htm //www.koonmotors.com/releases/2022/02/220210084939.htm A new study has shown that the effects of pollutants can be transmitted over many generations in water fleas and may persist long enough to influence the evolutionary process. The research adds new evidence to the debate on whether environmental influences can cause heritable changes to an animal's biology. Thu, 10 Feb 2022 08:49:39 EST //www.koonmotors.com/releases/2022/02/220210084939.htm //www.koonmotors.com/releases/2022/02/220208113905.htm Researchers discover a 'switch' specific to transcription factors that induce the genes essential for blood vessel development in postnatal periods. Mouse models further showed that the modifiers responsible for the switch are critical for postnatal angiogenesis. Tue, 08 Feb 2022 11:39:05 EST //www.koonmotors.com/releases/2022/02/220208113905.htm //www.koonmotors.com/releases/2022/01/220112121540.htm Hereditary diseases as well as cancers and cardiovascular diseases may be associated with a phenomenon known as genomic imprinting, in which only the maternally or paternally inherited gene is active. An international research team has now investigated the mechanisms responsible for the deactivation of the genes. Wed, 12 Jan 2022 12:15:40 EST //www.koonmotors.com/releases/2022/01/220112121540.htm //www.koonmotors.com/releases/2022/01/220111091353.htm A team has shown that the CLASSY gene family regulates which parts of the genome are turned off in a tissue-specific manner. The work identifies the CLSY genes as major factors underlying epigenetic diversity in plant tissues. This research has broad implications for both agriculture and medicine. Tue, 11 Jan 2022 09:13:53 EST //www.koonmotors.com/releases/2022/01/220111091353.htm //www.koonmotors.com/releases/2022/01/220104095557.htm Researchers generated mice with a specific DNA sequence inverted to determine if orientation affects expression of a gene called H19. Expression can also be impacted if the surrounding DNA is altered by a process called methylation. Interestingly, methylation was only relevant when the inverted sequence was inherited from the father. When inherited from the mother, the inversion had the opposite effect on H19 expression, suggesting a more complex mechanism is at play. Tue, 04 Jan 2022 09:55:57 EST //www.koonmotors.com/releases/2022/01/220104095557.htm //www.koonmotors.com/releases/2021/07/210709094505.htm A new study provides a potential tool for unraveling the mystery of how experiences can cause inheritable changes to an animal's biology. By mating nematode worms, they produced permanent epigenetic changes that lasted for more than 300 generations. Fri, 09 Jul 2021 09:45:05 EDT //www.koonmotors.com/releases/2021/07/210709094505.htm //www.koonmotors.com/releases/2021/07/210701140953.htm Hereditary information is passed from parent to offspring in the genetic code, DNA, and epigenetically through chemically induced modifications around the DNA. New research has uncovered a mechanism which adjusts these modifications, altering the way information beyond the genetic code is passed down the generations. Thu, 01 Jul 2021 14:09:53 EDT //www.koonmotors.com/releases/2021/07/210701140953.htm //www.koonmotors.com/releases/2021/06/210628170610.htm Researchers noted a significant difference in mice from mothers that were fed a diet rich in canola oil, compared with mothers fed a diet rich in corn oil. A maternal Omega 3-rich diet affected genome-wide epigenetic landscape changes in offspring and potentially modulated gene expression patterns. Mon, 28 Jun 2021 17:06:10 EDT //www.koonmotors.com/releases/2021/06/210628170610.htm //www.koonmotors.com/releases/2021/06/210621123819.htm Biologists have discovered 71 new 'imprinted' genes in the mouse genome, a finding that takes them a step closer to unravelling some of the mysteries of epigenetics - an area of science that describes how genes are switched on (and off) in different cells, at different stages in development and adulthood. Mon, 21 Jun 2021 12:38:19 EDT //www.koonmotors.com/releases/2021/06/210621123819.htm //www.koonmotors.com/releases/2021/06/210607161237.htm Computer simulations visualize in atomic detail how DNA opens while wrapped around proteins. Mon, 07 Jun 2021 16:12:37 EDT //www.koonmotors.com/releases/2021/06/210607161237.htm //www.koonmotors.com/releases/2021/05/210520133707.htm Small chemical 'epigenetic' modifications help plants control their genes. Baby plants erase these modifications to start with a fresh genome every generation. Scientists discovered a gene responsible for reinstalling the beneficial modifications important for survival. Reinstalling these modifications on mobile genetic elements called transposons may explain the diversity of flowering plants. Thu, 20 May 2021 13:37:07 EDT //www.koonmotors.com/releases/2021/05/210520133707.htm //www.koonmotors.com/releases/2021/05/210513173539.htm B cells are the immune cells responsible for creating antibodies, and most produce antibodies in response to a pathogen or a vaccine. A small subset of B cells instead spontaneously make antibodies that perform vital housekeeping functions. Understanding how epigenetics spur these differences in such similar cells is an important fundamental question in immunology. Thu, 13 May 2021 17:35:39 EDT //www.koonmotors.com/releases/2021/05/210513173539.htm //www.koonmotors.com/releases/2021/05/210506142039.htm The cerebellum -- a part of the brain once recognized mainly for its role in coordinating movement -- underwent evolutionary changes that may have contributed to human culture, language and tool use, according to a new study. Thu, 06 May 2021 14:20:39 EDT //www.koonmotors.com/releases/2021/05/210506142039.htm //www.koonmotors.com/releases/2021/04/210416131923.htm 科学家们已经想出了如何修改CRISPRbasic architecture to extend its reach beyond the genome and into what's known as the epigenome -- proteins and small molecules that latch onto DNA and control when and where genes are switched on or off. Fri, 16 Apr 2021 13:19:23 EDT //www.koonmotors.com/releases/2021/04/210416131923.htm //www.koonmotors.com/releases/2021/04/210415114120.htm The DNA molecule is not naked in the nucleus. Instead, it is folded in a very organized way by the help of different proteins to establish a unique spatial organization of the genetic information. This 3D spatial genome organization is fundamental for the regulation of our genes and has to be established de novo by each individual during early embryogenesis. Researchers now reveal a yet unknown and critical role of the protein HP1a in the 3D genome re-organization after fertilization. The study identifies HP1a as an epigenetic regulator that is involved in establishing the global structure of the genome in the early Drosophila embryo. Thu, 15 Apr 2021 11:41:20 EDT //www.koonmotors.com/releases/2021/04/210415114120.htm //www.koonmotors.com/releases/2021/04/210412114853.htm Histones are tiny proteins that bind to DNA and hold information that can help turn on or off individual genes. Researchers have developed a technique that makes it possible to examine how different versions of histones bind to the genome in tens of thousands of individual cells simultaneously. The technique was applied to the mouse brain and can be used to study epigenetics at a single-cell level in other complex tissues. Mon, 12 Apr 2021 11:48:53 EDT //www.koonmotors.com/releases/2021/04/210412114853.htm //www.koonmotors.com/releases/2021/03/210315132128.htm All female mammals, including humans, have two X chromosomes. Normal development requires one X chromosome to be inactivated. A balance of protein clusters called cohesins is needed to alter X chromosome shape and structure, a key step in inactivation. Better understanding of X chromosome inactivation could help scientists figure out how to reverse the process, potentially leading to cures for devastating genetic disorders. Mon, 15 Mar 2021 13:21:28 EDT //www.koonmotors.com/releases/2021/03/210315132128.htm //www.koonmotors.com/releases/2021/03/210310122516.htm A massive effort to map the precise binding locations of over 400 different kinds of proteins on the yeast genome has produced the most thorough and high-resolution map of chromosome architecture and gene regulation to date. Wed, 10 Mar 2021 12:25:16 EST //www.koonmotors.com/releases/2021/03/210310122516.htm //www.koonmotors.com/releases/2021/02/210209151853.htm Rice bioengineers harness the CRISPR/Cas9 system to program histones, the support proteins that wrap up and control human DNA, to manipulate gene activation and phosphorylation. The new technology enables innovative ways to find and manipulate genes and pathways responsible for diseases. Tue, 09 Feb 2021 15:18:53 EST //www.koonmotors.com/releases/2021/02/210209151853.htm //www.koonmotors.com/releases/2020/12/201228095419.htm Biochemists have developed a new strategy for controlling the biological functions of DNA (deoxyribonucleic acid) by means of light and therefore provide a tool to investigate processes which take place in cells. Mon, 28 Dec 2020 09:54:19 EST //www.koonmotors.com/releases/2020/12/201228095419.htm //www.koonmotors.com/releases/2020/12/201221121717.htm New research shows that pesticides alter how Colorado potato beetles manage their DNA. These epigenetic changes were passed down two generations suggesting that rapid resistance to pesticides may not require beetles to evolve their genetic code. Instead they may simply use existing genes to tolerate toxins already found in potatoes. The scientists were surprised that these epigenetic changes, triggered by tiny doses of pesticide, were maintained through multiple rounds of sexual reproduction. Mon, 21 Dec 2020 12:17:17 EST //www.koonmotors.com/releases/2020/12/201221121717.htm //www.koonmotors.com/releases/2020/12/201201124115.htm Researchers have uncovered the mechanism that allows plants to pass on their 'memories' to offspring, which results in growth and developmental defects. Tue, 01 Dec 2020 12:41:15 EST //www.koonmotors.com/releases/2020/12/201201124115.htm //www.koonmotors.com/releases/2020/11/201119083925.htm These slow growing bacteria have long puzzled TB researchers with their fairly rapid resistance to antibiotics. Researchers may have been barking up the wrong tree in exploring genetics, because the answer seems to lie in the epigenetic domain. 星期四,2020年11月19日08:39:25 EST //www.koonmotors.com/releases/2020/11/201119083925.htm //www.koonmotors.com/releases/2020/09/200921111629.htm 出现的一些遗传差异between domesticated chickens and their wild ancestors, the red junglefowl, are linked to epigenetic changes, according to a new study. Scientists have discovered a small number of 'hotspots' in the DNA that control epigenetic changes at hundreds of other locations throughout the genome. Mon, 21 Sep 2020 11:16:29 EDT //www.koonmotors.com/releases/2020/09/200921111629.htm //www.koonmotors.com/releases/2020/07/200727114751.htm Researchers have discovered a molecular mechanism that explains how Epstein-Barr virus (EBV) infection alters a host's epigenome to promote tumorigenesis (the transformation of normal cells into cancer cells) in certain types of stomach cancer. The findings suggest that EBV infection plays an important role in the development of EBV-associated stomach cancers, and provide fresh insights that may lead to new therapies for stomach and other virus-related malignancies. Mon, 27 Jul 2020 11:47:51 EDT //www.koonmotors.com/releases/2020/07/200727114751.htm //www.koonmotors.com/releases/2020/07/200707134208.htm If every cell has the same genetic blueprint, why does an eye cell look and act so differently than a brain cell or skin cell? In a new study, researchers come one step closer to solving this mystery, showing RNA plays a critical role. 星期二,07年2020年7月13日:42:08 EDT //www.koonmotors.com/releases/2020/07/200707134208.htm //www.koonmotors.com/releases/2020/06/200604152046.htm Parents pass genes along to their offspring which equip them for their future life. In recent years, research has shown that the reality is much more complex and that parents endow much more than just genes. A new study reveals that active epigenetic modifications are also passed from one generation to the next. Thu, 04 Jun 2020 15:20:46 EDT //www.koonmotors.com/releases/2020/06/200604152046.htm //www.koonmotors.com/releases/2020/06/200601120032.htm Scientists have developed a tool called FloChip, a new microfluidic take on the widely used chromatin immunoprecipitation (ChIP) technique. By automating and cutting the cost of ChIP and sequential-ChIP, FloChIP has the potential to become a widely used tool for the study of chromatin biology and gene regulation. Mon, 01 Jun 2020 12:00:32 EDT //www.koonmotors.com/releases/2020/06/200601120032.htm //www.koonmotors.com/releases/2020/03/200320192747.htm The rapid pace of climate change threatens all living species. An international team of researchers has demonstrated that fish living in the Baltic Sea evolve using epigenetic mechanisms, yet to a lesser extent than previously hypothesized. Fri, 20 Mar 2020 19:27:47 EDT //www.koonmotors.com/releases/2020/03/200320192747.htm //www.koonmotors.com/releases/2020/02/200211092335.htm A team of marine biology and environmental genomics researchers have demonstrated that epigenetic modifications in reef-building corals can be transmitted from parents to their offspring. Tue, 11 Feb 2020 09:23:35 EST //www.koonmotors.com/releases/2020/02/200211092335.htm //www.koonmotors.com/releases/2020/02/200210104112.htm A study undertaken by a molecular biologist sheds new light on the mechanisms that control the establishment of epigenetic modifications on newly synthesized histones following cell division. Mon, 10 Feb 2020 10:41:12 EST //www.koonmotors.com/releases/2020/02/200210104112.htm //www.koonmotors.com/releases/2020/01/200116121837.htm A research team has discovered the first conclusive evidence that selection may also occur at the level of the epigenome -- a term that refers to an assortment of chemical 'annotations' to the genome that determine whether, when and to what extent genes are activated -- and has done so for tens of millions of years. Thu, 16 Jan 2020 12:18:37 EST //www.koonmotors.com/releases/2020/01/200116121837.htm //www.koonmotors.com/releases/2019/12/191231111840.htm Parasites in the genus Plasmodium, which cause malaria, are transmitted to humans through bites from infected mosquitoes. The parasites manage to acclimatize to these two completely different hosts because the plasticity of their genome enables them to adapt as necessary. Scientists decided to investigate the epigenetic mechanisms behind this plasticity, in particular DNA methylation. They identified molecules capable of inhibiting DNA methylation and effectively killing even the most resistant Plasmodium falciparum parasites. Tue, 31 Dec 2019 11:18:40 EST //www.koonmotors.com/releases/2019/12/191231111840.htm //www.koonmotors.com/releases/2019/12/191204145739.htm A study in mice shows for the first time that epigenetics -- the molecular mechanisms that determine which genes are turned on or off -- plays a key role in determining an individual's innate drive to exercise. Wed, 04 Dec 2019 14:57:39 EST //www.koonmotors.com/releases/2019/12/191204145739.htm //www.koonmotors.com/releases/2019/11/191127121258.htm Silencing of retroviruses in the human genome is a crucial step in the production of induced pluripotent stem cells (iPSCs) from somatic cells. Researchers led by a team from the University of Tsukuba have now identified a protein that controls retrovirus silencing, allowing the production of high quality iPSCs that could be used in applications ranging from stem cell therapy and organ regeneration to drug discovery. Wed, 27 Nov 2019 12:12:58 EST //www.koonmotors.com/releases/2019/11/191127121258.htm //www.koonmotors.com/releases/2019/11/191126140411.htm Multifunctional tool CRUP makes enhancer prediction quick and easy. Tue, 26 Nov 2019 14:04:11 EST //www.koonmotors.com/releases/2019/11/191126140411.htm //www.koonmotors.com/releases/2019/11/191122113256.htm First direct analysis of pathogenic sequence repeats in the human genome. Fri, 22 Nov 2019 11:32:56 EST //www.koonmotors.com/releases/2019/11/191122113256.htm //www.koonmotors.com/releases/2019/11/191112114003.htm Researchers discovered that a protein called CoRest, a neural repressor that is also found in humans, plays a central role in determining the social behavior of ants. The study also revealed that worker ants called Majors, known as 'brawny' soldiers that protect colonies, can be reprogrammed to perform the foraging role -- generally reserved for their sisters, the Minor ants -- up to five days after they emerge as an adult ant. Tue, 12 Nov 2019 11:40:03 EST //www.koonmotors.com/releases/2019/11/191112114003.htm