//www.koonmotors.com/news/plants_animals/developmental_biology/ Developmental Biology News. Read the latest research news on everything to do with developmental biology, from embryology to model organisms. en-us Wed, 06 Sep 2023 14:53:34 EDT Wed, 06 Sep 2023 14:53:34 EDT 60 //www.koonmotors.com/images/scidaily-logo-rss.png//www.koonmotors.com/news/plants_animals/developmental_biology/ For more science news, visit ScienceDaily. //www.koonmotors.com/releases/2023/09/230906115617.htm Biomedical scientists have confirmed that newly discovered cells in the thymus are just like M cells, which are mostly known for their presence in the intestinal epithelium. Wed, 06 Sep 2023 11:56:17 EDT //www.koonmotors.com/releases/2023/09/230906115617.htm //www.koonmotors.com/releases/2023/09/230901143610.htm When fighting disease, our immune cells need to reach their target quickly. Researchers have now discovered that immune cells actively generate their own guidance system to navigate through complex environments. This challenges earlier notions about these movements. The researchers' findings enhance our knowledge of the immune system and offer potential new approaches to improve human immune response. Fri, 01 Sep 2023 14:36:10 EDT //www.koonmotors.com/releases/2023/09/230901143610.htm //www.koonmotors.com/releases/2023/09/230901124051.htm In a new study, researchers used mice to understand how DiNP affects pregnancy. Fri, 01 Sep 2023 12:40:51 EDT //www.koonmotors.com/releases/2023/09/230901124051.htm //www.koonmotors.com/releases/2023/08/230828162349.htm Findings can open up new avenues for targeted approaches toward therapeutic strategies against the malaria-causing P. falciparum that are aimed at stopping the parasite's life cycle progression and its sexual differentiation, thus blocking the transmission of the parasite into mosquitoes. Mon, 28 Aug 2023 16:23:49 EDT //www.koonmotors.com/releases/2023/08/230828162349.htm //www.koonmotors.com/releases/2023/08/230825165925.htm Researchers have developed and demonstrated a new method for high-throughput single-cell sorting that uses stimulated Raman spectroscopy rather than the traditional approach of fluorescence-activated cell sorting. The new approach could offer a label-free, nondestructive way to sort cells for a variety of applications, including microbiology, cancer detection and cell therapy. Fri, 25 Aug 2023 16:59:25 EDT //www.koonmotors.com/releases/2023/08/230825165925.htm //www.koonmotors.com/releases/2023/08/230825140357.htm The NSL (non-specific lethal) complex regulates thousands of genes in fruit flies and mammals. Silencing the NSL genes leads to the death of the organism, which gave the complex its curious name. Researchers have now discovered that the genes regulated by the NSL complex also include genes of the intraciliary transport system. This enables different cell types to form cilia on their surface, which are important for cell communication. The study shows that these genes are 'switched on' by the NSL complex, regardless of whether a particular cell has cilia or not. The researchers found that this class of cilia-associated genes is crucial for the function of podocytes. This is a highly specialized cell type of the kidney that, paradoxically, does not have cilia. These findings have important implications for ciliopathies and kidney disease. Fri, 25 Aug 2023 14:03:57 EDT //www.koonmotors.com/releases/2023/08/230825140357.htm //www.koonmotors.com/releases/2023/08/230824120153.htm A bitter taste in the mouth is often a symptom or side effect of illness, which may be the result of how the body reacts to pathogens. A new study sheds light on the mechanisms involved in the complex interplay between taste perception and immune function. Their work also highlights the potential of a sequencing tool for investigating epigenetic mechanisms that affect taste-cell gene expression. Thu, 24 Aug 2023 12:01:53 EDT //www.koonmotors.com/releases/2023/08/230824120153.htm //www.koonmotors.com/releases/2023/08/230824111925.htm Researchers have discovered a novel approach for engrafting engineered cells into injured lung tissue. These findings may lead to new ways for treating lung diseases, such as emphysema, pulmonary fibrosis and COVID-19. The two studies describe the methodologies for engineering lung stem cells and transplanting them into injured experimental lungs without immunosuppression. Thu, 24 Aug 2023 11:19:25 EDT //www.koonmotors.com/releases/2023/08/230824111925.htm //www.koonmotors.com/releases/2023/08/230824111805.htm Researchers have discovered how proteins work in tandem to regulate 'treadmilling', a mechanism used by the network of microtubules inside cells to ensure proper cell division. Thu, 24 Aug 2023 11:18:05 EDT //www.koonmotors.com/releases/2023/08/230824111805.htm //www.koonmotors.com/releases/2023/08/230823122549.htm 调控基因,基因控制其他genes are used -- are responsible for 69% of the heritability of dairy cattle traits such as milk production and fertility, according to a new study. This contribution is 44% more than expected and much higher than previous studies of regulatory genes in humans. The findings, reported by a team of animal and human geneticists, could improve the efficiency of agricultural breeding programs. The study also helps solve the longstanding mystery of why mammalian genomes contain so much noncoding DNA. Wed, 23 Aug 2023 12:25:49 EDT //www.koonmotors.com/releases/2023/08/230823122549.htm //www.koonmotors.com/releases/2023/08/230821114415.htm Researchers model and map how neurons across the tiny brain of a C. elegans worm encode its behaviors, revealing many new insights about the robustness and flexibility of its nervous system. Mon, 21 Aug 2023 11:44:15 EDT //www.koonmotors.com/releases/2023/08/230821114415.htm //www.koonmotors.com/releases/2023/08/230821114333.htm Genetic remnants of viruses that are naturally present in the human genome could affect the development of neurodegenerative diseases. Researchers come to this conclusion on the basis of studies on cell cultures. Mon, 21 Aug 2023 11:43:33 EDT //www.koonmotors.com/releases/2023/08/230821114333.htm //www.koonmotors.com/releases/2023/08/230816114207.htm Can you recognize an old friend, but forget what you had for breakfast yesterday? Our brains constantly rearrange their circuitry to retain information, but the molecular basis behind this process isn't well understood. New research suggests that complex sugars called glycosaminoglycans might play a major role in the 'plasticity' of the brains of mice and could be used to repair neural connections after injury. Wed, 16 Aug 2023 11:42:07 EDT //www.koonmotors.com/releases/2023/08/230816114207.htm //www.koonmotors.com/releases/2023/08/230816114121.htm A new method allows large quantities of muscle stem cells to be safely obtained in cell culture. This provides a potential for treating patients with muscle diseases -- and for those who would like to eat meat, but don't want to kill animals. Wed, 16 Aug 2023 11:41:21 EDT //www.koonmotors.com/releases/2023/08/230816114121.htm //www.koonmotors.com/releases/2023/08/230816114059.htm The Noelin family of secreted proteins bind to the external portion of AMPA glutamate receptors and stabilize them on the neuronal cellular membrane, a process necessary for transmission of full-strength signals between neurons, according to a new study. Wed, 16 Aug 2023 11:40:59 EDT //www.koonmotors.com/releases/2023/08/230816114059.htm //www.koonmotors.com/releases/2023/08/230815131838.htm Researchers have developed a new algorithm for recovering the 3D refractive index distribution of biological samples that exhibit multiple types of light scattering. 星期二,15 Aug 2023 13:18:38 EDT //www.koonmotors.com/releases/2023/08/230815131838.htm //www.koonmotors.com/releases/2023/08/230814122339.htm A mathematical model provides new insights into the distribution of genetic information during bacterial cell division Mon, 14 Aug 2023 12:23:39 EDT //www.koonmotors.com/releases/2023/08/230814122339.htm //www.koonmotors.com/releases/2023/08/230810141041.htm An international research team details changes in DNA that researchers found are shared by humans and other mammals throughout history and are associated with life span and numerous other traits. Thu, 10 Aug 2023 14:10:41 EDT //www.koonmotors.com/releases/2023/08/230810141041.htm //www.koonmotors.com/releases/2023/08/230810140813.htm Creating new technologically advanced sensors, scientists have engineered bacteria that detect the presence of tumor DNA in live organisms. Their innovation could pave the way to new biosensors capable of identifying various infections, cancers and other diseases. Thu, 10 Aug 2023 14:08:13 EDT //www.koonmotors.com/releases/2023/08/230810140813.htm //www.koonmotors.com/releases/2023/08/230810110338.htm New research has successfully reversed hearing loss in mice. Scientists used a genetic approach to fix deafness in mice, restoring their hearing abilities in low and middle frequency ranges. Thu, 10 Aug 2023 11:03:38 EDT //www.koonmotors.com/releases/2023/08/230810110338.htm //www.koonmotors.com/releases/2023/08/230809164644.htm 而参与细胞分裂研究,研究ers made a surprisingly quiet discovery. When cells express RNA, there is always some fluctuation, or noise, in how much RNA is produced. The scientists found several genes whose noise dips below a previously established threshold, known as the noise floor, during expression. Wed, 09 Aug 2023 16:46:44 EDT //www.koonmotors.com/releases/2023/08/230809164644.htm //www.koonmotors.com/releases/2023/08/230808151054.htm Researchers hope that a new, publicly available database they have created will shrink, not grow, over time. That's because it is a compendium of the thousands of understudied proteins encoded by genes in the human genome, whose existence is known but whose functions are mostly not. Tue, 08 Aug 2023 15:10:54 EDT //www.koonmotors.com/releases/2023/08/230808151054.htm //www.koonmotors.com/releases/2023/08/230807164413.htm Tumor cells are known to be fickle sleeper agents, often lying dormant in distant tissues for years before reactivating and forming metastasis. Numerous factors have been studied to understand why the activation occurs, from cells and molecules to other components in the so-called tissue microenvironment. Mon, 07 Aug 2023 16:44:13 EDT //www.koonmotors.com/releases/2023/08/230807164413.htm //www.koonmotors.com/releases/2023/08/230804140508.htm Bacteria make up more than 10% of all living things but until recently we had little realization that, as in humans, soil bacteria have internal clocks that synchronize their activities with the 24-hour cycles of day and night on Earth. New research shows just how complex and sophisticated these bacterial circadian clocks are, clearing the way for an exciting new phase of study. Fri, 04 Aug 2023 14:05:08 EDT //www.koonmotors.com/releases/2023/08/230804140508.htm //www.koonmotors.com/releases/2023/08/230804123751.htm Researchers have discovered a previously unknown mechanism by which bacteria share their genetic material through virus parasites. The insights could help scientists to better understand how bacteria rapidly adapt and evolve, and how they become more virulent and resistant to antibiotics. Fri, 04 Aug 2023 12:37:51 EDT //www.koonmotors.com/releases/2023/08/230804123751.htm //www.koonmotors.com/releases/2023/08/230803141655.htm The immune regulatory protein STING has a previously unknown function: acting as an ion channel that allows protons to leak into cells. This discovery makes it the first human immune sensor that can translate danger signals into ion flow. Thu, 03 Aug 2023 14:16:55 EDT //www.koonmotors.com/releases/2023/08/230803141655.htm //www.koonmotors.com/releases/2023/08/230803132228.htm Researchers have changed the way to look at DNA. They show that DNA is much more than a linear sequence of building blocks; it has a 3D structure that influences the variation of human genome-wide mutation rates meaningfully and consistently, and this is likely conserved among species. Thu, 03 Aug 2023 13:22:28 EDT //www.koonmotors.com/releases/2023/08/230803132228.htm //www.koonmotors.com/releases/2023/08/230802105830.htm A team of scientists has made an important breakthrough in the fight against RNA viruses that cause human diseases and pandemics. Wed, 02 Aug 2023 10:58:30 EDT //www.koonmotors.com/releases/2023/08/230802105830.htm //www.koonmotors.com/releases/2023/08/230801163220.htm In a breakthrough for bioengineering, researchers have developed organoids that can model the human respiratory tract. The organoids, called AirGels, allow them to uncover the mechanism by which antibiotic-resistant pathogens like Pseudomonas aeruginosa infect the respiratory tract. Tue, 01 Aug 2023 16:32:20 EDT //www.koonmotors.com/releases/2023/08/230801163220.htm //www.koonmotors.com/releases/2023/07/230731151600.htm 研究人员发现新的细胞类型visual system of flies, made possible by their creation of a tool that finds and labels neurons during development. The study combines single-cell sequencing data with a novel algorithm to identify pairs of genes that point to previously unknown cells in the brains of fruit flies. Mon, 31 Jul 2023 15:16:00 EDT //www.koonmotors.com/releases/2023/07/230731151600.htm //www.koonmotors.com/releases/2023/07/230728113459.htm Scientists have pinpointed a genetic cause for virgin birth for the first time, and once switched on the ability is passed down through generations of females. Fri, 28 Jul 2023 11:34:59 EDT //www.koonmotors.com/releases/2023/07/230728113459.htm //www.koonmotors.com/releases/2023/07/230728113422.htm 最初,提高细胞的能量来源,mitochondria, were independent organisms. Researchers have investigated to what extent their metabolism has blended with that of their host cells in the course of evolution, using the example of a mitochondrial stress response. They have discovered that mitochondria send two different biochemical signals. These are processed together in the cell and trigger a support mechanism to restore cellular balance (homeostasis). Fri, 28 Jul 2023 11:34:22 EDT //www.koonmotors.com/releases/2023/07/230728113422.htm //www.koonmotors.com/releases/2023/07/230728113401.htm A metabolic by-product that is more prevalent during fasting may supercharge immune cells as they fight infection and disease, reports an early stage study. The findings may pave the way for future personalized dietary recommendations to augment treatments for infection, cancer and other diseases. Fri, 28 Jul 2023 11:34:01 EDT //www.koonmotors.com/releases/2023/07/230728113401.htm //www.koonmotors.com/releases/2023/07/230727143928.htm Bees and wasps have converged on the same architectural solutions to nest-building problems, according to new research. Thu, 27 Jul 2023 14:39:28 EDT //www.koonmotors.com/releases/2023/07/230727143928.htm //www.koonmotors.com/releases/2023/07/230727143923.htm In a step forward in the development of genetic medicines, researchers have developed a proof-of-concept model for delivering gene editing tools to treat blood disorders, allowing for the modification of diseased blood cells directly within the body. If translated into the clinic, this approach could expand access and reduce the cost of gene therapies for blood disorders, many of which currently require patients receive chemotherapy and a stem cell transplant. Thu, 27 Jul 2023 14:39:23 EDT //www.koonmotors.com/releases/2023/07/230727143923.htm //www.koonmotors.com/releases/2023/07/230726171309.htm What happens inside the carnivorous plant Venus Flytrap when it catches an insect? New technology has led to discoveries about the electrical signalling that causes the trap to snap shut. Bioelectronic technology enables advanced research into how plants react to their surroundings, and to stress. Wed, 26 Jul 2023 17:13:09 EDT //www.koonmotors.com/releases/2023/07/230726171309.htm //www.koonmotors.com/releases/2023/07/230726134230.htm The lifespan of a small roundworm that has been used as a key model organism in aging research is limited by how it self-sacrifices to feed its young, finds a new study. Wed, 26 Jul 2023 13:42:30 EDT //www.koonmotors.com/releases/2023/07/230726134230.htm //www.koonmotors.com/releases/2023/07/230726113046.htm The results of a novel study has revealed exciting findings in the pursuit of an HIV cure. Wed, 26 Jul 2023 11:30:46 EDT //www.koonmotors.com/releases/2023/07/230726113046.htm //www.koonmotors.com/releases/2023/07/230726113018.htm Researchers have identified a genetic sequence that is essential for plant reproduction. As this region is found in all plant species, it is expected to contribute to future crossbreeding initiatives and help solve the important problem of seed formation defects. Wed, 26 Jul 2023 11:30:18 EDT //www.koonmotors.com/releases/2023/07/230726113018.htm //www.koonmotors.com/releases/2023/07/230721113116.htm Scientists show how a fertilized egg cell, or zygote, hits 'reset' so that the newly formed embryo can develop according to its own genetic program. Fri, 21 Jul 2023 11:31:16 EDT //www.koonmotors.com/releases/2023/07/230721113116.htm //www.koonmotors.com/releases/2023/07/230720125008.htm Like us, cells communicate. Well, in their own special way. Using waves as their common language, cells tell one another where and when to move. They talk, they share information, and they work together -- much like interdisciplinary teams. Researchers conducted research on how cells communicate -- and how that matters to future projects, e.g. application to wound healing. Thu, 20 Jul 2023 12:50:08 EDT //www.koonmotors.com/releases/2023/07/230720125008.htm //www.koonmotors.com/releases/2023/07/230720124846.htm A new mRNA vaccine targeting immune cells in the liver could be the key to tackling malaria, a disease that causes over half a million deaths each year according to the World Health Organization, yet has no effective long-lasting vaccine. Thu, 20 Jul 2023 12:48:46 EDT //www.koonmotors.com/releases/2023/07/230720124846.htm //www.koonmotors.com/releases/2023/07/230719145931.htm What determines whether we become overweight? Aside from lifestyle, predisposition plays a role, but genes cannot fully explain the inherited propensity to accumulate excess weight. A new study shows that a kind of formatting of the DNA code in one gene that is associated with satiety is implicated in a slightly elevated risk of excess body weight -- at least in women. This 'epigenetic marking' is established early on during the embryonic stage. Wed, 19 Jul 2023 14:59:31 EDT //www.koonmotors.com/releases/2023/07/230719145931.htm //www.koonmotors.com/releases/2023/07/230719112618.htm The same message can be interpreted differently by different individuals -- also among cells. This is shown in a study by researchers who studied cell communication through Wnt signalling, which plays a decisive role in embryo development and cancer. Their findings are surprising in light of the prevailing conception of how Wnt signalling works. Wed, 19 Jul 2023 11:26:18 EDT //www.koonmotors.com/releases/2023/07/230719112618.htm //www.koonmotors.com/releases/2023/07/230718164256.htm Parasitic hairworms manipulate the behavior of their hosts in what's sometimes called 'mind control.' A new study reveals another strange trait shared by different hairworm species: they're missing about 30% of the genes that researchers expected them to have. What's more, the missing genes are responsible for the development of cilia, the hair-like structures present in at least some of the cells of every other animal known. 星期二,18 Jul 2023 16:42:56 EDT //www.koonmotors.com/releases/2023/07/230718164256.htm //www.koonmotors.com/releases/2023/07/230718105722.htm Researchers have found an anti-aging function in a protein deep within human cells. Researchers have discovered that a protein called ATSF-1 controls a fine balance between the creation of new mitochondria and the repair of damaged mitochondria. 星期二,18 Jul 2023 10:57:22 EDT //www.koonmotors.com/releases/2023/07/230718105722.htm //www.koonmotors.com/releases/2023/07/230718105621.htm No, oxygen didn't catalyze the swift blossoming of Earth's first multicellular organisms. The result defies a 70-year-old assumption about what caused an explosion of oceanic fauna hundreds of millions of years ago. 星期二,18 Jul 2023 10:56:21 EDT //www.koonmotors.com/releases/2023/07/230718105621.htm //www.koonmotors.com/releases/2023/07/230717175955.htm 一个研究小组公布的新发现emphasize the crucial role of the urinary and genital tract microbiota in adverse pregnancy outcomes and genomic instability that originate in the womb during fetal development. The study established a new link between genomic instability and a protein from Mycoplasma fermentans, a kind of bacterium that commonly colonizes the urogenital tract. This bacterial protein also reduced fertility in mother mice and resulted in more birth defects in their newborn pups. Mon, 17 Jul 2023 17:59:55 EDT //www.koonmotors.com/releases/2023/07/230717175955.htm //www.koonmotors.com/releases/2023/07/230717143221.htm There is news from the immune system: Dendritic cells migrate in a network along the outside of blood vessels. Local cytokines keep this dynamic network stable. Mon, 17 Jul 2023 14:32:21 EDT //www.koonmotors.com/releases/2023/07/230717143221.htm //www.koonmotors.com/releases/2023/07/230713192852.htm Scientists have discovered a previously unknown 'housekeeping' process in kidney cells that ejects unwanted content, resulting in cells that rejuvenate themselves and remain functioning and healthy. The self-renewal process, which is fundamentally different from how other bodily tissues are thought to regenerate, helps explain how, barring injury or disease, the kidneys can remain healthy for a lifetime. Thu, 13 Jul 2023 19:28:52 EDT //www.koonmotors.com/releases/2023/07/230713192852.htm //www.koonmotors.com/releases/2023/07/230712203752.htm Heliconius butterflies' brains grew as they adopted a novel foraging behavior, scientists have found. Wed, 12 Jul 2023 20:37:52 EDT //www.koonmotors.com/releases/2023/07/230712203752.htm //www.koonmotors.com/releases/2023/07/230712124629.htm Like their viral cousins, retrotransposons have been found borrowing the cell's own machinery to achieve their goals. They hijack a little-known piece of the cell's DNA repair function to close themselves into a ring-like shape and then create a matching double strand. The finding upends 40 years of conventional wisdom and may offer new insights into cancer, viral infections and immune responses. It could also offer a new way to insert sequences into the genome. Wed, 12 Jul 2023 12:46:29 EDT //www.koonmotors.com/releases/2023/07/230712124629.htm //www.koonmotors.com/releases/2023/07/230711194440.htm The inside of a living cell is crowded with large, complex molecules. New research on how these molecules could spontaneously organize themselves could further our understanding of how cells manage their essential biochemistry in the crowded space. This research may also shed light on how the first living systems appeared and how they evolved their complexities. 星期二,2023年7月11日19:44:40美国东部时间 //www.koonmotors.com/releases/2023/07/230711194440.htm //www.koonmotors.com/releases/2023/07/230711133220.htm A 'biological camera' bypasses the constraints of current DNA storage methods, harnessing living cells and their inherent biological mechanisms to encode and store data. This represents a significant breakthrough in encoding and storing images directly within DNA, creating a new model for information storage reminiscent of a digital camera. Led by Principal Investigator Associate Professor Chueh Loo Poh from the College of Design and Engineering at the National University of Singapore, and the NUS Synthetic Biology for Clinical and Technological Innovation (SynCTI), the team's findings, which could potentially shake up the data-storage industry, were published in Nature Communications on 3 July 2023. 星期二,11 Jul 2023 13:32:20 EDT //www.koonmotors.com/releases/2023/07/230711133220.htm //www.koonmotors.com/releases/2023/07/230707153836.htm Plants regenerate using pluripotent callus tissues and initiating the de novo formation of shoot apical meristem (SAM). However, the mechanisms governing the efficiency of regeneration are unclear. Now, researchers have shown that the WOX13 gene in Arabidopsis thaliana negatively regulates SAM formation from callus and promotes its non-meristematic fate. The findings demonstrate that the targeted disruption of WOX13 can significantly enhance shoot regeneration efficiency, paving the way for future biotechnological advancements. Fri, 07 Jul 2023 15:38:36 EDT //www.koonmotors.com/releases/2023/07/230707153836.htm //www.koonmotors.com/releases/2023/07/230707111632.htm Researchers found that altered B cell function in children with mitochondrial disorders led to a weaker and less diverse antibody response to viral infections. Researchers analyzed gene activity of immune cells in children with mitochondrial disorders and found that B cells, which produce antibodies to fight viral infections, are less able to survive cellular stress. Fri, 07 Jul 2023 11:16:32 EDT //www.koonmotors.com/releases/2023/07/230707111632.htm //www.koonmotors.com/releases/2023/07/230706160116.htm Researchers showed that consuming THC while pregnant could potentially affect development of the fetus and lead to life-long health impacts for offspring. Thu, 06 Jul 2023 16:01:16 EDT //www.koonmotors.com/releases/2023/07/230706160116.htm //www.koonmotors.com/releases/2023/07/230705115142.htm A study using a synthetic 'minimal cell' organism stripped down to the 'bare essentials' for life demonstrates the tenacity of organism's power to evolve and adapt, even in the face of an unnatural genome that would seemingly provide little flexibility. Wed, 05 Jul 2023 11:51:42 EDT //www.koonmotors.com/releases/2023/07/230705115142.htm //www.koonmotors.com/releases/2023/07/230703133058.htm The study combines a deep learning model with CRISPR screens to control the expression of human genes in different ways -- such as flicking a light switch to shut them off completely or by using a dimmer knob to partially turn down their activity. These precise gene controls could be used to develop new CRISPR-based therapies. Mon, 03 Jul 2023 13:30:58 EDT //www.koonmotors.com/releases/2023/07/230703133058.htm //www.koonmotors.com/releases/2023/06/230630123210.htm Insights into healing and aging by those who studied how a tiny sea creature regenerates an entire new body from only its mouth. The researchers sequenced RNA from Hydractinia symbiolongicarpus, a small, tube-shaped animal that lives on the shells of hermit crabs. Just as the Hydractinia were beginning to regenerate new bodies, the researchers detected a molecular signature associated with the biological process of aging, also known as senescence. Fri, 30 Jun 2023 12:32:10 EDT //www.koonmotors.com/releases/2023/06/230630123210.htm